A convergent construction of [2,3]-fused indoline tetrahydropyridazines via an I2/tert-butyl hydroperoxide(TBHP) catalyzed three-component dearomative oxidative coupling of indoles, hydrazines and acetophenone was est...A convergent construction of [2,3]-fused indoline tetrahydropyridazines via an I2/tert-butyl hydroperoxide(TBHP) catalyzed three-component dearomative oxidative coupling of indoles, hydrazines and acetophenone was established in moderate to good yields. This protocol provides a new approach for the synthesis of these biologically interesting fused indolines.展开更多
基金supported by the Ministry of Science and Technology(2016YFA0602900)the National Natural Science Foundation of China(21372224,21232008,21420102003,21521002)+1 种基金Shandong Province Independent Innovation and Achievements Transformation of Special(2014XGC06001)the Chinese Academy of Sciences
文摘A convergent construction of [2,3]-fused indoline tetrahydropyridazines via an I2/tert-butyl hydroperoxide(TBHP) catalyzed three-component dearomative oxidative coupling of indoles, hydrazines and acetophenone was established in moderate to good yields. This protocol provides a new approach for the synthesis of these biologically interesting fused indolines.
