Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents

Alzheimer’s disease is a progressive neurodegenerative disorder and the most common cause of dementia that principally affects older adults.Pathogenic factors,such as oxidative stress,an increase in acetylcholinesterase activity,mitochondrial dysfunction,genotoxicity,and neuroinflammation are present in this syndrome,which leads to neurodegeneration.Neurodegenerative pathologies such as Alzheimer’s disease are considered late-onset diseases caused by the complex combination of genetic,epigenetic,and environmental factors.There are two main types of Alzheimer’s disease,known as familial Alzheimer’s disease(onset<65 years)and late-onset or sporadic Alzheimer’s disease(onset≥65 years).Patients with familial Alzheimer’s disease inherit the disease due to rare mutations on the amyloid precursor protein(APP),presenilin 1 and 2(PSEN1 and PSEN2)genes in an autosomaldominantly fashion with closely 100%penetrance.In contrast,a different picture seems to emerge for sporadic Alzheimer’s disease,which exhibits numerous non-Mendelian anomalies suggesting an epigenetic component in its etiology.Importantly,the fundamental pathophysiological mechanisms driving Alzheimer’s disease are interfaced with epigenetic dysregulation.However,the dynamic nature of epigenetics seems to open up new avenues and hope in regenerative neurogenesis to improve brain repair in Alzheimer’s disease or following injury or stroke in humans.In recent years,there has been an increase in interest in using natural products for the treatment of neurodegenerative illnesses such as Alzheimer’s disease.Through epigenetic mechanisms,such as DNA methylation,non-coding RNAs,histone modification,and chromatin conformation regulation,natural compounds appear to exert neuroprotective effects.While we do not purport to cover every in this work,we do attempt to illustrate how various phytochemical compounds regulate the epigenetic effects of a few Alzheimer’s disease-related genes.

A Study of Xi Jinping Thought on Governing the Country Based on the Unity of “Party Spirit-People’s Nature”

The unity of “party spirit-people’s nature” is the basic proposition of Xi Jinping’s governance.Deng Xiaoping summarized the experience and lessons in the early days of reform and opening up,and put forward the basic line of the “leadership and unity” of the party in the early stage of socialism around “one center,two basic points”;Xi Jinping’s so-called “unification”,which is based on the the basic line of Deng Xiaoping’s initial stage of building a socialist country that is “rich,strong,democratic,civilized,harmonious and beautiful”,has further established the importance of “people as the center” and “party’s leadership”.Therefore,the “people-centered” and “the party’s overall leadership” are unified and become the basic idea of General Secretary Xi Jinping’s governance of the country.Xi Jinping has put forward the unity of “party spirit-people’s nature”,the “consistency” between governing the country and politics,and the “integration” between the people’s interests and the party’s leadership,thus forming “persistence”,“comprehensive”,“confidence”,“maintenance” and other assertions.

New Properties of HM16 Ether, with Submicroparticles as Self-Functional Cells Interacting through Percussion Forces, Establishing Nature of Electrical Charges, including Gravitation

Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the modalities of interaction between two SMPs, based on periodic mechanical percussion forces, produced by fundamental vibrations FVs. A mechanism for describing the interaction between a SMPs and the ETH is presented. Positive and negative particles are defined by their membrane types of movement, such as +, −u/+, −v vibrations, and rotations at speeds +Ω/−Ω. The process of creating a pair of SMPs is discussed. Applying HFVI to the interaction between pairs of SMPs immobile in ETH, and considering longitudinal FVL, was obtained the forces of attraction/repulsion +FL21/–FL21, which correspond to the completed Coulomb force FCC including gravitation. The resultant FRL21 will form an oriented field of forces, which is a quasielectric field QE, equivalent to actual E electric field. Considering transversal FVT, was obtained the vibratory forces +, −FT21, whose resultant forms an vibrating field of forces, QHs, a quasimagnetic special field, which may explain some of the quantum properties of SMPs. Considering a mobile SMP, two new γ strains in ETH appear. Strains γL are created by the displacement of SMP with velocity V, whose force +, −FT12 is the support of a component of the magnetic field H (quasimagnetic field QH), giving the QHL component. Strains γR are created by the rotation of SMP with speed Ω, whose force +, −FR12 constitutes physical support of the component QHR of magnetic field H (i.e. QH). The creation of a photon PH is modelled as a special ESMP containing two zones of opposed rotations, and a mechanism is presented for its movement in the ETH with speed c based on the HS hypothesis of screwing in ETH, with frequency ν.

Characterization of FeCo Nanoparticles Reinforced Natural Rubber using Nanomechanical Mapping

The morphology, nanomechanical properties and interfacial regions of natural rubber（NR） and FeCo nanoparticles composite were determined by AFM nanomechanical mapping. The results showed that the size of FeCo particles was mostly from 40 to 100 nm and the FeCo nanoparticles were homogeneously dispersed in the NR bulk. The strength of NR composite increased with the FeCo nanoparticles loading. Young＇s modulus of NR region, FeCo region and interfacial region was measured by AFM nanomechanical tapping as 1.6 ± 0.6, 16.7 ±4.2 and 5.8 ± 1.5 MPa, respectively. The width of the interface for NR5, NR10 and NR15 was determined to be 15±8.1, 26±14.3 and 32±16.4 nm, respectively.

NATURE'S STOREHOUSE——SICHUAN PROVINCE

Sichuan province,called"Chuan"or"Shu"for short,lies on the upperreaches of the Yangtze River.It is in a subtropical zone and coversan area of 570,000 sq km,making it the fifth biggest in the country.Its population of 120 million is the largest in China.There are 13prefectures,seven prefecture-level districts and three autonomousprefecture of ethnic minority groups in the province,with 219counties and county-level cities and districts.Its provincial capital isChengdu.

Hilbert’s Fourth Problem: Searching for Harmonic Hyperbolic Worlds of Nature

Recently the new unique classes of hyperbolic functions-hyperbolic Fibonacci functions based on the “golden ratio”, and hyperbolic Fibonacci l-functions based on the “metallic proportions” (l is a given natural number), were introduced in mathematics. The principal distinction of the new classes of hyperbolic functions from the classic hyperbolic functions consists in the fact that they have recursive properties like the Fibonacci numbers (or Fibonacci l-numbers), which are “discrete” analogs of these hyperbolic functions. In the classic hyperbolic functions, such relationship with integer numerical sequences does not exist. This unique property of the new hyperbolic functions has been confirmed recently by the new geometric theory of phyllotaxis, created by the Ukrainian researcherOleg Bodnar(“Bodnar’s hyperbolic geometry). These new hyperbolic functions underlie the original solution of Hilbert’s Fourth Problem (Alexey Stakhov and Samuil Aranson). These fundamental scientific results are overturning our views on hyperbolic geometry, extending fields of its applications (“Bodnar’s hyperbolic geometry”) and putting forward the challenge for theoretical natural sciences to search harmonic hyperbolic worlds of Nature. The goal of the present article is to show the uniqueness of these scientific results and their vital importance for theoretical natural sciences and extend the circle of readers. Another objective is to show a deep connection of the new results in hyperbolic geometry with the “harmonic ideas” of Pythagoras, Plato and Euclid.

Hengshui Lake China’s Key Wetland Nature Reserve

WETLAND, an important eco-logical sys-tem, is of inestimable scientific, ecological, social and economic value. Bestowed liberally with nature’s bounty, China boasts various types of wetland, and during the past years has built over 130 wetland nature reserves, of which ten percent are

Digital Disparities:How Artificial Intelligence Can Facilitate Anti-Black Racism in the U.S.Healthcare Sector

This paper delves into the intricate interplay between artificial intelligence(AI)systems and the perpetuation of Anti-Black racism within the United States medical industry.Despite the promising potential of AI to enhance healthcare outcomes and reduce disparities,there is a growing concern that these technologies may inadvertently/advertently exacerbate existing racial inequalities.Focusing specifically on the experiences of Black patients,this research investigates how the following AI components:medical algorithms,machine learning,and natural learning processes are contributing to the unequal distribution of medical resources,diagnosis,and health care treatment of those classified as Black.Furthermore,this review employs a multidisciplinary approach,combining insights from computer science,medical ethics,and social justice theory to analyze the mechanisms through which AI systems may encode and reinforce racial biases.By dissecting the three primary components of AI,this paper aims to present a clear understanding of how these technologies work,how they intersect,and how they may inherently perpetuate harmful stereotypes resulting in negligent outcomes for Black patients.Furthermore,this paper explores the ethical implications of deploying AI in healthcare settings and calls for increased transparency,accountability,and diversity in the development and implementation of these technologies.Finally,it is important that I prefer the following paper with a clear and concise definition of what I refer to as Anti-Black racism throughout the text.Therefore,I assert the following:Anti-Black racism refers to prejudice,discrimination,or antagonism directed against individuals or communities of African descent based on their race.It involves the belief in the inherent superiority of one race over another and the systemic and institutional practices that perpetuate inequality and disadvantage for Black people.Furthermore,I proclaim that this form of racism can be manifested in various ways,such as unequal access to opportunities,resources,education,employment,and fair treatment within social,economic,and political systems.It is also pertinent to acknowledge that Anti-Black racism is deeply rooted in historical and societal structures throughout the U.S.borders and beyond,leading to systemic disadvantages and disparities that impact the well-being and life chances of Black individuals and communities.Addressing Anti-Black racism involves recognizing and challenging both individual attitudes and systemic structures that contribute to discrimination and inequality.Efforts to combat Anti-Black racism include promoting awareness,education,advocacy for policy changes,and fostering a culture of inclusivity and equality.

The foundation of the theory of the universe dark energy and its nature

Surprisingly recent astronomical observations have provided strong evidence that our universe is not only expanding, but also is expanding at an accelerating rate. This paper pre- sents a basis of the theory of universe space- time dark energy, a solution of Einstein’s cosmological constant problem, physical interpretation of universe dark energy and Einstein’s cosmological constant Lambda and its value ( = 0.29447 × 10-52 m-2), values of universe dark energy density 1.2622 × 10-26 kg/m3 = 6.8023 GeV, universe critical density 1.8069 × 10-26 kg/m3 = 9.7378 GeV, universe matter density 0.54207 × 10-26 kg/m3 = 2.9213 GeV, and universe radiation density 2.7103 × 10-31 kg/m3 = 1.455 MeV. The interpretation in this paper is based on geometric modeling of space-time as a perfect four- dimensional continuum cosmic fluid and the momentum generated by the time. In this modeling time is considered as a mechanical variable along with other variables and treated on an equal footing. In such a modeling, time is considered to have a mechanical nature so that the momentum associated with it is equal to the negative of the universe total energy. Since the momentum associated with the time as a mechanical variable is equal to the negative system total energy, the coupling in the time and its momentum leads to maximum increase in the space-time field with 70.7% of the total energy. Moreover, a null paraboloid is obtained and interpreted as a function of the momentum generated by time. This paper presents also an interpretation of space-time tri-dipoles, gravity field waves, and gravity carriers (the gravitons). This model suggests that the space-time has a polarity and is composed of dipoles which are responsible for forming the orbits and storing the space-time energy-momentum. The tri-di- poles can be unified into a solo space-time dipole with an angle of 45 degrees. Such a result shows that the space-time is not void, on the contrary, it is full of conserved and dynamic energy-momentum structure. Furthermore, the gravity field waves is modeled and assumed to be carried by the gravitons which move in the speed of light. The equivalent mass of the graviton (rest mass) is found to be equal to 0.707 of the equivalent mass of the light photons. Such a result indicates that the lightest particle (up to the author’s knowledge) in the nature is the graviton and has an equivalent mass equals to 2.5119 x 10-52 kg. Based on the fluidic nature of dark energy, a fourth law of thermodynamics is proposed and a new physical interpretation of Kepler’s Laws are presented. Additionally, based on the fact that what we are observing is just the history of our universe, on the Big Bang Theory, Einstein’s General Relativity, Hubble Parameter, cosmic inflation theory and on NASA’s observation of supernova 1a, then a second-order (parabolic) parametric model is obtained in this proposed paper to describe the accelerated ex- pansion of the universe. This model shows that the universe is approaching the universe cosmic horizon line and will pass through a critical point that will influence significantly its fate. Considering the breaking symmetry model and the variational principle of mechanics, then the universe will witness an infinitesimally stationary state and a symmetry breaking. As result of that, our universe will experience in the near future, a very massive impulse force in the order 1083 N. Subsequently, the universe will collapse. Finally, simulation results are demonstrated to verify the analytical results.

Whole Perfect Vectors and Fermat’s Last Theorem

A naïve discussion of Fermat’s last theorem conundrum is described. The present theorem’s proof is grounded on the well-known properties of sums of powers of the sine and cosine functions, the Minkowski norm definition, and some vector-specific structures.

Using Nature’s Gift

Kenya gets affordable solar-powered lighting and mobile phone charging

Using Nature’s Bounty

THE Maasai people are probably among the most well-known ethnic groups in East Africa for their reputations as brave warriors. But they have been plagued with a major problem for several generations： limited access to water. ＂Once you mention water, clean or unclean, what comes to my mind is long distance＇ said an elder leader in a Maasai village in Kenya. ＂We spend so much time looking for water for our animals and for our own consumption that we have no strength left for anything else.＂ It is true that the women and children in Maasai communities hardly have time for anything else after the trek to fetch water, which usually takes them 8 hours each day.

Nature's Bounty on the Western Frontier

Baoshan is a frontier city in western Yunnan Province that borders Myanmar. In bygone days, it was one of the Southwestern Silk Road trade routes, and a vital link between inland China and the outside world.The altitude of Baoshan ranges from 535 meters to 3,780 meters above sea level. Its climate varies over the terrain as the altitude changes. A local saying describes it as having "four seasons within one day, and. different climates within a five-kilometer radius."I visited Baoshan in the spring of 2003. Nestling in the moun-tains, it is a compact modern city, with six-lane urban roads, large billboards advertising world famous brands, flowers and lawns. The local people are justly proud of the changes that have occurred in the city over the past 20 years. They stem front the city’s rich tourism, resources and the initiative of its populace.

Footprint on the Sand： An Analysis of the State of Nature in Robinson Crusoe

Thomas Hobbes(1588-1679)put forward"state of nature",a term of political theory which had completely changed the Western political philosophy. Deeply influenced by this concept, Daniel Defoe(1660-1731) showed us an island of the state of nature in his Robinson Crusoe. A print of man's foot on the sand, which evoked Robinson's fear, had become a symbol of the state of nature for Robinson's life on the island, and finally brought him a"state of war".

The Natural Law of Transition of a Charged Particle into a Compound State under the Action of an Electroscalar Field

This article is the continuation of article [1] where the experimental facts of observation of the electroscalar radiation in the spectrum of the Sun have been presented [2]. This radiation comes into the world having a long wavelength, being longitudinal and extraordinarily penetrating. In accordance with the principle of least action, the Lagrangian of the electroscalar field and the tensor of energy-moment are determined using the variation the potential and coordinates. The equation of motion the charged particle in electroscalar field is determined and the energy of particle has the negative sign with respect to the mechanical energy of particle and the energy of electromagnetic field. So, this is decreasing the electrical potential of particle during the propagation. The electroscalar energy of charged particle and field’s force acting on the particle during their motion change the particle’s electrical status which, in its turn, may trigger the transition of the particle into a compound state during interaction with any object. Due to the continuity this process can lead the particle to the state which enters into a compound state with a negative energy for a different particle’s velocity. This state is the physical vacuum’s state. Analysis of the solar spectrum demonstrates that scattering and absorption of electroscalar wave go on the cavities of solids. The spreading out of electroscalar field obeys to the law of plane wave and the transfer the energy and information can occur in vacuum and any medium.

The Nature in The Red Badge of Courage

The Red Badge of Courage of Stephen Crane is very famous for its description of human being in the cold, manipulating world who act as animals.[1]In this novel, we can find not only the nature environment but also the natural shadow of human beings. In this critique, I will try to analyze the relationship between the natural world and human beings.

Natural history and long-term clinical course of Crohn's disease

Crohn’s disease is a chronic inflammatory disease process involving different sites in the gastrointestinal tract.Occasionally,so-called metastatic disease occurs in extra-intestinal sites.Granulomatous inflammation may be detected in endoscopic biopsies or resected tissues.Genetic,epigenetic and environmental factors appear to play a role.Multiple susceptibility genes have been described in both familial and non-familial forms while the disease is phenotypically heterogeneous with a female predominance.The disorder occurs over a broad age spectrum,from early childhood to late adulthood.More than 80%are diagnosed before age 40 years usually with terminal ileal and colonic involvement.Pediatric-onset disease is more severe and more extensive,usually with a higher chance of upper gastrointestinal tract disease,compared to adult-onset disease.Long-term studies have shown that the disorder may evolve with time into more complex disease with stricture formation and penetrating disease complications(i.e.,fistula,abscess).Although prolonged remission may occur,discrete periods of symptomatic disease may re-appear over many decades suggesting recurrence or re-activation of this inflammatory process.Eventual development of a cure will likely depend on identification of an etiologic cause and a fundamental understanding of its pathogenesis.Until now,treatment has focused on removing risk factors,particularly cigarette smoking,and improving symptoms.In clinical trials,clinical remission is largely defined as improved numerical and endoscopic indices for"mucosal healing"."Deep remission"is a conceptual,more"extended"goal that may or may not alter the long-term natural history of the disease in selected patients,albeit at a significant risk for treatment complications,including serious and unusual opportunistic infections.