Structure of Barium Tetrafluorborate Ba_2(BF_4)_4

The title compound Ba2 (BF4)4 crystallizes in the monoclinic spacegroup P21/n with crystallographic parameters: a = 8. 339 (3), b = 16. 530 (7), c =10. 212(4) A, V=1348. 7 A3, β= 106. 64(3)°, Z=4, Dc=3. 06 g/cm3, F(000)=1104, μ=5. 98 mm-1, (MoKa) =0. 71069, M= 621. 90. Least-squares refinementaffords the final residuals R=0. 0639 and Rw=0. 0676 for 2841 observed reflections (I>3(I)). The structure consists of columns of BF4 groups, which parallel to the b direction. All columns are linked together through Ba…F bonds, Both the two crystallographically different barium atoms are nine-coordinated by a distorted tri-capped prismof fluorine atoms from the nearest six BF4 tetrahedrons. There are two types of fluorineatoms, one connecting one barium atom and the other connecting two barium atoms.Each BF4 tetrahedron is connected to three barium atoms, so it (tetrahedron) can beviewed as unidentate ligand and bidentate ligand at the same time.

Hib多糖衍生物中残余CDAP检测方法的建立

目的在b型流感嗜血杆菌结合疫苗生产过程中有效监控1-氰基-4-二甲基氨基-吡啶四氟化硼(CDAP)的残留量。方法在已有针对流脑多糖衍生物的基于强阳离子交换层析检测法的基础上进行改进。结果该法具有良好的专属性、准确度、精密度,最低检出限为6μg/L,且在20~100μg/L的范围内线性良好。结论建立了一种针对b型流感嗜血杆菌多糖衍生物中CDAP的检测方法。