A CuSO_4 catalyzed ynamide formation/[4+2] cycloaddition relay reaction was achieved in one-pot.Various 4,7-cis-dihydroindolines were produced in good to high yields. The one-pot operation in conjunction with the chea...A CuSO_4 catalyzed ynamide formation/[4+2] cycloaddition relay reaction was achieved in one-pot.Various 4,7-cis-dihydroindolines were produced in good to high yields. The one-pot operation in conjunction with the cheap and benign copper catalysis renders this reaction highly sustainable.展开更多
An environmentally benign and efficient method has been developed for the synthesis of functionalized tetrahydroindole derivatives in aqueous media under catalyst-free conditions,by simply combining a phenylglyoxal mo...An environmentally benign and efficient method has been developed for the synthesis of functionalized tetrahydroindole derivatives in aqueous media under catalyst-free conditions,by simply combining a phenylglyoxal monohydrate,an enaminone,and a barbituric acid.The advantages of this method are that it is catalyst free,has an easy workup,provides good yields,and uses water as solvent,which make this procedure facile and practical.展开更多
基金the National Natural Science Foundation of China (No. 21672027)QingLan Project of Jiangsu Province (2016)SixTalent-Peaks Program of Jiangsu (2016) for financial support
文摘A CuSO_4 catalyzed ynamide formation/[4+2] cycloaddition relay reaction was achieved in one-pot.Various 4,7-cis-dihydroindolines were produced in good to high yields. The one-pot operation in conjunction with the cheap and benign copper catalysis renders this reaction highly sustainable.
基金This work was partially supported by the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions(No.10KJA150049)the Natural Science Foundation of Jiangsu Province(BK20131160)+1 种基金the Natural Science Foundation of the Jiangsu Higher Education Institutions(No.11KJB150014)A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions and the Foundation of Key Laboratory of Organic Synthesis of Jiangsu Province(No.KJS1210).
文摘An environmentally benign and efficient method has been developed for the synthesis of functionalized tetrahydroindole derivatives in aqueous media under catalyst-free conditions,by simply combining a phenylglyoxal monohydrate,an enaminone,and a barbituric acid.The advantages of this method are that it is catalyst free,has an easy workup,provides good yields,and uses water as solvent,which make this procedure facile and practical.
