Field Load Test Based SHM System Safety Standard Determination for Rigid Frame Bridge

The deteriorated continuous rigid frame bridge is strengthened by external prestressing. Static loading tests wereconducted before and after the bridge rehabilitation to verify the effectiveness of the rehabilitation process. Thestiffness of the repaired bridge is improved, and the maximum deflection of the load test is reduced from 37.9 to27.6 mm. A bridge health monitoring system is installed after the bridge is reinforced. To achieve an easy assessmentof the bridge’s safety status by directly using transferred data, a real-time safety warning system is createdbased on a five-level safety standard. The threshold for each safety level will be determined by theoretical calculationsand the outcomes of static loading tests. The highest risk threshold will be set at the ultimate limit statevalue. The remaining levels, namely middle risk, low risk, and very low risk, will be determined usingreduction coefficients of 0.95, 0.9, and 0.8, respectively.

Mode Innovation of School-Enterprise Cooperation on Food Safety Testing Laboratory Reform

In view of the difficulties about school-enterprise cooperation on food safety testing laboratory reform,the current training program,teaching methods and teaching forms are not suitable for the new platform.This paper provides new ideas and modes to solve these problems,such as integrating the resource elements between school and enterprise,establishing new platforms with the help of external force and innovating the cooperation modes to improve the laboratory,which can fully serve teaching,scientific research and enterprise production.

Safety Control Technology of Deepwater Perforated Gas Well Testing

Due to the high difficulties, high investment, and high risks in deepwater oil and gas well testing, major safety problems can occur easily. A key to prevent accidents is to conduct safety assessment and control on deepwater testing and to improve the testing technology. The deepwater of the South China Sea has some special environmental features: long distance from offshore, frequent typhoons in summer and constant monsoons in winter, and the presence of sandy slopes, sandy ridges and internal waves, coupled with the complex properties of oil and gas reserves which bring more challenges to deepwater well testing. In combination with deepwater well testing practice in the South China Sea, this paper analyzes the main potential risks in deepwater well testing and concludes that there are risks of failures of testing string, tools, and ground processes. Other risks are gas hydrate blockage, reservoir stratum sanding, and typhoon impacts. Specific precautions are also proposed in response to these risks in the paper.

Safety of the express freight train running over a long-span bridge

Purpose-Express freight transportation is in rapid development currently.Owing to the higher speed of express freight train,the deformation of the bridge deck worsens the railway line condition under the action of wind and train moving load when the train runs over a long-span bridge.Besides,the blunt car body of vehicle has poor aerodynamic characteristics,bringing a greater challenge on the running stability in the crosswind.Design/methodology/approach-In this study,the aerodynamic force coefficients of express freight vehicles on the bridge are measured by scale model wind tunnel test.The dynamic model of the train-long-span steel truss bridge coupling system is established,and the dynamic response as well as the running safety of vehicle are evaluated.Findings-The results show that wind speed has a significant influence on running safety,which is mainly reflected in the over-limitation of wheel unloading rate.The wind speed limit decreases with train speed,and it reduces to 18.83 m/s when the train speed is 160 km/h.Originality/value-This study deepens the theoretical understanding of the interaction between vehicles and bridges and proposes new methods for analyzing similar engineering problems.It also provides a new theoretical basis for the safety assessment of express freight trains.

Testing Result Statistics-Based Rapid Testing Method for Safety-Critical System

Safety-critical system （SCS） has highly demand for dependability, which requires plenty of resource to ensure that the system under test （SUT） satisfies the dependability requirement. In this paper, a new SCS rapid testing method is proposed to improve SCS adaptive dependability testing. The result of each test execution is saved in calculation memory unit and evaluated as an algorithm model. Then the least quantity of scenario test case for next test execution will be calculated according to the promised SUT＇s confidence level. The feedback data are generated to weight controller as the guideline for the further testing. Finally, a compre- hensive experiment study demonstrates that this adaptive testing method can really work in practice. This rapid testing method, testing result statistics-based adaptive control, makes the SCS dependability testing much more effective.

A method for preventing hydrates from blocking flow during deep-water gas well testing

Based on the research of the formation mechanism and evolution rule of hydrate flow obstacle during deep-water gas well testing,a new method for the prevention of hydrate flow obstacle based on safety testing window is proposed by changing the previous idea of"preventing formation"to the idea of"allowing formation,preventing plugging".The results show that the effective inner diameter of the testing tubing and the wellhead pressure decrease gradually with the formation and precipitation of hydrates during deep-water gas well testing,and it presents three typical processes of slow,fast and sudden changes.There is a safety testing window during deep-water gas well testing.The safety testing window of deep-water gas well testing decreases first and then increases with the increase of gas production rate,and increases with the increase of hydrate inhibitor concentrations.In the case with different testing production rates,a reasonable testing order with alternate low and high gas production rates has been proposed to further reduce the dosage of hydrate inhibitor and even avoid the use of hydrate inhibitors considering the decomposition and fall-off of hydrates.Compared with the traditional methods,the new method based on safety testing window can reduce the dosage of hydrate inhibitor by more than 50%.

Use of A Shatter Test Vessel to Assess Propellant Safety

At low temperatures,gun propellant grains may become brittle and this can lead to fracture or shatter of the grains during gun firing.Should this event occur then it will result in an increase in the burning surface of the propellant and will give rise to a change in ballistic performance.Also,if the resultant over pressure is sufficient,a breech failure may result.Understanding the propensity of a grain to fracture or shatter is therefore important in determining its safety in use.This document describes a test that may be used to derive knowledge and to quantify the physical behaviour of a gun propellant grain at the low temperatures at which fracture or shatter is most likely to occur.

Properties analysis of a large flow-rate safety valve test device

In order to solve the problem of property test of large flow-rate safety, the property parameter of safety valve test system was analyzed, and a device for property oflarge flow-rate safety valve test was designed.The device used accumulators as power source and a united function cylinder, which can realized the large flow-rate output for the test system.Analyzed the test data and made a particular research on the test device by testing different flow-rate safety valves;it verifies that the test device can be used tode-sign larger flow-rate safety valve test system and can make the flow-rate test and analysis and dynamic characteristics for the large-flow safety valve.

Process of Designing Robust, Dependable, Safe and Secure Software for Medical Devices: Point of Care Testing Device as a Case Study

This paper presents a holistic methodology for the design of medical device software, which encompasses of a new way of eliciting requirements, system design process, security design guideline, cloud architecture design, combinatorial testing process and agile project management. The paper uses point of care diagnostics as a case study where the software and hardware must be robust, reliable to provide accurate diagnosis of diseases. As software and software intensive systems are becoming increasingly complex, the impact of failures can lead to significant property damage, or damage to the environment. Within the medical diagnostic device software domain such failures can result in misdiagnosis leading to clinical complications and in some cases death. Software faults can arise due to the interaction among the software, the hardware, third party software and the operating environment. Unanticipated environmental changes and latent coding errors lead to operation faults despite of the fact that usually a significant effort has been expended in the design, verification and validation of the software system. It is becoming increasingly more apparent that one needs to adopt different approaches, which will guarantee that a complex software system meets all safety, security, and reliability requirements, in addition to complying with standards such as IEC 62304. There are many initiatives taken to develop safety and security critical systems, at different development phases and in different contexts, ranging from infrastructure design to device design. Different approaches are implemented to design error free software for safety critical systems. By adopting the strategies and processes presented in this paper one can overcome the challenges in developing error free software for medical devices (or safety critical systems).

Personal glucose meters coupled with signal amplification technologies for quantitative detection of non-glucose targets:Recent progress and challenges in food safety hazards analysis

Ensuring food safety is paramount worldwide.Developing effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix effects of food.Personal glucose meter(PGM),a classic point-of-care testing device,possesses unique application advantages,demonstrating promise in food safety.Currently,many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food hazards.Signal amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors,which is crucial for solving the challenges associated with the use of PGMs for food safety analysis.This review introduces the basic detection principle of a PGM-based sensing strategy,which consists of three key factors:target recognition,signal transduction,and signal output.Representative studies of existing PGM-based sensing strategies combined with various signal amplification technologies(nanomaterial-loaded multienzyme labeling,nucleic acid reaction,DNAzyme catalysis,responsive nanomaterial encapsulation,and others)in the field of food safety detection are reviewed.Future perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are discussed.Despite the need for complex sample preparation and the lack of standardization in the field,using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis.

Analyzing Effect of Demand Rate on Safety of Systems with Periodic Proof-tests

Quantitative safety assessment of safety systems plays an important role in decision making at all stages of system lifecycle, i.e., design, deployment and phase out. Most safety assessment methods consider only system parameters, such as configuration, hazard rate, coverage, repair rate, etc. along with periodic proof-tests （or inspection）. Not considering demand rate will give a pessimistic safety estimate for an application with low demand rate such as nuclear power plants, chemical plants, etc. In this paper, a basic model of IEC 61508 is used. The basic model is extended to incorporate process demand and behavior of electronic- and/or computer-based system following diagnosis or proof-test. A new safety index, probability of failure on actual demand （PFAD） based on extended model and demand rate is proposed. Periodic proof-test makes the model semi-Markovian, so a piece-wise continuous time Markov chain （CTMC） based method is used to derive mean state probabilities of elementary or aggregated state. Method to determine probability of failure on demand （PFD） （IEC 61508） and PFAD based on these state probabilities are described. In example, safety indices of PFD and PFAD are compared.

Current State of Numerical Simulations and Testing for the Blast and Impact Protection of the Build Civil Engineering Infrastructure

The identification of the critical infrastructure has shown that the build civil engineering infrastructure is almost involved everywhere, even with the IT-infrastructure. Therefore, the passive safety of structures is demanded. Security associations have analysed that most assaults came along with explosion and impact scenarios, which amount in 80% of assaults. Consequently, these are the extraordinary loads the structures have to be planned and designed for. To carry out such an engineering job, the engineer has to be educated in multiple disciplines as physics, material science , continuum mechanics, numerical mechanics, testing, structural engineering and related specific fields as wave propagation etc. In this paper we will concentrate on the subjects of numerical simulation and testing.

Analysis of Toxicological Test Results of 580 Detergents

To evaluate the safety of detergents,the toxicological test results of 580 collected detergents were analyzed.The results showed that,in the acute oral toxicity test,94.4%and 5.6%of the samples were classified as non-toxic and toxic respectively.In skin irritation test,95.1%of the samples were mild irritation or below,and 4.9%were moderate irritation or above.In the vaginal mucosa irritation test,79.0%of the samples were very mild irritation or below,while 21.0%were mild irritation or above.In the acute inhalation toxicity test,the proportion of the samples classified as actually non-toxic and toxic were 87.9%and 12.1%respectively.In the eye irritation test,95.7%of the samples belonged to mild irritation or below,and 4.3%of the samples belonged to moderate irritation or above.The products at risk in category A,B and C products account for 6.3%,7.7%and 14.2%respectively.Of the 580 tested samples,90.9%were relatively safe,while 9.1%were at risk.These data showed that most of the tested samples meet the safety requirements for use.

Critical analysis of ineffective post implantation implantable cardioverter-defibrillator-testing

AIM To test of the implantable-cardioverter-defibrillator is done at the time of implantation. We investigate if any testing should be performed.METHODS All consecutive patients between January 2006 and December 2008 undergoing implantable cardioverterdefibrillator(ICD) implantation/replacement(a total of 634 patients) were included in the retrospective study.RESULTS Sixteen patients(2.5%) were not tested(9 with LA/LVthrombus, 7 due to operator's decision). Analyzed were 618 patients [76% men, 66.4 + 11 years, 24% secondary prevention(SP), 46% with left ventricular ejection fraction(LVEF) < 20%, 56% had coronary artery disease(CAD)] undergoing defibrillation safety testing(SMT) with an energy of 21 + 2.3 J. In 22/618 patients(3.6%) induced ventricular fibrillation(VF) could not be terminated with maximum energy of the ICD. Six of those(27%) had successful SMT after system modification or shock lead repositioning, 14 patients(64%) received a subcutaneous electrode array. Younger age(P = 0.0003), non-CAD(P = 0.007) and VF as index event for SP(P = 0.05) were associated with a higher incidence of ineffective SMT. LVEF < 20% and incomplete revascularisation in patients with CAD had no impact on SMT.CONCLUSION Defibrillation testing is well-tolerated. An ineffective SMT occurred in 4% and two third of those needed implantation of a subcutaneous electrode array to passa SMT > 10 J.

油气管道组合缺陷漏磁检测信号数值模拟研究

为解决管道组合缺陷之间漏磁检测信号互相干扰,难以识别的问题,采用有限元方法建立仿真模型,研究管道内外、不同形状缺陷以及内外组合缺陷邻近情况下的漏磁场检测信号规律。研究结果表明:管道缺陷的漏磁检测信号在其轴向和径向分量上均存在显著差异;组合缺陷的检测信号存在相互干扰且具有一定的叠加性;当缺陷深度约为管壁厚的10%、25%、40%时,轴向信号干扰距离分别约为缺陷长度的1倍、2倍、3倍,径向信号干扰距离均约为长度的4倍,组合缺陷径向信号的互相干扰程度大于轴向信号,缺陷深度对轴向信号的影响大于径向信号。研究结果可为油气管道组合缺陷的识别提供理论依据。

微生物快速检测技术在食品安全检测中的应用

在食品安全领域,微生物检测是确保食品质量和消费者健康的关键环节。随着食品工业的快速发展和消费者对食品安全要求的提高,传统的微生物检测方法已难以满足现代食品安全检测的要求。因此,快速检测技术成为了食品微生物检测领域的重要发展趋势。微生物快速检测技术因操作简便、检测速度快、灵敏度高和准确性好等特点在食品安全检测中表现出了巨大的应用潜力。文章对微生物快速检测技术在食品安全检测中的应用展开探讨,以期为相关人员提供参考。

某钢筋混凝土栈桥的异常振动成因分析

为研究栈桥异常振动原因并对结构进行安全性评估,在缺失结构异常振动期间观测数据的情况下,基于现场检测、动力测试及数值仿真3种方式相结合,将导致异常振动的内因和外因逐一排查,筛选高可能性因素进行异常振动成因分析。研究表明,栈桥的异常振动是由水平承载系统的第2阶自振频率与激振频率共振以及托辊转速较小差异导致的“拍现象”综合导致。其中,托辊对栈桥产生的拉扯激振是导致其异常振动的主要因素。该研究成果可为类似水运工程结构的异常振动成因分析提供参考价值。

22种抗生素对梨火疫病菌的室内毒力测定及对花器安全性评价

【目的】筛选出抑制梨火疫病的药剂,为梨火疫病的绿色安全防控提供技术支持。【方法】采用抑菌圈法筛选22种抗生素,评价其在库尔勒香梨花器上的安全性。【结果】13种抗生素对梨火疫病菌有抑制作用,其中在抑菌圈直径达到9 mm时,氯霉素①、注射用头孢噻肟钠、注射用头孢曲松钠和诺氟沙星的药剂有效浓度由低至高是5.30、7.60、9.88、11.64 mg/L,使用同等剂量下4种药剂的抑制作用强于其它药剂;氯霉素①、注射用头孢噻肟钠、注射用头孢曲松钠、罗红霉素分散片、诺氟沙星对库尔勒香梨花器的危害较轻。【结论】氯霉素①、诺氟沙星、注射用头孢曲松钠和注射用头孢噻肟钠可在田间防治梨火疫病上应用。

应用于食品检测领域的分子即时检测技术研究进展

食品安全问题关系人类民生。为有效预防和控制食品安全风险,减少食品安全经济损失,迫切需要开发出针对食源性病原体、食物掺假、转基因作物的高特异性、高敏感性、快速的核酸检测技术。即时检测(point-of-care testing,POCT)作为一种新兴的快速检测手段,由于其检测速度快、操作简单、现场检查等特点,在食品检测领域应用广泛。本文首先介绍了POCT技术的发展历史,而后根据食品安全事件的特点,从食源性致病菌、食物掺假、转基因作物3个方向分析了食品检测的主要对象,阐述了分子POCT技术在食品检测领域的应用现状,最后对应用于食品检测领域的分子POCT技术存在的问题和解决办法进行了分析总结,对食品检测分子POCT技术的发展方向进行了展望。本文有助于进一步了解分子POCT技术在食品检测中的应用,并为分子POCT技术在食品快速检测中的研究和应用提供参考。

升压物质检查法在药品生物安全性检查中的应用及实验关键点

升压物质检查法是《中国药典》收录的一项药物安全性检查法。用以检测可能含有引起血压升高杂质的原料药及其制剂中升压物质的限度是否符合标准规定。该检查法的使用范围虽然较窄,但在临床用药安全上发挥着重要作用。本文就升压物质检查法的实验原理、实验系统、方法应用、各国药典收录情况、改进建议,以及实验要点进行综述,为相关实验人员提供参考。