The three-dimensional(3 D) structures of pores directly affect the CH4 flow.Therefore,it is very important to analyze the3 D spatial structure of pores and to simulate the CH4 flow with the connected pores as the carr...The three-dimensional(3 D) structures of pores directly affect the CH4 flow.Therefore,it is very important to analyze the3 D spatial structure of pores and to simulate the CH4 flow with the connected pores as the carrier.The result shows that the equivalent radius of pores and throats are 1-16 μm and 1.03-8.9 μm,respectively,and the throat length is 3.28-231.25 μm.The coordination number of pores concentrates around three,and the intersection point between the connectivity function and the X-axis is 3-4 μm,which indicate the macro-pores have good connectivity.During the single-channel flow,the pressure decreases along the direction of CH4 flow,and the flow velocity of CH4 decreases from the pore center to the wall.Under the dual-channel and the multi-channel flows,the pressure also decreases along the CH4 flow direction,while the velocity increases.The mean flow pressure gradually decreases with the increase of the distance from the inlet slice.The change of mean flow pressure is relatively stable in the direction horizontal to the bedding plane,while it is relatively large in the direction perpendicular to the bedding plane.The mean flow velocity in the direction horizontal to the bedding plane(Y-axis) is the largest,followed by that in the direction horizontal to the bedding plane(X-axis),and the mean flow velocity in the direction perpendicular to the bedding plane is the smallest.展开更多
Evolution of computational modeling and simulation has given more emphasis on the research activities related to carbon nanotube(CNT)reinforced polymer composites recently.This paper presents the composite cylinder as...Evolution of computational modeling and simulation has given more emphasis on the research activities related to carbon nanotube(CNT)reinforced polymer composites recently.This paper presents the composite cylinder assemblage(CCA)approach based on continuum mechanics for investigating the elastic properties of a polymer resin reinforced by multi-walled carbon nanotubes(MWCNTs).A three-phase cylindrical representative volume element(RVE)model is employed based on CCA technique to elucidate the effects of inter layers,chirality,interspacing,volume fraction of MWCNT,interphase properties and temperature conditions on the elastic modulus of the composite.The interface region between CNT and polymer matrix is modeled as the third phase with varying material properties.The constitutive relations for each material system have been derived based on solid mechanics and proper interfacial traction continuity conditions are imposed.The predicted results from the CCA approach are in well agreement with RVE-based finite element model.The outcomes reveal that temperature softening effect becomes more pronounced at higher volume fractions of CNTs.展开更多
According to Kirillov's idea, the irreducible unitary representations of a Lie group G roughly correspond to the coadjoint orbits (?).In the forward direction one applies the methods of geometric quantization to p...According to Kirillov's idea, the irreducible unitary representations of a Lie group G roughly correspond to the coadjoint orbits (?).In the forward direction one applies the methods of geometric quantization to produce a representation, and in the reverse direction one computes a transform of the character of a representation, to obtain a coadjoint orbit. The method of orbits in the representations of Lie groups suggests the detailed study of coadjoint orbits of a Lie group G in the space (?)~* dual to the Lie algebra (?) of G. In this paper, two primary goals are achieved: one is to completely classify the smooth coadjoint orbits of Virasoro group for nonzero central charge c; the other is to find representatives for coadjoint orbits. These questions have been considered previously by Segal, Kirillov, and Witten, but their results are not quite complete. To accomplish this, the authors start by describing the coadjoint action of D-the Lie group of all orientation preserving diffeomorphisms on the circle S^1, and its central extension (?), then the authors will give a complete classification of smooth coadjoint orbits. In fact, they can be parameterized by a subspace Of conjugacy classes of (?)(1,1). Finally, the authors will show how to find representatives f coadjoint orbits by analyzing the vector fields stabilizing the orbits, and describe the amazing connection between the characteristic (trace) of conjugacy classes of (?)(1, 1) and that of vector fields stabilizing orbits.展开更多
The research examines the way in which members of the U.S. House of Representative represent themselves on the social network site Facebook. Each member’s activity is observed on seven different occasions and the fre...The research examines the way in which members of the U.S. House of Representative represent themselves on the social network site Facebook. Each member’s activity is observed on seven different occasions and the frequency and substantive character of posts made during the second half of 2013 are established. The focus is on position-taking posts versus posts which mention the district the member serves in. Our expectation is that members from electorally safe districts will be more likely to advertise their policy positions while members from marginal districts will be more inclined to advertise their district connections. We control for minority party status, gender, and ideological extremism among other concerns and learn electoral safety is a good predictor of both “position-taking” and “district mentions”. Consistent with an electoral motive, we also find members from the minority party less likely to take positions on the issues of the day and more likely to mention the district they serve in.展开更多
Steeped in a civilization featuring inclusivity and peaceful nature,China seeks exchanges and mutual learning among civilizations rather than cultural hegemony.WHILE claiming its preeminent global economic status,Chin...Steeped in a civilization featuring inclusivity and peaceful nature,China seeks exchanges and mutual learning among civilizations rather than cultural hegemony.WHILE claiming its preeminent global economic status,China has also come to assert its equivalent position in world politics and diplomacy,typically representing the interests of the developing world.展开更多
For more than half a centurymanufacturers in search of independentrepresentatives to sell their products innew markets and to establishrelationships with prospective customershave relied upon the services of theManufa...For more than half a centurymanufacturers in search of independentrepresentatives to sell their products innew markets and to establishrelationships with prospective customershave relied upon the services of theManufacturers’ Agents NationalAssociation (MANA).展开更多
As the world continues to search for innovative therapeutic solutions,the field of natural medicines has emerged as a vibrant area of research.The potential of natural products to treat a wide range of diseases,couple...As the world continues to search for innovative therapeutic solutions,the field of natural medicines has emerged as a vibrant area of research.The potential of natural products to treat a wide range of diseases,coupled with the relatively low sideeffects of such products,has captured the attention of scientists,clinicians,and the general public alike.This Special Issue on Natural Medicine aims to present the latest advancements in this exciting field,highlighting both fundamental research and clinical applications.The collection of articles in this Special Issue covers a broad spectrum of topics,ranging from medicinal chemistry to biological mechanisms,and from the study of single botanic compounds to complex plant formulas.We are particularly pleased to include a comprehensive review by Yi Wang et al.on the bioactivities,mechanisms,production,and potential application of bile acids in preventing and treating infectious diseases.This review not only summarizes the current landscape of bile acids research but also highlights several promising compounds for future investigations,such as the recent interest in ursodeoxycholic acid.In a related topic,Shishan Yu’s team has developed artificial bear bile using synthetic chemistry and enzyme engineering,providing a sustainable substitute for natural bear bile.This innovation meets medical needs while addressing animal welfare issues,representing a notable progression in the field.展开更多
Greetings…Allow me to begin by extending,on behalf of the Philippine delegation,our heartfelt gratitude to the Chinese Association for International Understanding(CAFIU)for this excellent opportunity for greater unde...Greetings…Allow me to begin by extending,on behalf of the Philippine delegation,our heartfelt gratitude to the Chinese Association for International Understanding(CAFIU)for this excellent opportunity for greater understanding of China and its relations to the Philippines,the ASEAN and the rest of the world.This exchange has likewise been an important occasion for us to share our insights on these relations in the light of our common interests and aspirations展开更多
The global governance of large artificial intelligence(AI)models calls for urgent actions.Large models,representing a type of technological innovation,is advancing global technological progress and is also compelling ...The global governance of large artificial intelligence(AI)models calls for urgent actions.Large models,representing a type of technological innovation,is advancing global technological progress and is also compelling the international community’s attention to the role of global governance system in coordinating the development of AI.In building a global governance mechanism for large models,both traditional governance system and new international system should be explored to construct Regime Complexes for the governance of large models.展开更多
Afghanistan has faced extreme climatic crises such as drought,rising temperature,and scarce precipitation,and these crises will likely worsen in the future.Reduction in crop yield can affect food security in Afghanist...Afghanistan has faced extreme climatic crises such as drought,rising temperature,and scarce precipitation,and these crises will likely worsen in the future.Reduction in crop yield can affect food security in Afghanistan,where the majority of population and economy are completely dependent on agriculture.This study assessed the interaction between climate change and crop yield in Kabul of Afghanistan during the reference(1990–2020)and future(2025–2100)periods.Climate data(1990–2020)were collected from four meteorological stations and three local organizations,and wheat yield data(1990–2020)were acquired from the United States Agriculture Department.Data during the reference period(1990–2020)were used for the validation and calibration of the statistical downscaling models such as the Statistical Downscaling Model(SDSM)and Long Ashton Research Station Weather Generator(LARS-WG).Furthermore,the auto-regression model was used for trend analysis.The results showed that an increase in the average annual temperature of 2.15℃,2.89℃,and 4.13℃will lead to a reduction in the wheat yield of 9.14%,10.20%,and 12.00%under Representative Concentration Pathway(RCP)2.6,RCP4.5,and RCP8.5 during the future period(2025–2100),respectively.Moreover,an increase in the annual maximum temperature of 1.79℃,2.48℃,and 3.74℃also causes a significant reduction in the wheat yield of 2.60%,3.60%,and 10.50%under RCP2.6,RCP4.5,and RCP8.5,respectively.Furthermore,an increase in the annual minimum temperature of 2.98℃,2.23℃,and 4.30℃can result in an increase in the wheat yield of 6.50%,4.80%,and 9.30%under RCP2.6,RCP4.5,and RCP8.5,respectively.According to the SDSM,the decrease of the average monthly precipitation of 4.34%,4.10%,and 5.13%results in a decrease in the wheat yield of 2.60%,2.36%,and 3.18%under RCP2.6,RCP4.5,and RCP8.5,respectively.This study suggests that adaptation strategies can be applied to minimize the consequences of climate change on agricultural production.展开更多
Cable-stayed bridges have been widely used in high-speed railway infrastructure.The accurate determination of cable’s representative temperatures is vital during the intricate processes of design,construction,and mai...Cable-stayed bridges have been widely used in high-speed railway infrastructure.The accurate determination of cable’s representative temperatures is vital during the intricate processes of design,construction,and maintenance of cable-stayed bridges.However,the representative temperatures of stayed cables are not specified in the existing design codes.To address this issue,this study investigates the distribution of the cable temperature and determinates its representative temperature.First,an experimental investigation,spanning over a period of one year,was carried out near the bridge site to obtain the temperature data.According to the statistical analysis of the measured data,it reveals that the temperature distribution is generally uniform along the cable cross-section without significant temperature gradient.Then,based on the limited data,the Monte Carlo,the gradient boosted regression trees(GBRT),and univariate linear regression(ULR)methods are employed to predict the cable’s representative temperature throughout the service life.These methods effectively overcome the limitations of insufficient monitoring data and accurately predict the representative temperature of the cables.However,each method has its own advantages and limitations in terms of applicability and accuracy.A comprehensive evaluation of the performance of these methods is conducted,and practical recommendations are provided for their application.The proposed methods and representative temperatures provide a good basis for the operation and maintenance of in-service long-span cable-stayed bridges.展开更多
In order to implement the spirits of the Central Economic Work Conference and systematically promote the standardization work of commercial aerospace,SAC/TC 425,Space technology and operation,recently established thre...In order to implement the spirits of the Central Economic Work Conference and systematically promote the standardization work of commercial aerospace,SAC/TC 425,Space technology and operation,recently established three working groups for emerging fields and strategic emerging industries related to commercial aerospace.The work scope of WG 1 on commercial aircraft launching covers the standards research,development and revision for operation support,process,industrial chains,and other fields of launching.It is also responsible for the updating of standards documents published by correspondent international standardization organizations for further analysis and adoption.WG 2 on the application of satellite internet is responsible for the research,development and revision of standards in areas such as the application scenarios and demands,functions and process,interfaces and data forms of satellite internet.Its first batch of members consists of 29 service providers,operators,equipment manufacturers,and parties representing public interests in this field.展开更多
Bulked-segregant analysis coupled with next-generation sequencing(BSA-seq) has emerged as an efficient tool for genetic mapping of single genes or major quantitative trait loci controlling(agronomic) traits of interes...Bulked-segregant analysis coupled with next-generation sequencing(BSA-seq) has emerged as an efficient tool for genetic mapping of single genes or major quantitative trait loci controlling(agronomic) traits of interest. However, such a mapping-by-sequencing approach usually relies on deep sequencing and advanced statistical methods. Application of BSA-Seq based on construction of reduced-representation libraries and allele frequency analysis permitted anchoring the barley pale-green(pg) gene on chromosome 3 HL. With further marker-assisted validation, pg was mapped to a 3.9 Mb physical-map interval. In the pg mutant a complete deletion of chlorophyllide a oxygenase(HvCAO) gene was identified.Because the product of this gene converts Chl a to Chl b, the pg mutant is deficient in Chl b.An independent Chl b-less mutant line M4437_2 carried a nonsynonymous substitution(F263 L) in the C domain of HvCAO. The study demonstrates an optimized pooling strategy for fast mapping of agronomically important genes using a segregating population.展开更多
A method for determination of tool-chip contact length is theoreticallypresented in orthogonal metal machining. By using computer simulation and based on the analyses ofthe elastro-plastic deformation with lagrangian ...A method for determination of tool-chip contact length is theoreticallypresented in orthogonal metal machining. By using computer simulation and based on the analyses ofthe elastro-plastic deformation with lagrangian finite element method in the deformation zone, theaccumulated representative length of the low layer, the tool-chip contact length of the chipcontacting the tool rake are calculated, experimental studies are also carried out with 0.2 percentcarbon steel. It is shown that the tool-chip contact lengths obtained from computer simulation havea good agreement with those of measured values.展开更多
Nuts have received increased attention from the public in recent years as important sources of some essential elements, and information on the levels of elements in edible nuts is useful to consumers. Determination of...Nuts have received increased attention from the public in recent years as important sources of some essential elements, and information on the levels of elements in edible nuts is useful to consumers. Determination of the elemental distributions in nuts is not only necessary in evaluating the total dietary intake of the essential elements, but also useful in detecting heavy metal contamination in food. The aim of this study was to determine the mineral contents in edible nuts, and to assess the food safety of nuts in the Beijing market. Levels of Li, Cr, Mn, Co, Cu, Zn, As, Se, Rb, Sr, Mo, Cd, Cs, Ba, Pb, Th, and U in 11 types of edible nuts and seeds (macadamia nuts, lotus nuts, pistachios, sunflower seeds, pine nuts, almonds, walnuts, chestnuts, hazelnuts, cashews, and ginkgo nuts) as well as raisins were determined by inductively coupled plasma mass spectrometry (ICP-MS). The accuracy of the method was validated using standard reference materials GBWlO014 (cabbage) and GBWlO016 (tea). Our results provide useful information for evaluating the levels of trace elements in edible nuts in the Beijing market, will be helpful for improving food safety, and will aid in better protecting consumer interests.展开更多
Fully grouted bolts are a key component of the support system for underground openings.Although considerable effort has been made in the simulation of the reinforcement effect of the fully grouted bolts on the rock ma...Fully grouted bolts are a key component of the support system for underground openings.Although considerable effort has been made in the simulation of the reinforcement effect of the fully grouted bolts on the rock masses surrounding underground openings,most of the work has limited significance since the structural element approach is used.This study proposes a local homogenization approach(L-H approach)that integrates elastoplastic mechanics,composite mechanics,and analytical approaches with numerical simulation to effectively simulate the reinforcement effect of the fully grouted bolt on deep surrounding rock masses.In the L-H approach,the representative volume of bolted rock mass(RVBRM)with a fully grouted bolt is established based on the original mesh model utilized in the rockbolt element approach.The RVBRM is a regular quadrangular prism with a cross-sectional size equal to the bolt spacing and a length equal to the bolt length.The RVBRM is homogenized by the L-H approach from a unidirectional bolt-reinforced composite into a homogeneous transversely isotropic medium whose mechanical properties are described by a new transversely isotropic elastoplastic model.The L-H parameters for the RVBRM are obtained using analytical approaches,composite mechanics,and known parameters of the rock mass and bolt.Using the L-H approach,the reinforcement effect of the fully grouted bolt on the bolted rock specimen and the surrounding rock mass in Jinping II Diversion Tunnel#2 with a depth greater than 2000 m is simulated.The results show that the predictions of the L-H approach are more in agreement with the physical model results of bolted rock specimen and provide a more realistic response of the bolted surrounding rock mass.The L-H approach demonstrates that fully grouted bolts with common bolt spacings and diameters substantially enhance the elastic modulus,shear strength,and tensile strength of the rock mass in the direction of the bolt axis.展开更多
Projections of potential submerged area due to sea level rise are helpful for improving understanding of the influence of ongoing global warming on coastal areas. The Ensemble Empirical Mode Decomposition method is us...Projections of potential submerged area due to sea level rise are helpful for improving understanding of the influence of ongoing global warming on coastal areas. The Ensemble Empirical Mode Decomposition method is used to adaptively decompose the sea level time series in order to extract the secular trend component. Then the linear relationship between the global mean sea level (GMSL) change and the Zhujiang (Pearl) River Delta (PRD) sea level change is calculated: an increase of 1.0 m in the GMSL corresponds to a 1.3 m (uncertainty interval from 1.25 to 1.46 m) increase in the PRD. Based on this relationship and the GMSL rise projected by the Coupled Model Intercomparison Project Phase 5 under three greenhouse gas emission scenarios (representative concentration pathways, or RCPs, from low to high emission scenarios RCP2.6, RCP4.5, and RCP8.5), the PRD sea level is calculated and projected for the period 2006-2100. By around the year 2050, the PRD sea level will rise 0.29 (0.21 to 0.40) m under RCP2.6, 0.31 (0.22 to 0.42) m under RCP4.5, and 0.34 (0.25 to 0.46) m under RCP8.5, respectively. By 2100, it will rise 0.59 (0.36 to 0.88) m, 0.71 (0.47 to 1.02) m, and 1.0 (0.68 to 1.41) m, respectively. In addition, considering the extreme value of relative sea level due to land subsidence (i.e., 0.20 m) and that obtained from intermonthly variability (i.e., 0.33 m), the PRD sea level will rise 1.94 m by the year 2100 under the RCP8.5 scenario with the upper uncertainty level (i.e., 1.41 m). Accordingly, the potential submerged area is 8.57x103 km2 for the PRD, about 1.3 times its present area.展开更多
Thermal expansion coefficients play an important role in the design and analysis of composite structures. A detailed analysis of thermo-mechanical distortion can be performed on microscopic level of a structure. Howev...Thermal expansion coefficients play an important role in the design and analysis of composite structures. A detailed analysis of thermo-mechanical distortion can be performed on microscopic level of a structure. However, for a design and analysis of large structures, the knowledge of effective material properties is essential. Thus, either a theoretical prediction or a numerical estimation of the effective properties is indispensable. In some simple cases, exact analytical solutions for the effective properties can be derived. Moreover, bounds on the effective values exist. However, in dealing with complex heterogeneous composites, numerical methods are becoming increasingly important and more widely used, because of the limiting applicability of the existing (semi-)analytical approaches. In this study, finite-element methods for the calculation of effective thermal expansion coefficients of composites with arbitrary geometrical inclusion configurations are discussed and applied to a heterogeneous lightning protection coating made from Dexmet® copper foil 3CU7-100FA and HexPly® epoxy resin M21. A short overview of some often used (semi-)analytical formulas for effective thermal expansion coefficients of heterogeneous composites is given in addition.展开更多
DEAR EDITOR,The disk-footed bat Eudiscopus denticulus(Osgood,1932)is a rare species in Southeast Asia.During two chiropteran surveys in the summer of 1981 and 2019,eight and three small Myotis-like bats with distinct ...DEAR EDITOR,The disk-footed bat Eudiscopus denticulus(Osgood,1932)is a rare species in Southeast Asia.During two chiropteran surveys in the summer of 1981 and 2019,eight and three small Myotis-like bats with distinct disk-like hindfeet were collected from Yunnan Province,China,respectively.External,craniodental,and phylogenetic evidence confirmed these specimens as E.denticulus,representing a new genus in China.The complete mitochondrial genome consistently showed robust support for E.denticulus as a basal lineage within Myotinae.The coding patterns and characteristics of its mitochondrial genome were similar to that of other published genomes from Myotis.The echolocation signals of the newly collected individuals were analyzed.The potential distribution range of Eudiscopus in Southeast Asia inferred using the MaxEnt model indicated its potential occurrence along the southern border region of Yunnan,China.展开更多
基金financially supported by the National Key Research and Development Plan(No.2018YFB0605601)the National Natural Science Foundation of China(No.41972168)。
文摘The three-dimensional(3 D) structures of pores directly affect the CH4 flow.Therefore,it is very important to analyze the3 D spatial structure of pores and to simulate the CH4 flow with the connected pores as the carrier.The result shows that the equivalent radius of pores and throats are 1-16 μm and 1.03-8.9 μm,respectively,and the throat length is 3.28-231.25 μm.The coordination number of pores concentrates around three,and the intersection point between the connectivity function and the X-axis is 3-4 μm,which indicate the macro-pores have good connectivity.During the single-channel flow,the pressure decreases along the direction of CH4 flow,and the flow velocity of CH4 decreases from the pore center to the wall.Under the dual-channel and the multi-channel flows,the pressure also decreases along the CH4 flow direction,while the velocity increases.The mean flow pressure gradually decreases with the increase of the distance from the inlet slice.The change of mean flow pressure is relatively stable in the direction horizontal to the bedding plane,while it is relatively large in the direction perpendicular to the bedding plane.The mean flow velocity in the direction horizontal to the bedding plane(Y-axis) is the largest,followed by that in the direction horizontal to the bedding plane(X-axis),and the mean flow velocity in the direction perpendicular to the bedding plane is the smallest.
文摘Evolution of computational modeling and simulation has given more emphasis on the research activities related to carbon nanotube(CNT)reinforced polymer composites recently.This paper presents the composite cylinder assemblage(CCA)approach based on continuum mechanics for investigating the elastic properties of a polymer resin reinforced by multi-walled carbon nanotubes(MWCNTs).A three-phase cylindrical representative volume element(RVE)model is employed based on CCA technique to elucidate the effects of inter layers,chirality,interspacing,volume fraction of MWCNT,interphase properties and temperature conditions on the elastic modulus of the composite.The interface region between CNT and polymer matrix is modeled as the third phase with varying material properties.The constitutive relations for each material system have been derived based on solid mechanics and proper interfacial traction continuity conditions are imposed.The predicted results from the CCA approach are in well agreement with RVE-based finite element model.The outcomes reveal that temperature softening effect becomes more pronounced at higher volume fractions of CNTs.
文摘According to Kirillov's idea, the irreducible unitary representations of a Lie group G roughly correspond to the coadjoint orbits (?).In the forward direction one applies the methods of geometric quantization to produce a representation, and in the reverse direction one computes a transform of the character of a representation, to obtain a coadjoint orbit. The method of orbits in the representations of Lie groups suggests the detailed study of coadjoint orbits of a Lie group G in the space (?)~* dual to the Lie algebra (?) of G. In this paper, two primary goals are achieved: one is to completely classify the smooth coadjoint orbits of Virasoro group for nonzero central charge c; the other is to find representatives for coadjoint orbits. These questions have been considered previously by Segal, Kirillov, and Witten, but their results are not quite complete. To accomplish this, the authors start by describing the coadjoint action of D-the Lie group of all orientation preserving diffeomorphisms on the circle S^1, and its central extension (?), then the authors will give a complete classification of smooth coadjoint orbits. In fact, they can be parameterized by a subspace Of conjugacy classes of (?)(1,1). Finally, the authors will show how to find representatives f coadjoint orbits by analyzing the vector fields stabilizing the orbits, and describe the amazing connection between the characteristic (trace) of conjugacy classes of (?)(1, 1) and that of vector fields stabilizing orbits.
文摘The research examines the way in which members of the U.S. House of Representative represent themselves on the social network site Facebook. Each member’s activity is observed on seven different occasions and the frequency and substantive character of posts made during the second half of 2013 are established. The focus is on position-taking posts versus posts which mention the district the member serves in. Our expectation is that members from electorally safe districts will be more likely to advertise their policy positions while members from marginal districts will be more inclined to advertise their district connections. We control for minority party status, gender, and ideological extremism among other concerns and learn electoral safety is a good predictor of both “position-taking” and “district mentions”. Consistent with an electoral motive, we also find members from the minority party less likely to take positions on the issues of the day and more likely to mention the district they serve in.
文摘Steeped in a civilization featuring inclusivity and peaceful nature,China seeks exchanges and mutual learning among civilizations rather than cultural hegemony.WHILE claiming its preeminent global economic status,China has also come to assert its equivalent position in world politics and diplomacy,typically representing the interests of the developing world.
文摘For more than half a centurymanufacturers in search of independentrepresentatives to sell their products innew markets and to establishrelationships with prospective customershave relied upon the services of theManufacturers’ Agents NationalAssociation (MANA).
文摘As the world continues to search for innovative therapeutic solutions,the field of natural medicines has emerged as a vibrant area of research.The potential of natural products to treat a wide range of diseases,coupled with the relatively low sideeffects of such products,has captured the attention of scientists,clinicians,and the general public alike.This Special Issue on Natural Medicine aims to present the latest advancements in this exciting field,highlighting both fundamental research and clinical applications.The collection of articles in this Special Issue covers a broad spectrum of topics,ranging from medicinal chemistry to biological mechanisms,and from the study of single botanic compounds to complex plant formulas.We are particularly pleased to include a comprehensive review by Yi Wang et al.on the bioactivities,mechanisms,production,and potential application of bile acids in preventing and treating infectious diseases.This review not only summarizes the current landscape of bile acids research but also highlights several promising compounds for future investigations,such as the recent interest in ursodeoxycholic acid.In a related topic,Shishan Yu’s team has developed artificial bear bile using synthetic chemistry and enzyme engineering,providing a sustainable substitute for natural bear bile.This innovation meets medical needs while addressing animal welfare issues,representing a notable progression in the field.
文摘Greetings…Allow me to begin by extending,on behalf of the Philippine delegation,our heartfelt gratitude to the Chinese Association for International Understanding(CAFIU)for this excellent opportunity for greater understanding of China and its relations to the Philippines,the ASEAN and the rest of the world.This exchange has likewise been an important occasion for us to share our insights on these relations in the light of our common interests and aspirations
文摘The global governance of large artificial intelligence(AI)models calls for urgent actions.Large models,representing a type of technological innovation,is advancing global technological progress and is also compelling the international community’s attention to the role of global governance system in coordinating the development of AI.In building a global governance mechanism for large models,both traditional governance system and new international system should be explored to construct Regime Complexes for the governance of large models.
文摘Afghanistan has faced extreme climatic crises such as drought,rising temperature,and scarce precipitation,and these crises will likely worsen in the future.Reduction in crop yield can affect food security in Afghanistan,where the majority of population and economy are completely dependent on agriculture.This study assessed the interaction between climate change and crop yield in Kabul of Afghanistan during the reference(1990–2020)and future(2025–2100)periods.Climate data(1990–2020)were collected from four meteorological stations and three local organizations,and wheat yield data(1990–2020)were acquired from the United States Agriculture Department.Data during the reference period(1990–2020)were used for the validation and calibration of the statistical downscaling models such as the Statistical Downscaling Model(SDSM)and Long Ashton Research Station Weather Generator(LARS-WG).Furthermore,the auto-regression model was used for trend analysis.The results showed that an increase in the average annual temperature of 2.15℃,2.89℃,and 4.13℃will lead to a reduction in the wheat yield of 9.14%,10.20%,and 12.00%under Representative Concentration Pathway(RCP)2.6,RCP4.5,and RCP8.5 during the future period(2025–2100),respectively.Moreover,an increase in the annual maximum temperature of 1.79℃,2.48℃,and 3.74℃also causes a significant reduction in the wheat yield of 2.60%,3.60%,and 10.50%under RCP2.6,RCP4.5,and RCP8.5,respectively.Furthermore,an increase in the annual minimum temperature of 2.98℃,2.23℃,and 4.30℃can result in an increase in the wheat yield of 6.50%,4.80%,and 9.30%under RCP2.6,RCP4.5,and RCP8.5,respectively.According to the SDSM,the decrease of the average monthly precipitation of 4.34%,4.10%,and 5.13%results in a decrease in the wheat yield of 2.60%,2.36%,and 3.18%under RCP2.6,RCP4.5,and RCP8.5,respectively.This study suggests that adaptation strategies can be applied to minimize the consequences of climate change on agricultural production.
基金Project(2017G006-N)supported by the Project of Science and Technology Research and Development Program of China Railway Corporation。
文摘Cable-stayed bridges have been widely used in high-speed railway infrastructure.The accurate determination of cable’s representative temperatures is vital during the intricate processes of design,construction,and maintenance of cable-stayed bridges.However,the representative temperatures of stayed cables are not specified in the existing design codes.To address this issue,this study investigates the distribution of the cable temperature and determinates its representative temperature.First,an experimental investigation,spanning over a period of one year,was carried out near the bridge site to obtain the temperature data.According to the statistical analysis of the measured data,it reveals that the temperature distribution is generally uniform along the cable cross-section without significant temperature gradient.Then,based on the limited data,the Monte Carlo,the gradient boosted regression trees(GBRT),and univariate linear regression(ULR)methods are employed to predict the cable’s representative temperature throughout the service life.These methods effectively overcome the limitations of insufficient monitoring data and accurately predict the representative temperature of the cables.However,each method has its own advantages and limitations in terms of applicability and accuracy.A comprehensive evaluation of the performance of these methods is conducted,and practical recommendations are provided for their application.The proposed methods and representative temperatures provide a good basis for the operation and maintenance of in-service long-span cable-stayed bridges.
文摘In order to implement the spirits of the Central Economic Work Conference and systematically promote the standardization work of commercial aerospace,SAC/TC 425,Space technology and operation,recently established three working groups for emerging fields and strategic emerging industries related to commercial aerospace.The work scope of WG 1 on commercial aircraft launching covers the standards research,development and revision for operation support,process,industrial chains,and other fields of launching.It is also responsible for the updating of standards documents published by correspondent international standardization organizations for further analysis and adoption.WG 2 on the application of satellite internet is responsible for the research,development and revision of standards in areas such as the application scenarios and demands,functions and process,interfaces and data forms of satellite internet.Its first batch of members consists of 29 service providers,operators,equipment manufacturers,and parties representing public interests in this field.
基金supported by the Young Elite Scientists Sponsorship Program by China Association for Science and Technology (2015QNRC001)the National Natural Science Foundation of China (31370032)+1 种基金the China Agriculture Research System (CARS-05)the Agricultural Science and Technology Innovation Program
文摘Bulked-segregant analysis coupled with next-generation sequencing(BSA-seq) has emerged as an efficient tool for genetic mapping of single genes or major quantitative trait loci controlling(agronomic) traits of interest. However, such a mapping-by-sequencing approach usually relies on deep sequencing and advanced statistical methods. Application of BSA-Seq based on construction of reduced-representation libraries and allele frequency analysis permitted anchoring the barley pale-green(pg) gene on chromosome 3 HL. With further marker-assisted validation, pg was mapped to a 3.9 Mb physical-map interval. In the pg mutant a complete deletion of chlorophyllide a oxygenase(HvCAO) gene was identified.Because the product of this gene converts Chl a to Chl b, the pg mutant is deficient in Chl b.An independent Chl b-less mutant line M4437_2 carried a nonsynonymous substitution(F263 L) in the C domain of HvCAO. The study demonstrates an optimized pooling strategy for fast mapping of agronomically important genes using a segregating population.
基金This project is supported by Provincial Natural Science Foundation of Heilongjiang(No.A9809).
文摘A method for determination of tool-chip contact length is theoreticallypresented in orthogonal metal machining. By using computer simulation and based on the analyses ofthe elastro-plastic deformation with lagrangian finite element method in the deformation zone, theaccumulated representative length of the low layer, the tool-chip contact length of the chipcontacting the tool rake are calculated, experimental studies are also carried out with 0.2 percentcarbon steel. It is shown that the tool-chip contact lengths obtained from computer simulation havea good agreement with those of measured values.
基金supported by the Chinese Ministry of Science and Technology(Grant No.2013BAK03B00 and 2014FY211000)
文摘Nuts have received increased attention from the public in recent years as important sources of some essential elements, and information on the levels of elements in edible nuts is useful to consumers. Determination of the elemental distributions in nuts is not only necessary in evaluating the total dietary intake of the essential elements, but also useful in detecting heavy metal contamination in food. The aim of this study was to determine the mineral contents in edible nuts, and to assess the food safety of nuts in the Beijing market. Levels of Li, Cr, Mn, Co, Cu, Zn, As, Se, Rb, Sr, Mo, Cd, Cs, Ba, Pb, Th, and U in 11 types of edible nuts and seeds (macadamia nuts, lotus nuts, pistachios, sunflower seeds, pine nuts, almonds, walnuts, chestnuts, hazelnuts, cashews, and ginkgo nuts) as well as raisins were determined by inductively coupled plasma mass spectrometry (ICP-MS). The accuracy of the method was validated using standard reference materials GBWlO014 (cabbage) and GBWlO016 (tea). Our results provide useful information for evaluating the levels of trace elements in edible nuts in the Beijing market, will be helpful for improving food safety, and will aid in better protecting consumer interests.
基金funded by the National Natural Science Foundation of China(Nos.51979268,U1765206,and 52079027)。
文摘Fully grouted bolts are a key component of the support system for underground openings.Although considerable effort has been made in the simulation of the reinforcement effect of the fully grouted bolts on the rock masses surrounding underground openings,most of the work has limited significance since the structural element approach is used.This study proposes a local homogenization approach(L-H approach)that integrates elastoplastic mechanics,composite mechanics,and analytical approaches with numerical simulation to effectively simulate the reinforcement effect of the fully grouted bolt on deep surrounding rock masses.In the L-H approach,the representative volume of bolted rock mass(RVBRM)with a fully grouted bolt is established based on the original mesh model utilized in the rockbolt element approach.The RVBRM is a regular quadrangular prism with a cross-sectional size equal to the bolt spacing and a length equal to the bolt length.The RVBRM is homogenized by the L-H approach from a unidirectional bolt-reinforced composite into a homogeneous transversely isotropic medium whose mechanical properties are described by a new transversely isotropic elastoplastic model.The L-H parameters for the RVBRM are obtained using analytical approaches,composite mechanics,and known parameters of the rock mass and bolt.Using the L-H approach,the reinforcement effect of the fully grouted bolt on the bolted rock specimen and the surrounding rock mass in Jinping II Diversion Tunnel#2 with a depth greater than 2000 m is simulated.The results show that the predictions of the L-H approach are more in agreement with the physical model results of bolted rock specimen and provide a more realistic response of the bolted surrounding rock mass.The L-H approach demonstrates that fully grouted bolts with common bolt spacings and diameters substantially enhance the elastic modulus,shear strength,and tensile strength of the rock mass in the direction of the bolt axis.
基金The Strategic Priority Research Program of the Chinese Academy of Sciences No.XDA11010404the National Natural Science Foundation of China under contract Nos 41375096,41175079 and 41405082the Macao Meteorological and Geophysical Bureau Project under contract No.9231048
文摘Projections of potential submerged area due to sea level rise are helpful for improving understanding of the influence of ongoing global warming on coastal areas. The Ensemble Empirical Mode Decomposition method is used to adaptively decompose the sea level time series in order to extract the secular trend component. Then the linear relationship between the global mean sea level (GMSL) change and the Zhujiang (Pearl) River Delta (PRD) sea level change is calculated: an increase of 1.0 m in the GMSL corresponds to a 1.3 m (uncertainty interval from 1.25 to 1.46 m) increase in the PRD. Based on this relationship and the GMSL rise projected by the Coupled Model Intercomparison Project Phase 5 under three greenhouse gas emission scenarios (representative concentration pathways, or RCPs, from low to high emission scenarios RCP2.6, RCP4.5, and RCP8.5), the PRD sea level is calculated and projected for the period 2006-2100. By around the year 2050, the PRD sea level will rise 0.29 (0.21 to 0.40) m under RCP2.6, 0.31 (0.22 to 0.42) m under RCP4.5, and 0.34 (0.25 to 0.46) m under RCP8.5, respectively. By 2100, it will rise 0.59 (0.36 to 0.88) m, 0.71 (0.47 to 1.02) m, and 1.0 (0.68 to 1.41) m, respectively. In addition, considering the extreme value of relative sea level due to land subsidence (i.e., 0.20 m) and that obtained from intermonthly variability (i.e., 0.33 m), the PRD sea level will rise 1.94 m by the year 2100 under the RCP8.5 scenario with the upper uncertainty level (i.e., 1.41 m). Accordingly, the potential submerged area is 8.57x103 km2 for the PRD, about 1.3 times its present area.
文摘Thermal expansion coefficients play an important role in the design and analysis of composite structures. A detailed analysis of thermo-mechanical distortion can be performed on microscopic level of a structure. However, for a design and analysis of large structures, the knowledge of effective material properties is essential. Thus, either a theoretical prediction or a numerical estimation of the effective properties is indispensable. In some simple cases, exact analytical solutions for the effective properties can be derived. Moreover, bounds on the effective values exist. However, in dealing with complex heterogeneous composites, numerical methods are becoming increasingly important and more widely used, because of the limiting applicability of the existing (semi-)analytical approaches. In this study, finite-element methods for the calculation of effective thermal expansion coefficients of composites with arbitrary geometrical inclusion configurations are discussed and applied to a heterogeneous lightning protection coating made from Dexmet® copper foil 3CU7-100FA and HexPly® epoxy resin M21. A short overview of some often used (semi-)analytical formulas for effective thermal expansion coefficients of heterogeneous composites is given in addition.
基金This study was financially supported by the National Natural Science Foundation of China(31970394,31670381,31672258)Guangzhou University’s 2017 Training Program for Young High-Achieving Personnel(BJ201707)+8 种基金Science-Technology Basic Condition Platform from the Ministry of Science and Technology of the People’s Republic of China(2005DKA21402)Lancang-Mekong Cooperation Special Fund(Biodiversity Monitoring and Network Construction Along Lancang-Mekong River Basin Project)Biodiversity Investigation in Xishuangbanna National Nature Reserve,Biodiversity Investigation,Observation,and Assessment Program(2019-2023)the Ministry of Ecology and Environment of China(8-2-3-4-5)Scientific Research Foundation of the Education Department of Sichuan Province,China(11ZA164)Research Foundation of Mianyang Teachers’College(MYHQ2016A01)Gabor Csorba received support from the National Research,Development,and Innovation Fund of Hungary(NKFIH KH130360)SYNTHESYS Project,which is financed by the European Community Research Infrastructure Action under the FP7“Capacities”ProgramWe are grateful to the anonymous referees for their constructive comments.We also thank Yi-Feng Hu,Yang Yue,and Han-Bo Zhang for their help in field survey and assistance during lab work.
文摘DEAR EDITOR,The disk-footed bat Eudiscopus denticulus(Osgood,1932)is a rare species in Southeast Asia.During two chiropteran surveys in the summer of 1981 and 2019,eight and three small Myotis-like bats with distinct disk-like hindfeet were collected from Yunnan Province,China,respectively.External,craniodental,and phylogenetic evidence confirmed these specimens as E.denticulus,representing a new genus in China.The complete mitochondrial genome consistently showed robust support for E.denticulus as a basal lineage within Myotinae.The coding patterns and characteristics of its mitochondrial genome were similar to that of other published genomes from Myotis.The echolocation signals of the newly collected individuals were analyzed.The potential distribution range of Eudiscopus in Southeast Asia inferred using the MaxEnt model indicated its potential occurrence along the southern border region of Yunnan,China.