In this paper,we introduce the censored composite conditional quantile coefficient(cC-CQC)to rank the relative importance of each predictor in high-dimensional censored regression.The cCCQC takes advantage of all usef...In this paper,we introduce the censored composite conditional quantile coefficient(cC-CQC)to rank the relative importance of each predictor in high-dimensional censored regression.The cCCQC takes advantage of all useful information across quantiles and can detect nonlinear effects including interactions and heterogeneity,effectively.Furthermore,the proposed screening method based on cCCQC is robust to the existence of outliers and enjoys the sure screening property.Simulation results demonstrate that the proposed method performs competitively on survival datasets of high-dimensional predictors,particularly when the variables are highly correlated.展开更多
We studied seedling survival and growth ofAquilaria malaccensis in three different environmental conditions (homegardens, green house and in different canopy conditions) of northeast India. Results show that mean se...We studied seedling survival and growth ofAquilaria malaccensis in three different environmental conditions (homegardens, green house and in different canopy conditions) of northeast India. Results show that mean seasonal survival was highest in green house (95.53%±2.33), followed by homegardens (89.3%±1.89) and different canopy conditions (77.62%±6.73); the highest values were found during February to April for both the homegardens (96%±1.68) and green house (98% ± 0.88) and lowest during November to January (78%±2.99) in homegardens and May to July (90%:t:4.53) in green house. In case of transplanted seedlings in different canopy conditions, mean seasonal survival was highest during May to July (98%±1.92) and lowest during August to October (66%±12.81). However, mean seasonal growth of collar diameter was highest in different canopy conditions (23.99%±1.76) compared to green house (21.52%±2.70) and homegardens (12.44%±1.33) and it was highest during rainy season (May to July) and lowest during dry winter (November to January) in all the three experi- mental sites. These variations may be due to the different microclimatic conditions as well as nutrient status of the soil in all the three experimen- tal sites. Although, seedling quality plays a great role in their survival and growth, based on the result of green house experiment, it can be concluded that maintenance of seedlings in green house conditions during their early growth period may improve both the survival and growth for large scale plantation of the species. Thus, the species can be reintroduced in its natural forest range to compensate the loss of natural population of this precious species in northeast India.展开更多
In this paper, an algebraic method which is based on the groebner bases theory is proposed to solve the polynomial functions conditional extreme. Firstly, we describe how to solve conditional extreme value problems by...In this paper, an algebraic method which is based on the groebner bases theory is proposed to solve the polynomial functions conditional extreme. Firstly, we describe how to solve conditional extreme value problems by establishing Lagrange functions and calculating the differential equations derived from the Lagrange functions. Then, by solving the single variable polynomials in the groebner basis, the solution of polynomial equations could be derived successively. We overcome the high number of variables and constraints in the extreme value problem. Finally, this paper illustrates the calculation process of this method through the general procedures and examples in solving questions of conditional extremum of polynomial function.展开更多
In this paper we generalize the aggregated premium income process from a constant rate process to a poisson process for the classical compound Poinsson risk model,then for the generalized model and the classical compo...In this paper we generalize the aggregated premium income process from a constant rate process to a poisson process for the classical compound Poinsson risk model,then for the generalized model and the classical compound poisson risk model ,we respectively get its survival probability in finite time period in case of exponential claim amounts.展开更多
Using data from the Surveillance, Epidemiology, and End Results (SEER) Program based at the National Cancer Institute in the US, conditional survival rates are reported for 1,988 Ewing Sarcoma patients diagnosed durin...Using data from the Surveillance, Epidemiology, and End Results (SEER) Program based at the National Cancer Institute in the US, conditional survival rates are reported for 1,988 Ewing Sarcoma patients diagnosed during the period 2000-2015. These patients represent the experience of 26.5% of the US population. Specifically, 5-year conditional relative survival rates are calculated for these patients for the first eight years subsequent to diagnosis of their cancer by Extent of Disease (EOD) (Localized, Regional, and Distant as coded by the SEER Program), gender, and age (<18, 18 - 34, and 35+). Findings include showing how the conditional survival rate patterns improve over time and that there are differences by gender, age, and EOD.展开更多
This paper studies the deterioration of bridge substructures utilizing the Long-Term Bridge Performance(LTBP)Program InfoBridge^(TM)and develops a survival model using Cox proportional hazards regression.The survival ...This paper studies the deterioration of bridge substructures utilizing the Long-Term Bridge Performance(LTBP)Program InfoBridge^(TM)and develops a survival model using Cox proportional hazards regression.The survival analysis is based on the National Bridge Inventory(NBI)dataset.The study calculates the survival rate of reinforced and prestressed concrete piles on bridges under marine conditions over a 29-year span(from 1992 to 2020).The state of Maryland is the primary focus of this study,with data from three neighboring regions,the District of Columbia,Virginia,and Delaware to expand the sample size.The data obtained from the National Bridge Inventory are condensed and filtered to acquire the most relevant information for model development.The Cox proportional hazards regression is applied to the condensed NBI data with six parameters:Age,ADT,ADTT,number of spans,span length,and structural length.Two survival models are generated for the bridge substructures:Reinforced and prestressed concrete piles in Maryland and reinforced and prestressed concrete piles in wet service conditions in the District of Columbia,Maryland,Delaware,and Virginia.Results from the Cox proportional hazards regression are used to construct Markov chains to demonstrate the sequence of the deterioration of bridge substructures.The Markov chains can be used as a tool to assist in the prediction and decision-making for repair,rehabilitation,and replacement of bridge piles.Based on the numerical model,the Pile Assessment Matrix Program(PAM)is developed to facilitate the assessment and maintenance of current bridge structures.The program integrates the NBI database with the inspection and research reports from various states’department of transportation,to serve as a tool for condition state simulation based on maintenance or rehabilitation strategies.展开更多
Continuously differentiable radial basis functions (C<sup>∞</sup>-RBFs), while being theoretically exponentially convergent are considered impractical computationally because the coefficient matrices are ...Continuously differentiable radial basis functions (C<sup>∞</sup>-RBFs), while being theoretically exponentially convergent are considered impractical computationally because the coefficient matrices are full and can become very ill- conditioned. Similarly, the Hilbert and Vandermonde have full matrices and become ill-conditioned. The difference between a coefficient matrix generated by C<sup>∞</sup>-RBFs for partial differential or integral equations and Hilbert and Vandermonde systems is that C<sup>∞</sup>-RBFs are very sensitive to small changes in the adjustable parameters. These parameters affect the condition number and solution accuracy. The error terrain has many local and global maxima and minima. To find stable and accurate numerical solutions for full linear equation systems, this study proposes a hybrid combination of block Gaussian elimination (BGE) combined with arbitrary precision arithmetic (APA) to minimize the accumulation of rounding errors. In the future, this algorithm can execute faster using preconditioners and implemented on massively parallel computers.展开更多
Background: Conditional survival(CS) has been established as a clinically relevant prognostic factor for cancer survivors, and the CS in gallbladder(GB) cancer has not yet been fully evaluated. In this study, we evalu...Background: Conditional survival(CS) has been established as a clinically relevant prognostic factor for cancer survivors, and the CS in gallbladder(GB) cancer has not yet been fully evaluated. In this study, we evaluated the cancerspecific CS rate and cancer-specific survival(CSS) rate in patients with GB cancer at multiple time points and investigated prognostic factors which affect cancer-specific CS rate to provide more accurate survival information.Methods: Between 2004 and 2013, a total of 9760 patients with GB cancer were identified from the Surveillance,Epidemiology, and End Results(SEER) data. The 3-year cancer-specific CS rate was calculated using the covariateadjusted survival function in the Cox model for each year since diagnosis, and the results were analyzed together with the adjusted CSS rates at the same time points. Cox proportional hazards regression was performed to ascertain the individual contribution of factors associated with CSS rate at diagnosis and cancer-specific CS rates at 1,3, and 5 years after diagnosis.Results: The adjusted 5-year CSS rate was 26.1 %. The adjusted 3-year cancer-specific CS rates at 1,2,3,4, and 5 years after diagnosis were 55.5,72.2,81.5,86.8, and 90.5%, respectively. At the time of diagnosis, age, race, histology, grade,T, N, and M categories, surgery, radiotherapy, insurance status, and marriage status were significant prognostic factors of CSS. Five years after diagnosis, however,T and M categories were significant prognostic factors for survivors(P = 0.007 and P = 0.009, respectively), whereas surgery and radiotherapy were not.Conclusions: T and M categories were significant prognostic factors even 5 years after the initial diagnosis, whereas local treatments at the time of diagnosis were not, suggesting that patients with GB cancer at high risks might need further adjuvant therapy after primary treatments. The combined analysis of CSS and cancer-specific CS rates offered more accurate survival information for patients who have already survived a certain period of time after diagnosis.展开更多
An engineering numerical model for three dimensional motion of multichain-buoy mooring system in shallow water and survival condition is given in this paper. Shooting-aim method is employed for solving the dynamic equ...An engineering numerical model for three dimensional motion of multichain-buoy mooring system in shallow water and survival condition is given in this paper. Shooting-aim method is employed for solving the dynamic equations of chain system in order to match the computation of buoy motion. The responses of buoy and chain have been computed for different wind-wave-current directions and different rigidity of chain. The results show that the present numerical model is reasonable.展开更多
Despite the widely accepted view that planted forests are valuable habitat for wildlife species,there is a lack of empirical evidence showing the suitability of this novel habitat,especially in relation to plantations...Despite the widely accepted view that planted forests are valuable habitat for wildlife species,there is a lack of empirical evidence showing the suitability of this novel habitat,especially in relation to plantations of exotic tree species.Furthermore,little is known about the effects of forest management on the ecology and dynamics of wild populations in the Neotropics.During the breeding season,the migrant flycatcher White-crested Elaenia is the most abundant bird species in forested landscapes in Chile.For several years we have studied different aspects of these artificial forests in the coastal range of south-central Chile as habitat for the species,particularly in contrast to the native forest.In general,our results indicate that plantation forests offer a poorer quality habitat,where the density of the species tends to be lower than in the native forest,although a significant edge effect suggests that its quality can be mitigated by planting as a matrix mosaic with native forest.Furthermore,compared to native forests,populations in plantations contained a higher proportion of younger adult individuals maintaining larger territories,and showing poorer body condition.We suggest that these differences could also have an impact on the birds'longevity and survival.展开更多
While clinical data have suggested that the diabetic heart is more susceptible to ischemic heart disease(IHD),animal data have so far pointed to a lower probability of IHD. Thus,the aim of this present review is to lo...While clinical data have suggested that the diabetic heart is more susceptible to ischemic heart disease(IHD),animal data have so far pointed to a lower probability of IHD. Thus,the aim of this present review is to look at these conflicting results and discuss the protective mechanisms that conditioned hyperglycemia may confer to the heart against ischemic injury. Several mechanisms have been proposed to explain the cardioprotective action of high glucose exposure,namely,upregulation of anti-apoptotic factor Bcl-2,inactivation of pro-apoptotic factor bad,and activation of pro-survival factors such as protein kinase B(Akt),vascular endothelial growth factor(VEGF),hypoxia inducible factor-1α and protein kinase C-ε. Indeed,cytosolic increase in Ca2+ concentration,the mitochondrial permeability transition pore,plays a key role in the genesis of ischemic injury. Previous studies have shown that the diabetic heart decreased Na+/Ca2+ and Na+/H+ exchanger activity and as such it accumulates less Ca2+ in cardiomyocyte,thus preventing cardiac injury and the associated heart dysfunctions. In addition,the expression of VEGFin diabetic animals leads to increased capillary density before myocardial infarction. Despite poor prognostic in the long-term,all these results suggest that diabetes mellitus and consequently hyperglycemia may indeed play a cardioprotective role against myocardial infarction in the short term.展开更多
BACKGROUND The prognosis of many patients with distant metastatic hepatocellular carcinoma(HCC)improved after they survived for several months.Compared with tradi-tional survival analysis,conditional survival(CS)which...BACKGROUND The prognosis of many patients with distant metastatic hepatocellular carcinoma(HCC)improved after they survived for several months.Compared with tradi-tional survival analysis,conditional survival(CS)which takes into account changes in survival risk could be used to describe dynamic survival probabilities.AIM To evaluate CS of distant metastatic HCC patients.METHODS Patients diagnosed with distant metastatic HCC between 2010 and 2015 were extracted from the Surveillance,Epidemiology and End Results database.Univariate and multivariate Cox regression analysis were used to identify factors for overall survival(OS),while competing risk model was used to identify risk factors for cancer-specific survival(CSS).Six-month CS was used to calculate the probability of survival for an additional 6 mo at a specific time after initial diagnosis,and standardized difference(d)was used to evaluate the survival differences between subgroups.Nomograms were constructed to predict CS.Positiveα-fetoprotein expression,higher T stage(T3 and T4),N1 stage,non-primary site surgery,non-chemotherapy,non-radiotherapy,and lung metastasis were independent risk factors for actual OS and CSS through univariate and multivariate analysis.Actual survival rates decreased over time,while CS rates gradually increased.As for the 6-month CS,the survival difference caused by chemotherapy and radiotherapy gradually disappeared over time,and the survival difference caused by lung metastasis reversed.Moreover,the influence of age and gender on survival gradually appeared.Nomograms were fitted for patients who have lived for 2,4 and 6 mo to predict 6-month conditional OS and CSS,respectively.The area under the curve(AUC)of nomograms for conditional OS decreased as time passed,and the AUC for conditional CSS gradually increased.CONCLUSION CS for distant metastatic HCC patients substantially increased over time.With dynamic risk factors,nomograms constructed at a specific time could predict more accurate survival rates.展开更多
A supported framework of a gyroscope's rotor is designed and the B-Spline wavelet finite element model of nonlinear supported magnetic field is worked out. A new finite element space is studied in which the scaling f...A supported framework of a gyroscope's rotor is designed and the B-Spline wavelet finite element model of nonlinear supported magnetic field is worked out. A new finite element space is studied in which the scaling function of the B-spline wavelet is considered as the shape function of a tetrahedton. The magnetic field is spited by an artificial absorbing body which used the condition of field radiating, so the solution is unique. The resolution is improved via the varying gradient of the B-spline function under the condition of unchanging gridding. So there are some advantages in dealing with the focus flux and a high varying gradient result from a nonlinear magnetic field. The result is more practical. Plots of flux and in the space is studied via simulating the supported system model. The results of the study are useful in the research of the supported magnetic system for the gyroscope rotor.展开更多
Purpose:This study aimed to examine the effect of radiation esophagitis(RE)and the dynamics of RE on subse-quent survival in non-small cell lung cancer(NSCLC)patients who underwent radiotherapy.Experimental Design:Pat...Purpose:This study aimed to examine the effect of radiation esophagitis(RE)and the dynamics of RE on subse-quent survival in non-small cell lung cancer(NSCLC)patients who underwent radiotherapy.Experimental Design:Patients with NSCLC treated with fractionated thoracic radiotherapy enrolled in prospective trials were eligible.RE was graded prospectively according to Common Terminology Criteria for Adverse Events(CTCAE)v3.0 per protocol requirement weekly during-RT and 1 month after RT.This study applied conditional survival assessment which has advantage over traditional survival analysis as it assesses the survival from the event instead of from the baseline.P-value less than 0.05 was considered to be significant.The primary endpoint is overall survival.Results:A total of 177 patients were eligible,with a median follow-up of 5 years.The presence of RE,the maximum RE grade,the evolution of RE and the onset timing of RE events were all correlated with subsequent survival.At all conditional time points,patients first presented with RE grade1(initial RE1)had significant inferior subsequent survival(multivariable HRs median:1.63,all P-values<0.05);meanwhile those with RE progressed had significant inferior subsequent survival than those never develop RE(multivariable HRs median:2.08,all P-values<0.05).Multivariable Cox proportional-hazards analysis showed significantly higher C-indexes for models with inclusion of RE events than those without(all P-values<0.05).Conclusion:This study comprehensively evaluated the impact of RE with conditional survival assessment and demonstrated that RE is associated with inferior survival in NSCLC patients treated with RT.展开更多
Suppose M and N are two r×r and s×s dilation matrices,respectively.LetΓM andΓN represent the complete sets of representatives of distinct cosets of the quotient groups M-T Zr/Zr and N-T Zs/Zs,respectively....Suppose M and N are two r×r and s×s dilation matrices,respectively.LetΓM andΓN represent the complete sets of representatives of distinct cosets of the quotient groups M-T Zr/Zr and N-T Zs/Zs,respectively.Two methods for constructing nonseparable Ω-filter banks from M-filter banks and N-filter banks are presented,where Ω is a(r+s) ×(r+s) dilation matrix such that one of its complete sets of representatives of distinct cosets of the quotient groups Ω-T Zr+s/Zr+s areΓΩ={[γT h,ζ T q] T:γh∈ΓM,ζq∈ΓN}.Specially,Ω can be [MΘ0N],whereΘis a r×s integer matrix with M-1Θbeing also an integer matrix.Moreover,if the constructed filter bank satisfies Lawton's condition,which can be easy to verify,then it generates an orthonormal nonseparable Ω-wavelet basis for L2(Rr+s).Properties,including Lawton's condition,vanishing moments and regularity of the new Ω-filter banks or new Ω-wavelet basis are discussed then.Finally,a class of nonseparable Ω-wavelet basis for L2(Rr+1) are constructed and three other examples are given to illustrate the results.In particular,when M=N=2,all results obtained in this paper appeared in[1].展开更多
基金Outstanding Youth Foundation of Hunan Provincial Department of Education(Grant No.22B0911)。
文摘In this paper,we introduce the censored composite conditional quantile coefficient(cC-CQC)to rank the relative importance of each predictor in high-dimensional censored regression.The cCCQC takes advantage of all useful information across quantiles and can detect nonlinear effects including interactions and heterogeneity,effectively.Furthermore,the proposed screening method based on cCCQC is robust to the existence of outliers and enjoys the sure screening property.Simulation results demonstrate that the proposed method performs competitively on survival datasets of high-dimensional predictors,particularly when the variables are highly correlated.
基金supported by DBT,Govt. of India through the project "Mapping and quantitative assessment of geographic distribution and population status of plant resources of Eastern Himalayan Region"
文摘We studied seedling survival and growth ofAquilaria malaccensis in three different environmental conditions (homegardens, green house and in different canopy conditions) of northeast India. Results show that mean seasonal survival was highest in green house (95.53%±2.33), followed by homegardens (89.3%±1.89) and different canopy conditions (77.62%±6.73); the highest values were found during February to April for both the homegardens (96%±1.68) and green house (98% ± 0.88) and lowest during November to January (78%±2.99) in homegardens and May to July (90%:t:4.53) in green house. In case of transplanted seedlings in different canopy conditions, mean seasonal survival was highest during May to July (98%±1.92) and lowest during August to October (66%±12.81). However, mean seasonal growth of collar diameter was highest in different canopy conditions (23.99%±1.76) compared to green house (21.52%±2.70) and homegardens (12.44%±1.33) and it was highest during rainy season (May to July) and lowest during dry winter (November to January) in all the three experi- mental sites. These variations may be due to the different microclimatic conditions as well as nutrient status of the soil in all the three experimen- tal sites. Although, seedling quality plays a great role in their survival and growth, based on the result of green house experiment, it can be concluded that maintenance of seedlings in green house conditions during their early growth period may improve both the survival and growth for large scale plantation of the species. Thus, the species can be reintroduced in its natural forest range to compensate the loss of natural population of this precious species in northeast India.
文摘In this paper, an algebraic method which is based on the groebner bases theory is proposed to solve the polynomial functions conditional extreme. Firstly, we describe how to solve conditional extreme value problems by establishing Lagrange functions and calculating the differential equations derived from the Lagrange functions. Then, by solving the single variable polynomials in the groebner basis, the solution of polynomial equations could be derived successively. We overcome the high number of variables and constraints in the extreme value problem. Finally, this paper illustrates the calculation process of this method through the general procedures and examples in solving questions of conditional extremum of polynomial function.
基金Supported by the Natural Science Foundation of China(10071019)
文摘In this paper we generalize the aggregated premium income process from a constant rate process to a poisson process for the classical compound Poinsson risk model,then for the generalized model and the classical compound poisson risk model ,we respectively get its survival probability in finite time period in case of exponential claim amounts.
文摘Using data from the Surveillance, Epidemiology, and End Results (SEER) Program based at the National Cancer Institute in the US, conditional survival rates are reported for 1,988 Ewing Sarcoma patients diagnosed during the period 2000-2015. These patients represent the experience of 26.5% of the US population. Specifically, 5-year conditional relative survival rates are calculated for these patients for the first eight years subsequent to diagnosis of their cancer by Extent of Disease (EOD) (Localized, Regional, and Distant as coded by the SEER Program), gender, and age (<18, 18 - 34, and 35+). Findings include showing how the conditional survival rate patterns improve over time and that there are differences by gender, age, and EOD.
基金This research receives funding from the Maryland Department of Transportation State Highway Administration.
文摘This paper studies the deterioration of bridge substructures utilizing the Long-Term Bridge Performance(LTBP)Program InfoBridge^(TM)and develops a survival model using Cox proportional hazards regression.The survival analysis is based on the National Bridge Inventory(NBI)dataset.The study calculates the survival rate of reinforced and prestressed concrete piles on bridges under marine conditions over a 29-year span(from 1992 to 2020).The state of Maryland is the primary focus of this study,with data from three neighboring regions,the District of Columbia,Virginia,and Delaware to expand the sample size.The data obtained from the National Bridge Inventory are condensed and filtered to acquire the most relevant information for model development.The Cox proportional hazards regression is applied to the condensed NBI data with six parameters:Age,ADT,ADTT,number of spans,span length,and structural length.Two survival models are generated for the bridge substructures:Reinforced and prestressed concrete piles in Maryland and reinforced and prestressed concrete piles in wet service conditions in the District of Columbia,Maryland,Delaware,and Virginia.Results from the Cox proportional hazards regression are used to construct Markov chains to demonstrate the sequence of the deterioration of bridge substructures.The Markov chains can be used as a tool to assist in the prediction and decision-making for repair,rehabilitation,and replacement of bridge piles.Based on the numerical model,the Pile Assessment Matrix Program(PAM)is developed to facilitate the assessment and maintenance of current bridge structures.The program integrates the NBI database with the inspection and research reports from various states’department of transportation,to serve as a tool for condition state simulation based on maintenance or rehabilitation strategies.
文摘Continuously differentiable radial basis functions (C<sup>∞</sup>-RBFs), while being theoretically exponentially convergent are considered impractical computationally because the coefficient matrices are full and can become very ill- conditioned. Similarly, the Hilbert and Vandermonde have full matrices and become ill-conditioned. The difference between a coefficient matrix generated by C<sup>∞</sup>-RBFs for partial differential or integral equations and Hilbert and Vandermonde systems is that C<sup>∞</sup>-RBFs are very sensitive to small changes in the adjustable parameters. These parameters affect the condition number and solution accuracy. The error terrain has many local and global maxima and minima. To find stable and accurate numerical solutions for full linear equation systems, this study proposes a hybrid combination of block Gaussian elimination (BGE) combined with arbitrary precision arithmetic (APA) to minimize the accumulation of rounding errors. In the future, this algorithm can execute faster using preconditioners and implemented on massively parallel computers.
文摘Background: Conditional survival(CS) has been established as a clinically relevant prognostic factor for cancer survivors, and the CS in gallbladder(GB) cancer has not yet been fully evaluated. In this study, we evaluated the cancerspecific CS rate and cancer-specific survival(CSS) rate in patients with GB cancer at multiple time points and investigated prognostic factors which affect cancer-specific CS rate to provide more accurate survival information.Methods: Between 2004 and 2013, a total of 9760 patients with GB cancer were identified from the Surveillance,Epidemiology, and End Results(SEER) data. The 3-year cancer-specific CS rate was calculated using the covariateadjusted survival function in the Cox model for each year since diagnosis, and the results were analyzed together with the adjusted CSS rates at the same time points. Cox proportional hazards regression was performed to ascertain the individual contribution of factors associated with CSS rate at diagnosis and cancer-specific CS rates at 1,3, and 5 years after diagnosis.Results: The adjusted 5-year CSS rate was 26.1 %. The adjusted 3-year cancer-specific CS rates at 1,2,3,4, and 5 years after diagnosis were 55.5,72.2,81.5,86.8, and 90.5%, respectively. At the time of diagnosis, age, race, histology, grade,T, N, and M categories, surgery, radiotherapy, insurance status, and marriage status were significant prognostic factors of CSS. Five years after diagnosis, however,T and M categories were significant prognostic factors for survivors(P = 0.007 and P = 0.009, respectively), whereas surgery and radiotherapy were not.Conclusions: T and M categories were significant prognostic factors even 5 years after the initial diagnosis, whereas local treatments at the time of diagnosis were not, suggesting that patients with GB cancer at high risks might need further adjuvant therapy after primary treatments. The combined analysis of CSS and cancer-specific CS rates offered more accurate survival information for patients who have already survived a certain period of time after diagnosis.
基金This work was financially supported by the National Natural Science Foundation of China
文摘An engineering numerical model for three dimensional motion of multichain-buoy mooring system in shallow water and survival condition is given in this paper. Shooting-aim method is employed for solving the dynamic equations of chain system in order to match the computation of buoy motion. The responses of buoy and chain have been computed for different wind-wave-current directions and different rigidity of chain. The results show that the present numerical model is reasonable.
基金Comisión Nacional de Investigación Científica y Tecnológica CONICYT,Gobierno de Chile,for funding his graduate studiesFondo Nacional de Desarrollo Científico y Tecnológico FONDECYT,Gobierno de Chile,supported this research through the proyect Id:1120314。
文摘Despite the widely accepted view that planted forests are valuable habitat for wildlife species,there is a lack of empirical evidence showing the suitability of this novel habitat,especially in relation to plantations of exotic tree species.Furthermore,little is known about the effects of forest management on the ecology and dynamics of wild populations in the Neotropics.During the breeding season,the migrant flycatcher White-crested Elaenia is the most abundant bird species in forested landscapes in Chile.For several years we have studied different aspects of these artificial forests in the coastal range of south-central Chile as habitat for the species,particularly in contrast to the native forest.In general,our results indicate that plantation forests offer a poorer quality habitat,where the density of the species tends to be lower than in the native forest,although a significant edge effect suggests that its quality can be mitigated by planting as a matrix mosaic with native forest.Furthermore,compared to native forests,populations in plantations contained a higher proportion of younger adult individuals maintaining larger territories,and showing poorer body condition.We suggest that these differences could also have an impact on the birds'longevity and survival.
文摘While clinical data have suggested that the diabetic heart is more susceptible to ischemic heart disease(IHD),animal data have so far pointed to a lower probability of IHD. Thus,the aim of this present review is to look at these conflicting results and discuss the protective mechanisms that conditioned hyperglycemia may confer to the heart against ischemic injury. Several mechanisms have been proposed to explain the cardioprotective action of high glucose exposure,namely,upregulation of anti-apoptotic factor Bcl-2,inactivation of pro-apoptotic factor bad,and activation of pro-survival factors such as protein kinase B(Akt),vascular endothelial growth factor(VEGF),hypoxia inducible factor-1α and protein kinase C-ε. Indeed,cytosolic increase in Ca2+ concentration,the mitochondrial permeability transition pore,plays a key role in the genesis of ischemic injury. Previous studies have shown that the diabetic heart decreased Na+/Ca2+ and Na+/H+ exchanger activity and as such it accumulates less Ca2+ in cardiomyocyte,thus preventing cardiac injury and the associated heart dysfunctions. In addition,the expression of VEGFin diabetic animals leads to increased capillary density before myocardial infarction. Despite poor prognostic in the long-term,all these results suggest that diabetes mellitus and consequently hyperglycemia may indeed play a cardioprotective role against myocardial infarction in the short term.
文摘BACKGROUND The prognosis of many patients with distant metastatic hepatocellular carcinoma(HCC)improved after they survived for several months.Compared with tradi-tional survival analysis,conditional survival(CS)which takes into account changes in survival risk could be used to describe dynamic survival probabilities.AIM To evaluate CS of distant metastatic HCC patients.METHODS Patients diagnosed with distant metastatic HCC between 2010 and 2015 were extracted from the Surveillance,Epidemiology and End Results database.Univariate and multivariate Cox regression analysis were used to identify factors for overall survival(OS),while competing risk model was used to identify risk factors for cancer-specific survival(CSS).Six-month CS was used to calculate the probability of survival for an additional 6 mo at a specific time after initial diagnosis,and standardized difference(d)was used to evaluate the survival differences between subgroups.Nomograms were constructed to predict CS.Positiveα-fetoprotein expression,higher T stage(T3 and T4),N1 stage,non-primary site surgery,non-chemotherapy,non-radiotherapy,and lung metastasis were independent risk factors for actual OS and CSS through univariate and multivariate analysis.Actual survival rates decreased over time,while CS rates gradually increased.As for the 6-month CS,the survival difference caused by chemotherapy and radiotherapy gradually disappeared over time,and the survival difference caused by lung metastasis reversed.Moreover,the influence of age and gender on survival gradually appeared.Nomograms were fitted for patients who have lived for 2,4 and 6 mo to predict 6-month conditional OS and CSS,respectively.The area under the curve(AUC)of nomograms for conditional OS decreased as time passed,and the AUC for conditional CSS gradually increased.CONCLUSION CS for distant metastatic HCC patients substantially increased over time.With dynamic risk factors,nomograms constructed at a specific time could predict more accurate survival rates.
文摘A supported framework of a gyroscope's rotor is designed and the B-Spline wavelet finite element model of nonlinear supported magnetic field is worked out. A new finite element space is studied in which the scaling function of the B-spline wavelet is considered as the shape function of a tetrahedton. The magnetic field is spited by an artificial absorbing body which used the condition of field radiating, so the solution is unique. The resolution is improved via the varying gradient of the B-spline function under the condition of unchanging gridding. So there are some advantages in dealing with the focus flux and a high varying gradient result from a nonlinear magnetic field. The result is more practical. Plots of flux and in the space is studied via simulating the supported system model. The results of the study are useful in the research of the supported magnetic system for the gyroscope rotor.
基金supported by Shenzhen Fundamental Research Program(JCYJ2020109150427184)Shenzhen Science and Technology Program(KQTD20180411185028798)Shenzhen Fun-damental Research Program(JCYJ20180508153249223).
文摘Purpose:This study aimed to examine the effect of radiation esophagitis(RE)and the dynamics of RE on subse-quent survival in non-small cell lung cancer(NSCLC)patients who underwent radiotherapy.Experimental Design:Patients with NSCLC treated with fractionated thoracic radiotherapy enrolled in prospective trials were eligible.RE was graded prospectively according to Common Terminology Criteria for Adverse Events(CTCAE)v3.0 per protocol requirement weekly during-RT and 1 month after RT.This study applied conditional survival assessment which has advantage over traditional survival analysis as it assesses the survival from the event instead of from the baseline.P-value less than 0.05 was considered to be significant.The primary endpoint is overall survival.Results:A total of 177 patients were eligible,with a median follow-up of 5 years.The presence of RE,the maximum RE grade,the evolution of RE and the onset timing of RE events were all correlated with subsequent survival.At all conditional time points,patients first presented with RE grade1(initial RE1)had significant inferior subsequent survival(multivariable HRs median:1.63,all P-values<0.05);meanwhile those with RE progressed had significant inferior subsequent survival than those never develop RE(multivariable HRs median:2.08,all P-values<0.05).Multivariable Cox proportional-hazards analysis showed significantly higher C-indexes for models with inclusion of RE events than those without(all P-values<0.05).Conclusion:This study comprehensively evaluated the impact of RE with conditional survival assessment and demonstrated that RE is associated with inferior survival in NSCLC patients treated with RT.
基金Supported by the National Natural Science Foundation of China(11071152)the Natural Science Foundation of Guangdong Province(10151503101000025)
文摘Suppose M and N are two r×r and s×s dilation matrices,respectively.LetΓM andΓN represent the complete sets of representatives of distinct cosets of the quotient groups M-T Zr/Zr and N-T Zs/Zs,respectively.Two methods for constructing nonseparable Ω-filter banks from M-filter banks and N-filter banks are presented,where Ω is a(r+s) ×(r+s) dilation matrix such that one of its complete sets of representatives of distinct cosets of the quotient groups Ω-T Zr+s/Zr+s areΓΩ={[γT h,ζ T q] T:γh∈ΓM,ζq∈ΓN}.Specially,Ω can be [MΘ0N],whereΘis a r×s integer matrix with M-1Θbeing also an integer matrix.Moreover,if the constructed filter bank satisfies Lawton's condition,which can be easy to verify,then it generates an orthonormal nonseparable Ω-wavelet basis for L2(Rr+s).Properties,including Lawton's condition,vanishing moments and regularity of the new Ω-filter banks or new Ω-wavelet basis are discussed then.Finally,a class of nonseparable Ω-wavelet basis for L2(Rr+1) are constructed and three other examples are given to illustrate the results.In particular,when M=N=2,all results obtained in this paper appeared in[1].