Fetal liver tissues obtained from 28 human fetuses with gestation age from 3 to 6 months and fetal bone marrow from 35 human fetuses from 3 to 7 months were observed by immunochemical staining with anti-platelet GPⅡ ...Fetal liver tissues obtained from 28 human fetuses with gestation age from 3 to 6 months and fetal bone marrow from 35 human fetuses from 3 to 7 months were observed by immunochemical staining with anti-platelet GPⅡ b / Ⅲa monoclonal antibody and ABC technique. In the fetal liver, megakaryocytes were wholly located among growing fetal liver cells and near foci of hemopoiesis. Some megakaryocytes in the fetal liver were small7890- lymphoid-like megakaryocytes. The size of megakaryocytes both in the fetal liver (14.79 ± 4.52μm) and in the fetal bone marrow (16.08±7.39 μm) was small, which did not vary significantly over the gestation age ranging from 3 to 6 or 7 months. However, the maturation stage of megakaryocytes in the fetal liver shifted to more mature stage with the advancement of gestation, although the maturation stage of megakaryocytes in the fetal bone marrow did not change with the advancement of gestation from 4 to 7 months, the megakaryocyte in the fetal bone marrow was less mature展开更多
Forty four consecutive subjects aged 29-58 years (21 males and 23 females) with a clinical diagnosis of heterozygous familial hypercholesterolemia periodically treated every 30 days with LDL-apheresis for statin resis...Forty four consecutive subjects aged 29-58 years (21 males and 23 females) with a clinical diagnosis of heterozygous familial hypercholesterolemia periodically treated every 30 days with LDL-apheresis for statin resistance, were enrolled in this study. A lipid profile was obtained immediately before starting LDL-apheresis, a second profile was obtained within four hours after LDL-apheresis. Chit activity and anti-oxLDL levels were determined with appropriate methods in all patients before and after LDL- apheresis. Total cholesterol, LDL-cholesterol, HDL- cholesterol and triglycerides decreased significantly after LDL-apheresis, while the variations of Chit activity and anti-oxLDL were not significant after LDL-apheresis. The correlation between Chit and total cholesterol was negative (r= –0.44 and –0.50 res- pectively) before and after LDL-apheresis as between Chit and LDL-cholesterol (r= –0.45 and –0.55 respectively). Anti-oxLDL concentration before and after LDL-apheresis positively correlated with Chit activity (r= 0.52 and r = 0.63 respectively), negatively with total cholesterol (r= –0.33 and r = –0.35 res- pectively) and with LDL (r = –0.32 and r = –0.21 respectively). We think that removing LDL with LDL-apheresis the anti-oxLDL/oxLDL ratio could increase and the excess of anti-oxLDL could induce macrophage activation through the surface Fc receptors. Alternatively with high levels of LDL- cholesterol, the deposition of foam cells represent the characteristic evolution of atherosclerosis process. Macrophage activation in the heterozygous familial hypercholesterolemia could represent an attempt for re-modeling the vessel wall, reducing the growth of lipid plaques.展开更多
In this paper,the influence of heave and pitch motions on green water impact on the deck is numerically investigated.The vessel motions are determined using a potential theory based method and provided as input to fin...In this paper,the influence of heave and pitch motions on green water impact on the deck is numerically investigated.The vessel motions are determined using a potential theory based method and provided as input to finite volume based CFD computations of green water phenomenon.A dynamic mesh approach is adopted to determine instantaneous body positioning in the fluid domain.Detailed validation studies with published experimental results for 2D and 3D fixed vessel cases are initially performed to validate the present numerical approach before studying the moving vessel problem.The results show that inclusion of heave and pitch motion changes the disturbed wave field near the bow which influences the free surface as well as the impact loading due to green water.The effect of wave steepness on green water impact is also investigated and it is seen that the present numerical method is capable of capturing green water load.It is observed that the effects of vessel motions on green water load are not negligible and one should consider this effect too.The incorporation of vessel motions in the vertical plane affects the green water loading on the deck.展开更多
应用常规天气资料、自动站和强天气监测数据、WebGIS雷达回波拼图等资料,采用统计对比分析和特征提取方法,对2017年5月11日江西强飑线天气过程进行分析,结果表明:"511"强飑线过程是由500 h Pa高空小槽引导、低空切变和低空急...应用常规天气资料、自动站和强天气监测数据、WebGIS雷达回波拼图等资料,采用统计对比分析和特征提取方法,对2017年5月11日江西强飑线天气过程进行分析,结果表明:"511"强飑线过程是由500 h Pa高空小槽引导、低空切变和低空急流等多因素共同作用下产生的。江西飑线回波系统多数是由省外产生且有规律移入的带状回波系统,具有4个不同阶段的回波特征。超级单体风暴常伴有雷雨大风、短时强降水、冰雹等强对流天气,往往发生在飑线回波带的前方暖区中。弓形回波带由一个个对流回波核组成,回波长度往往超过100 km。雷雨大风发生在弓形回波的前沿,而最强的雷雨大风发生在弓形回波的顶部"逗点"头部,也就是回波移速较快向前突出的部位。展开更多
On May 28,2018,a strong hailstorm accompanying gale(with speed of 17 m/s)and hail(with the maximum diameter of 42 mm)occurred in Yantai in Shandong Peninsula.Based on the conventional weather observation,Doppler weath...On May 28,2018,a strong hailstorm accompanying gale(with speed of 17 m/s)and hail(with the maximum diameter of 42 mm)occurred in Yantai in Shandong Peninsula.Based on the conventional weather observation,Doppler weather radar,and automatic weather station data,the evolution characteristics of the strong hailstorm in Shandong Peninsula were analyzed.The results show that this multi-cell strong storm occurred under the background of high-altitude cold vortex.The strong cold advection at the middle and high altitudes and the weak warm advection at the low altitude formed a strong unstable stratification,and also led to cooling at the middle altitudes at the same time.The height of 0 and-20℃dropped significantly,which provided better environmental conditions for the growth of hail in the air.The lower temperature 0℃also ensured less melting of hail during falling,and the middle dry layer was conducive to the formation of thunderstorm gale.The vertical wind shear above medium intensity was the development and maintenance mechanism of thunderstorm cells gradually evolving into a strong hailstorm.From the analysis of radar echo characteristics,it is found that it was a strong hailstorm weather process caused by the linear multi-cell storm.The thunderstorm cells that could produce large hail occurred and developed,and the whole process lasted for 2 h under the triggering of the convergence line formed by the interaction of the sea breeze front and ground cold front.It had obvious characteristics of hail such as three-body scattering spikes,side-lobe echoes,high-hanging strong echoes,as well as the characteristics of thunderstorm gale such as arcuate echoes,middle-level radial convergence,and back side inflow.The storm development process was accompanied by backward propagation,but the long axis of the line storm was basically perpendicular to the movement direction of the storm,so there was no short-term heavy precipitation.The stratification instability conditions,water vapor conditions and ground convergence conditions in the eastern part of the peninsula were significantly worse than those in the western part.As a result,the thunderstorm cells first appeared in Laizhou,and then developed into the linear multi-cell storm in the process of eastward movement.Finally,it was rapidly weakened and disappeared after passing through Yantai.展开更多
文摘Fetal liver tissues obtained from 28 human fetuses with gestation age from 3 to 6 months and fetal bone marrow from 35 human fetuses from 3 to 7 months were observed by immunochemical staining with anti-platelet GPⅡ b / Ⅲa monoclonal antibody and ABC technique. In the fetal liver, megakaryocytes were wholly located among growing fetal liver cells and near foci of hemopoiesis. Some megakaryocytes in the fetal liver were small7890- lymphoid-like megakaryocytes. The size of megakaryocytes both in the fetal liver (14.79 ± 4.52μm) and in the fetal bone marrow (16.08±7.39 μm) was small, which did not vary significantly over the gestation age ranging from 3 to 6 or 7 months. However, the maturation stage of megakaryocytes in the fetal liver shifted to more mature stage with the advancement of gestation, although the maturation stage of megakaryocytes in the fetal bone marrow did not change with the advancement of gestation from 4 to 7 months, the megakaryocyte in the fetal bone marrow was less mature
文摘Forty four consecutive subjects aged 29-58 years (21 males and 23 females) with a clinical diagnosis of heterozygous familial hypercholesterolemia periodically treated every 30 days with LDL-apheresis for statin resistance, were enrolled in this study. A lipid profile was obtained immediately before starting LDL-apheresis, a second profile was obtained within four hours after LDL-apheresis. Chit activity and anti-oxLDL levels were determined with appropriate methods in all patients before and after LDL- apheresis. Total cholesterol, LDL-cholesterol, HDL- cholesterol and triglycerides decreased significantly after LDL-apheresis, while the variations of Chit activity and anti-oxLDL were not significant after LDL-apheresis. The correlation between Chit and total cholesterol was negative (r= –0.44 and –0.50 res- pectively) before and after LDL-apheresis as between Chit and LDL-cholesterol (r= –0.45 and –0.55 respectively). Anti-oxLDL concentration before and after LDL-apheresis positively correlated with Chit activity (r= 0.52 and r = 0.63 respectively), negatively with total cholesterol (r= –0.33 and r = –0.35 res- pectively) and with LDL (r = –0.32 and r = –0.21 respectively). We think that removing LDL with LDL-apheresis the anti-oxLDL/oxLDL ratio could increase and the excess of anti-oxLDL could induce macrophage activation through the surface Fc receptors. Alternatively with high levels of LDL- cholesterol, the deposition of foam cells represent the characteristic evolution of atherosclerosis process. Macrophage activation in the heterozygous familial hypercholesterolemia could represent an attempt for re-modeling the vessel wall, reducing the growth of lipid plaques.
文摘In this paper,the influence of heave and pitch motions on green water impact on the deck is numerically investigated.The vessel motions are determined using a potential theory based method and provided as input to finite volume based CFD computations of green water phenomenon.A dynamic mesh approach is adopted to determine instantaneous body positioning in the fluid domain.Detailed validation studies with published experimental results for 2D and 3D fixed vessel cases are initially performed to validate the present numerical approach before studying the moving vessel problem.The results show that inclusion of heave and pitch motion changes the disturbed wave field near the bow which influences the free surface as well as the impact loading due to green water.The effect of wave steepness on green water impact is also investigated and it is seen that the present numerical method is capable of capturing green water load.It is observed that the effects of vessel motions on green water load are not negligible and one should consider this effect too.The incorporation of vessel motions in the vertical plane affects the green water loading on the deck.
文摘应用常规天气资料、自动站和强天气监测数据、WebGIS雷达回波拼图等资料,采用统计对比分析和特征提取方法,对2017年5月11日江西强飑线天气过程进行分析,结果表明:"511"强飑线过程是由500 h Pa高空小槽引导、低空切变和低空急流等多因素共同作用下产生的。江西飑线回波系统多数是由省外产生且有规律移入的带状回波系统,具有4个不同阶段的回波特征。超级单体风暴常伴有雷雨大风、短时强降水、冰雹等强对流天气,往往发生在飑线回波带的前方暖区中。弓形回波带由一个个对流回波核组成,回波长度往往超过100 km。雷雨大风发生在弓形回波的前沿,而最强的雷雨大风发生在弓形回波的顶部"逗点"头部,也就是回波移速较快向前突出的部位。
基金Supported by the Special Project for Forecaster of Shandong Meteorological Bureau(SDYBY2016-10)
文摘On May 28,2018,a strong hailstorm accompanying gale(with speed of 17 m/s)and hail(with the maximum diameter of 42 mm)occurred in Yantai in Shandong Peninsula.Based on the conventional weather observation,Doppler weather radar,and automatic weather station data,the evolution characteristics of the strong hailstorm in Shandong Peninsula were analyzed.The results show that this multi-cell strong storm occurred under the background of high-altitude cold vortex.The strong cold advection at the middle and high altitudes and the weak warm advection at the low altitude formed a strong unstable stratification,and also led to cooling at the middle altitudes at the same time.The height of 0 and-20℃dropped significantly,which provided better environmental conditions for the growth of hail in the air.The lower temperature 0℃also ensured less melting of hail during falling,and the middle dry layer was conducive to the formation of thunderstorm gale.The vertical wind shear above medium intensity was the development and maintenance mechanism of thunderstorm cells gradually evolving into a strong hailstorm.From the analysis of radar echo characteristics,it is found that it was a strong hailstorm weather process caused by the linear multi-cell storm.The thunderstorm cells that could produce large hail occurred and developed,and the whole process lasted for 2 h under the triggering of the convergence line formed by the interaction of the sea breeze front and ground cold front.It had obvious characteristics of hail such as three-body scattering spikes,side-lobe echoes,high-hanging strong echoes,as well as the characteristics of thunderstorm gale such as arcuate echoes,middle-level radial convergence,and back side inflow.The storm development process was accompanied by backward propagation,but the long axis of the line storm was basically perpendicular to the movement direction of the storm,so there was no short-term heavy precipitation.The stratification instability conditions,water vapor conditions and ground convergence conditions in the eastern part of the peninsula were significantly worse than those in the western part.As a result,the thunderstorm cells first appeared in Laizhou,and then developed into the linear multi-cell storm in the process of eastward movement.Finally,it was rapidly weakened and disappeared after passing through Yantai.
