The deteriorated continuous rigid frame bridge is strengthened by external prestressing. Static loading tests wereconducted before and after the bridge rehabilitation to verify the effectiveness of the rehabilitation ...The deteriorated continuous rigid frame bridge is strengthened by external prestressing. Static loading tests wereconducted before and after the bridge rehabilitation to verify the effectiveness of the rehabilitation process. Thestiffness of the repaired bridge is improved, and the maximum deflection of the load test is reduced from 37.9 to27.6 mm. A bridge health monitoring system is installed after the bridge is reinforced. To achieve an easy assessmentof the bridge’s safety status by directly using transferred data, a real-time safety warning system is createdbased on a five-level safety standard. The threshold for each safety level will be determined by theoretical calculationsand the outcomes of static loading tests. The highest risk threshold will be set at the ultimate limit statevalue. The remaining levels, namely middle risk, low risk, and very low risk, will be determined usingreduction coefficients of 0.95, 0.9, and 0.8, respectively.展开更多
In view of the difficulties about school-enterprise cooperation on food safety testing laboratory reform,the current training program,teaching methods and teaching forms are not suitable for the new platform.This pape...In view of the difficulties about school-enterprise cooperation on food safety testing laboratory reform,the current training program,teaching methods and teaching forms are not suitable for the new platform.This paper provides new ideas and modes to solve these problems,such as integrating the resource elements between school and enterprise,establishing new platforms with the help of external force and innovating the cooperation modes to improve the laboratory,which can fully serve teaching,scientific research and enterprise production.展开更多
Due to the high difficulties, high investment, and high risks in deepwater oil and gas well testing, major safety problems can occur easily. A key to prevent accidents is to conduct safety assessment and control on de...Due to the high difficulties, high investment, and high risks in deepwater oil and gas well testing, major safety problems can occur easily. A key to prevent accidents is to conduct safety assessment and control on deepwater testing and to improve the testing technology. The deepwater of the South China Sea has some special environmental features: long distance from offshore, frequent typhoons in summer and constant monsoons in winter, and the presence of sandy slopes, sandy ridges and internal waves, coupled with the complex properties of oil and gas reserves which bring more challenges to deepwater well testing. In combination with deepwater well testing practice in the South China Sea, this paper analyzes the main potential risks in deepwater well testing and concludes that there are risks of failures of testing string, tools, and ground processes. Other risks are gas hydrate blockage, reservoir stratum sanding, and typhoon impacts. Specific precautions are also proposed in response to these risks in the paper.展开更多
Purpose-Express freight transportation is in rapid development currently.Owing to the higher speed of express freight train,the deformation of the bridge deck worsens the railway line condition under the action of win...Purpose-Express freight transportation is in rapid development currently.Owing to the higher speed of express freight train,the deformation of the bridge deck worsens the railway line condition under the action of wind and train moving load when the train runs over a long-span bridge.Besides,the blunt car body of vehicle has poor aerodynamic characteristics,bringing a greater challenge on the running stability in the crosswind.Design/methodology/approach-In this study,the aerodynamic force coefficients of express freight vehicles on the bridge are measured by scale model wind tunnel test.The dynamic model of the train-long-span steel truss bridge coupling system is established,and the dynamic response as well as the running safety of vehicle are evaluated.Findings-The results show that wind speed has a significant influence on running safety,which is mainly reflected in the over-limitation of wheel unloading rate.The wind speed limit decreases with train speed,and it reduces to 18.83 m/s when the train speed is 160 km/h.Originality/value-This study deepens the theoretical understanding of the interaction between vehicles and bridges and proposes new methods for analyzing similar engineering problems.It also provides a new theoretical basis for the safety assessment of express freight trains.展开更多
Safety-critical system (SCS) has highly demand for dependability, which requires plenty of resource to ensure that the system under test (SUT) satisfies the dependability requirement. In this paper, a new SCS rapi...Safety-critical system (SCS) has highly demand for dependability, which requires plenty of resource to ensure that the system under test (SUT) satisfies the dependability requirement. In this paper, a new SCS rapid testing method is proposed to improve SCS adaptive dependability testing. The result of each test execution is saved in calculation memory unit and evaluated as an algorithm model. Then the least quantity of scenario test case for next test execution will be calculated according to the promised SUT's confidence level. The feedback data are generated to weight controller as the guideline for the further testing. Finally, a compre- hensive experiment study demonstrates that this adaptive testing method can really work in practice. This rapid testing method, testing result statistics-based adaptive control, makes the SCS dependability testing much more effective.展开更多
Based on the research of the formation mechanism and evolution rule of hydrate flow obstacle during deep-water gas well testing,a new method for the prevention of hydrate flow obstacle based on safety testing window i...Based on the research of the formation mechanism and evolution rule of hydrate flow obstacle during deep-water gas well testing,a new method for the prevention of hydrate flow obstacle based on safety testing window is proposed by changing the previous idea of"preventing formation"to the idea of"allowing formation,preventing plugging".The results show that the effective inner diameter of the testing tubing and the wellhead pressure decrease gradually with the formation and precipitation of hydrates during deep-water gas well testing,and it presents three typical processes of slow,fast and sudden changes.There is a safety testing window during deep-water gas well testing.The safety testing window of deep-water gas well testing decreases first and then increases with the increase of gas production rate,and increases with the increase of hydrate inhibitor concentrations.In the case with different testing production rates,a reasonable testing order with alternate low and high gas production rates has been proposed to further reduce the dosage of hydrate inhibitor and even avoid the use of hydrate inhibitors considering the decomposition and fall-off of hydrates.Compared with the traditional methods,the new method based on safety testing window can reduce the dosage of hydrate inhibitor by more than 50%.展开更多
At low temperatures,gun propellant grains may become brittle and this can lead to fracture or shatter of the grains during gun firing.Should this event occur then it will result in an increase in the burning surface o...At low temperatures,gun propellant grains may become brittle and this can lead to fracture or shatter of the grains during gun firing.Should this event occur then it will result in an increase in the burning surface of the propellant and will give rise to a change in ballistic performance.Also,if the resultant over pressure is sufficient,a breech failure may result.Understanding the propensity of a grain to fracture or shatter is therefore important in determining its safety in use.This document describes a test that may be used to derive knowledge and to quantify the physical behaviour of a gun propellant grain at the low temperatures at which fracture or shatter is most likely to occur.展开更多
In order to solve the problem of property test of large flow-rate safety, the property parameter of safety valve test system was analyzed, and a device for property oflarge flow-rate safety valve test was designed.The...In order to solve the problem of property test of large flow-rate safety, the property parameter of safety valve test system was analyzed, and a device for property oflarge flow-rate safety valve test was designed.The device used accumulators as power source and a united function cylinder, which can realized the large flow-rate output for the test system.Analyzed the test data and made a particular research on the test device by testing different flow-rate safety valves;it verifies that the test device can be used tode-sign larger flow-rate safety valve test system and can make the flow-rate test and analysis and dynamic characteristics for the large-flow safety valve.展开更多
This paper presents a holistic methodology for the design of medical device software, which encompasses of a new way of eliciting requirements, system design process, security design guideline, cloud architecture desi...This paper presents a holistic methodology for the design of medical device software, which encompasses of a new way of eliciting requirements, system design process, security design guideline, cloud architecture design, combinatorial testing process and agile project management. The paper uses point of care diagnostics as a case study where the software and hardware must be robust, reliable to provide accurate diagnosis of diseases. As software and software intensive systems are becoming increasingly complex, the impact of failures can lead to significant property damage, or damage to the environment. Within the medical diagnostic device software domain such failures can result in misdiagnosis leading to clinical complications and in some cases death. Software faults can arise due to the interaction among the software, the hardware, third party software and the operating environment. Unanticipated environmental changes and latent coding errors lead to operation faults despite of the fact that usually a significant effort has been expended in the design, verification and validation of the software system. It is becoming increasingly more apparent that one needs to adopt different approaches, which will guarantee that a complex software system meets all safety, security, and reliability requirements, in addition to complying with standards such as IEC 62304. There are many initiatives taken to develop safety and security critical systems, at different development phases and in different contexts, ranging from infrastructure design to device design. Different approaches are implemented to design error free software for safety critical systems. By adopting the strategies and processes presented in this paper one can overcome the challenges in developing error free software for medical devices (or safety critical systems).展开更多
Ensuring food safety is paramount worldwide.Developing effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix ...Ensuring food safety is paramount worldwide.Developing effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix effects of food.Personal glucose meter(PGM),a classic point-of-care testing device,possesses unique application advantages,demonstrating promise in food safety.Currently,many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food hazards.Signal amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors,which is crucial for solving the challenges associated with the use of PGMs for food safety analysis.This review introduces the basic detection principle of a PGM-based sensing strategy,which consists of three key factors:target recognition,signal transduction,and signal output.Representative studies of existing PGM-based sensing strategies combined with various signal amplification technologies(nanomaterial-loaded multienzyme labeling,nucleic acid reaction,DNAzyme catalysis,responsive nanomaterial encapsulation,and others)in the field of food safety detection are reviewed.Future perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are discussed.Despite the need for complex sample preparation and the lack of standardization in the field,using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis.展开更多
Quantitative safety assessment of safety systems plays an important role in decision making at all stages of system lifecycle, i.e., design, deployment and phase out. Most safety assessment methods consider only syste...Quantitative safety assessment of safety systems plays an important role in decision making at all stages of system lifecycle, i.e., design, deployment and phase out. Most safety assessment methods consider only system parameters, such as configuration, hazard rate, coverage, repair rate, etc. along with periodic proof-tests (or inspection). Not considering demand rate will give a pessimistic safety estimate for an application with low demand rate such as nuclear power plants, chemical plants, etc. In this paper, a basic model of IEC 61508 is used. The basic model is extended to incorporate process demand and behavior of electronic- and/or computer-based system following diagnosis or proof-test. A new safety index, probability of failure on actual demand (PFAD) based on extended model and demand rate is proposed. Periodic proof-test makes the model semi-Markovian, so a piece-wise continuous time Markov chain (CTMC) based method is used to derive mean state probabilities of elementary or aggregated state. Method to determine probability of failure on demand (PFD) (IEC 61508) and PFAD based on these state probabilities are described. In example, safety indices of PFD and PFAD are compared.展开更多
The identification of the critical infrastructure has shown that the build civil engineering infrastructure is almost involved everywhere, even with the IT-infrastructure. Therefore, the passive safety of structures i...The identification of the critical infrastructure has shown that the build civil engineering infrastructure is almost involved everywhere, even with the IT-infrastructure. Therefore, the passive safety of structures is demanded. Security associations have analysed that most assaults came along with explosion and impact scenarios, which amount in 80% of assaults. Consequently, these are the extraordinary loads the structures have to be planned and designed for. To carry out such an engineering job, the engineer has to be educated in multiple disciplines as physics, material science , continuum mechanics, numerical mechanics, testing, structural engineering and related specific fields as wave propagation etc. In this paper we will concentrate on the subjects of numerical simulation and testing.展开更多
To evaluate the safety of detergents,the toxicological test results of 580 collected detergents were analyzed.The results showed that,in the acute oral toxicity test,94.4%and 5.6%of the samples were classified as non-...To evaluate the safety of detergents,the toxicological test results of 580 collected detergents were analyzed.The results showed that,in the acute oral toxicity test,94.4%and 5.6%of the samples were classified as non-toxic and toxic respectively.In skin irritation test,95.1%of the samples were mild irritation or below,and 4.9%were moderate irritation or above.In the vaginal mucosa irritation test,79.0%of the samples were very mild irritation or below,while 21.0%were mild irritation or above.In the acute inhalation toxicity test,the proportion of the samples classified as actually non-toxic and toxic were 87.9%and 12.1%respectively.In the eye irritation test,95.7%of the samples belonged to mild irritation or below,and 4.3%of the samples belonged to moderate irritation or above.The products at risk in category A,B and C products account for 6.3%,7.7%and 14.2%respectively.Of the 580 tested samples,90.9%were relatively safe,while 9.1%were at risk.These data showed that most of the tested samples meet the safety requirements for use.展开更多
AIM To test of the implantable-cardioverter-defibrillator is done at the time of implantation. We investigate if any testing should be performed.METHODS All consecutive patients between January 2006 and December 2008 ...AIM To test of the implantable-cardioverter-defibrillator is done at the time of implantation. We investigate if any testing should be performed.METHODS All consecutive patients between January 2006 and December 2008 undergoing implantable cardioverterdefibrillator(ICD) implantation/replacement(a total of 634 patients) were included in the retrospective study.RESULTS Sixteen patients(2.5%) were not tested(9 with LA/LVthrombus, 7 due to operator's decision). Analyzed were 618 patients [76% men, 66.4 + 11 years, 24% secondary prevention(SP), 46% with left ventricular ejection fraction(LVEF) < 20%, 56% had coronary artery disease(CAD)] undergoing defibrillation safety testing(SMT) with an energy of 21 + 2.3 J. In 22/618 patients(3.6%) induced ventricular fibrillation(VF) could not be terminated with maximum energy of the ICD. Six of those(27%) had successful SMT after system modification or shock lead repositioning, 14 patients(64%) received a subcutaneous electrode array. Younger age(P = 0.0003), non-CAD(P = 0.007) and VF as index event for SP(P = 0.05) were associated with a higher incidence of ineffective SMT. LVEF < 20% and incomplete revascularisation in patients with CAD had no impact on SMT.CONCLUSION Defibrillation testing is well-tolerated. An ineffective SMT occurred in 4% and two third of those needed implantation of a subcutaneous electrode array to passa SMT > 10 J.展开更多
文摘The deteriorated continuous rigid frame bridge is strengthened by external prestressing. Static loading tests wereconducted before and after the bridge rehabilitation to verify the effectiveness of the rehabilitation process. Thestiffness of the repaired bridge is improved, and the maximum deflection of the load test is reduced from 37.9 to27.6 mm. A bridge health monitoring system is installed after the bridge is reinforced. To achieve an easy assessmentof the bridge’s safety status by directly using transferred data, a real-time safety warning system is createdbased on a five-level safety standard. The threshold for each safety level will be determined by theoretical calculationsand the outcomes of static loading tests. The highest risk threshold will be set at the ultimate limit statevalue. The remaining levels, namely middle risk, low risk, and very low risk, will be determined usingreduction coefficients of 0.95, 0.9, and 0.8, respectively.
基金Supported by Natural Science Foundation of Shandong Province(ZR2018PC010)Teaching and Research Project of Binzhou University(BZXYSYXM201810).
文摘In view of the difficulties about school-enterprise cooperation on food safety testing laboratory reform,the current training program,teaching methods and teaching forms are not suitable for the new platform.This paper provides new ideas and modes to solve these problems,such as integrating the resource elements between school and enterprise,establishing new platforms with the help of external force and innovating the cooperation modes to improve the laboratory,which can fully serve teaching,scientific research and enterprise production.
文摘Due to the high difficulties, high investment, and high risks in deepwater oil and gas well testing, major safety problems can occur easily. A key to prevent accidents is to conduct safety assessment and control on deepwater testing and to improve the testing technology. The deepwater of the South China Sea has some special environmental features: long distance from offshore, frequent typhoons in summer and constant monsoons in winter, and the presence of sandy slopes, sandy ridges and internal waves, coupled with the complex properties of oil and gas reserves which bring more challenges to deepwater well testing. In combination with deepwater well testing practice in the South China Sea, this paper analyzes the main potential risks in deepwater well testing and concludes that there are risks of failures of testing string, tools, and ground processes. Other risks are gas hydrate blockage, reservoir stratum sanding, and typhoon impacts. Specific precautions are also proposed in response to these risks in the paper.
基金supported by the Research Major Project of China Academy of Railway Sciences Group Co.,Ltd(Grant No.2021YJ270)the China National Railway Group Science and Technology Program(Grant No.N2022T001).
文摘Purpose-Express freight transportation is in rapid development currently.Owing to the higher speed of express freight train,the deformation of the bridge deck worsens the railway line condition under the action of wind and train moving load when the train runs over a long-span bridge.Besides,the blunt car body of vehicle has poor aerodynamic characteristics,bringing a greater challenge on the running stability in the crosswind.Design/methodology/approach-In this study,the aerodynamic force coefficients of express freight vehicles on the bridge are measured by scale model wind tunnel test.The dynamic model of the train-long-span steel truss bridge coupling system is established,and the dynamic response as well as the running safety of vehicle are evaluated.Findings-The results show that wind speed has a significant influence on running safety,which is mainly reflected in the over-limitation of wheel unloading rate.The wind speed limit decreases with train speed,and it reduces to 18.83 m/s when the train speed is 160 km/h.Originality/value-This study deepens the theoretical understanding of the interaction between vehicles and bridges and proposes new methods for analyzing similar engineering problems.It also provides a new theoretical basis for the safety assessment of express freight trains.
基金the National 863 Program under Grant No. 2006AA01Z173.
文摘Safety-critical system (SCS) has highly demand for dependability, which requires plenty of resource to ensure that the system under test (SUT) satisfies the dependability requirement. In this paper, a new SCS rapid testing method is proposed to improve SCS adaptive dependability testing. The result of each test execution is saved in calculation memory unit and evaluated as an algorithm model. Then the least quantity of scenario test case for next test execution will be calculated according to the promised SUT's confidence level. The feedback data are generated to weight controller as the guideline for the further testing. Finally, a compre- hensive experiment study demonstrates that this adaptive testing method can really work in practice. This rapid testing method, testing result statistics-based adaptive control, makes the SCS dependability testing much more effective.
基金Supported by the National Natural Science Foundation of China(51991363,51974350)Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(GML2019ZD0501)Changjiang Scholars Program(Q2016135)
文摘Based on the research of the formation mechanism and evolution rule of hydrate flow obstacle during deep-water gas well testing,a new method for the prevention of hydrate flow obstacle based on safety testing window is proposed by changing the previous idea of"preventing formation"to the idea of"allowing formation,preventing plugging".The results show that the effective inner diameter of the testing tubing and the wellhead pressure decrease gradually with the formation and precipitation of hydrates during deep-water gas well testing,and it presents three typical processes of slow,fast and sudden changes.There is a safety testing window during deep-water gas well testing.The safety testing window of deep-water gas well testing decreases first and then increases with the increase of gas production rate,and increases with the increase of hydrate inhibitor concentrations.In the case with different testing production rates,a reasonable testing order with alternate low and high gas production rates has been proposed to further reduce the dosage of hydrate inhibitor and even avoid the use of hydrate inhibitors considering the decomposition and fall-off of hydrates.Compared with the traditional methods,the new method based on safety testing window can reduce the dosage of hydrate inhibitor by more than 50%.
文摘At low temperatures,gun propellant grains may become brittle and this can lead to fracture or shatter of the grains during gun firing.Should this event occur then it will result in an increase in the burning surface of the propellant and will give rise to a change in ballistic performance.Also,if the resultant over pressure is sufficient,a breech failure may result.Understanding the propensity of a grain to fracture or shatter is therefore important in determining its safety in use.This document describes a test that may be used to derive knowledge and to quantify the physical behaviour of a gun propellant grain at the low temperatures at which fracture or shatter is most likely to occur.
基金Supported by China Coal Research Institute Innovation Item(2007CX06)
文摘In order to solve the problem of property test of large flow-rate safety, the property parameter of safety valve test system was analyzed, and a device for property oflarge flow-rate safety valve test was designed.The device used accumulators as power source and a united function cylinder, which can realized the large flow-rate output for the test system.Analyzed the test data and made a particular research on the test device by testing different flow-rate safety valves;it verifies that the test device can be used tode-sign larger flow-rate safety valve test system and can make the flow-rate test and analysis and dynamic characteristics for the large-flow safety valve.
文摘This paper presents a holistic methodology for the design of medical device software, which encompasses of a new way of eliciting requirements, system design process, security design guideline, cloud architecture design, combinatorial testing process and agile project management. The paper uses point of care diagnostics as a case study where the software and hardware must be robust, reliable to provide accurate diagnosis of diseases. As software and software intensive systems are becoming increasingly complex, the impact of failures can lead to significant property damage, or damage to the environment. Within the medical diagnostic device software domain such failures can result in misdiagnosis leading to clinical complications and in some cases death. Software faults can arise due to the interaction among the software, the hardware, third party software and the operating environment. Unanticipated environmental changes and latent coding errors lead to operation faults despite of the fact that usually a significant effort has been expended in the design, verification and validation of the software system. It is becoming increasingly more apparent that one needs to adopt different approaches, which will guarantee that a complex software system meets all safety, security, and reliability requirements, in addition to complying with standards such as IEC 62304. There are many initiatives taken to develop safety and security critical systems, at different development phases and in different contexts, ranging from infrastructure design to device design. Different approaches are implemented to design error free software for safety critical systems. By adopting the strategies and processes presented in this paper one can overcome the challenges in developing error free software for medical devices (or safety critical systems).
基金supported by the Natural Science Foundation of Shandong Province(Grant No.:ZR2020QC250)China Agriculture Research System(Grant No.:CARS-38)+1 种基金Modern Agricultural Technology Industry System of Shandong Province(Grant No.:SDAIT10-10)Key Technology Research and Development Program of Shandong(Grant Nos.:2021CXGC010809 and 2021TZXD012).
文摘Ensuring food safety is paramount worldwide.Developing effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix effects of food.Personal glucose meter(PGM),a classic point-of-care testing device,possesses unique application advantages,demonstrating promise in food safety.Currently,many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food hazards.Signal amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors,which is crucial for solving the challenges associated with the use of PGMs for food safety analysis.This review introduces the basic detection principle of a PGM-based sensing strategy,which consists of three key factors:target recognition,signal transduction,and signal output.Representative studies of existing PGM-based sensing strategies combined with various signal amplification technologies(nanomaterial-loaded multienzyme labeling,nucleic acid reaction,DNAzyme catalysis,responsive nanomaterial encapsulation,and others)in the field of food safety detection are reviewed.Future perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are discussed.Despite the need for complex sample preparation and the lack of standardization in the field,using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis.
文摘Quantitative safety assessment of safety systems plays an important role in decision making at all stages of system lifecycle, i.e., design, deployment and phase out. Most safety assessment methods consider only system parameters, such as configuration, hazard rate, coverage, repair rate, etc. along with periodic proof-tests (or inspection). Not considering demand rate will give a pessimistic safety estimate for an application with low demand rate such as nuclear power plants, chemical plants, etc. In this paper, a basic model of IEC 61508 is used. The basic model is extended to incorporate process demand and behavior of electronic- and/or computer-based system following diagnosis or proof-test. A new safety index, probability of failure on actual demand (PFAD) based on extended model and demand rate is proposed. Periodic proof-test makes the model semi-Markovian, so a piece-wise continuous time Markov chain (CTMC) based method is used to derive mean state probabilities of elementary or aggregated state. Method to determine probability of failure on demand (PFD) (IEC 61508) and PFAD based on these state probabilities are described. In example, safety indices of PFD and PFAD are compared.
文摘The identification of the critical infrastructure has shown that the build civil engineering infrastructure is almost involved everywhere, even with the IT-infrastructure. Therefore, the passive safety of structures is demanded. Security associations have analysed that most assaults came along with explosion and impact scenarios, which amount in 80% of assaults. Consequently, these are the extraordinary loads the structures have to be planned and designed for. To carry out such an engineering job, the engineer has to be educated in multiple disciplines as physics, material science , continuum mechanics, numerical mechanics, testing, structural engineering and related specific fields as wave propagation etc. In this paper we will concentrate on the subjects of numerical simulation and testing.
文摘To evaluate the safety of detergents,the toxicological test results of 580 collected detergents were analyzed.The results showed that,in the acute oral toxicity test,94.4%and 5.6%of the samples were classified as non-toxic and toxic respectively.In skin irritation test,95.1%of the samples were mild irritation or below,and 4.9%were moderate irritation or above.In the vaginal mucosa irritation test,79.0%of the samples were very mild irritation or below,while 21.0%were mild irritation or above.In the acute inhalation toxicity test,the proportion of the samples classified as actually non-toxic and toxic were 87.9%and 12.1%respectively.In the eye irritation test,95.7%of the samples belonged to mild irritation or below,and 4.3%of the samples belonged to moderate irritation or above.The products at risk in category A,B and C products account for 6.3%,7.7%and 14.2%respectively.Of the 580 tested samples,90.9%were relatively safe,while 9.1%were at risk.These data showed that most of the tested samples meet the safety requirements for use.
文摘AIM To test of the implantable-cardioverter-defibrillator is done at the time of implantation. We investigate if any testing should be performed.METHODS All consecutive patients between January 2006 and December 2008 undergoing implantable cardioverterdefibrillator(ICD) implantation/replacement(a total of 634 patients) were included in the retrospective study.RESULTS Sixteen patients(2.5%) were not tested(9 with LA/LVthrombus, 7 due to operator's decision). Analyzed were 618 patients [76% men, 66.4 + 11 years, 24% secondary prevention(SP), 46% with left ventricular ejection fraction(LVEF) < 20%, 56% had coronary artery disease(CAD)] undergoing defibrillation safety testing(SMT) with an energy of 21 + 2.3 J. In 22/618 patients(3.6%) induced ventricular fibrillation(VF) could not be terminated with maximum energy of the ICD. Six of those(27%) had successful SMT after system modification or shock lead repositioning, 14 patients(64%) received a subcutaneous electrode array. Younger age(P = 0.0003), non-CAD(P = 0.007) and VF as index event for SP(P = 0.05) were associated with a higher incidence of ineffective SMT. LVEF < 20% and incomplete revascularisation in patients with CAD had no impact on SMT.CONCLUSION Defibrillation testing is well-tolerated. An ineffective SMT occurred in 4% and two third of those needed implantation of a subcutaneous electrode array to passa SMT > 10 J.