Objective: To assess the secondary sex ratio (SSR) of assisted reproduction technology babies within a fertility clinic in Melbourne, Australia. Methods: A retrospective cohort study was conducted on 3369 babies who w...Objective: To assess the secondary sex ratio (SSR) of assisted reproduction technology babies within a fertility clinic in Melbourne, Australia. Methods: A retrospective cohort study was conducted on 3369 babies who were born following single embryo transfer between 2011 and 2016. Variables examined included embryo creation date, maternal and paternal ages, maternal body mass index (BMI), type of infertility, sperm parameters, fertilization method, type of embryo and stage of transfer. Multivariate regression analysis was performed on the data set using STRATA V9.2. Results: More males were found to be born to embryos created in summer (adjusted odds ratio=1.46, 95% confidence interval: 1.08-1.95;P=0.01). Lower BMI of mother (≤30 kg/m 2) and younger age of parents (≤35 years) were associated with an increase in SSR (50.1% vs. 47.1%;50.6% vs. 48.8%;50.0% vs. 48.9%) respectively. Decreased SSR value was associated with primary subfertility, using in-vitro fertilization procedure and fresh embryo compared to those with secondary subfertility, using intracytoplasmic sperm injection procedure and thawed embryo (49.3% vs. 50.6%;47.1% vs. 50.8%;49.4% vs. 50.1%) respectively. Conclusions: The fertilization methods, type of embryo, stage of embryo transfer, parameters of the sperm and status of subfertility do not significantly affect the SSR. SSR is affected by the seasonality, maternal age, and BMI.展开更多
Wavelet packet multicarrier system gains widespread concern because of its better resistance performance to Inter-Symbol Interference (ISI) and Inter-Carrier Interference (ICI), as well as the higher spectrum efficien...Wavelet packet multicarrier system gains widespread concern because of its better resistance performance to Inter-Symbol Interference (ISI) and Inter-Carrier Interference (ICI), as well as the higher spectrum efficiency. However, multicarrier system has a high Peak to Average Power Ratio (PAPR), which will lead to many problems such as lower system performance. In order to solve the problem, a kind of PAPR reduction method based on pruning Wavelet Packet Modulation (WPM) and Partial Transmit Sequences (PTS) technology is proposed in this paper, through proper pruning of the full-tree structure of wavelet packet modulation in the PTS technology to reduce the number of nodes in the system, and finally improve the reduction effect of PAPR. Simulation results show that when Complementary Cumulative Distribution Function (CCDF) is 10 -3 , PTS based on pruning WPM compared with PTS technique and pruning technique has improved about 1 dB and 1.5 dB, which will not affect the system's Bit Error Rate (BER) performance in the wavelet packet multicarrier system.展开更多
An improved STT (skid to turn) autopilot was developed to solve the problem of roll control saturation for the gliding missile with large aspect ratio. A lateral acceleration feedback was introduced in the roll channe...An improved STT (skid to turn) autopilot was developed to solve the problem of roll control saturation for the gliding missile with large aspect ratio. A lateral acceleration feedback was introduced in the roll channel of the autopilot to ensure that the roll angle could closely follow the lateral acceleration,so that the sideslip angle and the roll rudder deflection could be reduced,and the roll control saturation was avoided. A six-DOF ( degree of freedom) nonlinear simulation model was set up. The simulation results indicate that the model and the control scheme are effective.展开更多
目的:评估中性粒细胞-淋巴细胞比值(NLR)对初始治疗失败的社区获得性肺炎(CAP)的预测价值,并探讨二代测序技术(NGS)在初始治疗失败的CAP病原体检测中的应用价值。方法:回顾性分析2023年1月~2024年1月188例在吉林省人民医院治疗的CAP患...目的:评估中性粒细胞-淋巴细胞比值(NLR)对初始治疗失败的社区获得性肺炎(CAP)的预测价值,并探讨二代测序技术(NGS)在初始治疗失败的CAP病原体检测中的应用价值。方法:回顾性分析2023年1月~2024年1月188例在吉林省人民医院治疗的CAP患者。根据患者对初始治疗72 h后的反应,将患者分为初始治疗有效组(n=139)和初始治疗失败组(n=49),比较组间血常规、降钙素原(PCT)、NLR水平差异,并根据二分类Logistic回归法筛选出影响CAP患者发生初始治疗失败的危险因素。根据受试者工作特征(ROC)曲线分析NLR对初始治疗失败的CAP的预测价值,并与CURB-65评分进行比较。其中30例初始治疗失败的CAP患者同时行NGS和传统病原学检测,比较两种检测方法在病原体检测结果中的差异。结果:初始治疗失败组NLR、PCT、血白细胞计数(WBC)、中性粒细胞计数(NEU)高于初始治疗有效组,淋巴细胞计数(LYM)低于初始治疗有效组,差异有统计学意义(P<0.05);初始治疗失败组CURB-65评分高于初始治疗有效组,差异有统计学意义(P<0.05)。二分类Logistic回归显示NLR是初始治疗失败的CAP的独立预测因素。ROC曲线分析显示,与经典指标CURB-65评分比较,NLR对初始治疗失败的CAP具有更高的预测价值[曲线下面积(AUC):0.746 vs 0.698,均P>0.05]。本研究中当NLR截断值为6.62时,敏感度为65.3%,特异度为77.7%。与传统检测方法比较,NGS检测病原微生物阳性率更高,差异有统计学意义(66.7%vs 33.3%,P<0.05),微生物检出种类更多(35 vs 14)。结论:NLR是CAP患者发生初始治疗失败的独立危险因素,具有较高的独立预测价值。NGS作为新型病原体检测技术,与传统检测方法相比具有较高的阳性率,为初始治疗失败的CAP提供了更加快速准确的病原体检测技术,不仅提高了患者的治愈率,而且改善患者的远期预后。展开更多
文摘Objective: To assess the secondary sex ratio (SSR) of assisted reproduction technology babies within a fertility clinic in Melbourne, Australia. Methods: A retrospective cohort study was conducted on 3369 babies who were born following single embryo transfer between 2011 and 2016. Variables examined included embryo creation date, maternal and paternal ages, maternal body mass index (BMI), type of infertility, sperm parameters, fertilization method, type of embryo and stage of transfer. Multivariate regression analysis was performed on the data set using STRATA V9.2. Results: More males were found to be born to embryos created in summer (adjusted odds ratio=1.46, 95% confidence interval: 1.08-1.95;P=0.01). Lower BMI of mother (≤30 kg/m 2) and younger age of parents (≤35 years) were associated with an increase in SSR (50.1% vs. 47.1%;50.6% vs. 48.8%;50.0% vs. 48.9%) respectively. Decreased SSR value was associated with primary subfertility, using in-vitro fertilization procedure and fresh embryo compared to those with secondary subfertility, using intracytoplasmic sperm injection procedure and thawed embryo (49.3% vs. 50.6%;47.1% vs. 50.8%;49.4% vs. 50.1%) respectively. Conclusions: The fertilization methods, type of embryo, stage of embryo transfer, parameters of the sperm and status of subfertility do not significantly affect the SSR. SSR is affected by the seasonality, maternal age, and BMI.
文摘Wavelet packet multicarrier system gains widespread concern because of its better resistance performance to Inter-Symbol Interference (ISI) and Inter-Carrier Interference (ICI), as well as the higher spectrum efficiency. However, multicarrier system has a high Peak to Average Power Ratio (PAPR), which will lead to many problems such as lower system performance. In order to solve the problem, a kind of PAPR reduction method based on pruning Wavelet Packet Modulation (WPM) and Partial Transmit Sequences (PTS) technology is proposed in this paper, through proper pruning of the full-tree structure of wavelet packet modulation in the PTS technology to reduce the number of nodes in the system, and finally improve the reduction effect of PAPR. Simulation results show that when Complementary Cumulative Distribution Function (CCDF) is 10 -3 , PTS based on pruning WPM compared with PTS technique and pruning technique has improved about 1 dB and 1.5 dB, which will not affect the system's Bit Error Rate (BER) performance in the wavelet packet multicarrier system.
文摘An improved STT (skid to turn) autopilot was developed to solve the problem of roll control saturation for the gliding missile with large aspect ratio. A lateral acceleration feedback was introduced in the roll channel of the autopilot to ensure that the roll angle could closely follow the lateral acceleration,so that the sideslip angle and the roll rudder deflection could be reduced,and the roll control saturation was avoided. A six-DOF ( degree of freedom) nonlinear simulation model was set up. The simulation results indicate that the model and the control scheme are effective.
文摘目的:评估中性粒细胞-淋巴细胞比值(NLR)对初始治疗失败的社区获得性肺炎(CAP)的预测价值,并探讨二代测序技术(NGS)在初始治疗失败的CAP病原体检测中的应用价值。方法:回顾性分析2023年1月~2024年1月188例在吉林省人民医院治疗的CAP患者。根据患者对初始治疗72 h后的反应,将患者分为初始治疗有效组(n=139)和初始治疗失败组(n=49),比较组间血常规、降钙素原(PCT)、NLR水平差异,并根据二分类Logistic回归法筛选出影响CAP患者发生初始治疗失败的危险因素。根据受试者工作特征(ROC)曲线分析NLR对初始治疗失败的CAP的预测价值,并与CURB-65评分进行比较。其中30例初始治疗失败的CAP患者同时行NGS和传统病原学检测,比较两种检测方法在病原体检测结果中的差异。结果:初始治疗失败组NLR、PCT、血白细胞计数(WBC)、中性粒细胞计数(NEU)高于初始治疗有效组,淋巴细胞计数(LYM)低于初始治疗有效组,差异有统计学意义(P<0.05);初始治疗失败组CURB-65评分高于初始治疗有效组,差异有统计学意义(P<0.05)。二分类Logistic回归显示NLR是初始治疗失败的CAP的独立预测因素。ROC曲线分析显示,与经典指标CURB-65评分比较,NLR对初始治疗失败的CAP具有更高的预测价值[曲线下面积(AUC):0.746 vs 0.698,均P>0.05]。本研究中当NLR截断值为6.62时,敏感度为65.3%,特异度为77.7%。与传统检测方法比较,NGS检测病原微生物阳性率更高,差异有统计学意义(66.7%vs 33.3%,P<0.05),微生物检出种类更多(35 vs 14)。结论:NLR是CAP患者发生初始治疗失败的独立危险因素,具有较高的独立预测价值。NGS作为新型病原体检测技术,与传统检测方法相比具有较高的阳性率,为初始治疗失败的CAP提供了更加快速准确的病原体检测技术,不仅提高了患者的治愈率,而且改善患者的远期预后。
