In this study, calcium phosphate cements （CPC） were prepared by mixing cement powders of tetracalcium phosphate （TTCP） with a cement liquid of phosphate acid saline solution. Tetracycline （TTC）-CPC, chitosan-CPC...In this study, calcium phosphate cements （CPC） were prepared by mixing cement powders of tetracalcium phosphate （TTCP） with a cement liquid of phosphate acid saline solution. Tetracycline （TTC）-CPC, chitosan-CPC and chitosan-TTC-CPC were investigated with different premixed schedule. It was demonstrate that both TTC and chitosan worked on the phase transition and crystal characteristics. TTCP mixed with phosphate acid saline solution had similar features of Fourier transform-infrared spectrometry （FT-IR） no matter it was mixed with chitosan or TTC or both. TTC premixed with cement liquid or powder had significant different features of FT-IR and 876 cm-1 seemed to be a special peak for TTC when TTC was premixed with cement liquid. This was also supported by XRD analysis, which showed that TTC premixed with cement liquid improved phase transition of TTCP to OCP. Chitosan, as organic additive, regulates the regular crystal formation and inhibits the phase transition of TTCP to OCP, except when it is mingled with cement liquid premixed with TTC in field scanning electron microscope. It was concluded that the premixed schedule influences the crystal formation and phase transition, which may be associated with its biocompatibility and bioactivities in vivo.展开更多
用模拟体液(simulated body fluid,SBF)作为固化液,对磷酸四钙(TTCP)+一水磷酸二氢钙(MCPM)+β-磷酸三钙(β-TCP)系骨水泥理化性质进行研究。结果表明,随液固比增大,抗压强度先增加后降低,当液固比为0.445时,抗压强度达到最大值15.23 M...用模拟体液(simulated body fluid,SBF)作为固化液,对磷酸四钙(TTCP)+一水磷酸二氢钙(MCPM)+β-磷酸三钙(β-TCP)系骨水泥理化性质进行研究。结果表明,随液固比增大,抗压强度先增加后降低,当液固比为0.445时,抗压强度达到最大值15.23 MPa;骨水泥固化较快,液固比为0.594时,tf为12 min;随着浸泡时间的增加抗压强度逐渐减小;X射线(XRD)和扫描电镜(SEM)分析结果显示,随液固比改变,固化反应结晶物均有羟基磷灰石(HA)相出现;浸泡后的骨水泥没有新物相产生。展开更多
基金the National Program 863 (No. 2006AA0320433)Natural Science Fund of Wuhan City (No. 20045006071-6)Hubei Province (No. 2004AA301C15) of China
文摘In this study, calcium phosphate cements （CPC） were prepared by mixing cement powders of tetracalcium phosphate （TTCP） with a cement liquid of phosphate acid saline solution. Tetracycline （TTC）-CPC, chitosan-CPC and chitosan-TTC-CPC were investigated with different premixed schedule. It was demonstrate that both TTC and chitosan worked on the phase transition and crystal characteristics. TTCP mixed with phosphate acid saline solution had similar features of Fourier transform-infrared spectrometry （FT-IR） no matter it was mixed with chitosan or TTC or both. TTC premixed with cement liquid or powder had significant different features of FT-IR and 876 cm-1 seemed to be a special peak for TTC when TTC was premixed with cement liquid. This was also supported by XRD analysis, which showed that TTC premixed with cement liquid improved phase transition of TTCP to OCP. Chitosan, as organic additive, regulates the regular crystal formation and inhibits the phase transition of TTCP to OCP, except when it is mingled with cement liquid premixed with TTC in field scanning electron microscope. It was concluded that the premixed schedule influences the crystal formation and phase transition, which may be associated with its biocompatibility and bioactivities in vivo.
文摘用模拟体液(simulated body fluid,SBF)作为固化液,对磷酸四钙(TTCP)+一水磷酸二氢钙(MCPM)+β-磷酸三钙(β-TCP)系骨水泥理化性质进行研究。结果表明,随液固比增大,抗压强度先增加后降低,当液固比为0.445时,抗压强度达到最大值15.23 MPa;骨水泥固化较快,液固比为0.594时,tf为12 min;随着浸泡时间的增加抗压强度逐渐减小;X射线(XRD)和扫描电镜(SEM)分析结果显示,随液固比改变,固化反应结晶物均有羟基磷灰石(HA)相出现;浸泡后的骨水泥没有新物相产生。
