Okra(Abelmoschus esculentus[L.]Moench.)is one of the most frequently used herbals in East or West Africa,and its various biological activities have been widely studied.Flavonoids extracted from many plants are reporte...Okra(Abelmoschus esculentus[L.]Moench.)is one of the most frequently used herbals in East or West Africa,and its various biological activities have been widely studied.Flavonoids extracted from many plants are reported to have neurological properties,e.g antidepressant and antifatigue.However,its neurological protect in antidepressant-like effect of flavonoids extracted from okra have not yet been demonstrated.The present study was aimed at investigating the antidepressant-like eff ect of the flavonoids extracted from okra fruit(FOF)using the forced swimming test(FST)pattern and preliminary exploration its potential mechanism.We also used the open fi eld test(OFT)to estimate the spontaneous locomotor activity.We found that oral administration(p.o.)of FOF(300 mg/kg)alone signifi cantly reduced the immobility time in the FST without changes in locomotor activity in the OPT.The experimental data indicated the antidepressant-like eff ect of FOF involved in noradrenergic,glutamatergic and dopaminergic systems.展开更多
目的:探讨石榴籽油对小鼠抗抑郁作用的影响。方法:120只小鼠随机分为3组,每组各40只。每组小鼠随机分为对照组、模型组、石榴籽油高剂量组及石榴籽油低剂量组,每组各10只。石榴籽油高剂量组、石榴籽油低剂量组灌胃剂量分别为0.03 m L...目的:探讨石榴籽油对小鼠抗抑郁作用的影响。方法:120只小鼠随机分为3组,每组各40只。每组小鼠随机分为对照组、模型组、石榴籽油高剂量组及石榴籽油低剂量组,每组各10只。石榴籽油高剂量组、石榴籽油低剂量组灌胃剂量分别为0.03 m L·g-1、0.015 m L·g-1,对照组给予盐酸多塞平片,50 mg·kg-1,模型组每日给予等量生理盐水灌胃。给药后分别用于小鼠悬尾绝望实验(TST)、强迫游泳实验(FST)和利血平诱发的小鼠体温降低实验,观察石榴籽油对小鼠游泳不动时间和体温的影响。结果:石榴籽油高剂量组、低剂量组在一定程度可减少小鼠游泳不动时间,与模型组比较,差异具有统计学意义(P<0.05);石榴籽油高剂量组、低剂量组可减少小鼠悬尾不动时间,与模型组比较,有显著性差异(P<0.05);石榴籽油高剂量组、低剂量组与模型组比较,具有明显拮抗小鼠体温下降的作用,差异具有统计学意义(P<0.05)。结论:石榴籽油具有抗抑郁作用。展开更多
Low frequency vibrations induced by underground railways have attracted increasing attention in recent years. To obtain the characteristics of low frequency vibrations and the low frequency performance of a floating s...Low frequency vibrations induced by underground railways have attracted increasing attention in recent years. To obtain the characteristics of low frequency vibrations and the low frequency performance of a floating slab track (FST), low frequency vibration tests on an FST in an underground laboratory at Beijing Jiaotong University were carried out. The FST and an unbalanced shaker SBZ30 for dynamic simulation were designed for use in low frequency vibration experiments. Vibration measurements were performed on the bogie of the unbalanced shaker, the rail, the slab, the tunnel invert, the tunnel wall, the tunnel apex, and on the ground surface at distances varying from 0 to 80 m from the track. Measurements were also made on several floors of an adjacent building. Detailed results of low frequency vibration tests were reported. The attenuation of low frequency vibrations with the distance from the track was presented, as well as the responses of different floors of the building. The experimental results could be regarded as a reference for developing methods to control low frequency vibrations and for adopting countermeasures.展开更多
基金This research was supported by Shenyang Scientific Project(No.F13-287-1-00)Liaoning Province Natural Science Foundation(No.2014020076).
文摘Okra(Abelmoschus esculentus[L.]Moench.)is one of the most frequently used herbals in East or West Africa,and its various biological activities have been widely studied.Flavonoids extracted from many plants are reported to have neurological properties,e.g antidepressant and antifatigue.However,its neurological protect in antidepressant-like effect of flavonoids extracted from okra have not yet been demonstrated.The present study was aimed at investigating the antidepressant-like eff ect of the flavonoids extracted from okra fruit(FOF)using the forced swimming test(FST)pattern and preliminary exploration its potential mechanism.We also used the open fi eld test(OFT)to estimate the spontaneous locomotor activity.We found that oral administration(p.o.)of FOF(300 mg/kg)alone signifi cantly reduced the immobility time in the FST without changes in locomotor activity in the OPT.The experimental data indicated the antidepressant-like eff ect of FOF involved in noradrenergic,glutamatergic and dopaminergic systems.
文摘目的:探讨石榴籽油对小鼠抗抑郁作用的影响。方法:120只小鼠随机分为3组,每组各40只。每组小鼠随机分为对照组、模型组、石榴籽油高剂量组及石榴籽油低剂量组,每组各10只。石榴籽油高剂量组、石榴籽油低剂量组灌胃剂量分别为0.03 m L·g-1、0.015 m L·g-1,对照组给予盐酸多塞平片,50 mg·kg-1,模型组每日给予等量生理盐水灌胃。给药后分别用于小鼠悬尾绝望实验(TST)、强迫游泳实验(FST)和利血平诱发的小鼠体温降低实验,观察石榴籽油对小鼠游泳不动时间和体温的影响。结果:石榴籽油高剂量组、低剂量组在一定程度可减少小鼠游泳不动时间,与模型组比较,差异具有统计学意义(P<0.05);石榴籽油高剂量组、低剂量组可减少小鼠悬尾不动时间,与模型组比较,有显著性差异(P<0.05);石榴籽油高剂量组、低剂量组与模型组比较,具有明显拮抗小鼠体温下降的作用,差异具有统计学意义(P<0.05)。结论:石榴籽油具有抗抑郁作用。
基金Project supported by the National Natural Science Foundation of China (No. 51008017)the Fundamental Research Funds for the Central Universities of China (Nos. 2009JBM074 and 2009JBM075)
文摘Low frequency vibrations induced by underground railways have attracted increasing attention in recent years. To obtain the characteristics of low frequency vibrations and the low frequency performance of a floating slab track (FST), low frequency vibration tests on an FST in an underground laboratory at Beijing Jiaotong University were carried out. The FST and an unbalanced shaker SBZ30 for dynamic simulation were designed for use in low frequency vibration experiments. Vibration measurements were performed on the bogie of the unbalanced shaker, the rail, the slab, the tunnel invert, the tunnel wall, the tunnel apex, and on the ground surface at distances varying from 0 to 80 m from the track. Measurements were also made on several floors of an adjacent building. Detailed results of low frequency vibration tests were reported. The attenuation of low frequency vibrations with the distance from the track was presented, as well as the responses of different floors of the building. The experimental results could be regarded as a reference for developing methods to control low frequency vibrations and for adopting countermeasures.
