The Editor welcomes submissions for possible publication in the Letters to the Editor section.Letters commenting on an article published in the Journal or other interesting pieces will be considered if they are receiv...The Editor welcomes submissions for possible publication in the Letters to the Editor section.Letters commenting on an article published in the Journal or other interesting pieces will be considered if they are received within 6 weeks of the time the article was published.展开更多
To the Editor:We read with great interest the recent paper by Baran and colleagues,[1]published in the journal of Hepatobiliary Pancreatic Diseases International.The authors presented nails abnormalities in a 65-year-...To the Editor:We read with great interest the recent paper by Baran and colleagues,[1]published in the journal of Hepatobiliary Pancreatic Diseases International.The authors presented nails abnormalities in a 65-year-old woman with cryptogenic cirrhosis and hepatocellular carcinoma and described them as Terry’s nails.Whether they were Terry’s nails remains controversial,at least far away from展开更多
We present a case of Reiter syndrome (RS) associated with Terry nail in a 32-year-old male patient who also had subungual keratosis and onycholysis. The case had all the characteristic findings of complete RS includin...We present a case of Reiter syndrome (RS) associated with Terry nail in a 32-year-old male patient who also had subungual keratosis and onycholysis. The case had all the characteristic findings of complete RS including urethritis, conjunctivitis, arthritis and skin lesions, and based on these findings a clinical diagnosis was established. The patient complained of milky-white coloured leakage that was more frequent in the mornings, and dysuria. Urinary analysis revealed leucocytes and erythrocytes. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values were high. The case was considered as RS due to gonococcic urethritis. However, there was no growth in the culture. Self-report of the patient revealed that he had had continued symptoms and 9 months after the development of RS he developed Terry nail. To the best of our knowledge this is the first case of RS associated with Terry nail.展开更多
Terry Border是美国的艺术家,他总能在平凡无奇的生活中发现快乐元素,而快乐就是创作的第一步。"对我来说最重要的是自得其乐。如果我自己觉得某个创意有趣,那么别人也会感同身受。这是我学到的最重要的东西。"——Terry Bor...Terry Border是美国的艺术家,他总能在平凡无奇的生活中发现快乐元素,而快乐就是创作的第一步。"对我来说最重要的是自得其乐。如果我自己觉得某个创意有趣,那么别人也会感同身受。这是我学到的最重要的东西。"——Terry Border如是说。展开更多
In order to investigate the hydro-mechanical （HM） and chemical perturbations induced in an argillaceous formation by forced ventilation during the operational period of a nuclear waste repository, a specific experim...In order to investigate the hydro-mechanical （HM） and chemical perturbations induced in an argillaceous formation by forced ventilation during the operational period of a nuclear waste repository, a specific experiment has been performed in a tunnel, at Mont Terri Underground Research Laboratory （URL） in Switzerland. This experiment has been selected in the international project DECOVALEX for model vali- dation and the numerical simulation of this ventilation experiment （VE） is the object of the present paper. Since the argillaceous rock exhibits anisotropic properties, particular attention is given to the evaluation of the effects of various anisotropic features on the predicted results. In situ measurements such as relative humidity （RH）, global water mass extracted, pore water pressure, water content, and relative displace- ments are compared to predictions using both isotropic and anisotropic parameters. Water permeability anisotropy is shown to be the most influencing parameter by far, whereas in situ stress anisotropy has an effect only during the excavation phase. The anisotropy for mechanical parameterization has also some influence, in particular through HM couplings. These HM couplings have the potential to be very significant in terms of providing confidence in describing the experimental observation, and should be considered for further investigation.展开更多
In this paper, a modelling benchmark exercise from the DECOVALEX-2011 project is presented. The bench- mark is based on the performance and results of a laboratory drying test and of the ventilation experiment （VE） ...In this paper, a modelling benchmark exercise from the DECOVALEX-2011 project is presented. The bench- mark is based on the performance and results of a laboratory drying test and of the ventilation experiment （VE） carried out in the Mont Terri Underground Rock Laboratory （URL）. Both tests involve Opalinus clay. The work aims at the identification, understanding and quantification of mechanisms taking place during the ventilation of a gallery in argillaceous host rocks on one hand and at investigating the capacity of different codes and individuals to reproduce these processes on the other hand. The 4-year in situ VE took place in a 1.3 m diameter unlined tunnel and included two resaturation-desaturation cycles. The test area was equipped with over one hundred sensors （including the global water mass balance of the system, relative humidity （RH）, water content, liquid pressure, relative displacement and concentration of some chemical species） to monitor the rock behaviour during ventilation. The laboratory drying experiment, carried out before the VE, was designed to mimic the in situ conditions. The work was organized in a progressive manner in terms of complexity of the computations to be performed, geared towards the full hydro-mechano-chemical （HMC） understanding of the VE, the final objective. The main results from the modelling work reported herein are that the response of the host rock to ventilation in argillaceous rocks is mainly governed by hydraulic processes （advective Darcy flow and non-advective vapour diffu- sion） and that the hydro-mechanical （TM） back coupling is weak. A ventilation experiment may thus be regarded as a large scale-long time pump test and it is used to determine the hydraulic conductivity of the rock mass.展开更多
At Mont Terri Underground Research Laboratory （URL） Switzerland, a specific experiment has been per- formed in a tunnel, in order to investigate the hydro-mechano-chemical （HMC） perturbations induced in the argill...At Mont Terri Underground Research Laboratory （URL） Switzerland, a specific experiment has been per- formed in a tunnel, in order to investigate the hydro-mechano-chemical （HMC） perturbations induced in the argillaceous formation by forced ventilation. This experiment has been selected in the international project DECOVALEX to be used for process model development and validation. The numerical simula- tion of the geochemical response to the ventilation experiment （VE） is the object of the present paper, focusing on the transport of chloride as a conservative species and sulphate as a reactive species. Uti- lising the validated hydro-mechanical （HM） results from earlier steps of the DECOVALEX task, reactive and non-reactive transport models, incorporating the current understanding of the geochemistry at the site, were successfully constructed for the whole experimental period. The associated parametric and process uncertainty analyses clearly demonstrate that the basic HM understanding must be sound. How- ever, to demonstrate this degree of robustness, the explicit inclusion of process representations of water desaturation, liquid vaporisation, species exclusion porosity, and redox processes, is required.展开更多
At the Mont Terri Underground Research Laboratory （Switzerland）, a field-scale investigation has been conducted in order to investigate the hydro-mechanical and chemical perturbations induced in the argilla- ceous f...At the Mont Terri Underground Research Laboratory （Switzerland）, a field-scale investigation has been conducted in order to investigate the hydro-mechanical and chemical perturbations induced in the argilla- ceous formation by forced ventilation through a tunnel. This experiment has been selected to be used for processing model development and validation in the international project DECOVALEX-2011. The con- ceptual and mathematical representation of the engineered void, which itself forms a major part of the experiment and is not simply a boundary condition, is the subject of this paper. A variety of approaches have been examined by the contributors to DECOVALEX and a summary of their findings is presented here. Two major aspects are discussed. Firstly, the approaches for the treatment of the surface condition at the porous media/tunnel interface are examined, with two equivalent but differing formulations successfully demonstrated. Secondly, approaches for representing the tunnel with associated air and water vapour movement, when coupled with the hydro-mechanical （HM） representation of the porous medium, are also examined. It is clearly demonstrated that, for the experimental conditions of the ventilation experiment （VE） that abstracted physical and empirical models of the tunnel, can be used successfully to represent the hydraulic behaviour of the tunnel and the hydraulic interaction between the tunnel and the surrounding rock mass.展开更多
文摘The Editor welcomes submissions for possible publication in the Letters to the Editor section.Letters commenting on an article published in the Journal or other interesting pieces will be considered if they are received within 6 weeks of the time the article was published.
文摘To the Editor:We read with great interest the recent paper by Baran and colleagues,[1]published in the journal of Hepatobiliary Pancreatic Diseases International.The authors presented nails abnormalities in a 65-year-old woman with cryptogenic cirrhosis and hepatocellular carcinoma and described them as Terry’s nails.Whether they were Terry’s nails remains controversial,at least far away from
文摘We present a case of Reiter syndrome (RS) associated with Terry nail in a 32-year-old male patient who also had subungual keratosis and onycholysis. The case had all the characteristic findings of complete RS including urethritis, conjunctivitis, arthritis and skin lesions, and based on these findings a clinical diagnosis was established. The patient complained of milky-white coloured leakage that was more frequent in the mornings, and dysuria. Urinary analysis revealed leucocytes and erythrocytes. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values were high. The case was considered as RS due to gonococcic urethritis. However, there was no growth in the culture. Self-report of the patient revealed that he had had continued symptoms and 9 months after the development of RS he developed Terry nail. To the best of our knowledge this is the first case of RS associated with Terry nail.
基金the context of the international DECOVALEX Project (DEmonstration of Coupled models and their VALidation against EXperiments)Quintessa Ltd. and University of Edinburgh were supported by the Nuclear Decommissioning Authority (NDA), UK+2 种基金CEA was supported by Institut de Radioprotection et de Sreté Nucléaire(IRSN)The Japan Atomic Energy Agency (JAEA) and the Institute of Rock and Soil Mechanics, Chinese Academy of Sciences (CAS)funded DECOVALEX and participated in the workEC project NF-PRO (Contract number FI6W-CT-2003-02389) under the coordination of ENRESA (Empresa Nacional de Residuos Radiactivos)
文摘In order to investigate the hydro-mechanical （HM） and chemical perturbations induced in an argillaceous formation by forced ventilation during the operational period of a nuclear waste repository, a specific experiment has been performed in a tunnel, at Mont Terri Underground Research Laboratory （URL） in Switzerland. This experiment has been selected in the international project DECOVALEX for model vali- dation and the numerical simulation of this ventilation experiment （VE） is the object of the present paper. Since the argillaceous rock exhibits anisotropic properties, particular attention is given to the evaluation of the effects of various anisotropic features on the predicted results. In situ measurements such as relative humidity （RH）, global water mass extracted, pore water pressure, water content, and relative displace- ments are compared to predictions using both isotropic and anisotropic parameters. Water permeability anisotropy is shown to be the most influencing parameter by far, whereas in situ stress anisotropy has an effect only during the excavation phase. The anisotropy for mechanical parameterization has also some influence, in particular through HM couplings. These HM couplings have the potential to be very significant in terms of providing confidence in describing the experimental observation, and should be considered for further investigation.
基金conducted within the context of the international DECOVALEX Projectthe Funding Organizations who supported the workthe EC project NF-PRO (Contract number FI6W-CT-2003-02389) under the coor-dination of ENRESA (Empresa Nacional de Residuos Radiactivos)
文摘In this paper, a modelling benchmark exercise from the DECOVALEX-2011 project is presented. The bench- mark is based on the performance and results of a laboratory drying test and of the ventilation experiment （VE） carried out in the Mont Terri Underground Rock Laboratory （URL）. Both tests involve Opalinus clay. The work aims at the identification, understanding and quantification of mechanisms taking place during the ventilation of a gallery in argillaceous host rocks on one hand and at investigating the capacity of different codes and individuals to reproduce these processes on the other hand. The 4-year in situ VE took place in a 1.3 m diameter unlined tunnel and included two resaturation-desaturation cycles. The test area was equipped with over one hundred sensors （including the global water mass balance of the system, relative humidity （RH）, water content, liquid pressure, relative displacement and concentration of some chemical species） to monitor the rock behaviour during ventilation. The laboratory drying experiment, carried out before the VE, was designed to mimic the in situ conditions. The work was organized in a progressive manner in terms of complexity of the computations to be performed, geared towards the full hydro-mechano-chemical （HMC） understanding of the VE, the final objective. The main results from the modelling work reported herein are that the response of the host rock to ventilation in argillaceous rocks is mainly governed by hydraulic processes （advective Darcy flow and non-advective vapour diffu- sion） and that the hydro-mechanical （TM） back coupling is weak. A ventilation experiment may thus be regarded as a large scale-long time pump test and it is used to determine the hydraulic conductivity of the rock mass.
基金conducted within thecontext of the international DECOVALEX Project (DEmonstrationof COupled models and their VALidation against EXperiments)Quintessa Ltd. and University of Edinburgh were supported by the Nuclear Decommissioning Authority (NDA), UK+2 种基金CEA was supported by Institut de Radioprotection et de S retéNucléaire (IRSN)The Japan Atomic Energy Agency (JAEA) and the Institute of Rock and Soil Mechanics, Chinese Academy of Sciences(CAS) funded DECOVALEX and participated in the workthe framework of the EC project NF-PRO(Contract number FI6W-CT-2003-02389) under the coordination of ENRESA (Empresa Nacional de Residuos Radiactivos)
文摘At Mont Terri Underground Research Laboratory （URL） Switzerland, a specific experiment has been per- formed in a tunnel, in order to investigate the hydro-mechano-chemical （HMC） perturbations induced in the argillaceous formation by forced ventilation. This experiment has been selected in the international project DECOVALEX to be used for process model development and validation. The numerical simula- tion of the geochemical response to the ventilation experiment （VE） is the object of the present paper, focusing on the transport of chloride as a conservative species and sulphate as a reactive species. Uti- lising the validated hydro-mechanical （HM） results from earlier steps of the DECOVALEX task, reactive and non-reactive transport models, incorporating the current understanding of the geochemistry at the site, were successfully constructed for the whole experimental period. The associated parametric and process uncertainty analyses clearly demonstrate that the basic HM understanding must be sound. How- ever, to demonstrate this degree of robustness, the explicit inclusion of process representations of water desaturation, liquid vaporisation, species exclusion porosity, and redox processes, is required.
基金the context of the international DECOVALEX Project (DEmonstration of COupled models and their VALidation against EXperiments)EC project NF-PRO (Contract number FI6W-CT-2003-02389) under the coordination of ENRESA (Empresa Nacional de Residuos Radiactivos)
文摘At the Mont Terri Underground Research Laboratory （Switzerland）, a field-scale investigation has been conducted in order to investigate the hydro-mechanical and chemical perturbations induced in the argilla- ceous formation by forced ventilation through a tunnel. This experiment has been selected to be used for processing model development and validation in the international project DECOVALEX-2011. The con- ceptual and mathematical representation of the engineered void, which itself forms a major part of the experiment and is not simply a boundary condition, is the subject of this paper. A variety of approaches have been examined by the contributors to DECOVALEX and a summary of their findings is presented here. Two major aspects are discussed. Firstly, the approaches for the treatment of the surface condition at the porous media/tunnel interface are examined, with two equivalent but differing formulations successfully demonstrated. Secondly, approaches for representing the tunnel with associated air and water vapour movement, when coupled with the hydro-mechanical （HM） representation of the porous medium, are also examined. It is clearly demonstrated that, for the experimental conditions of the ventilation experiment （VE） that abstracted physical and empirical models of the tunnel, can be used successfully to represent the hydraulic behaviour of the tunnel and the hydraulic interaction between the tunnel and the surrounding rock mass.
