Mechanism of traditional Chinese medicine in the treatment of psoriasis with depression:A review

Psoriasis is a kind of immune-mediated, chronic, inflammatory skin disease, which is often associated with different degrees of psychological disorders. Specifically, there is a significant correlation between psoriasis and depression, and they show the relationships of reciprocal causation and mutual promotion. Psoriasis with depression is more harmful than simple psoriasis, and its prognosis is worse, which brings a huge burden to the family and society and is worthy of clinical attention. Based on the pathogenic factors of western medicine and pathogenesis of traditional Chinese medicine in psoriasis with depression, the paper summarized and elaborated the research progress on the mechanism of traditional Chinese medicine in the treatment of psoriasis with depression, in order to provide new ideas for clinical treatment.

Effect of thermal processing and fermentation with Chinese traditional starters on characteristics and allergenicity of wheat matrix

Wheat allergy has become a serious health threat worldwide and its prevalence has increased alarmingly in the past few years.Factors such as food matrix and food processing may alter the structure of wheat proteins,and hence affect its allergenic properties.However,few reports have focused on the influence of Chinese traditional starter fermentation on wheat allergy.In this study,5 starters from different regions of China were used for fermentation,and protein characteristics were monitored by sodium dodecyl sulfate polyacrylamide gel electropheresis,and immunoreactivity analyzed by immunoassay with allergenic serum was obtained from New Zealand white rabbits.The allergenicity of steamed and baked matrices was also evaluated.The results showed that the allergenicity of wheat dough was basically increased at the beginning and then decreased during fermentation,but specific trends depend on different starters.With the progress of fermentation,especially as pH value decreased to 3.0-4.0,the allergenicity decreased significantly.Baking and steaming can reduce the allergenicity of wheat matrix,but fermentation is not a key factor affecting the allergenic activity of proteins.Our results can provide a theoretical basis for controlling wheat allergenicity in food proces sing or producing hypoallergenic food.

The Protection of Chinese Traditional Villages and Construction of Beautiful Countryside in the Wuling Mountain Area

Chinese traditional villages have the characteristics of both intangible and tangible cultural heritage,and are the largest cultural heritage left by farming civilization in China. Under the synchronous propulsion of new four modernizations and the coordinated development of urban and rural areas,the important issues we face are to protect the Chinese traditional villages,inherit the agricultural heritage,and develop the farming culture resources. There are 60 Chinese traditional villages in the Wuling Mountain area. This article introduces the Chinese traditional villages in the area,analyzes its Chinese traditional village protection and beautiful village construction,and puts forward corresponding recommendations.

Study on Agricultural Intellectual Property Protection and High-Quality Development of Traditional Chinese Medicine of Ginseng

Agricultural intellectual property has the functions of carrying forward agricultural cultural heritage,encouraging agricultural scientific and technological innovation,cultivating the brand of agricultural products and so on. The protection and application of agricultural intellectual property rights can enhance the vitality,innovation and competitiveness of agricultural economy,and promote the strategy of high-quality agricultural development and rural revitalization. Ginseng is a traditional medicinal variety with superior characteristics in Northeast China,and it is one of the most famous " three treasures" in Northeast China. This paper introduces ginseng( Panax ginseng C. A. Mey.) and its medicinal value,analyzes the traditional knowledge,biological genetic resources,new plant varieties,patents,geographical indications,trademarks and other agricultural intellectual property resources of ginseng,studies the traditional Chinese medicine GAP certification and certification of " Three Agricultural Products" and the construction of the dominant area of agricultural product( Fusong ginseng) with Chinese characteristics,and explores the rural revitalization strategy and traditional Chinese medicine development strategy,ginseng agricultural intellectual property protection and high quality development strategy.

Protection of Intellectual Property and Authenticity of Chinese Herbal Medicine Chrysanthemum morifolium

This paper first introduced Chrysanthemum morifolium Ramat. and its medicinal value. Then, it studied agricultural intellectual property resources such as geographical indications, trademarks, patents, new plant varieties, biological genetic resources, and traditional knowledge related to C. morifolium . Finally, it summarized poverty-stricken areas ecologically suitable for planting C. morifolium , analyzed the GAP certification of C. morifolium , pollution-free agricultural product certification, green food certification, and organic food certification, and discussed the strategies for C. morifolium intellectual property protection and authenticity protection in the context of TCM development strategy and rural revitalization strategy.

Application and Practice of Traditional Chinese Medicine Characteristic Technology Inheritance in Research and Development of Traditional Chinese Medicine Preparations in Medical Institutions

Medical institution preparations play an important role in the development of hospitals,being one of the main forms of traditional Chinese medicine clinical characteristic medication,as well as an important carrier for the inheritance and innovation of traditional Chinese medicine.In recent years,the research and development of traditional Chinese medicine preparations has become a hot spot in the research and development of preparations by medical institutions.Traditional Chinese medicine preparations prepared by traditional processes and their entrusted preparation matters have changed from the current licensing management to filing management.The registration model of traditional Chinese medicine preparations has undergone significant changes,emphasizing more on real data and evaluation results from the objective world,respecting traditional medication experience,and emphasizing the inheritance and innovative development of traditional technological experience.In the process of following teachers in the inheritance project of traditional Chinese medicine,we combined the inheritance of traditional Chinese medicine characteristic technology with the research and development practice of traditional Chinese medicine preparations in medical institutions,and focused on the analysis and discussion of technical problems such as prescription screening,dosage form selection,process route design and clinical observation of traditional Chinese medicine preparations,hoping to provide reference for scholars in the same field of traditional Chinese medicine.

Characteristics and Value of Traditional Lotus Culture System in Guangchang,Jiangxi Province

Jiangxi Guangchang traditional lotus culture system was selected into the fourth batch of China's important agricultural cultural heritage in 2017.The system consists of three parts:lotus,lotus cultivation techniques and lotus culture.It has notable characteristics of ancient origin,regional distribution,system complexity,biodiversity,advanced technology and extensive influence,and has ten kinds of value,i.e.,edible value,medical value,economic value,social value,ecological value,cultural value,tourism value,popular science value,scientific research value and educational value.

Unique Traditional Chinese Medicine Therapy for Painful Diabetic Peripheral Neuropathy

Painful diabetic peripheral neuropathy is one of the common chronic complications of diabetes."Pain"is the most typical symptom in patients,which seriously affects their quality of life.Traditional Chinese medicine(TCM)treatment of the disease includes oral administration of Chinese medicine,TCM fumigation and acupuncture,etc.,which can significantly reduce the pain of patients and reduce the frequency of disease.Chinese decoctions regulate the imbalance of yin and yang in the human body through syndrome differentiation,so as to achieve the balance of yin and yang,which will then eliminate the disease.Chinese medicine fumigation make the medicine seep into the body from the skin to exert the medical effects,and nourish and dredge the meridians.There is no pain if the meridians are smooth flowing,there will be pain if the meridians are blocked,fumigation can be used alone or assisted by other treatment methods to enhance the efficacy.The characteristics of acupuncture are rapid painrelief,economic and convenient,and can quickly relieve pain for patients with low tolerance.

Composition analysis of acid hydrolysates from Cucurbita moschata Duch.polysaccharides and their effect on oxidative stress resistance of Caenorhabditis elegans

Pumpkin polysaccharides(PPe)have a variety of bioactive effects and our previous research showed the acid hydrolysate(PPe-S,a mixture)from PPe had an antioxidative capacity both in vitro and in viro.The aim of this study was to purify PPe-S and investigate the antioxidant stress effects of 2 purified components(PPe-S-1 and PPe-S-2)using Caenorhabditis elegans as model organism.The results showed that PPe-S-2 had a notable antioxidant effect,and could significantly enhance the activities of antioxidant enzymes including superoxide dismutase(SOD)(P<0.01),catalase(CAT)(P<0.01)and glutathione reductase(GR)(P<0.05),and increase the level of glutathione(GSH)(P<0.01),and decreased the content of malondialdehyde(MDA)(P<0.05).PPe-S-2 could significantly extend the survival time of C.elegans(P<0.01),which were stress-induced by hydrogen peroxide and methyl viologen.PPe-S-2 was a heteropolys accharide composed of glucose,arabinose,rhamnose and galactose with the molar ratio of 1.00:0.03:0.02:0.14.The molecular weight of PPe-S-2 was 0.73 kDa detected by high performance liquid chromatography.These studies demonstrated that PPe-S-2 obtained by the acid hydrolysis of PPe had a prominent protective effect to the damage induced by the intracellular free radical generating agents.

Multifactor dimensionality reduction analysis of syndrome characteristics of chronic persistent asthma

Objective:To analyze the syndrome characteristics in patients with chronic persistent asthma.Methods:365 patients(121 males,244 females,60.829.1 years old)with chronic persistent asthma were enrolled in this cross-sectional study.The information of syndrome,symptoms,signs,tongue coating and pulse were collected from all patients.The syndrome characteristics of chronic persistent asthma were examined through the multifactor dimensionality reduction(MDR)analysis and the results were verified by the Chi-square test.Results:The results of the MDR analysis and the Chi-square test showed the following positive correlation of the interaction among:the deficiency syndrome of the lung and spleen and deep pulse,disinclination to talk due to lack of qi,fatigue,lassitude and thick tongue coating;the deficiency syndrome of the lung and kidney and dizziness and disinclination to talk due to lack of qi,fatigue,lassitude and pallid complexion;the syndrome of phlegm-heat obstructing the lung and rapid pulse,abdominal distension,disinclination to talk due to lack of qi,frequent urination and lassitude;the syndrome of phlegm-dampness obstructing the lung and disinclination to talk due to lack of qi,greasy coating,fatigue and lassitude.(P<.05 for all).Conclusion:The syndrome of chronic persistent asthma is characterized by fatigue and lassitude due to dysfunction of the lung,spleen and kidney.

Through a Century: Traditional Chinese Medicine Since 1912

Since 1912,traditional Chinese medicine(TCM)went through the stages of the struggle,foundation,and growth.The all-round developing TCM is academically progressing and promoted worldwide.Characteristics of the centennial development of TCM have cultural relevance,policy pertinency,mutual supplement between Chinese and western medicine and TCM is treatment directed by pattern diagnosis.Researches show that the historical inevitable development of TCM will benefit the people for generations to come when taken as a national strategy.

Experimental study on seismic characteristics of typical mortisetenon joints of Chinese southern traditional timber frame buildings

The seismic characteristics of four typical mortise-tenon joints of Chinese southern traditional timber frame buildings were researched, including Yanwei mortise-tenon joint （including dropping Yanwei mortise-tenon joint）, Shizigutou mortise-tenon joint, Ban mortise-tenon joint and Mantou mortise-tenon joint. Experiments on thirteen specimens were carried out. Failure modes, hysteresis curves, skeleton curves and rotational stiffness were studied. The results provided a theoretical basis for seismic research, protection and maintenance of Chinese southern traditional timber flame buildings.

基于PubMed和Web of Science数据平台的中医药网络药理学论文特征分析

目的:基于PubMed和Web of Science两大外文数据库,运用文献计量学的方法对中医药网络药理学的相关论文进行特征分析,以期评价目前国内外中医网络药理学的科研水平,总结研究热点,预判研究趋势。方法:以"network pharmacology"和"中医药"为并列主题词,在PubMed和Web of Science中检索2008-2018年的相关论文,并对年发文数,发表地区分布,研究内容,期刊分布,参考文献引用等内容进行描述性统计分析。对参考文献的篇引用数和普赖斯指数以中英文进行独立样本t检验。结果:研究共纳入447篇论文。中医药网络药理学的发文数量逐年上升,至今仍处于上升期。论文作者的单位以国内占据多数。从研究内容来看,以复方的网络药理学研究为主,而复方中又以自拟方占据一半之多。研究方向主要涉及循环系统疾病、肿瘤、消化系统疾病和神经系统疾病。从期刊来看,高影响因子的论文较少,青睐发Scientific Reports,Frontiers in Pharmacology和Journal of Ethnopharmacology等。再者,从参考文献的引用情况分析,中英文刊的参考文献篇引用数具有显著差异(P<0.001),而普赖斯指数没有差异。结论:中医药网络药理学的发展仍处于上升期,近些年来,对所得虚拟网络要求进行验证的期刊越来越多。高影响因子中医药网络药理学的论文仍是短板。

Biomechanical analysis of optic nerve injury treated by compound light granules and ciliary neurotrophic factor

In this study, rabbit models of optic nerve injury were reproduced by the clamp method. After modeling, rabbit models were given one injection of 50 ng recombinant human ciliary neurotrophic factor into the vitreous body and/or intragastric injection of 4 g/kg compound light granules containing Radix Angelicae Sinensis and Raidix Paeoniae Alba at 4 days after modeling, once per day for 30 consecutive days. After administration, the animals were sacrificed and the intraorbital optic nerve was harvested. Hematoxylin-eosin staining revealed that the injured optic nerve was thinner and optic nerve fibers were irregular. After treatment with recombinant human ciliary neurotrophic factor, the arrangement of optic nerve fibers was disordered but they were not markedly thinner. After treatment with compound light granules, the arrangement of optic nerve fibers was slightly disordered and their structure was intact. After combined treatment with recombinant human ciliary neurotrophic factor and compound light granules, the arrangement of optic nerve fibers was slightly disordered and the degree of injury was less than after either treatment alone. Results of tensile mechanical testing of the optic nerve showed that the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly lower than the normal optic nerve. After treatment with recombinant human ciliary neurotrophic factor and/or compound light granules, the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly increased, especially after the combined treatment. These experimental findings indicate that compound light granules and ciliary neurotrophic factor can alleviate optic nerve injury at the histological and biochemical levels, and the combined treatment is more effective than either treatment alone.

Perspective on the Development of Traditional Chinese Medicine and World Medicine

Following the spirit of Central Committee about the Opinions on Promoting the Inheritance, Innovation and Development of Traditional Chinese Medicine, professor Kai-Xian Chen, from Shanghai University of Traditional Chinese Medicine, delivered a comprehensive lecture on the development of traditional Chinese medicine (TCM) and world medicine. The lecture deeply elaborated on five aspects:the characteristics and advantages of TCM, the challenges faced by contemporary medicine, the status and role of TCM in the contemporary era, the inheritance and innovation of TCM, and the cooperation and development of "Belt and Road".

退变性腰椎管狭窄Coflex装置内固定术后的中医特色护理

[目的]探讨退变性腰椎管狭窄症(degenerative lumbar spinal stenosis,DLSS)行Coflex装置内固定术后中医特色护理的体会。[方法]84例肾阳虚型DLSS患者行Coflex装置内固定术,术后患者被随机分为观察组(n=42)和对照组(n=42)两组,对照组给予常规护理,观察组在对照组基础上给予中医特色护理,在术后第1d、第15d、第90d进行Oswestry功能障碍指数(oswestry disability index,ODI)及日本骨科协会评估治疗(Japanese orthopaedic association scores,JOA)评分,比较两组护理效果。[结果]两组患者术后第1d ODI及JOA评分比较差异均无统计学意义(P>0.05)。观察组患者术后第15d、第90dODI评分及JOA评分明显优于对照组,差异均有统计学意义(P<0.05)。[结论]对DLSS术后患者在常规护理的基础上采取中医特色护理,能明显减轻症状,降低疼痛,巩固手术疗效,促进患者全面康复。

Comparison of intestinal absorption characteristics between rhubarb traditional Chinese medicine preparation and activity ingredients using in situ and in vitro model

Objective: The intestinal absorption characteristics of active ingredients are very important for oral administration of traditional Chinese medicine(TCM) to achieve the desired therapeutic effect.However, a deeper understanding about active ingredients absorption characteristics is still lack. The aim of this study was to investigate the absorption properties and mechanism of rhubarb active ingredients in TCM preparation and pure form.Methods: The intestinal absorption behavior of active ingredients in Shenkang extract(SKE) and rhubarb anthraquinone ingredients(RAI) were investigated by in situ single-pass intestinal perfusion model. And the bidirectional transport characteristics of these active ingredients were assessed by in vitro Caco-2 cell monolayer model.Results: In situ experiment on Sprague-Dawley rats, the effective permeability coefficient values of aloeemodin, emodin and chrysophanol in RAI were higher than those in SKE, and the value of rhein in RAI was lower than that in SKE. But the easily absorbed segments of intestine were consistent for all ingredients,whether in SKE or in RAI. In vitro experiment, the apparent permeability coefficient values of rhein, emodin and chrysophanol in RAI were higher than those in SKE, and this value of aloe-emodin in RAI was lower than that in SKE. But their efflux ratio(ER) values in SKE and RAI were all similar.Conclusion: Four rhubarb anthraquinone ingredients in SKE and RAI have similar absorption mechanism and different absorption behavior, and the microenvironment of the study models influenced their absorption behavior. The results may provide an aid for understanding of the absorption characteristics of the TCM active ingredients in complex environments and the complementarities of different research models.

Historical Contributions and Innovative Development of China's Inclusive Culture

Inclusive culture is a dynamic pattern of cultural integration and innovative development formed in the interactions between man and nature, man and society, and man and others. Chinese culture is among the sources of inclusive culture. Being inheritable, open, assimilative, innovative and self–driven, this inclusive culture significantly contributes to China's ideological evolution, ethnic integration, religious development, economic openness, literature and art prosperity, as well as political wisdom in building a community with a shared future for mankind. Inclusiveness is key to the lasting and sustainable development of traditional Chinese culture. During China's construction of a great modern socialist country, the CPC's leadership over cultural innovation and development must be strengthened; a strong cultural confidence must always be maintained; the prosperity of socialist culture with Chinese characteristics must be further enhanced; the sustainable and integrated development of socialist culture with Chinese characteristics must be promoted; people's need for an enriched cultural life must be satisfied; and more efforts must be made to build a community with a shared future for mankind. Only in this way can the light of China's inclusive culture illuminate the future of globalization.

共同富裕:理论比较、思想渊源与中国经验

扎实推动共同富裕是新时代最重要的历史任务之一,也是中国特色社会主义政治经济学最重要的研究议题之一。从理论上来看,西方经济学理论只能促进“富裕”,而无法实现“共同”,马克思主义的共同富裕理论才是中国式现代化的共同富裕的理论基石。尤其需要强调的是,共同富裕不等于西方高福利社会。从历史上来看,共同富裕是中华民族千百年来孜孜以求的目标,具有深厚的思想渊源。中国共产党自成立以来就以共同富裕作为初心使命,在实践中不断探索实现共同富裕的道路,积累了丰富的中国经验。基本国情是制定共同富裕目标的出发点;改革开放是共同富裕的关键之举;全面建成小康社会是共同富裕的阶段性目标;“五位一体”是推动共同富裕的总体布局;中国式现代化是共同富裕的实现路径。

中华优秀传统文化:中国特色社会主义教育学话语体系的根脉

确立教育学的文化性,把中国特色社会主义教育学话语体系建立在中华优秀传统文化基础上,是增强中国教育学的文化主体性和文化自信之需。中国特色社会主义教育学话语体系根植于中华优秀传统文化,这意味着,构建中国特色社会主义教育学话语体系,必须深刻把握中华优秀传统文化的精神,把中国传统文化的基本精神有机融入中国特色社会主义教育学话语体系中,加快构建具有主体性、原创性的中国特色社会主义教育学话语体系。