China is currently vigorously implementing the“energy conservation and emission reduction”and“dual carbon”strategies.As the most resource-advantaged light metal material in China,Magnesium(Mg)alloy is progressivel...China is currently vigorously implementing the“energy conservation and emission reduction”and“dual carbon”strategies.As the most resource-advantaged light metal material in China,Magnesium(Mg)alloy is progressively expanding its application in automobile,rail transportation,aerospace,medical,and electronic products.Chongqing University,Shanghai Jiaotong University,and Australian National University have conducted extensive research on the preparation,properties,and processes of Mg alloys.In the past 20 years,the proportion of Mg alloy in the automotive industry has gradually expanded,whereas currently the design and development of Mg alloy parts for automobiles has rarely been reported.Thus,the application models and typical parts cases of Mg alloy are summarized mainly from the four systems of the whole vehicle(body system,chassis system,powertrain system,interior,and exterior system).Subsequently,two actual original equipment manufacturers(OEM)cases are used to introduce the development logic of reliable die-cast Mg alloy,including forward design,formability analysis,process design analysis,structural redesign,manufacturing,and testing,aiming to share the methods,processes,and focus of attention of automotive OEMs for developing Mg alloy parts to enhance the confidence and motivation of applying Mg alloy in automotive field.Eventually,the multiple challenges faced by Mg alloy materials are sorted out and how to face these challenges are discussed.National policies and regulations,environmental protection and energy saving,and consumer demand will continue to promote the application of Mg.展开更多
Traditional Chinese Medicine (TCM) is the medical science based on theories and practicing experience of traditional Chinese medicine to study transferring principles of health and sickness,as well as prevention, diag...Traditional Chinese Medicine (TCM) is the medical science based on theories and practicing experience of traditional Chinese medicine to study transferring principles of health and sickness,as well as prevention, diagnosis,treatment,rehabilitation and healthcare.TCM is marked with its long history of development,integrated theory system and abundant practicing experience.展开更多
The underground brine resource along the coast of Laizhou Bay is the world’s rare shallow underground brine resource,which occurs in the Laizhou city in the east,and extends to the coastal area of the Binzhou city in
More than 40 medical history and classical medical literature on the nomenclature of Bi syndrome were systematically arranged,induced and analyzed,the prescriptions named after the medicine include RHIZOMA ET RADIX NO...More than 40 medical history and classical medical literature on the nomenclature of Bi syndrome were systematically arranged,induced and analyzed,the prescriptions named after the medicine include RHIZOMA ET RADIX NOTOPTERYGII,os tigris,RADIX ASTRAGALI,RADIX SAPOSHNIKOVIAE,Prepared common monkshood daughter root,doubleteeth pubescent angelica root,RADIX ANGELICAE SINENSIS,frankincense,RADIX STEPHANIAE TETRANDRAE,RADIX ACHYRANTHIS BIDENTATAE,myrrh,RADIX ACONITI、RADIX DIPSACI,RHIZOMA GASTRODIAE,ginseng root,HERBA DENDROBII,CORNU SAIGAE TATARICAE,RADIX MORINDAE OFFICINALIS,PORIA,SEMEN COICIS,poison yam,and so on.It basically reflected the ancient and modern treatment of Bi syndrome in traditional Chinese medicine named after the formula.展开更多
The developmental origins of health and diseases(DOHaD)is a concept stating that adverse intrauterine environments contribute to the health risks of offspring.Since the theory emerged more than 30 years ago,many epide...The developmental origins of health and diseases(DOHaD)is a concept stating that adverse intrauterine environments contribute to the health risks of offspring.Since the theory emerged more than 30 years ago,many epidemiological and animal studies have confirmed that in utero exposure to environmental insults,including hyperglycemia and chemicals,increased the risk of developing noncommunicable diseases(NCDs).These NCDs include metabolic syndrome,type 2 diabetes,and complications such as diabetic cardiomyopathy.Studying the effects of different environmental insults on early embryo development would aid in understanding the underlying mechanisms by which these insults promote NCD development.Embryonic stem cells(ESCs)have also been utilized by researchers to study the DOHaD.ESCs have pluripotent characteristics and can be differentiated into almost every cell lineage;therefore,they are excellent in vitro models for studying early developmental events.More importantly,human ESCs(hESCs)are the best alternative to human embryos for research because of ethical concerns.In this review,we will discuss different maternal conditions associated with DOHaD,focusing on the complications of maternal diabetes.Next,we will review the differentiation protocols developed to generate different cell lineages from hESCs.Additionally,we will review how hESCs are utilized as a model for research into the DOHaD.The effects of environmental insults on hESC differentiation and the possible involvement of epigenetic regulation will be discussed.展开更多
Since the rise of the economic and financial development theory, around economic and financial development of the determinants and what financial arrangements for promoting economic growth and other issues, thus resul...Since the rise of the economic and financial development theory, around economic and financial development of the determinants and what financial arrangements for promoting economic growth and other issues, thus resulted in a variety of important theoretical debate. This paper will Define what is meant by key terms such as legal tradition and endowment, explain the channels through which legal tradition and endowment affect financial development through talking about the relationship between legal origin, initial in endowment and financial development. By comparing different legal traditions or the"Origins"between the The Continental Law System and Common Law System, a comprehensive analysis of the effects of different origin of law on the financial and economic development.展开更多
I.The History of the Drafting of the Universal Declaration of Human Rights:the Position and Role of the UN Economic and Social Council and the General Assembly of the United Nations should not be Ignored The reason fo...I.The History of the Drafting of the Universal Declaration of Human Rights:the Position and Role of the UN Economic and Social Council and the General Assembly of the United Nations should not be Ignored The reason for me to use the term "source"in the discussion on the right to subsistence展开更多
Based on the theory of structural analysis,the characteristics and structural patterns of subtle faults are studied using 3D seismic data of the Bohai Sea to analyze the development process and origin of the subtle fa...Based on the theory of structural analysis,the characteristics and structural patterns of subtle faults are studied using 3D seismic data of the Bohai Sea to analyze the development process and origin of the subtle faults.A method of identifying subtle faults is proposed,forming a complete system for analyzing origins of subtle faults in the Bohai Sea.The complex strike-slip fault patterns under the strike-slip and extension stress background,diverse formation rocks,and strong neotectonic movement are the reasons for the development of subtle faults.According to the tectonic origin and development location,the subtle faults in Bohai Sea can be divided into 12 types in the three categories of strike slip dominant,extension dominant and strike slip and extension composite,and the different types of subtle faults occur in different regions of the Bohai Sea.Unreasonable variation of sedimentary stratum thickness,inherited distortion or even abrupt change of stratum occurrence,zonation of plane fault combination and the variation of oil-water system in the same structure with no-lithologic change are the important signs for identifying subtle faults in Bohai Sea.The subtle faults greatly enlarge the size of the structural trap groups,and areas with dense subtle faults are often active area of hydrocarbon migration and accumulation and favorable exploration zones,which have strong control on the hydrocarbon accumulation.The identification method for subtle faults has guided the exploration in the mature areas of Bohai Sea effectively,with a number of large and medium oil and gas fields discovered,such as Bozhong 29-6 and Penglai 20-2.展开更多
Since the 18th National Congress of the Communist Party of China,the Party Central Committee with President Xi Jinping has put forward a new development concept of innovation,coordination,green,openness,and sharing ba...Since the 18th National Congress of the Communist Party of China,the Party Central Committee with President Xi Jinping has put forward a new development concept of innovation,coordination,green,openness,and sharing based on profound insight into the basic characteristics of the new development stage.The party scientific grasps the essential requirements and development direction of socialism with Chinese characteristics,and continuously deepens understanding of the laws of economic and social development.Starting from three aspects of the times background,theoretical origin,and scientific connotation,the party aims to deeply understand the specific content and profound implication of the shared development concept in the new era.展开更多
The number of people who are sickened by alcohol is rising every year in China,and Traditional Chinese Medicine(TCM)has a long history and remarkable therapeutic effect on the treatment of"Alcohol Injury"dis...The number of people who are sickened by alcohol is rising every year in China,and Traditional Chinese Medicine(TCM)has a long history and remarkable therapeutic effect on the treatment of"Alcohol Injury"diseases.Therefore,it is of great practical significance to study the theory of"Alcohol Injury".This paper expounds the historical origin,treatment prescription and related diseases of the theory of"Alcohol Injury".展开更多
Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of FUO.Methods:A multi-center study for infectious causes of FUO...Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of FUO.Methods:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,2023.In total,15 participating centers from seven different countries provided the data,which were collected through the Infectious DiseasesInternational Research Initiative platform.Only adult patients with confirmed infection as the cause of FUO were included in the study.The severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the study.Overall,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired infections.The most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for diagnosis.The mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not rare.Overall,38(23.8%)patients had at least one of the severity parameters.The mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)patients.Conclusions:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.展开更多
基金supported partly by the Fundamental Research Funds for Central Universities(No.06500203 and No.00007735).
文摘China is currently vigorously implementing the“energy conservation and emission reduction”and“dual carbon”strategies.As the most resource-advantaged light metal material in China,Magnesium(Mg)alloy is progressively expanding its application in automobile,rail transportation,aerospace,medical,and electronic products.Chongqing University,Shanghai Jiaotong University,and Australian National University have conducted extensive research on the preparation,properties,and processes of Mg alloys.In the past 20 years,the proportion of Mg alloy in the automotive industry has gradually expanded,whereas currently the design and development of Mg alloy parts for automobiles has rarely been reported.Thus,the application models and typical parts cases of Mg alloy are summarized mainly from the four systems of the whole vehicle(body system,chassis system,powertrain system,interior,and exterior system).Subsequently,two actual original equipment manufacturers(OEM)cases are used to introduce the development logic of reliable die-cast Mg alloy,including forward design,formability analysis,process design analysis,structural redesign,manufacturing,and testing,aiming to share the methods,processes,and focus of attention of automotive OEMs for developing Mg alloy parts to enhance the confidence and motivation of applying Mg alloy in automotive field.Eventually,the multiple challenges faced by Mg alloy materials are sorted out and how to face these challenges are discussed.National policies and regulations,environmental protection and energy saving,and consumer demand will continue to promote the application of Mg.
文摘Traditional Chinese Medicine (TCM) is the medical science based on theories and practicing experience of traditional Chinese medicine to study transferring principles of health and sickness,as well as prevention, diagnosis,treatment,rehabilitation and healthcare.TCM is marked with its long history of development,integrated theory system and abundant practicing experience.
文摘The underground brine resource along the coast of Laizhou Bay is the world’s rare shallow underground brine resource,which occurs in the Laizhou city in the east,and extends to the coastal area of the Binzhou city in
基金Supported by"Project of Strengthening Health through Science and Education"of Wuxi Health Commission:The Effect of Huli Powder on Anti-inflammation and Bone Metabolism of Hand Osteoarthritis(2016,No.ZDRCPY013)Study on the Key Technology of"Yiqi Tongluo"Therapy of Wumen for Osteoarthritis(SS201876).
文摘More than 40 medical history and classical medical literature on the nomenclature of Bi syndrome were systematically arranged,induced and analyzed,the prescriptions named after the medicine include RHIZOMA ET RADIX NOTOPTERYGII,os tigris,RADIX ASTRAGALI,RADIX SAPOSHNIKOVIAE,Prepared common monkshood daughter root,doubleteeth pubescent angelica root,RADIX ANGELICAE SINENSIS,frankincense,RADIX STEPHANIAE TETRANDRAE,RADIX ACHYRANTHIS BIDENTATAE,myrrh,RADIX ACONITI、RADIX DIPSACI,RHIZOMA GASTRODIAE,ginseng root,HERBA DENDROBII,CORNU SAIGAE TATARICAE,RADIX MORINDAE OFFICINALIS,PORIA,SEMEN COICIS,poison yam,and so on.It basically reflected the ancient and modern treatment of Bi syndrome in traditional Chinese medicine named after the formula.
文摘The developmental origins of health and diseases(DOHaD)is a concept stating that adverse intrauterine environments contribute to the health risks of offspring.Since the theory emerged more than 30 years ago,many epidemiological and animal studies have confirmed that in utero exposure to environmental insults,including hyperglycemia and chemicals,increased the risk of developing noncommunicable diseases(NCDs).These NCDs include metabolic syndrome,type 2 diabetes,and complications such as diabetic cardiomyopathy.Studying the effects of different environmental insults on early embryo development would aid in understanding the underlying mechanisms by which these insults promote NCD development.Embryonic stem cells(ESCs)have also been utilized by researchers to study the DOHaD.ESCs have pluripotent characteristics and can be differentiated into almost every cell lineage;therefore,they are excellent in vitro models for studying early developmental events.More importantly,human ESCs(hESCs)are the best alternative to human embryos for research because of ethical concerns.In this review,we will discuss different maternal conditions associated with DOHaD,focusing on the complications of maternal diabetes.Next,we will review the differentiation protocols developed to generate different cell lineages from hESCs.Additionally,we will review how hESCs are utilized as a model for research into the DOHaD.The effects of environmental insults on hESC differentiation and the possible involvement of epigenetic regulation will be discussed.
文摘Since the rise of the economic and financial development theory, around economic and financial development of the determinants and what financial arrangements for promoting economic growth and other issues, thus resulted in a variety of important theoretical debate. This paper will Define what is meant by key terms such as legal tradition and endowment, explain the channels through which legal tradition and endowment affect financial development through talking about the relationship between legal origin, initial in endowment and financial development. By comparing different legal traditions or the"Origins"between the The Continental Law System and Common Law System, a comprehensive analysis of the effects of different origin of law on the financial and economic development.
文摘I.The History of the Drafting of the Universal Declaration of Human Rights:the Position and Role of the UN Economic and Social Council and the General Assembly of the United Nations should not be Ignored The reason for me to use the term "source"in the discussion on the right to subsistence
基金Supported by the China National Science and Technology Major Project(2016ZX05024-003)CNOOC Science and Technology Major Project(CNOOC-KJ135ZDXM36TJ08TJ)。
文摘Based on the theory of structural analysis,the characteristics and structural patterns of subtle faults are studied using 3D seismic data of the Bohai Sea to analyze the development process and origin of the subtle faults.A method of identifying subtle faults is proposed,forming a complete system for analyzing origins of subtle faults in the Bohai Sea.The complex strike-slip fault patterns under the strike-slip and extension stress background,diverse formation rocks,and strong neotectonic movement are the reasons for the development of subtle faults.According to the tectonic origin and development location,the subtle faults in Bohai Sea can be divided into 12 types in the three categories of strike slip dominant,extension dominant and strike slip and extension composite,and the different types of subtle faults occur in different regions of the Bohai Sea.Unreasonable variation of sedimentary stratum thickness,inherited distortion or even abrupt change of stratum occurrence,zonation of plane fault combination and the variation of oil-water system in the same structure with no-lithologic change are the important signs for identifying subtle faults in Bohai Sea.The subtle faults greatly enlarge the size of the structural trap groups,and areas with dense subtle faults are often active area of hydrocarbon migration and accumulation and favorable exploration zones,which have strong control on the hydrocarbon accumulation.The identification method for subtle faults has guided the exploration in the mature areas of Bohai Sea effectively,with a number of large and medium oil and gas fields discovered,such as Bozhong 29-6 and Penglai 20-2.
文摘Since the 18th National Congress of the Communist Party of China,the Party Central Committee with President Xi Jinping has put forward a new development concept of innovation,coordination,green,openness,and sharing based on profound insight into the basic characteristics of the new development stage.The party scientific grasps the essential requirements and development direction of socialism with Chinese characteristics,and continuously deepens understanding of the laws of economic and social development.Starting from three aspects of the times background,theoretical origin,and scientific connotation,the party aims to deeply understand the specific content and profound implication of the shared development concept in the new era.
基金National Science Foundation of China(81673862)Science and Technology Support Plan Project of Guizhou Province(Qian KH SY word[2014]3026)+1 种基金High-level innovative talents training plan of Guizhou Province(Qian KHRC(2016)4032)Graduate Tutor-Zhu Yang’s studio of"TCM Oncology"of Guizhou Province,(Qian JYH GZS word[2016]08).
文摘The number of people who are sickened by alcohol is rising every year in China,and Traditional Chinese Medicine(TCM)has a long history and remarkable therapeutic effect on the treatment of"Alcohol Injury"diseases.Therefore,it is of great practical significance to study the theory of"Alcohol Injury".This paper expounds the historical origin,treatment prescription and related diseases of the theory of"Alcohol Injury".
文摘Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of FUO.Methods:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,2023.In total,15 participating centers from seven different countries provided the data,which were collected through the Infectious DiseasesInternational Research Initiative platform.Only adult patients with confirmed infection as the cause of FUO were included in the study.The severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the study.Overall,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired infections.The most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for diagnosis.The mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not rare.Overall,38(23.8%)patients had at least one of the severity parameters.The mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)patients.Conclusions:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.
