Objective:To investigate the effect of Kangfuxin Solution(康复新液)combined with low-level laser therapy(LLLT)on cytokines and immune function in patients with radiation-induced oral mucositis.Methods:There were 84 na...Objective:To investigate the effect of Kangfuxin Solution(康复新液)combined with low-level laser therapy(LLLT)on cytokines and immune function in patients with radiation-induced oral mucositis.Methods:There were 84 nasopharyngeal carcinoma patients with oral mucositis after intensity-modulated radiation therapy(IMRT)were randomly divided into the control group(CG)and the observation group(OG),with 42 cases in each group.The CG was given LLLT,and the OG was treated with Kangfuxin Solution in addition to LLLT for 10 consecutive days.The healing time of oral mucosa,mucositis grading,oral pain scores,cytokines(interleukin-6,interleukin-1βand tumor necrosis factor-α)and T lymphocyte subsets were compared between the 2 groups before and after treatment.Results:The healing time of oral mucosa in the OG was(6.8±1.4)d,which was significantly shorter than(8.6±1.9)d in the CG(t=4.943,P<0.01).After treatment,the grading of oral mucositis in the OG was better than that in the CG,with a statistically significant difference(Z=2.942,P<0.05).The oral pain scores of the OG was lower than that in the CG at different time points after treatment,and the difference was statistically significant(t=8.207,11.017,P<0.01).After treatment,the levels of IL-6,IL-1βand TNF-αin peripheral blood of the OG were significantly lower than those in the CG(t=5.217,2.775,4.053,P<0.01).There were statistically significant differences in CD4+,CD8+and CD4+/CD8+between the OG and the CG after treatment(t=5.692,6.093,3.658,P<0.01).Conclusion:Kangfuxin Solution combined with LLLT can significantly shorten the healing time of oral mucosal,reduce the grading of oral mucositis,relieve oral pain,reduce inflammatory response and improve the immune function of patients.展开更多
The combination of radiotherapy(RT)and chemotherapy is associated with a high cure rate but an increased risk of radiation-induced oral mucositis(RIOM)in patients with nasopharyngeal carcinoma(NPC).As a dose-limiting ...The combination of radiotherapy(RT)and chemotherapy is associated with a high cure rate but an increased risk of radiation-induced oral mucositis(RIOM)in patients with nasopharyngeal carcinoma(NPC).As a dose-limiting complication,RIOM remains a critical dilemma for patients and physicians,potentially leading to radiation interruptions and compromised tumor control.In this review,we discuss and analyze the pathological mechanisms and factors affecting prevention/treatment of RIOM.RT may induce RIOM via a positive feedback loop,consequently amplifying superoxide production,the immunoinflammatory response,dysbacteriosis,infection,and epithelial basal cell death.Routine interventions for RIOM focus on oral care,oral-pain relief,nutritional support,and infection control;however,recent novel and effective methods have been proposed according to the pathological mechanisms and influencing factors.Some patients with low-recurrence-risk NPCs may be treated with reduced-dose RT,reduced-dose chemotherapy,or RT alone(without chemotherapy)to prevent severe RIOM.Furthermore,traditional herbal medicine extracts,such as Kangfuxin and honey,may help to control RIOM.In addition to the routine application of antibiotics to treat oral dysbacteriosis and hormones to suppress immune inflammatory responses,edaravone and GC4419 can also be used to scavenge oxygen free radicals and reduce superoxide ions to protect the oral mucosa and limit the occurrence of RIOM.展开更多
目的观察滋阴清热法防治鼻咽癌患者急性放射性口腔炎属阴虚内热证的效果。方法将60例确诊为鼻咽癌并进行首次放疗的患者,分为两组:治疗组(31例)采用滋阴清热法治疗方案,对照组(29例)采用西医治疗方案。观察治疗期间口腔黏膜情况,检测唾...目的观察滋阴清热法防治鼻咽癌患者急性放射性口腔炎属阴虚内热证的效果。方法将60例确诊为鼻咽癌并进行首次放疗的患者,分为两组:治疗组(31例)采用滋阴清热法治疗方案,对照组(29例)采用西医治疗方案。观察治疗期间口腔黏膜情况,检测唾液中表皮生长因子(epidermal growth factor,EGF)的含量,并利用欧洲癌症研究与治疗组织(European Organization for Researeh and Treatment of Cancer,EORTC)的生活质量核心量表QLQ-C30(quality of life questionnaire-core 30)评价患者的生活质量。结果所有患者在放疗中均出现放射性口腔黏膜反应,治疗组的反应轻于对照组(P<0.01)。随着放疗剂量的增加,两组唾液中EGF的含量呈下降趋势,在放疗至40 Gy时下降明显(P<0.01),至70 Gy时降到最低值(P<0.01),治疗组下降程度均较对照组轻,差异有统计学意义(P<0.01)。两组患者放疗后QLQ-C30生活质量比较显示:治疗组患者的生活质量总健康状况要优于对照组,两组比较差异有统计学意义(P<0.01)。结论滋阴清热法可推迟放射性口腔炎出现的时间,减轻放疗反应,能改善患者总体生活质量,对防治急性放射性口腔黏膜炎有较好的疗效,具有一定的临床推广应用价值。展开更多
文摘Objective:To investigate the effect of Kangfuxin Solution(康复新液)combined with low-level laser therapy(LLLT)on cytokines and immune function in patients with radiation-induced oral mucositis.Methods:There were 84 nasopharyngeal carcinoma patients with oral mucositis after intensity-modulated radiation therapy(IMRT)were randomly divided into the control group(CG)and the observation group(OG),with 42 cases in each group.The CG was given LLLT,and the OG was treated with Kangfuxin Solution in addition to LLLT for 10 consecutive days.The healing time of oral mucosa,mucositis grading,oral pain scores,cytokines(interleukin-6,interleukin-1βand tumor necrosis factor-α)and T lymphocyte subsets were compared between the 2 groups before and after treatment.Results:The healing time of oral mucosa in the OG was(6.8±1.4)d,which was significantly shorter than(8.6±1.9)d in the CG(t=4.943,P<0.01).After treatment,the grading of oral mucositis in the OG was better than that in the CG,with a statistically significant difference(Z=2.942,P<0.05).The oral pain scores of the OG was lower than that in the CG at different time points after treatment,and the difference was statistically significant(t=8.207,11.017,P<0.01).After treatment,the levels of IL-6,IL-1βand TNF-αin peripheral blood of the OG were significantly lower than those in the CG(t=5.217,2.775,4.053,P<0.01).There were statistically significant differences in CD4+,CD8+and CD4+/CD8+between the OG and the CG after treatment(t=5.692,6.093,3.658,P<0.01).Conclusion:Kangfuxin Solution combined with LLLT can significantly shorten the healing time of oral mucosal,reduce the grading of oral mucositis,relieve oral pain,reduce inflammatory response and improve the immune function of patients.
文摘The combination of radiotherapy(RT)and chemotherapy is associated with a high cure rate but an increased risk of radiation-induced oral mucositis(RIOM)in patients with nasopharyngeal carcinoma(NPC).As a dose-limiting complication,RIOM remains a critical dilemma for patients and physicians,potentially leading to radiation interruptions and compromised tumor control.In this review,we discuss and analyze the pathological mechanisms and factors affecting prevention/treatment of RIOM.RT may induce RIOM via a positive feedback loop,consequently amplifying superoxide production,the immunoinflammatory response,dysbacteriosis,infection,and epithelial basal cell death.Routine interventions for RIOM focus on oral care,oral-pain relief,nutritional support,and infection control;however,recent novel and effective methods have been proposed according to the pathological mechanisms and influencing factors.Some patients with low-recurrence-risk NPCs may be treated with reduced-dose RT,reduced-dose chemotherapy,or RT alone(without chemotherapy)to prevent severe RIOM.Furthermore,traditional herbal medicine extracts,such as Kangfuxin and honey,may help to control RIOM.In addition to the routine application of antibiotics to treat oral dysbacteriosis and hormones to suppress immune inflammatory responses,edaravone and GC4419 can also be used to scavenge oxygen free radicals and reduce superoxide ions to protect the oral mucosa and limit the occurrence of RIOM.
文摘目的观察滋阴清热法防治鼻咽癌患者急性放射性口腔炎属阴虚内热证的效果。方法将60例确诊为鼻咽癌并进行首次放疗的患者,分为两组:治疗组(31例)采用滋阴清热法治疗方案,对照组(29例)采用西医治疗方案。观察治疗期间口腔黏膜情况,检测唾液中表皮生长因子(epidermal growth factor,EGF)的含量,并利用欧洲癌症研究与治疗组织(European Organization for Researeh and Treatment of Cancer,EORTC)的生活质量核心量表QLQ-C30(quality of life questionnaire-core 30)评价患者的生活质量。结果所有患者在放疗中均出现放射性口腔黏膜反应,治疗组的反应轻于对照组(P<0.01)。随着放疗剂量的增加,两组唾液中EGF的含量呈下降趋势,在放疗至40 Gy时下降明显(P<0.01),至70 Gy时降到最低值(P<0.01),治疗组下降程度均较对照组轻,差异有统计学意义(P<0.01)。两组患者放疗后QLQ-C30生活质量比较显示:治疗组患者的生活质量总健康状况要优于对照组,两组比较差异有统计学意义(P<0.01)。结论滋阴清热法可推迟放射性口腔炎出现的时间,减轻放疗反应,能改善患者总体生活质量,对防治急性放射性口腔黏膜炎有较好的疗效,具有一定的临床推广应用价值。
