Ten-eleven translocation(TET)methylcytosine dioxygenases catalyze the oxidative reactions of 5-methylcytosine(5-mC)to 5-hydroxymethylcytosine(5-hmC),5-formylcytosine(5-fC),and 5-carboxylcytosine(5-caC),which are inter...Ten-eleven translocation(TET)methylcytosine dioxygenases catalyze the oxidative reactions of 5-methylcytosine(5-mC)to 5-hydroxymethylcytosine(5-hmC),5-formylcytosine(5-fC),and 5-carboxylcytosine(5-caC),which are intermediate steps during DNA demethylation.It is reported that somatic mutations of TET2 gene are identified in a variety of human tumors,especially in hematological malignancies.The tendency and mechanism of cellular differentiation in different systems are affected by TET2 via regulation of associated gene expression or maintenance of demethylated state.TET2 acts as a critical driver of tumorigenesis through the conversion of 5-mC to 5-hmC and successive oxidation products.Sometimes,it requires special interactions and cofactors.Here,we reviewed recent advances in understanding the function of TET2 proteins in regulating cell differentiation,and its role in various tumors focusing on several digestive cancers.展开更多
BACKGROUND The concurrence of acute myeloid leukemia(AML)and chronic lymphocytic leukemia(CLL)is rare.Previous reports of such cases have focused mainly on clinical diagnosis and characteristics,so the mechanism remai...BACKGROUND The concurrence of acute myeloid leukemia(AML)and chronic lymphocytic leukemia(CLL)is rare.Previous reports of such cases have focused mainly on clinical diagnosis and characteristics,so the mechanism remains unclear,and therapy options have been poorly explored.CASE SUMMARY Here,we report two cases of synchronous AML and CLL.Flow cytometry revealed two distinct abnormal cell populations(myeloblasts and lymphoid cells)according to scatter characteristics.CD5-positive B cell lymphoma with myeloid leukemia invasion was observed on lymph node biopsy.Chemotherapy regimens indicated for both AML and CLL were used in our patients,and our patients achieved complete response after chemotherapy.Next-generation sequencing of 88 genes was performed.CONCLUSION We conclude that early mutation and dysregulation at the hematopoietic stem cell stage and the accumulation of multiple rearrangements may cause the concurrence of CLL and AML.The treatment of infection and combination therapy aimed at the CLL component are significant in the management of patients with concurrent CLL and AML.展开更多
基金This study was supported by a grant from the Health Commission Joint Foundation Project of Hubei Province(WJ2019H056).
文摘Ten-eleven translocation(TET)methylcytosine dioxygenases catalyze the oxidative reactions of 5-methylcytosine(5-mC)to 5-hydroxymethylcytosine(5-hmC),5-formylcytosine(5-fC),and 5-carboxylcytosine(5-caC),which are intermediate steps during DNA demethylation.It is reported that somatic mutations of TET2 gene are identified in a variety of human tumors,especially in hematological malignancies.The tendency and mechanism of cellular differentiation in different systems are affected by TET2 via regulation of associated gene expression or maintenance of demethylated state.TET2 acts as a critical driver of tumorigenesis through the conversion of 5-mC to 5-hmC and successive oxidation products.Sometimes,it requires special interactions and cofactors.Here,we reviewed recent advances in understanding the function of TET2 proteins in regulating cell differentiation,and its role in various tumors focusing on several digestive cancers.
文摘BACKGROUND The concurrence of acute myeloid leukemia(AML)and chronic lymphocytic leukemia(CLL)is rare.Previous reports of such cases have focused mainly on clinical diagnosis and characteristics,so the mechanism remains unclear,and therapy options have been poorly explored.CASE SUMMARY Here,we report two cases of synchronous AML and CLL.Flow cytometry revealed two distinct abnormal cell populations(myeloblasts and lymphoid cells)according to scatter characteristics.CD5-positive B cell lymphoma with myeloid leukemia invasion was observed on lymph node biopsy.Chemotherapy regimens indicated for both AML and CLL were used in our patients,and our patients achieved complete response after chemotherapy.Next-generation sequencing of 88 genes was performed.CONCLUSION We conclude that early mutation and dysregulation at the hematopoietic stem cell stage and the accumulation of multiple rearrangements may cause the concurrence of CLL and AML.The treatment of infection and combination therapy aimed at the CLL component are significant in the management of patients with concurrent CLL and AML.
