OBJECTIVE: To investigate the mechanism of Ping-wei capsules(PWC) in improving gastrointestinal m otility in rats with functional dyspepsia(FD).METHODS: We established an FD model by stimu-lating semi-starvation rats ...OBJECTIVE: To investigate the mechanism of Ping-wei capsules(PWC) in improving gastrointestinal m otility in rats with functional dyspepsia(FD).METHODS: We established an FD model by stimu-lating semi-starvation rats via tail damping, provo-cation, and forced exercise fatigue. The FD model group was further divided into five groups accord-ing to the treatment received: normal saline, dom-peridone, low-dose PWC, mid-dose PWC, or highdose PWC. The effect of PWC on FD was evaluated by measuring gastrointestinal motility. Changes in leptin and cholecystokinin(CCK) were detected through enzyme-linked immunosorbent assay, re-verse transcription-polymerase chain reaction, and immunohistochemistry.RESULTS: PWC significantly increased gastrointesti-nal m otility in FD rats. Furthermore, PWC signifi-cantly increased CCK m RNA and protein concentra-tions in the duodenum and antrum, decreased leptin protein concentrations in the duodenum, an-trum, and hypothalamus, and decreased CCK pro-tein concentration in the hypothalamus.CONCLUSION: PWC improves gastrointestinal mo-tor function in FD rats by decreasing the leptin con-centration in serum and the brain-gut axis, and by increasing the CCK concentration in gastrointesti-nal tissue. Our findings help to elucidate the mech-anism of FD and provide further insight into the pharmacokinetics of PWC.展开更多
Testin云测近日宣布与A R M建立战略伙伴合作关系,设立A R M应用测试中心。该中心旨在帮助全球开发者,通过ARM所提供的技术支持,包括CPU、引擎、GPU和用户体验在内的多方面测试,满足用户需求,进而加快应用进入中国市场。此次战略合作帮...Testin云测近日宣布与A R M建立战略伙伴合作关系,设立A R M应用测试中心。该中心旨在帮助全球开发者,通过ARM所提供的技术支持,包括CPU、引擎、GPU和用户体验在内的多方面测试,满足用户需求,进而加快应用进入中国市场。此次战略合作帮助开发者获得Testin云测平台兼容性优化指导,同时也能取得ARM提供包括ARM Cortex CPU。展开更多
基金Supported by the Natural Science Foundation of China(Based on Brain-Gut Axis to Study Peptidomics of Liver Stag-nation and Spleen Deficiency with Functional Dyspepsia and Its Intervention of Shugan Jianpi Method,No.8136-0540)the Administration of Gansu Traditional Chinese Medicine and Chinese Herbs(A Study about Intervening Ef-fects of a Chinese Herbal Preparation w ith Resveratrol on In-sulin Resistance of Type 2 Diabetes Mellitus,No.GZK-2015-23)
文摘OBJECTIVE: To investigate the mechanism of Ping-wei capsules(PWC) in improving gastrointestinal m otility in rats with functional dyspepsia(FD).METHODS: We established an FD model by stimu-lating semi-starvation rats via tail damping, provo-cation, and forced exercise fatigue. The FD model group was further divided into five groups accord-ing to the treatment received: normal saline, dom-peridone, low-dose PWC, mid-dose PWC, or highdose PWC. The effect of PWC on FD was evaluated by measuring gastrointestinal motility. Changes in leptin and cholecystokinin(CCK) were detected through enzyme-linked immunosorbent assay, re-verse transcription-polymerase chain reaction, and immunohistochemistry.RESULTS: PWC significantly increased gastrointesti-nal m otility in FD rats. Furthermore, PWC signifi-cantly increased CCK m RNA and protein concentra-tions in the duodenum and antrum, decreased leptin protein concentrations in the duodenum, an-trum, and hypothalamus, and decreased CCK pro-tein concentration in the hypothalamus.CONCLUSION: PWC improves gastrointestinal mo-tor function in FD rats by decreasing the leptin con-centration in serum and the brain-gut axis, and by increasing the CCK concentration in gastrointesti-nal tissue. Our findings help to elucidate the mech-anism of FD and provide further insight into the pharmacokinetics of PWC.
文摘Testin云测近日宣布与A R M建立战略伙伴合作关系,设立A R M应用测试中心。该中心旨在帮助全球开发者,通过ARM所提供的技术支持,包括CPU、引擎、GPU和用户体验在内的多方面测试,满足用户需求,进而加快应用进入中国市场。此次战略合作帮助开发者获得Testin云测平台兼容性优化指导,同时也能取得ARM提供包括ARM Cortex CPU。
