By the use of cross-correlation measures, the response of a symmetric Schmitt trigger (ST) driven by a random binary signal and white Gaussian noise is investigated. The results show that the information transmission...By the use of cross-correlation measures, the response of a symmetric Schmitt trigger (ST) driven by a random binary signal and white Gaussian noise is investigated. The results show that the information transmission can be enhanced when a certain amount of noise is presented, i.e., aperiodic stochastic resonance (ASR). Then, the influence of signal amplitude and the ST threshold on ASR is examined, the applicability of the ST in reducing the noise level of random signal transmission and improving the quality of output signal via ASR effect is illustrated. This research is of great interest in the field of digital communications.展开更多
The popularly used circulant matrix model of deconvolution is mostly heavily ill-posed or singular and it is not suitable to many blind deconvolution problems. The aperiodic matrix model can improve the condition numb...The popularly used circulant matrix model of deconvolution is mostly heavily ill-posed or singular and it is not suitable to many blind deconvolution problems. The aperiodic matrix model can improve the condition number of deconvolution problems and its accommodation is much wider than the circulant one's. This paper discusses a comparison of the two models including their ill-posedness, the rationality of the approximation by the models, and their computational efficiency. The comparison shows that the aperiodic model is promising in the development of new restoration algorithms.展开更多
Stochastic resonance (SR) is based on the cooperative effect between the stochastic dynamical system and the external forcing. As is well known, the cooperative effect is produced by adding noises. In this paper, we...Stochastic resonance (SR) is based on the cooperative effect between the stochastic dynamical system and the external forcing. As is well known, the cooperative effect is produced by adding noises. In this paper, we show the evidence that by changing the system parameters and the signal intensity, a nonlinear system in the presence of an input aperiodic signal can yield the cooperative effect, with the noise fixed. To quantify the nonlinear system output, we determine the theoretical bit error rate (BER). By numerical simulation, the validity of the theoretical derivation is checked. Besides, we show that parameter-induced SR is more realizable than SR via adding noises, especially when the noise intensity exceeds the resonance level, or when the characteristic of the noise is not known.展开更多
Because of descriptive nonlinearity and computational inefficiency,topology optimization with fatigue life under aperiodic loads has developed slowly.A fatigue constraint topology optimization method based on bidirect...Because of descriptive nonlinearity and computational inefficiency,topology optimization with fatigue life under aperiodic loads has developed slowly.A fatigue constraint topology optimization method based on bidirectional evolutionary structural optimization(BESO)under an aperiodic load is proposed in this paper.In viewof the severe nonlinearity of fatigue damagewith respect to design variables,effective stress cycles are extracted through transient dynamic analysis.Based on the Miner cumulative damage theory and life requirements,a fatigue constraint is first quantified and then transformed into a stress problem.Then,a normalized termination criterion is proposed by approximatemaximum stress measured by global stress using a P-normaggregation function.Finally,optimization examples show that the proposed algorithm can not only meet the requirements of fatigue life but also obtain a reasonable configuration.展开更多
This paper examines the stabilization problem of a distributed networked control system under the effect of cyberattacks by employing a hybrid aperiodic triggering mechanism.The cyber-attack considered in the paper is...This paper examines the stabilization problem of a distributed networked control system under the effect of cyberattacks by employing a hybrid aperiodic triggering mechanism.The cyber-attack considered in the paper is a stochastic deception attack at the sensor-controller end. The probability of the occurrence of attack on a subsystem is represented using a random variable. A decentralized hybrid sampled-data strategy is introduced to save energy consumption and reduce the transmission load of the network. In the proposed decentralized strategy, each subsystem can decide independently whether its state should be transmitted to the controller or not. The scheme of the hybrid triggering mechanism for each subsystem composed of two stages: In the first stage, the next sampling instant is computed using a self-triggering strategy. Subsequently, in the second stage, an event-triggering condition is checked at these sampling instants and the control signal is computed only if the event-triggering condition is violated. The self-triggering condition used in the first stage is dependent on the selection of eventtriggering condition of the second stage. Finally, a comparison of the proposed approach with other triggering mechanisms existing in the literature is presented in terms of the sampling instants,transmission frequency and performance measures through simulation examples.展开更多
We study the entanglement between the internal(coin)and the external(position)degrees of freedom in the dynamic and the static deterministic aperiodic quantum walks(QWs).For the dynamic(static)aperiodic QWs,the coin d...We study the entanglement between the internal(coin)and the external(position)degrees of freedom in the dynamic and the static deterministic aperiodic quantum walks(QWs).For the dynamic(static)aperiodic QWs,the coin depends on the time(position)and takes two coins C(α)and C(β)arranged in the two classes of generalized Fibonacci(GF)and the Thue–Morse(TM)sequences.We found that for the dynamic QWs,the entanglement of three kinds of the aperiodic QWs are close to the maximal value,which are all much larger than that of the homogeneous QWs.Further,the first class of GF(1st GF)QWs can achieve the maximum entangled state,which is similar to that of the dynamic disordered QWs.And the entanglement of 1st GF QWs is greater than that of the TM QWs,being followed closely by the entanglement of the second class of GF(2nd GF)QWs.For the static QWs,the entanglement of three kinds of the aperiodic QWs are also close to the maximal value and 1st GF QWs can achieve the maximum entangled state.The entanglement of the TM QWs is between1st GF QWs and 2nd GF QWs.However,the entanglement of the static disordered QWs is less than that of three kinds of the aperiodic QWs.This is different from those of the dynamic QWs.From these results,we can conclude that the dynamic and static 1st GF QWs can also be considered as maximal entanglement generators.展开更多
In this paper, a novel scheduling mechanism is proposed to handle the real-time overload problem by maximizing the cumulative values of three types of tasks: the soft, the hard and the imprecise tasks. The simulation...In this paper, a novel scheduling mechanism is proposed to handle the real-time overload problem by maximizing the cumulative values of three types of tasks: the soft, the hard and the imprecise tasks. The simulation results show that the performance of our presented mechanism in this paper is greatly improved, much better than that of the other three mechanisms: earliest deadline first (EDF), highest value first (HVF) and highest density first (HDF), under the same conditions of all nominal loads and task type proportions.展开更多
The minimum aperiodic crosscorrelation of binary sequences of size M and length n over the alphabet E={1, -1} has been obtained by Levenshtein for M≥4 and n≥2 These bounds improve a long standing bound giv...The minimum aperiodic crosscorrelation of binary sequences of size M and length n over the alphabet E={1, -1} has been obtained by Levenshtein for M≥4 and n≥2 These bounds improve a long standing bound given by Welch. In this paper, the Sarwate bounds for codes over the p th roots of unity with the same parameters M and n are discussed, that is,the lower bounds and trade off are established for the maximum magnitude of the aperiodic crosscorrelation function and the maximum magnitude of the out of phase aperiodic autocorrelation function for the sets of periodic sequences with the same parameters M and n by using the modified Levenshtein method. The results show that new bounds are tighter than Sarwate bounds and Levenshtein bounds.展开更多
The structure aperiodicities can influence seriously the features of motion of soliton excited in the α-helix protein molecules with three channels. We study the influence of structure aperiodicities on the features ...The structure aperiodicities can influence seriously the features of motion of soliton excited in the α-helix protein molecules with three channels. We study the influence of structure aperiodicities on the features of the soliton in the improved model by numerical simulation and Runge-Kulta method. The results obtained show that the new soliton is very robust against the structure aperiodieities including large disorder in the sequence of mass of the amino acids and fluctuations of spring constant, coupling constant, dipole-dipole interactional constant, ground state energy and chain-chain interaction. However, very strong structure aperiodieities can also destroy the stability of the soliton in the α-helix protein molecules.展开更多
Multilayer interference mirrors play a pivotal role in spectroscopic diagnostic systems,which probe electron temperature and density during inertial confinement fusion processes.In this study,aperiodic Mo/B_(4)C multi...Multilayer interference mirrors play a pivotal role in spectroscopic diagnostic systems,which probe electron temperature and density during inertial confinement fusion processes.In this study,aperiodic Mo/B_(4)C multilayer mirrors of varied thick-nesses were investigated for X-ray plasma diagnostics at the 9.67-keV W-Lβline.The thickness distribution of the aperiodic multilayers was designed using the first Bragg diffraction condition and then optimized through a simplex algorithm to realize a narrow bandwidth and consistent spectral response.To enhance spectral accuracy,further refinements were undertaken by matching the grazing incidence X-ray reflectivity data with actual structural parameters.X-ray reflectivity measurements from the SSRF synchrotron radiation facility on the optimized sample showed a reflectivity of 29.7±2.6%,flat-band range of 1.3 keV,and bandwidth of 1.7 keV,making it suitable for high-temperature plasma diagnostics.The study explored the potential of predicting the 9.67 keV reflectivity spectrum using the fitting data from the grazing incidence X-ray reflectivity curves at 8.05 keV.Additionally,the short-term thermal stability of an aperiodic multilayer was assessed using temperature-dependent in situ X-ray measurements.Shifts in the reflectivity spectrum during annealing were attributed to interdiffusion and interfacial relaxation.The research team recommends the aperiodic Mo/B_(4)C multilayer mirror for operations below 300℃.展开更多
In this article we summarize some aperiodic checkpoint placement algorithms for a software system over infinite and finite operation time horizons, and compare them in terms of computational accuracy. The underlying p...In this article we summarize some aperiodic checkpoint placement algorithms for a software system over infinite and finite operation time horizons, and compare them in terms of computational accuracy. The underlying problem is formulated as the maximization of steady-state system availability and is to determine the optimal aperiodic checkpoint sequence. We present two exact computation algorithms in both forward and backward manners and two approximate ones;constant hazard approximation and fluid approximation, toward this end. In numerical examples with Weibull system failure time distribution, it is shown that the combined algorithm with the fluid approximation can calculate effectively the exact solutions on the optimal aperiodic checkpoint sequence.展开更多
The idea of network splitting according to time delay and weight is introduced.Based on the cyber physical systems(CPS),a class of multi-weighted complex transportation networks with multiple delays is modeled.The fin...The idea of network splitting according to time delay and weight is introduced.Based on the cyber physical systems(CPS),a class of multi-weighted complex transportation networks with multiple delays is modeled.The finite-time synchronization of the proposed complex transportation networks model is studied systematically.On the basis of the theory of stability,the technique of adaptive control,aperiodically intermittent control and finite-time control,the aperiodically intermittent adaptive finite-time synchronization controller is designed.The controller designed in this paper is beneficial for understanding the synchronization in multi-weighted complex transportation networks with multiple delays.In addition,the conditions for the existence of finite time synchronization have been discussed in detail.And the specific value of the settling finite time for synchronization is obtained.Moreover,the outer coupling configuration matrices are not required to be irreducible or symmetric.Finally,simulation results of the finite-time synchronization problem are given to illustrate the correctness of the results obtained.展开更多
This paper addresses the new algebraic test to check the aperiodic stability of two dimensional linear time invariant discrete systems. Initially, the two dimensional characteristics equations are converted into equiv...This paper addresses the new algebraic test to check the aperiodic stability of two dimensional linear time invariant discrete systems. Initially, the two dimensional characteristics equations are converted into equivalent one-dimensional equation. Further Fuller’s idea is applied on the equivalent one-dimensional characteristics equation. Then using the co-efficient of the characteristics equation, the routh table is formed to ascertain the aperiodic stability of the given two-dimensional linear discrete system. The illustrations were presented to show the applicability of the proposed technique.展开更多
In the previous work of garbage collection (GC) models, scheduling analysis was given based on an assumption that there were no aperiodic mutator tasks. However, it is not true in practical real-time systems. The GC...In the previous work of garbage collection (GC) models, scheduling analysis was given based on an assumption that there were no aperiodic mutator tasks. However, it is not true in practical real-time systems. The GC algorithm which can schedule aperiodic tasks is proposed, and the variance of live memory is analyzed. In this algorithm, active tasks are deferred to be processed by GC until the states of tasks become inactive, and the saved sporadic server time can be used to schedule aperiodic tasks. Scheduling the sample task sets demonstrates that this algorithm in this paper can schedule aperiodic tasks and decrease GC work. Thus, the GC algorithm proposed is more flexible and portable.展开更多
Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Cu...Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.展开更多
文摘By the use of cross-correlation measures, the response of a symmetric Schmitt trigger (ST) driven by a random binary signal and white Gaussian noise is investigated. The results show that the information transmission can be enhanced when a certain amount of noise is presented, i.e., aperiodic stochastic resonance (ASR). Then, the influence of signal amplitude and the ST threshold on ASR is examined, the applicability of the ST in reducing the noise level of random signal transmission and improving the quality of output signal via ASR effect is illustrated. This research is of great interest in the field of digital communications.
文摘The popularly used circulant matrix model of deconvolution is mostly heavily ill-posed or singular and it is not suitable to many blind deconvolution problems. The aperiodic matrix model can improve the condition number of deconvolution problems and its accommodation is much wider than the circulant one's. This paper discusses a comparison of the two models including their ill-posedness, the rationality of the approximation by the models, and their computational efficiency. The comparison shows that the aperiodic model is promising in the development of new restoration algorithms.
基金Project supported by the National Natural Science Foundation of China (Grant No 10332030) and the State Key Program for Basic Research of China (Grant No 5132103ZZT21B).
文摘Stochastic resonance (SR) is based on the cooperative effect between the stochastic dynamical system and the external forcing. As is well known, the cooperative effect is produced by adding noises. In this paper, we show the evidence that by changing the system parameters and the signal intensity, a nonlinear system in the presence of an input aperiodic signal can yield the cooperative effect, with the noise fixed. To quantify the nonlinear system output, we determine the theoretical bit error rate (BER). By numerical simulation, the validity of the theoretical derivation is checked. Besides, we show that parameter-induced SR is more realizable than SR via adding noises, especially when the noise intensity exceeds the resonance level, or when the characteristic of the noise is not known.
基金Chinese National Natural Science Foundation(No.51890881)Science and Technology Project of Hebei Education Department(Nos.ZD2020156,QN2018228).
文摘Because of descriptive nonlinearity and computational inefficiency,topology optimization with fatigue life under aperiodic loads has developed slowly.A fatigue constraint topology optimization method based on bidirectional evolutionary structural optimization(BESO)under an aperiodic load is proposed in this paper.In viewof the severe nonlinearity of fatigue damagewith respect to design variables,effective stress cycles are extracted through transient dynamic analysis.Based on the Miner cumulative damage theory and life requirements,a fatigue constraint is first quantified and then transformed into a stress problem.Then,a normalized termination criterion is proposed by approximatemaximum stress measured by global stress using a P-normaggregation function.Finally,optimization examples show that the proposed algorithm can not only meet the requirements of fatigue life but also obtain a reasonable configuration.
文摘This paper examines the stabilization problem of a distributed networked control system under the effect of cyberattacks by employing a hybrid aperiodic triggering mechanism.The cyber-attack considered in the paper is a stochastic deception attack at the sensor-controller end. The probability of the occurrence of attack on a subsystem is represented using a random variable. A decentralized hybrid sampled-data strategy is introduced to save energy consumption and reduce the transmission load of the network. In the proposed decentralized strategy, each subsystem can decide independently whether its state should be transmitted to the controller or not. The scheme of the hybrid triggering mechanism for each subsystem composed of two stages: In the first stage, the next sampling instant is computed using a self-triggering strategy. Subsequently, in the second stage, an event-triggering condition is checked at these sampling instants and the control signal is computed only if the event-triggering condition is violated. The self-triggering condition used in the first stage is dependent on the selection of eventtriggering condition of the second stage. Finally, a comparison of the proposed approach with other triggering mechanisms existing in the literature is presented in terms of the sampling instants,transmission frequency and performance measures through simulation examples.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11575087 and 11175087)
文摘We study the entanglement between the internal(coin)and the external(position)degrees of freedom in the dynamic and the static deterministic aperiodic quantum walks(QWs).For the dynamic(static)aperiodic QWs,the coin depends on the time(position)and takes two coins C(α)and C(β)arranged in the two classes of generalized Fibonacci(GF)and the Thue–Morse(TM)sequences.We found that for the dynamic QWs,the entanglement of three kinds of the aperiodic QWs are close to the maximal value,which are all much larger than that of the homogeneous QWs.Further,the first class of GF(1st GF)QWs can achieve the maximum entangled state,which is similar to that of the dynamic disordered QWs.And the entanglement of 1st GF QWs is greater than that of the TM QWs,being followed closely by the entanglement of the second class of GF(2nd GF)QWs.For the static QWs,the entanglement of three kinds of the aperiodic QWs are also close to the maximal value and 1st GF QWs can achieve the maximum entangled state.The entanglement of the TM QWs is between1st GF QWs and 2nd GF QWs.However,the entanglement of the static disordered QWs is less than that of three kinds of the aperiodic QWs.This is different from those of the dynamic QWs.From these results,we can conclude that the dynamic and static 1st GF QWs can also be considered as maximal entanglement generators.
基金supported by the Shanghai Applied Materials Foundation (Grant No.06SA18)
文摘In this paper, a novel scheduling mechanism is proposed to handle the real-time overload problem by maximizing the cumulative values of three types of tasks: the soft, the hard and the imprecise tasks. The simulation results show that the performance of our presented mechanism in this paper is greatly improved, much better than that of the other three mechanisms: earliest deadline first (EDF), highest value first (HVF) and highest density first (HDF), under the same conditions of all nominal loads and task type proportions.
文摘The minimum aperiodic crosscorrelation of binary sequences of size M and length n over the alphabet E={1, -1} has been obtained by Levenshtein for M≥4 and n≥2 These bounds improve a long standing bound given by Welch. In this paper, the Sarwate bounds for codes over the p th roots of unity with the same parameters M and n are discussed, that is,the lower bounds and trade off are established for the maximum magnitude of the aperiodic crosscorrelation function and the maximum magnitude of the out of phase aperiodic autocorrelation function for the sets of periodic sequences with the same parameters M and n by using the modified Levenshtein method. The results show that new bounds are tighter than Sarwate bounds and Levenshtein bounds.
基金supported by the National "973" Project of China under Grant No. 2007CB936103
文摘The structure aperiodicities can influence seriously the features of motion of soliton excited in the α-helix protein molecules with three channels. We study the influence of structure aperiodicities on the features of the soliton in the improved model by numerical simulation and Runge-Kulta method. The results obtained show that the new soliton is very robust against the structure aperiodieities including large disorder in the sequence of mass of the amino acids and fluctuations of spring constant, coupling constant, dipole-dipole interactional constant, ground state energy and chain-chain interaction. However, very strong structure aperiodieities can also destroy the stability of the soliton in the α-helix protein molecules.
基金This work was supported by the National Natural Science Foundation of China(NSFC)(Nos.11875204 and U1932167)Fundamental Research Funds for the Central Universities(Nos.22120210446 and 22120180070)the Presidential Foundation of China Academy of Engineering Physics(No.YZJJLX2019011).
文摘Multilayer interference mirrors play a pivotal role in spectroscopic diagnostic systems,which probe electron temperature and density during inertial confinement fusion processes.In this study,aperiodic Mo/B_(4)C multilayer mirrors of varied thick-nesses were investigated for X-ray plasma diagnostics at the 9.67-keV W-Lβline.The thickness distribution of the aperiodic multilayers was designed using the first Bragg diffraction condition and then optimized through a simplex algorithm to realize a narrow bandwidth and consistent spectral response.To enhance spectral accuracy,further refinements were undertaken by matching the grazing incidence X-ray reflectivity data with actual structural parameters.X-ray reflectivity measurements from the SSRF synchrotron radiation facility on the optimized sample showed a reflectivity of 29.7±2.6%,flat-band range of 1.3 keV,and bandwidth of 1.7 keV,making it suitable for high-temperature plasma diagnostics.The study explored the potential of predicting the 9.67 keV reflectivity spectrum using the fitting data from the grazing incidence X-ray reflectivity curves at 8.05 keV.Additionally,the short-term thermal stability of an aperiodic multilayer was assessed using temperature-dependent in situ X-ray measurements.Shifts in the reflectivity spectrum during annealing were attributed to interdiffusion and interfacial relaxation.The research team recommends the aperiodic Mo/B_(4)C multilayer mirror for operations below 300℃.
文摘In this article we summarize some aperiodic checkpoint placement algorithms for a software system over infinite and finite operation time horizons, and compare them in terms of computational accuracy. The underlying problem is formulated as the maximization of steady-state system availability and is to determine the optimal aperiodic checkpoint sequence. We present two exact computation algorithms in both forward and backward manners and two approximate ones;constant hazard approximation and fluid approximation, toward this end. In numerical examples with Weibull system failure time distribution, it is shown that the combined algorithm with the fluid approximation can calculate effectively the exact solutions on the optimal aperiodic checkpoint sequence.
基金Project supported by the National Natural Science Foundation of China(Grant No.61803275)Liaoning Provincial Department of Education Scientific Research Fund Project,China(Grant Nos.lnjc202018 and lnzd202007)+1 种基金Liaoning BaiQianWan Talents Program(Grant No.2017076)Liaoning Province Doctor Starting Foundation(Grant No.20170520283).
文摘The idea of network splitting according to time delay and weight is introduced.Based on the cyber physical systems(CPS),a class of multi-weighted complex transportation networks with multiple delays is modeled.The finite-time synchronization of the proposed complex transportation networks model is studied systematically.On the basis of the theory of stability,the technique of adaptive control,aperiodically intermittent control and finite-time control,the aperiodically intermittent adaptive finite-time synchronization controller is designed.The controller designed in this paper is beneficial for understanding the synchronization in multi-weighted complex transportation networks with multiple delays.In addition,the conditions for the existence of finite time synchronization have been discussed in detail.And the specific value of the settling finite time for synchronization is obtained.Moreover,the outer coupling configuration matrices are not required to be irreducible or symmetric.Finally,simulation results of the finite-time synchronization problem are given to illustrate the correctness of the results obtained.
文摘This paper addresses the new algebraic test to check the aperiodic stability of two dimensional linear time invariant discrete systems. Initially, the two dimensional characteristics equations are converted into equivalent one-dimensional equation. Further Fuller’s idea is applied on the equivalent one-dimensional characteristics equation. Then using the co-efficient of the characteristics equation, the routh table is formed to ascertain the aperiodic stability of the given two-dimensional linear discrete system. The illustrations were presented to show the applicability of the proposed technique.
基金supported by the 863 Program under Grant No2007AA01Z131
文摘In the previous work of garbage collection (GC) models, scheduling analysis was given based on an assumption that there were no aperiodic mutator tasks. However, it is not true in practical real-time systems. The GC algorithm which can schedule aperiodic tasks is proposed, and the variance of live memory is analyzed. In this algorithm, active tasks are deferred to be processed by GC until the states of tasks become inactive, and the saved sporadic server time can be used to schedule aperiodic tasks. Scheduling the sample task sets demonstrates that this algorithm in this paper can schedule aperiodic tasks and decrease GC work. Thus, the GC algorithm proposed is more flexible and portable.
基金supported by the National Natural Science Foundation of China,No.82071254(to WZ).
文摘Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.
基金supported by the National Natural Science Foundation of the People’s Republic of China“Dynamic characteristics and synchronization control of inertial neural network models based on non-reduced order method”(61866036),“Synchronization control and topology identification within fixed time and preassigned time of multilayer complex network”(62263029)。