New food sources and production systems:a comparison of international regulations and China’s advancements in novel foods with synthetic biology

The global shift towards sustainable food systems has sparked innovations in food sources and production systems,including cell-based meat,plant-based food products,precision fermentation,and 3D food printing.These advancements pose regulatory challenges and opportunities,with China emerging as a critical player in adopting and regulating new food technologies.This review explores the international landscape of new food sources and production systems(NFPS),focusing on China’s role and regulatory approaches compared to global practices.Through this comparative analysis,we aim to contribute to the ongoing dialogue on food safety regulation,offering insights and recommendations for policymakers,industry stakeholders,and researchers engaged in the global food system’s evolution.This comprehensive overview underscores the dynamic nature of regulatory frameworks governing NFPS,highlighting the international efforts to ensure food safety,consumer protection,and the sustainable evolution of the food industry.

The impact of environmental regulations on international competitiveness of textile industry in China

A greater focus of environmental protection is directed toward environmental regulations in China. This paper focuses on environmental regulations and their impact on textile industry. The academic circle does not reach a consensus on the relationship between environmental regulations and international competitiveness. Some hold the view that environmental regulations lower international competitiveness while others think that environmental regulations improve both environment and economic performance. This paper aims to analyze the impact of the environmental regulations on the international competitiveness of textile industry in China. This study starts with theories relative to this subject; the second part, based on the impact mechanism of environmental regulations on competitiveness, analyzes the environmental impact on textile from the perspective of cost and market. The conceptual exploration comes to the conclusion that environmental regulations make a negative impact on the international competitiveness on the cost side and improve it by means ofinnovation and product differentiation on market side; the third part gives time series evidence to examine the impact. In this part the Pearson Correlation Analysis is conducted based on the data of China's textile industry of the period from 1991 to 2005. It turns out to prove that the negative environmental impact on cost side exceeds the positive environmental impact on market side, namely, environmental regulations deteriorate the international competitiveness in textile industry as a whole during the inspected period.

Regulations for the Manufacture and Control of Live Poliovirus Vaccine: International Experience and China’s Path

The eradication of poliomyelitis is a landmark achievement in the history of public health, providing strong protection for children’s health. The introduction of the Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine is a prerequisite and safeguard for the large-scale production and use of domestically produced live poliovirus vaccines, serving as an indispensable component of vaccine safety. This article, based on archival documents, letters, collections of essays, and oral interviews, examines the historical experience of the development of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine. It contends that the emphasis on localization and the active engagement in international cooperation are critical factors in the swift introduction of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine.

GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization,mitochondria-targeting and-activating properties of human salivary histatin 1

Human salivary histatin 1(Hst1)exhibits a series of cell-activating properties,such as promoting cell spreading,migration,and metabolic activity.We recently have shown that fluorescently labeled Hst1(F-Hst1)targets and activates mitochondria,presenting an important molecular mechanism.However,its regulating signaling pathways remain to be elucidated.We investigated the influence of specific inhibitors of G protein-coupled receptors(GPCR),endocytosis pathways,extracellular signal-regulated kinases1/2(ERK1/2)signaling,p38 signaling,mitochondrial respiration and Na+/K+-ATPase activity on the uptake,mitochondria-targeting and-activating properties of F-Hst1.We performed a si RNA knockdown(KD)to assess the effect of Sigma-2 receptor(S2R)/Transmembrane Protein 97(TMEM97)—a recently identified target protein of Hst1.We also adopted live cell imaging to monitor the whole intracellular trafficking process of F-Hst1.Our results showed that the inhibition of cellular respiration hindered the internalization of F-Hst1.The inhibitors of GPCR,ERK1/2,phagocytosis,and clathrin-mediated endocytosis(CME)as well as siRNA KD of S2R/TMEM97 significantly reduced the uptake,which was accompanied by the nullification of the promoting effect of F-Hst1 on cell metabolic activity.Only the inhibitor of CME and KD of S2R/TMEM97 significantly compromised the mitochondria-targeting of Hst1.We further showed the intracellular trafficking and targeting process of F-Hst1,in which early endosome plays an important role.Overall,phagocytosis,CME,GPCR,ERK signaling,and S2R/TMEM97 are involved in the internalization of Hst1,while only CME and S2R/TMEM97 are critical for its subcellular targeting.The inhibition of either internalization or mitochondria-targeting of Hst1 could significantly compromise its mitochondria-activating property.

International Comparative Study on Education Laws of the Persons with Disabilities: An Observation on Regulations on the Education of Persons with Disabilities

The issue of education for people with disabilities has become of increasing concern. How can we effectively guarantee the basic right to education for persons with disabilities? Will the revised Regulation on Education for Persons with Disabilities meet their needs? This article takes the Regulation on Education for Persons with Disabilities as the core and compares it with the related special educational laws of the United States, Britain and Japan. The following conclusions were drawn from this study: In terms of educational concept, the three countries follow the concept of inclusive education, and pursue equity and educational justice. They not only pay attention to inclusive education but also focus on improving the quality of education for students with disabilities. All three countries focus on accommodating children with special needs, but each implements its programs in a different way. These practices can be used as reference for the development of a special needs education law in China.

Post-transcriptional regulation of vascular endothelial growth factor: Implications for tumor angiogenesis

Vascular endothelial growth factor （VEGF） is a potent secreted mitogen critical for physiologic and tumor angiogenesis. Regulation of VEGF occurs at several levels, including transcription, mRNA stabilization, translation, and differential cellular localization of various isoforms. Recent advances in our understanding of post-transcriptional regulation of VEGF include identification of the stabilizing mRNA binding protein, HuR, and the discovery of internal ribosomal entry sites in the 5＇UTR of the VEGF mRNA. Monoclonal anti-VEGF antibody was recently approved for use in humans, but suffers from the need for high systemic doses. RNA interference （RNAi） technology is being used in vitro and in animal models with promising results. Here, we review the literature on post-transcriptional regulation of VEGF and describe recent progress in targeting these mechanisms for therapeutic benefit.

基于Thevenin模型的蓄电池内阻监测装置的现场校验方法研究

蓄电池组在线监测系统在发电厂和变电站广泛应用,但其监测性能在交接验收和后期运行中缺乏行之有效的现场校准评价手段,导致运行中监测的有效性如何评价成为一个亟需解决的问题。文章基于Thevenin模型和GB/T 19638.1(IEC 60896-22 MOD)中的蓄电池内阻测量方法,提出了"标定电池+校验装置比对"的蓄电池组在线监测系统现场校验方法。通过该方法测得的标定电池内阻值与现场测量内阻值比率值E_(n)<0.191,符合ISO/IEC 17025标准要求。结果表明,该方法可对蓄电池组内阻值进行现场测试,实现对蓄电池组在线监测系统的在线校验,提高厂站用蓄电池组的运维管理水平。

Remedies for loss and damage caused by climate change from the dimension of climate justice

Adverse consequences to the ecological system and human health caused by impacts potentially attributable to climate change have already drawn great and widespread concern of many scientists and international organizations.However,we still have a hard time determining exactly the impact of climate change on the environment or the damage that climate change inflicts on countries comprising small islands or low-lying lands in light of today's science and technology.The progress for dealing with the issue of loss and damage has been struggling for a long time from the beginning to the present.In this paper,the author begins by summarizing talks on the concept and the positions of commentators.The author is proposing that the development of future climate negotiations and rule-making process be based on global climate justice as a standard for measuring value.Also,the author proposes that a holistic view of climate justice be established.Generally,three aspects of climate justice can be derived.First,the dimension of human rights protection shows that protection of fundamental human rights is a logical precondition if small-island and low-lying countries are able to achieve climate justice.Second,the definite and traditional concepts of distributive justice and corrective justice hold the view that the principle of common but differentiated responsibilities should be upheld as a basic standard of allocating rights and duties associated with climate change.Third,climate justice requires that any state follow the "no-harm principle," which is regarded as an international customary rule.According to the principle,the obligation of states to prevent the use of their territory for causing trans-boundary harm to the environment shall be a violation of state responsibility,which incurs international punishment.Then we put forward three remedial approaches in light of climate justice,including the approach of State Responsibility(SR) based on the principles and rules of international human rights law and international environmental law.Based on clear rules,the judge can determine whether the damaging behavior or the damage perpetrated by a state party constitutes a state responsibility.The International Environmental Regulation(IEB),which means solving the problems within the framework established by the Conventions on Climate Change,takes advantage of the market mechanisms and incentives such as fund and insurance support system to relieve or compensate the loss and damage.International Environmental Dispute Settlement Mechanism(IEDSM),which includes the means such as consultations,negotiations,nonmandatory ways and international arbitration,international judicial ways to solve these disputes,functions as a procedural safeguard.As an active promoter of global climate governance,China should no doubt stand by the principle of Common But Differentiated Responsibility(CBDR) and take it as a basis for negotiations,actively strengthen the work of South-South cooperation,fulfill her international climate commitments without reservation,vigorously develop a low-carbon economy,and actively promote international negotiations on the subject of loss and damage.

China introduces the 24-hour rule

Recently, international movement measures that may be causing tension between the of cargo had been the subject of increasing border control needs for security and the needs for trade facilitations. On the one hand customs authorities are charged with the responsibility for policing a country＇s borders, and consequently they need to have in place measures to ensure that only legitimate trade takes place and that this trade does not present security concerns. On the other hand we have the requirements of traders, who benefit from an environment of trade facilitation with speedy and efficient movement of cargo across international borders, with minimal bureaucratic intervention. This paper focuses on and provides early discussion and comments on the possible ramifications of the introduction of the 24-hour rule in China, effective for all exports and imports of sea freight container traffic since January 1, 2009. The new rules will have significant impact on the logistics flows of exporters and importers alike. Specifically, the reporting requirements timelines are likely to result in increased costs in cargo processing at wharves that traders will have to bear; place added pressure on storage facilities at wharves, or at container depots; and may additionally increase the amount of inventory buffer because of the timing of the data reporting requirements. The paper concludes that security needs have prevailed over trade facilitation considerations and that traders should urgently implement a review of existing practices to ensure they comply with the China Customs requirements, whilst simultaneously minimizing cost increases.

The Development of Accounting Regulation in Extractive Industries in Australia, South Africa and Canada

In view of the economic significance of extractive industries, the special accounting issues raised, and the numerous calls over many years for standardization, there has been less regulation of their accounting than as expected. The development of accounting regulations and practices in the extractive industries in 3 countries is reviewed, which are Australia, South Africa and Canada.

Auditing the Auditors： The Audit Oversight Board and Regulating Audit Quality in Malaysia

The setting-up of the Malaysian Audit Oversight Board （AOB） in 2010 under the Securities Commission Amendment Act 2010 has extended the role of regulators into the statutory audit domain for public listed companies. Although the auditing profession in Malaysia has International Auditing Standards as prescribed minimum level of quality in the delivery of audit assurance services, self-regulation by the profession alone appears inadequate to ensure the delivery of quality audit services. With co-regulation, auditors now are monitored not just by the profession but also by a new statutory body with considerable regulatory powers to sanction auditors where quality of the audit process has been found wanting. This study solicits the opinions of auditors on their expectations of what the new regulator can achieve. Based on interviews with a sample of 30 auditors, the study finds that the majority believe that audit quality will be taken to a new level following AOB＇s remit of registration of auditors, compliance inspection with International Standard on Quality Control （ISQC）, monitoring of financial statement quality, and its power of sanctions. A review of AOB＇s early years＇ inspection confirms these expectations.

Analysis on the Evolution and Signficance to the Determination of‘Like Product＇

Overviewing the international trade both in theoretical studies and legal cases, there is a notion known as ‘like product’, occurs in both the WTO law and the GATT 1994. Even though this concept occurs in the several of agreements, nevertheless, the concept of ‘like product’ is not defined in the GATT 1994. However, it plays a dominant role in the international trade, and it is a key point to deal with some issues of international trade, particularly in anti-dumping issues. Product and ‘Like product＇ both are most important elements in GATT, mostly in every principle rules has concerned it since GATT has been signed. World economy is developing and growing faster, and had pushed the GATT into playing an even more central role. The product also developing and been evolution, Therefore there were certainly changes in the subjects here addressed. But the changes came largely in the form of filling in the gaps-again both in the rules and in the institution. This thesis will be concerned with the evolution and significance of the notion of ‘like product’ under the GATT fundamental principles.

The synergies between international health regulations and One Health in safeguarding global health security

The World Health Organization established International Health Regulations(IHRs)to give nations a legal framework for preventing,identifying,and responding to public health threats of international concern.On the other hand,One Health advocates for integrated approaches to health risks,acknowledging the interdependence of human,animal,and ecosystem health.By integrating these frameworks,stakeholders can leverage their respective strengths to enhance surveillance,early detection,and response mechanisms,as well as promote sustainable development and resilience against emerging health threats.This article explores the shared objectives,interconnectedness of health systems,collaborative mechanisms,and capacity-building initiatives that indicate the synergistic effects of IHRs and One Health in safeguarding global health security.

Land Demand and Land Use Regulation for the Building of International Tourist Island in Hainan Province

We conduct analysis on the urban construction's demand for land, tourism's demand for land, infant industry's demand for land and infrastructure's demand for land in Hainan Province, respectively, and forecast the amount of newly-added land in Hainan Province in 2015 compared to 2008. Based on regional characteristics, we analyze the main problems in land use in Hainan Province, and work out the regional land use regulation plan, to provide scientific guidance for the building of International tourist island in Hainan Province.

数字规制的场景、困境与进路:作为法治场域的元宇宙

元宇宙是数字规制的新场景,相关参与场景和产品应用的广泛性决定了元宇宙风险丛生、亟待治理。元宇宙治理面临伦理治理困境,具体体现在主体性、算法正义、数据伦理等方面,这些也是数字规制的难题,在人工智能等运用场景也有显现。由于技术基础设施发展、传统法律监管滞后、数字货币监管缺位等客观情况,元宇宙法律监管也面临挑战,针对元宇宙的治理困境进行规则设计具有必要性。设计进路方面,元宇宙治理的相关规则应当以元宇宙的技术特征为底座,以算法和数据规制为抓手,以国际法与国内法的互动为方案,在国内法治、涉外法治和国际法治等不同层面确保元宇宙治理规则的宽覆盖、高效力与体系化。数字规制在确保实现人的价值的同时,需要推动数字经济和数字法治的发展。

基于改进快速行进平方法的无人帆船动态避碰方法

[目的]为解决无人帆船在开阔水域的多船避碰问题,对基于改进快速行进平方(IFMS)法的局部动态避碰算法进行研究。[方法]考虑到帆船的速度不可控,将其避碰行为转化为航向控制问题,并以总势场梯度下降方向为期望避碰航向。当帆船没有碰撞危险或顺风航行时,仅通过构造时间势场来避开所有静止不规则障碍并到达目标点;而当帆船存在航行约束时,根据《国际海上避碰规则》(COLREGS)为特定会遇场景设计高斯似然函数用以动态地构建障碍势场。同时,考虑到帆船的航行死区,引入局部风势场,实现帆船动态避碰与“之”字形航行策略相结合的应用需求。[结果]结果显示,所提算法可以使无人帆船在遵守避碰规则和避免航行死区的同时,成功地在各种会遇场景下实现与其他帆船、受限机动船的避碰操作,相比原始快速行进平方(FMS)算法,逆风航行时间大大缩短,避碰航迹也更加合理、安全。[结论]所提方法符合帆船运动特性及避碰规则,在复杂环境下具有较高的安全性和鲁棒性,对无人帆船自主避障技术发展具有一定的科学价值。

可能与现实:元宇宙技术下的网络隔空性侵问题研究

元宇宙相关技术中特别是脑机接口技术的爆发式发展,使得各种网络隔空性侵行为特别是网络性交行为成为现实可能。网络隔空性侵行为的构成要素主要是行为工具(“网络社交平台类”和“远程情趣设备+网络平台”类)、性接触程度(五级)和行为类型(五类)。目前现行刑法对网络隔空性侵行为只能以猥亵类犯罪规制,无法适用强奸罪和负有照护职责人员性侵罪。反思现行刑法对性侵犯罪的规制体系,提出以“性器插入—被插入中心论”的观点来划分性交行为和猥亵行为的界限,建议扩大强奸罪和负有照护职责人员性侵罪的行为对象范围,改强奸罪为强制性交罪。通过构建新的性侵犯罪刑法规制体系,以应对元宇宙技术下各种复杂的网络隔空性侵行为的出现,并以此为契机推动性侵犯罪国际标准的构建。

“三驾马车”和“三支柱”监管——美国保险业监管模式的实践与启示

美国保险业监管框架特点鲜明,其职能分工呈现各州、联邦政府、美国保险监督官协会“三驾马车”并行的特征。具体到保险监管操作上,美国保险业监管以公司治理、偿付能力和市场行为监管“三支柱”统筹协调保险业市场。美国各州的保险业监管规则差异较大,联邦与州的监管之间存在持续博弈,同时也展现出明显关注企业行为的趋势。对美国保险业监管现状展开分析研究,对我国保险业监管进一步增强统筹协调、开展多层协同、丰富监管层次具有借鉴意义。

海洋塑料污染国际法规制的推进及中国参与

日益严重的海洋塑料污染已发展成为全球面临的仅次于气候变化的第二大环境危机。目前,全球海洋塑料污染治理的国际法律框架体系尚未建立,海洋塑料污染治理的国际法规制主要散见于《巴塞尔公约》等国际法文件中,法律治理存在规则碎片化、遵守与实施困难等多重困境,而有约束力的全球协议制定进程刚刚开启。未来,海洋塑料污染的国际法规制需要从强化不同规制规则之间的协调、推进国际立法、完善履约保障机制等多个方面作出改善。中国作为塑料生产和消费大国需要在国际和国内两个层面积极应对。在国际层面,推动不同涉塑国际法规则之间的协调和涉塑国际立法进程、有效促进海洋塑料污染规制规则的遵守与实施;在国内层面,加强技术创新、健全各类涉塑制度和完善国内立法等。

构建新发展格局视域下的营商环境治理研究

营商环境治理作为中国国家治理的重要部分,是国家治理体系和治理能力现代化的重要标志,也是中国式现代化在经济领域的突出表现,彰显着国家治理现代化水平。因此,要牢牢把握营商环境发展方向,坚持以习近平新时代中国特色社会主义思想和党的二十大精神为指导、以中国式现代化为目标、以马克思主义中国化时代性成果和经验为基础,将营商环境的制度优势转化为国家治理效能。文章以中国式现代化作为营商环境治理的方向引领,以大国经济发展理论、新新贸易理论、马克思主义政治经济学为理论支撑,剖析了构建新发展格局视域下营商环境治理的内在机制,即大国经济理论从“人口规模巨大的现代化”出发,从人口规模多样性和市场多样性的现实角度,揭示了构建形成强大国内市场的重要意义;共同富裕、物质文明与精神文明相协调、人与自然和谐共生的中国式现代化目标,与新新贸易理论中基于企业异质性、挖掘企业潜力、关注企业参与度与社会责任感、最终实现产业整体效益的逻辑相符合;马克思主义政治经济学追求的国民经济良性循环目标,从国内国际“双循环”的角度,诠释了“和平发展道路”的政治经济学内涵。其次,文章基于三大理论基础,解析新发展格局视域下营商环境治理促进经济发展的多维动态逻辑,即基于大国经济发展理论的要素市场化配置逻辑、基于新新贸易理论的产业链供应链升级逻辑与基于马克思主义政治经济学的现代流通体系建设逻辑。最后,文章将营商环境治理的多维动态逻辑融入中国当前构建新发展格局的目标取向和战略选择中,提出构建新发展格局视域下营商环境治理的市场化改革路径、创新驱动路径和“放管服”改革路径,三条作用路径相辅相成、协同发力,以制度创新为新发展格局经济体系注入源源不断的活力。