The editorial board of Acupuncture and Herbal Medicine recently convened an academic seminar with a focus on studies regarding the mechanisms mediating acupuncture efficacy and moxibustion action inspired by the 2021 ...The editorial board of Acupuncture and Herbal Medicine recently convened an academic seminar with a focus on studies regarding the mechanisms mediating acupuncture efficacy and moxibustion action inspired by the 2021 Nobel Prize in Physiology or Medicine.Specifically,Professor Bailong Xiao introduced the Nobel Prize for research on the mechanically activated Piezo ion channel,evaluating the structure of the Piezo channel and its physiological and pathological functions,and proposed a possible role for the Piezo channel in acupuncture mechanical stimulation.Professor Michael Xi Zhu introduced the discovery of the transient receptor potential(TRP)family,reporting that the therapeutic effects of Chinese medicine and acupuncture may be achieved via the TRP family,and that information regarding associations between the meridian and lymphatic systems may have important research and medical value.In addition,Professor Tianle Xu reviewed the history of ion channel research,particularly the physiological and pharmacological effects of non-classical ion channels(eg,the acid sensing ion channel family)and pointed out that the characterization and neural circuits of acupuncture deqi manipulation are important for elucidating the mechanisms of acupuncture actions.Professor Yongming Li similarly proposed that the 2021 Nobel Prize may open the door to disclosing the histological basis of acupuncture and moxibustion and analyzing the main scientific concerns regarding the clinical translation of acupuncture and moxibustion from basic to translational research.Finally,Professor Yi Guo summarized the study progress of the acupoint microenvironment induced by acupuncture over the course of nearly 30 years and put forward the hypothesis that acupuncture may initiate the physical-chemical coupling network by activating ion channel receptors in acupoints via physical and mechanical stimulation.Therefore,we conclude that a primary achievement of the 2021 Nobel Prize in Physiology or Medicine is in helping interpret how acupuncture and moxibustion adjust homeostasis(ie,by activating mechanical and thermal sensation),which is conducive to validating and promoting the clinical efficacy of acupuncture modalities.展开更多
Over the past 40 years,scientific research workers of integrated traditional Chinese and Western medicine have kept their original aspirations,self-reliance with selfless dedication and sincere heart.They have been pu...Over the past 40 years,scientific research workers of integrated traditional Chinese and Western medicine have kept their original aspirations,self-reliance with selfless dedication and sincere heart.They have been pursuing excellence and innovation;they have devoted themselves to research and worked hard,and related achievements have won the Nobel Prize in Physiology or Medicine,the National Highest Science and Technology Award,the National Science and Technology Progress Award,the Science and Technology Award of the China Integrative Medicine Society,etc.;and these demonstrate innovative features in clinical efficacy,play an important role in the fight against the COVID-19 epidemic,and occupy a prominent position in the field of drug research and development.展开更多
Research on the molecular mechanisms controlling circadian rhythm in Western medicine is comparable to the study of a day-night rhythm in Chinese medicine(CM),as also focus on the same life phenomenon.By comparing the...Research on the molecular mechanisms controlling circadian rhythm in Western medicine is comparable to the study of a day-night rhythm in Chinese medicine(CM),as also focus on the same life phenomenon.By comparing the two,this paper elaborates on the differences between them in their respective issues of consciousness,ways of thinking,research methods and research results.Relatively speaking,Nobel Prize research has a stronger sense of the problems and concerns about the essence of“what”,while CM focuses on“how a thing functions”.The former mainly adopts experimental and mathematical methods,while the latter primarily depends on observation and understanding.The natural philosophy and natural science eventually lead to the results and the inevitable,quantitative and qualitative differences.Research on the life rhythm in CM should be proposed,scientific problems should be fully grasped,and research should be carried out with the aid of multidisciplinary new knowledge and new achievements through cross-disciplinary studies.On the basis of clinical epidemiological research and experimental research,a systematic review should be made of the human physiology of CM and the pathological rhythm model to explore the regulatory mechanism of time rhythm and create a new theory of time medicine.展开更多
The 2018 Medicine Nobel Prize was awarded jointly to two immunologists, James P. Allison at the University of Texas MD Anderson Cancer Center in Houston and Tasuku Honjo at Kyoto University in Japan, who pioneered a n...The 2018 Medicine Nobel Prize was awarded jointly to two immunologists, James P. Allison at the University of Texas MD Anderson Cancer Center in Houston and Tasuku Honjo at Kyoto University in Japan, who pioneered a new way to treat cancers (Ledford et al. 2018).展开更多
Chinese scientist TU You-you on October 5, 2015 won the Nobel Prize in Physiology or Medicine amongst a trio for discovering parasite therapies. She and the other two scientists, William Campbell and Satoshi Omura, fo...Chinese scientist TU You-you on October 5, 2015 won the Nobel Prize in Physiology or Medicine amongst a trio for discovering parasite therapies. She and the other two scientists, William Campbell and Satoshi Omura, found ＂therapies that have revolutionized the treatment of some of the most devastating parasitic diseases＂. 85-year-old Tu is awarded this world-renowned prize for developing artemisinin, a drug therapy for malaria that has saved millions of lives across the globe, especially in the developing world.展开更多
基金the National Natural Science Foundation of China(Nos.82030125 and 81873369)。
文摘The editorial board of Acupuncture and Herbal Medicine recently convened an academic seminar with a focus on studies regarding the mechanisms mediating acupuncture efficacy and moxibustion action inspired by the 2021 Nobel Prize in Physiology or Medicine.Specifically,Professor Bailong Xiao introduced the Nobel Prize for research on the mechanically activated Piezo ion channel,evaluating the structure of the Piezo channel and its physiological and pathological functions,and proposed a possible role for the Piezo channel in acupuncture mechanical stimulation.Professor Michael Xi Zhu introduced the discovery of the transient receptor potential(TRP)family,reporting that the therapeutic effects of Chinese medicine and acupuncture may be achieved via the TRP family,and that information regarding associations between the meridian and lymphatic systems may have important research and medical value.In addition,Professor Tianle Xu reviewed the history of ion channel research,particularly the physiological and pharmacological effects of non-classical ion channels(eg,the acid sensing ion channel family)and pointed out that the characterization and neural circuits of acupuncture deqi manipulation are important for elucidating the mechanisms of acupuncture actions.Professor Yongming Li similarly proposed that the 2021 Nobel Prize may open the door to disclosing the histological basis of acupuncture and moxibustion and analyzing the main scientific concerns regarding the clinical translation of acupuncture and moxibustion from basic to translational research.Finally,Professor Yi Guo summarized the study progress of the acupoint microenvironment induced by acupuncture over the course of nearly 30 years and put forward the hypothesis that acupuncture may initiate the physical-chemical coupling network by activating ion channel receptors in acupoints via physical and mechanical stimulation.Therefore,we conclude that a primary achievement of the 2021 Nobel Prize in Physiology or Medicine is in helping interpret how acupuncture and moxibustion adjust homeostasis(ie,by activating mechanical and thermal sensation),which is conducive to validating and promoting the clinical efficacy of acupuncture modalities.
文摘Over the past 40 years,scientific research workers of integrated traditional Chinese and Western medicine have kept their original aspirations,self-reliance with selfless dedication and sincere heart.They have been pursuing excellence and innovation;they have devoted themselves to research and worked hard,and related achievements have won the Nobel Prize in Physiology or Medicine,the National Highest Science and Technology Award,the National Science and Technology Progress Award,the Science and Technology Award of the China Integrative Medicine Society,etc.;and these demonstrate innovative features in clinical efficacy,play an important role in the fight against the COVID-19 epidemic,and occupy a prominent position in the field of drug research and development.
基金Supported by the National Key Basic Research Development Plan("973"Plan)Funded Projects(No.2013CB532002)。
文摘Research on the molecular mechanisms controlling circadian rhythm in Western medicine is comparable to the study of a day-night rhythm in Chinese medicine(CM),as also focus on the same life phenomenon.By comparing the two,this paper elaborates on the differences between them in their respective issues of consciousness,ways of thinking,research methods and research results.Relatively speaking,Nobel Prize research has a stronger sense of the problems and concerns about the essence of“what”,while CM focuses on“how a thing functions”.The former mainly adopts experimental and mathematical methods,while the latter primarily depends on observation and understanding.The natural philosophy and natural science eventually lead to the results and the inevitable,quantitative and qualitative differences.Research on the life rhythm in CM should be proposed,scientific problems should be fully grasped,and research should be carried out with the aid of multidisciplinary new knowledge and new achievements through cross-disciplinary studies.On the basis of clinical epidemiological research and experimental research,a systematic review should be made of the human physiology of CM and the pathological rhythm model to explore the regulatory mechanism of time rhythm and create a new theory of time medicine.
基金supported by the National Natural Science Foundation of China (91742114 and 91642118)the National Scientific and Technological Major Project of China (2017ZX10202203)the Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College, Huazhong University of Science and Technology and the Sino-German Virtual Institute for Viral Immunology
文摘The 2018 Medicine Nobel Prize was awarded jointly to two immunologists, James P. Allison at the University of Texas MD Anderson Cancer Center in Houston and Tasuku Honjo at Kyoto University in Japan, who pioneered a new way to treat cancers (Ledford et al. 2018).
文摘Chinese scientist TU You-you on October 5, 2015 won the Nobel Prize in Physiology or Medicine amongst a trio for discovering parasite therapies. She and the other two scientists, William Campbell and Satoshi Omura, found ＂therapies that have revolutionized the treatment of some of the most devastating parasitic diseases＂. 85-year-old Tu is awarded this world-renowned prize for developing artemisinin, a drug therapy for malaria that has saved millions of lives across the globe, especially in the developing world.
