Crohn’s disease is a chronic inflammatory disease process involving different sites in the gastrointestinal tract. Occasionally, so-called metastatic disease occurs in extra-intestinal sites. Granulomatous...Crohn’s disease is a chronic inflammatory disease process involving different sites in the gastrointestinal tract. Occasionally, so-called metastatic disease occurs in extra-intestinal sites. Granulomatous inflammation may be detected in endoscopic biopsies or resected tissues. Genetic, epigenetic and environmental factors appear to play a role. Multiple susceptibility genes have been described in both familial and non-familial forms while the disease is phenotypically heterogeneous with a female predominance. The disorder occurs over a broad age spectrum, from early childhood to late adulthood. More than 80% are diagnosed before age 40 years usually with terminal ileal and colonic involvement. Pediatric-onset disease is more severe and more extensive, usually with a higher chance of upper gastrointestinal tract disease, compared to adult-onset disease. Long-term studies have shown that the disorder may evolve with time into more complex disease with stricture formation and penetrating disease complications (i.e., fistula, abscess). Although prolonged remission may occur, discrete periods of symptomatic disease may re-appear over many decades suggesting recurrence or re-activation of this inflammatory process. Eventual development of a cure will likely depend on identification of an etiologic cause and a fundamental understanding of its pathogenesis. Until now, treatment has focused on removing risk factors, particularly cigarette smoking, and improving symptoms. In clinical trials, clinical remission is largely defined as improved numerical and endoscopic indices for “mucosal healing”. “Deep remission” is a conceptual, more “extended” goal that may or may not alter the long-term natural history of the disease in selected patients, albeit at a significant risk for treatment complications, including serious and unusual opportunistic infections.展开更多
AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United States.METHODS We performed...AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United States.METHODS We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States.We compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential confounders.RESULTS We recruited 49 participants from China and 145 from the United States.The prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in China.Ileal involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two countries.CONCLUSION The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States.Despite the potential difference in etiology,surgery and ileal involvement were similar in the two countries.Examining the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD.展开更多
Crohn’s disease is a chronic inflammatory granulomatous process that usually involves different sites in the intestinal tract. Genetic and environmental factors are thought to play a role in its etiology and pathogen...Crohn’s disease is a chronic inflammatory granulomatous process that usually involves different sites in the intestinal tract. Genetic and environmental factors are thought to play a role in its etiology and pathogenesis. The disorder has a heterogeneous clinical expression and data from tertiary care settings have documented its female predominance, occasional familial nature, and high rate of stricture formation and penetrating disease. It may appear from early childhood to late adulthood, although over 80% are currently diagnosed before age 40 years, usually with terminal ileal and colonic involvement. Several studies have now shown differences in phenotypic clinical expression depending on the initial age at diagnosis, with pediatric-onset disease being more severe and more extensive with more involvement of the upper gastrointestinal tract compared to adult-onset disease. In addition, long- term studies from these tertiary care settings have documented that the disorder may evolve with time into a more complex disease with stricture formation and penetrating disease complications (i.e. fistula and abscess). Although prolonged remission with no evidence of inflammatory disease may occur, discrete periods of symptomatic and active granulomatous inflammatory disease may re-appear over many decades. Long-term studies on the natural history have also suggested that discrete events (or agents) may precipitate this granulomatous inflammatory process.展开更多
Inflammatory bowel diseases(IBD),including ulcerative colitis(UC) and Crohn's disease(CD),are chronic,progressive and disabling disorders.Over the last few decades,new therapeutic approaches have been introduced w...Inflammatory bowel diseases(IBD),including ulcerative colitis(UC) and Crohn's disease(CD),are chronic,progressive and disabling disorders.Over the last few decades,new therapeutic approaches have been introduced which have led not only to a reduction in the mortality rate but also offered the possibility of a favorable modification in the natural history of IBD.The identification of clinical,genetic and serological prognostic factors has permitted a better stratification of the disease,thus allowing the opportunity to indicate the most appropriate therapy.Early treatment with immunosuppressive drugs and biologics has offered the opportunity to change,at least in the short term,the course of the disease by reducing,in a subset of patients with IBD,hospitalization and the need for surgery.In this review,the crucial steps in the natural history of both UC and CD will be discussed,as well as the factors that may change their clinical course.The methodological requirements for high quality studies on the course and prognosis of IBD,the true impact of environmental and dietary factors on the clinical course of IBD,the clinical,serological and genetic predictors of the IBD course(in particular,which of these are rel-evant and appropriate for use in clinical practice),the impact of the various forms of medical treatment on the IBD complication rate,the role of surgery for IBD in the biologic era,the true magnitude of risk of colorectal cancer associated with IBD,as well as the mortality rate related to IBD will be stressed;all topics that are extensively discussed in separate reviews included in this issue of World Journal of Gastroenterology.展开更多
Crohn’s disease (CD) is a multifactorial potentially debilitating disease. It has a variable disease course, but the majority of patients eventually develop penetrating or stricturing complications leading...Crohn’s disease (CD) is a multifactorial potentially debilitating disease. It has a variable disease course, but the majority of patients eventually develop penetrating or stricturing complications leading to repeated surgeries and disability. Studies on the natural history of CD provide invaluable data on its course and clinical predictors, and may help to identify patient subsets based on clinical phenotype. Most data are available from referral centers, however these outcomes may be different from those in population-based cohorts. New data suggest the possibility of a change in the natural history in Crohn’s disease, with an increasing percentage of patients diagnosed with inflammatory disease behavior. Hospitalization rates remain high, while surgery rates seem to have decreased in the last decade. In addition, mortality rates still exceed that of the general population. The impact of changes in treatment strategy, including increased, earlier use of immunosuppressives, biological therapy, and patient monitoring on the natural history of the disease are still conflictive. In this review article, the authors summarize the available evidence on the natural history, current trends, and predictive factors for evaluating the disease course of CD.展开更多
Barrett's esophagus(BE)is the precursor to esophageal adenocarcinoma(EAC).Progression to cancer typically occurs in a stepwise fashion through worsening dysplasia and ultimately,invasive neoplasia.Established EAC ...Barrett's esophagus(BE)is the precursor to esophageal adenocarcinoma(EAC).Progression to cancer typically occurs in a stepwise fashion through worsening dysplasia and ultimately,invasive neoplasia.Established EAC with deep involvement of the esophageal wall and/or metastatic disease is invariably associated with poor long-term survival rates.This guides the rationale of surveillance of Barrett’s in an attempt to treat lesions at an earlier,and potentially curative stage.The last two decades have seen a paradigm shift in management of Barrett’s with rapid expansion in the role of endoscopic eradication therapy(EET)for management of dysplastic and early neoplastic BE,and there have been substantial changes to international consensus guidelines for management of early BE based on evolving evidence.This review aims to assist the physician in the therapeutic decision-making process with patients by comprehensive review and summary of literature surrounding natural history of Barrett’s by histological stage,and the effectiveness of interventions in attenuating the risk posed by its natural history.Key findings were as follows.Non-dysplastic Barrett’s is associated with extremely low risk of progression,and interventions cannot be justified.The annual risk of cancer progression in low grade dysplasia is between 1%-3%;EET can be offered though evidence for its benefit remains confined to highly select settings.High-grade dysplasia progresses to cancer in 5%-10%per year;EET is similarly effective to and less morbid than surgery and should be routinely performed for this indication.Risk of nodal metastases in intramucosal cancer is 2%-4%,which is comparable to operative mortality rate,so EET is usually preferred.Submucosal cancer is associated with nodal metastases in 14%-41%hence surgery remains standard of care,except for select situations.展开更多
Teachers of the ideological and political theory course should be confident in the ideological and political course,insist on the unity of explicit education and recessive education,be good at exploring the ideologica...Teachers of the ideological and political theory course should be confident in the ideological and political course,insist on the unity of explicit education and recessive education,be good at exploring the ideological and political education resources contained in other courses and teaching methods,and realize the full-time education of all employees.At present,there is still much room for improvement in the collaborative education of aesthetic education and moral education.Teachers of the ideological and political theory course should actively guide and explore the ideological and political education resources of music resources,and use the artistic discourse system to interpret the historical process of modern Chinese social development and revolution,construction,and reform,and its inherent regularity,which reflects the national history and national conditions,reflects the positive results of Marxism in China,the era,and the popularization,guiding students to profoundly understand the history and how the people chose Marxism,chose the Chinese Communist Party,chose the socialist road,and chose reform and opening up;strengthening the road self-confidence,theoretical self-confidence,institutional self-confidence,and cultural self-confidence of socialism with Chinese characteristics;earnestly establish the belief that“only socialism can save China,only socialism with Chinese characteristics can develop China.”展开更多
Discussions on grasping the laws and trends of historical development take a fundamental theoretical position in the scientific system of Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era.Xi J...Discussions on grasping the laws and trends of historical development take a fundamental theoretical position in the scientific system of Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era.Xi Jinping’s important statements have systematically answered such questions as what type of laws and trends of historical development should be followed,how did the Party follow the laws and trends of historical development in its centennial history,and how should the laws and trends of historical development be followed in a new era.The birth of the Communist Party of China(CPC),the victory of China’s War of Resistance against Japanese Aggression,the founding of the People’s Republic of China,and the unveiling of a new era for reform and opening up and socialism with Chinese characteristics are all the results of grasping the laws and trends of historical development.Over the past century,the Party has followed the laws and trends of historical development and continuously advanced the sinicization of Marxism on the basis of adhering to the unification between truth and values.In pursuit of“putting people first,”the Party has courageously been reforming itself and made relentless progress in the great endeavor of Party building.History shows that a keen appreciation of the laws and trends of historical development is an important sign of political maturity for a proletarian party.Only by applying Marxism according to current times and conditions will we keep abreast with the laws and trends of historical development.We should establish a broader concept of history and identify the laws and trends of historical development from the interactions and linkages between China and the rest of the world.We must recognize and promote the outstanding role of great leaders in steering the country in line with the laws and trends of historical development.展开更多
The significance of discourse construction in the civilization discussion of Xi Jinping is explored in this paper: The 500-year history of world socialism and the 5000-year history of Chinese civilization, Xi Jinping&...The significance of discourse construction in the civilization discussion of Xi Jinping is explored in this paper: The 500-year history of world socialism and the 5000-year history of Chinese civilization, Xi Jinping' s studies of Socialism with Chinese characteristics in the long history of civilization development, highlighting Socialism with Chinese characteristics as a product in the development of human civilization, the great contribution to world civilization progress and the creative development of Marxism which has been the most distinctive feature in Chinese discourse structure since the 18 th National Congress of the CPC. As the conscious construction of epistemology, it has given unprecedented historical and cultural implications to China' s road and opened the new theory space for the discourse construction of Socialism with Chinese characteristics or the academic expression of China' s road.展开更多
The article focuses on sources of Brazilian sports journalism and demonstrates the role of organized soccer fan groups in Rio de Janeiro between the 1940s and 1980s, this is achieved through reports provided by the Br...The article focuses on sources of Brazilian sports journalism and demonstrates the role of organized soccer fan groups in Rio de Janeiro between the 1940s and 1980s, this is achieved through reports provided by the Brazilian newspaper Jornal dos Sports. From the beginning, there are biographical notes made about the most well-known fan leaders in Rio, such as Jaime de Carvalho, who founded the Charanga （1942）. The emergence of dissent among the fans, in the late 1960s, is then covered, which establishes itself within the organized fans in Rio with these individuals beginning to question the authority of the old fan group leaders. This is against the principle of giving unconditional support to the club and it is postulated that the fans have the right to criticize and protest against the club＇s management, even if this means using forceful tactics. Along with the journalistic narrative, there is a break-off by the ＂Young Fans＂ and a process of emancipation begins which occurs over the 1970s, this happens by means of the use of fan coaches and the invention of a lifestyle that is associated with soccer. Finally, the 1980s is marked by the constructive and destructive potential that is linked to fan groups. On the one hand, creating an Association of fans--Astorj--is pointed to in order to reach a mutual understanding, but it should be noted, on the other, that there are feuds, in a scenario of spiraling violence, in which fights, beatings, and even murders begin to be commonplace.展开更多
Both national and local governments have been paying great attention to the work of industrial standardization with the enormous increase in international trade after China joined WTO. According to the standards r... Both national and local governments have been paying great attention to the work of industrial standardization with the enormous increase in international trade after China joined WTO. According to the standards revising plan of Standardization Administration Committee of China (SAC),TC54 has already revised a series of national standards and industrial standards for foundry operations,and proposed some new ones. As a result,some old fashioned standards containing low-level techniques have been gradually discontinued or replaced with new versions.……展开更多
More women than men have Alzheimer's disease(AD)or other dementias.There are a number of potential biological and social reasons for the sex difference in the risk of AD,such as women live longer than men on avera...More women than men have Alzheimer's disease(AD)or other dementias.There are a number of potential biological and social reasons for the sex difference in the risk of AD,such as women live longer than men on average,and estrogen depletion after menopause in women,biological or genetic variations,and education,occupation or rates of heart disease.Recent studies showed a link between reproductive history and dementia risk in women.Women with fertility history showed lower risk of dementia compared to women with no child.Other studies also suggested that women's pregnancy history may influence AD's risk.In this review,we will focus on the relationship between women fertility and cognition and discuss the potential role of sex hormones in the brain and cognition,especially on AD pathogenesis.展开更多
The novel Banengannen’s Soccer Team published in 1967has been classified as historical"meta narration"of Kenzaburo Oe.In the novel,there are two main characters—Mitsusaburo and Takashi,both of whom represe...The novel Banengannen’s Soccer Team published in 1967has been classified as historical"meta narration"of Kenzaburo Oe.In the novel,there are two main characters—Mitsusaburo and Takashi,both of whom represent two ways of exploring the historical truth.In the process of exploration of the two characters,Kenzaburo Oe symbolically analyzed the value presetting of the Japanese people—getting one’s own value through projecting the"Emperor",recreating a new chapter of history from personal experience.展开更多
Europe and the EU have been facing many crises and challenges in recent years.From Brexit and rising nationalism to economic problems and unanimous refugee policies,most of them remain unsolved.Instead of moving forwa...Europe and the EU have been facing many crises and challenges in recent years.From Brexit and rising nationalism to economic problems and unanimous refugee policies,most of them remain unsolved.Instead of moving forward with the European integration project,Europe seems to regress in many instances.Considering this turmoil,it seems all the more important to historicize the affirmative discourse of Europe and to expand the knowledge of the European unification process with novel insights into its history.Only if a broad understanding of its roots and developments prevails,the conflicts of the present can be better evaluated and addressed.Particularly one set of so far neglected sources from Europe’s past serves as guiding light in that respect:the early modern Europe literature written in the Latin language.Between 1400 and 1800,Latin enjoyed a similar status in promoting scientific discoveries,negotiating political affairs and generally communicating on an international level as modern-day English.By offering a brief glance at some historically influential Latin texts from the early modern discourse of Europe,this article will show that the early modern European crises strikingly resemble Europe’s current crises despite the difference in political,social,and economic circumstances.The discourse of Europe has from the beginning been a stable discourse,characterized by the same recurring questions for centuries.When used as reference point for the crises of the 21st century,the prospects for the European integration look better than presumed.展开更多
Currently, colleges and universities, Post-90s college students has gradually become the main force of college students party, how to play their constructive role as a college party workers is a problem in front of us...Currently, colleges and universities, Post-90s college students has gradually become the main force of college students party, how to play their constructive role as a college party workers is a problem in front of us. To solve this problem, we propose effective measures must be taken to enable them to overcome some of the wrong ideology, such as student centered consciousness, making nice consciousness, Abandon rights, abandon obligations consciousness, party members community spirit is not vested in the party organization, the sense of thought like good learning is more important than good thought consciousness, so as to guide the Post-90s college students to actively join the party building.展开更多
文摘Crohn’s disease is a chronic inflammatory disease process involving different sites in the gastrointestinal tract. Occasionally, so-called metastatic disease occurs in extra-intestinal sites. Granulomatous inflammation may be detected in endoscopic biopsies or resected tissues. Genetic, epigenetic and environmental factors appear to play a role. Multiple susceptibility genes have been described in both familial and non-familial forms while the disease is phenotypically heterogeneous with a female predominance. The disorder occurs over a broad age spectrum, from early childhood to late adulthood. More than 80% are diagnosed before age 40 years usually with terminal ileal and colonic involvement. Pediatric-onset disease is more severe and more extensive, usually with a higher chance of upper gastrointestinal tract disease, compared to adult-onset disease. Long-term studies have shown that the disorder may evolve with time into more complex disease with stricture formation and penetrating disease complications (i.e., fistula, abscess). Although prolonged remission may occur, discrete periods of symptomatic disease may re-appear over many decades suggesting recurrence or re-activation of this inflammatory process. Eventual development of a cure will likely depend on identification of an etiologic cause and a fundamental understanding of its pathogenesis. Until now, treatment has focused on removing risk factors, particularly cigarette smoking, and improving symptoms. In clinical trials, clinical remission is largely defined as improved numerical and endoscopic indices for “mucosal healing”. “Deep remission” is a conceptual, more “extended” goal that may or may not alter the long-term natural history of the disease in selected patients, albeit at a significant risk for treatment complications, including serious and unusual opportunistic infections.
基金Supported by (in part)Johns Hopkins Institute for Clinical and Translational Research,No.UL1TR001079
文摘AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United States.METHODS We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States.We compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential confounders.RESULTS We recruited 49 participants from China and 145 from the United States.The prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in China.Ileal involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two countries.CONCLUSION The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States.Despite the potential difference in etiology,surgery and ileal involvement were similar in the two countries.Examining the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD.
文摘Crohn’s disease is a chronic inflammatory granulomatous process that usually involves different sites in the intestinal tract. Genetic and environmental factors are thought to play a role in its etiology and pathogenesis. The disorder has a heterogeneous clinical expression and data from tertiary care settings have documented its female predominance, occasional familial nature, and high rate of stricture formation and penetrating disease. It may appear from early childhood to late adulthood, although over 80% are currently diagnosed before age 40 years, usually with terminal ileal and colonic involvement. Several studies have now shown differences in phenotypic clinical expression depending on the initial age at diagnosis, with pediatric-onset disease being more severe and more extensive with more involvement of the upper gastrointestinal tract compared to adult-onset disease. In addition, long- term studies from these tertiary care settings have documented that the disorder may evolve with time into a more complex disease with stricture formation and penetrating disease complications (i.e. fistula and abscess). Although prolonged remission with no evidence of inflammatory disease may occur, discrete periods of symptomatic and active granulomatous inflammatory disease may re-appear over many decades. Long-term studies on the natural history have also suggested that discrete events (or agents) may precipitate this granulomatous inflammatory process.
文摘Inflammatory bowel diseases(IBD),including ulcerative colitis(UC) and Crohn's disease(CD),are chronic,progressive and disabling disorders.Over the last few decades,new therapeutic approaches have been introduced which have led not only to a reduction in the mortality rate but also offered the possibility of a favorable modification in the natural history of IBD.The identification of clinical,genetic and serological prognostic factors has permitted a better stratification of the disease,thus allowing the opportunity to indicate the most appropriate therapy.Early treatment with immunosuppressive drugs and biologics has offered the opportunity to change,at least in the short term,the course of the disease by reducing,in a subset of patients with IBD,hospitalization and the need for surgery.In this review,the crucial steps in the natural history of both UC and CD will be discussed,as well as the factors that may change their clinical course.The methodological requirements for high quality studies on the course and prognosis of IBD,the true impact of environmental and dietary factors on the clinical course of IBD,the clinical,serological and genetic predictors of the IBD course(in particular,which of these are rel-evant and appropriate for use in clinical practice),the impact of the various forms of medical treatment on the IBD complication rate,the role of surgery for IBD in the biologic era,the true magnitude of risk of colorectal cancer associated with IBD,as well as the mortality rate related to IBD will be stressed;all topics that are extensively discussed in separate reviews included in this issue of World Journal of Gastroenterology.
文摘Crohn’s disease (CD) is a multifactorial potentially debilitating disease. It has a variable disease course, but the majority of patients eventually develop penetrating or stricturing complications leading to repeated surgeries and disability. Studies on the natural history of CD provide invaluable data on its course and clinical predictors, and may help to identify patient subsets based on clinical phenotype. Most data are available from referral centers, however these outcomes may be different from those in population-based cohorts. New data suggest the possibility of a change in the natural history in Crohn’s disease, with an increasing percentage of patients diagnosed with inflammatory disease behavior. Hospitalization rates remain high, while surgery rates seem to have decreased in the last decade. In addition, mortality rates still exceed that of the general population. The impact of changes in treatment strategy, including increased, earlier use of immunosuppressives, biological therapy, and patient monitoring on the natural history of the disease are still conflictive. In this review article, the authors summarize the available evidence on the natural history, current trends, and predictive factors for evaluating the disease course of CD.
文摘Barrett's esophagus(BE)is the precursor to esophageal adenocarcinoma(EAC).Progression to cancer typically occurs in a stepwise fashion through worsening dysplasia and ultimately,invasive neoplasia.Established EAC with deep involvement of the esophageal wall and/or metastatic disease is invariably associated with poor long-term survival rates.This guides the rationale of surveillance of Barrett’s in an attempt to treat lesions at an earlier,and potentially curative stage.The last two decades have seen a paradigm shift in management of Barrett’s with rapid expansion in the role of endoscopic eradication therapy(EET)for management of dysplastic and early neoplastic BE,and there have been substantial changes to international consensus guidelines for management of early BE based on evolving evidence.This review aims to assist the physician in the therapeutic decision-making process with patients by comprehensive review and summary of literature surrounding natural history of Barrett’s by histological stage,and the effectiveness of interventions in attenuating the risk posed by its natural history.Key findings were as follows.Non-dysplastic Barrett’s is associated with extremely low risk of progression,and interventions cannot be justified.The annual risk of cancer progression in low grade dysplasia is between 1%-3%;EET can be offered though evidence for its benefit remains confined to highly select settings.High-grade dysplasia progresses to cancer in 5%-10%per year;EET is similarly effective to and less morbid than surgery and should be routinely performed for this indication.Risk of nodal metastases in intramucosal cancer is 2%-4%,which is comparable to operative mortality rate,so EET is usually preferred.Submucosal cancer is associated with nodal metastases in 14%-41%hence surgery remains standard of care,except for select situations.
基金The phased achievements of:the 2019 Shanghai School Art Research Project——“Study on the Collaborative Education of Music Education and Ideological and Political Education”(Project No.:HJYS-2019-A02)the 2018 Ministry of Education Demonstrate Marxist College and the Excellent Teaching and Research Team Construction Project——Study of the Early Marxists’Understanding and Application of Chinese Excellent Traditional Culture(Project No.:18JDSZK075)and the 2019 General Task of Shanghai’s Philosophical and Social Planning——“Study on the Origin of Red Culture in Shanghai”(Project No.:2019BDS008).
文摘Teachers of the ideological and political theory course should be confident in the ideological and political course,insist on the unity of explicit education and recessive education,be good at exploring the ideological and political education resources contained in other courses and teaching methods,and realize the full-time education of all employees.At present,there is still much room for improvement in the collaborative education of aesthetic education and moral education.Teachers of the ideological and political theory course should actively guide and explore the ideological and political education resources of music resources,and use the artistic discourse system to interpret the historical process of modern Chinese social development and revolution,construction,and reform,and its inherent regularity,which reflects the national history and national conditions,reflects the positive results of Marxism in China,the era,and the popularization,guiding students to profoundly understand the history and how the people chose Marxism,chose the Chinese Communist Party,chose the socialist road,and chose reform and opening up;strengthening the road self-confidence,theoretical self-confidence,institutional self-confidence,and cultural self-confidence of socialism with Chinese characteristics;earnestly establish the belief that“only socialism can save China,only socialism with Chinese characteristics can develop China.”
文摘Discussions on grasping the laws and trends of historical development take a fundamental theoretical position in the scientific system of Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era.Xi Jinping’s important statements have systematically answered such questions as what type of laws and trends of historical development should be followed,how did the Party follow the laws and trends of historical development in its centennial history,and how should the laws and trends of historical development be followed in a new era.The birth of the Communist Party of China(CPC),the victory of China’s War of Resistance against Japanese Aggression,the founding of the People’s Republic of China,and the unveiling of a new era for reform and opening up and socialism with Chinese characteristics are all the results of grasping the laws and trends of historical development.Over the past century,the Party has followed the laws and trends of historical development and continuously advanced the sinicization of Marxism on the basis of adhering to the unification between truth and values.In pursuit of“putting people first,”the Party has courageously been reforming itself and made relentless progress in the great endeavor of Party building.History shows that a keen appreciation of the laws and trends of historical development is an important sign of political maturity for a proletarian party.Only by applying Marxism according to current times and conditions will we keep abreast with the laws and trends of historical development.We should establish a broader concept of history and identify the laws and trends of historical development from the interactions and linkages between China and the rest of the world.We must recognize and promote the outstanding role of great leaders in steering the country in line with the laws and trends of historical development.
文摘The significance of discourse construction in the civilization discussion of Xi Jinping is explored in this paper: The 500-year history of world socialism and the 5000-year history of Chinese civilization, Xi Jinping' s studies of Socialism with Chinese characteristics in the long history of civilization development, highlighting Socialism with Chinese characteristics as a product in the development of human civilization, the great contribution to world civilization progress and the creative development of Marxism which has been the most distinctive feature in Chinese discourse structure since the 18 th National Congress of the CPC. As the conscious construction of epistemology, it has given unprecedented historical and cultural implications to China' s road and opened the new theory space for the discourse construction of Socialism with Chinese characteristics or the academic expression of China' s road.
文摘The article focuses on sources of Brazilian sports journalism and demonstrates the role of organized soccer fan groups in Rio de Janeiro between the 1940s and 1980s, this is achieved through reports provided by the Brazilian newspaper Jornal dos Sports. From the beginning, there are biographical notes made about the most well-known fan leaders in Rio, such as Jaime de Carvalho, who founded the Charanga （1942）. The emergence of dissent among the fans, in the late 1960s, is then covered, which establishes itself within the organized fans in Rio with these individuals beginning to question the authority of the old fan group leaders. This is against the principle of giving unconditional support to the club and it is postulated that the fans have the right to criticize and protest against the club＇s management, even if this means using forceful tactics. Along with the journalistic narrative, there is a break-off by the ＂Young Fans＂ and a process of emancipation begins which occurs over the 1970s, this happens by means of the use of fan coaches and the invention of a lifestyle that is associated with soccer. Finally, the 1980s is marked by the constructive and destructive potential that is linked to fan groups. On the one hand, creating an Association of fans--Astorj--is pointed to in order to reach a mutual understanding, but it should be noted, on the other, that there are feuds, in a scenario of spiraling violence, in which fights, beatings, and even murders begin to be commonplace.
文摘 Both national and local governments have been paying great attention to the work of industrial standardization with the enormous increase in international trade after China joined WTO. According to the standards revising plan of Standardization Administration Committee of China (SAC),TC54 has already revised a series of national standards and industrial standards for foundry operations,and proposed some new ones. As a result,some old fashioned standards containing low-level techniques have been gradually discontinued or replaced with new versions.……
文摘More women than men have Alzheimer's disease(AD)or other dementias.There are a number of potential biological and social reasons for the sex difference in the risk of AD,such as women live longer than men on average,and estrogen depletion after menopause in women,biological or genetic variations,and education,occupation or rates of heart disease.Recent studies showed a link between reproductive history and dementia risk in women.Women with fertility history showed lower risk of dementia compared to women with no child.Other studies also suggested that women's pregnancy history may influence AD's risk.In this review,we will focus on the relationship between women fertility and cognition and discuss the potential role of sex hormones in the brain and cognition,especially on AD pathogenesis.
文摘The novel Banengannen’s Soccer Team published in 1967has been classified as historical"meta narration"of Kenzaburo Oe.In the novel,there are two main characters—Mitsusaburo and Takashi,both of whom represent two ways of exploring the historical truth.In the process of exploration of the two characters,Kenzaburo Oe symbolically analyzed the value presetting of the Japanese people—getting one’s own value through projecting the"Emperor",recreating a new chapter of history from personal experience.
文摘Europe and the EU have been facing many crises and challenges in recent years.From Brexit and rising nationalism to economic problems and unanimous refugee policies,most of them remain unsolved.Instead of moving forward with the European integration project,Europe seems to regress in many instances.Considering this turmoil,it seems all the more important to historicize the affirmative discourse of Europe and to expand the knowledge of the European unification process with novel insights into its history.Only if a broad understanding of its roots and developments prevails,the conflicts of the present can be better evaluated and addressed.Particularly one set of so far neglected sources from Europe’s past serves as guiding light in that respect:the early modern Europe literature written in the Latin language.Between 1400 and 1800,Latin enjoyed a similar status in promoting scientific discoveries,negotiating political affairs and generally communicating on an international level as modern-day English.By offering a brief glance at some historically influential Latin texts from the early modern discourse of Europe,this article will show that the early modern European crises strikingly resemble Europe’s current crises despite the difference in political,social,and economic circumstances.The discourse of Europe has from the beginning been a stable discourse,characterized by the same recurring questions for centuries.When used as reference point for the crises of the 21st century,the prospects for the European integration look better than presumed.
文摘Currently, colleges and universities, Post-90s college students has gradually become the main force of college students party, how to play their constructive role as a college party workers is a problem in front of us. To solve this problem, we propose effective measures must be taken to enable them to overcome some of the wrong ideology, such as student centered consciousness, making nice consciousness, Abandon rights, abandon obligations consciousness, party members community spirit is not vested in the party organization, the sense of thought like good learning is more important than good thought consciousness, so as to guide the Post-90s college students to actively join the party building.
