Marine sediments collected from the Zhujiang(Pearl) River Estuary(ZRE) and South China Sea(SCS) were utilized to study the occurrence and spatial distribution of tetrabromobisphenol A(TBBPA) and hexabromocyclododecane...Marine sediments collected from the Zhujiang(Pearl) River Estuary(ZRE) and South China Sea(SCS) were utilized to study the occurrence and spatial distribution of tetrabromobisphenol A(TBBPA) and hexabromocyclododecane(HBCDD).The levels of TBBPA and HBCDD in sediments ranged from not detected(nd) to 6.14 ng/g dry weight(dw) and nd to 0.42 ng/g dw.TBBPA concentrations in marine sediments were substantially higher than HBCDD.The concentrations of TBBPA and HBCDD in the ZRE sediments were significantly greater than those in the SCS.α-HBCDD(48.7%) and γ-HBCDD(46.2%) were the two main diastereoisomers of HBCDD in sediments from the ZRE,with minor contribution of β-HBCDD(5.1%).HBCDD were only found in one sample from the northern SCS.The enantiomeric fraction of α-HBCDD in sediments from the ZRE was obviously greater than 0.5,indicating an accumulation of(+)-α-HBCDD.The enantiomers of HBCDD were not measured in sediments from the SCS.This work highlighted the environmental behaviors of TBBPA and HBCDD in marine sediments.展开更多
Sorption of tetrabromobisphenol A (TBBPA) by soil influences its fate and transport in the environment. The presence of dissolved organic matter (DOM) may complicate the sorption process in soil. The effects of DOM fr...Sorption of tetrabromobisphenol A (TBBPA) by soil influences its fate and transport in the environment. The presence of dissolved organic matter (DOM) may complicate the sorption process in soil. The effects of DOM from sewage sludge on TBBPA sorption by three soils were investigated using batch equilibration experiments in the study. DOM was observed to be sorbed on the soils and the isotherms could be fitted by the Langmuir model. The effects of DOM on TBBPA sorption were dependent on the characteristics ...展开更多
The present study determined the thyroid hormone interference of tetrabromobisphenol A (TBBPA) in Sprague-Dawley (SD) rats, and the derived-reference dose (RfD) of different endpoint effects on mammals based on ...The present study determined the thyroid hormone interference of tetrabromobisphenol A (TBBPA) in Sprague-Dawley (SD) rats, and the derived-reference dose (RfD) of different endpoint effects on mammals based on experimental results and data collection. Based on repeated exposure toxicity tests on mammals and extensive research, the present study used BMDS240 Software to derive a benchmark dose, and analyzed the accuracy and uncertainty, and similarity with other studies. Test results on triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) demonstrated that all the indicators presented a non-monotonous dose-effect relationship clearly, except TSH in male rats exposed to 0-1000 mg/kg BW per day. Therefore, RfDs were derived from different critical effects. In summary, RfD for mammals in the present study was found to be 0.6 mg/kg per day.展开更多
基金The Guangdong Basic and Applied Basic Research Foundation under contract Nos 2021B1515020040 and 2021A1515011526the National Natural Science Foundation of China under contract Nos 42277246 and U2244221+1 种基金the Hainan Provincial Natural Science Foundation of China under contract No.422CXTD533the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) under contract No.2019BT02H594。
文摘Marine sediments collected from the Zhujiang(Pearl) River Estuary(ZRE) and South China Sea(SCS) were utilized to study the occurrence and spatial distribution of tetrabromobisphenol A(TBBPA) and hexabromocyclododecane(HBCDD).The levels of TBBPA and HBCDD in sediments ranged from not detected(nd) to 6.14 ng/g dry weight(dw) and nd to 0.42 ng/g dw.TBBPA concentrations in marine sediments were substantially higher than HBCDD.The concentrations of TBBPA and HBCDD in the ZRE sediments were significantly greater than those in the SCS.α-HBCDD(48.7%) and γ-HBCDD(46.2%) were the two main diastereoisomers of HBCDD in sediments from the ZRE,with minor contribution of β-HBCDD(5.1%).HBCDD were only found in one sample from the northern SCS.The enantiomeric fraction of α-HBCDD in sediments from the ZRE was obviously greater than 0.5,indicating an accumulation of(+)-α-HBCDD.The enantiomers of HBCDD were not measured in sediments from the SCS.This work highlighted the environmental behaviors of TBBPA and HBCDD in marine sediments.
基金the National Natural Science Foundation of China (No. 20577020, 20737001)
文摘Sorption of tetrabromobisphenol A (TBBPA) by soil influences its fate and transport in the environment. The presence of dissolved organic matter (DOM) may complicate the sorption process in soil. The effects of DOM from sewage sludge on TBBPA sorption by three soils were investigated using batch equilibration experiments in the study. DOM was observed to be sorbed on the soils and the isotherms could be fitted by the Langmuir model. The effects of DOM on TBBPA sorption were dependent on the characteristics ...
基金supported by the National Natural Science Foundation of China(No.21377045)Joint Innovation Funding of Production and Research-a Prospective Joint Research Project(BY2015027-05)
文摘The present study determined the thyroid hormone interference of tetrabromobisphenol A (TBBPA) in Sprague-Dawley (SD) rats, and the derived-reference dose (RfD) of different endpoint effects on mammals based on experimental results and data collection. Based on repeated exposure toxicity tests on mammals and extensive research, the present study used BMDS240 Software to derive a benchmark dose, and analyzed the accuracy and uncertainty, and similarity with other studies. Test results on triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) demonstrated that all the indicators presented a non-monotonous dose-effect relationship clearly, except TSH in male rats exposed to 0-1000 mg/kg BW per day. Therefore, RfDs were derived from different critical effects. In summary, RfD for mammals in the present study was found to be 0.6 mg/kg per day.