Xi Jinping’s discourses on respecting and protect-ing human rights stand as a shining example of the sinicization and modernization of Marxist human rights theory,embodying profound theoretical,political,practical,an...Xi Jinping’s discourses on respecting and protect-ing human rights stand as a shining example of the sinicization and modernization of Marxist human rights theory,embodying profound theoretical,political,practical,and cultural logic.Existing research has conducted comprehensive and systematic theoretical analysis and academic extractions on the following contents:the core essence in-herent in these important discourses,including the“theory of human rights concepts,”the“theory of human rights paths,”the“theory of human rights practices,”the“theory of human rights protection,”and the“theory of human rights governance,”along with their profound theoretical significance,practical significance,and global signifi-cance.In the future,researchers should emphasize efforts on studying the original texts and understanding the original principles.While focusing on the precision of concepts,the scientific nature of the prop-ositions,the maturity of theoretical systems,and the rigor of internal logic related to Xi Jinping’s discourses on respecting and protecting human rights,researchers should also pay attention to constructing a discourse system on human rights from the dimensions of discourse power,discourse cluster,and discourse field.Researchers should be adept at drawing innovative insights into human rights theory from China’s vibrant human rights practices and the vast masses of people.This approach will facilitate the systematic unfolding,academic trans-formation,and innovative development of Xi Jinping’s discourses on respecting and protecting human rights.展开更多
This study aimed to alert people that the harmony between human beings and nature has already become an urgent problem. All people are responsible for maintaining the harmony, which is the also the inexorable trend of...This study aimed to alert people that the harmony between human beings and nature has already become an urgent problem. All people are responsible for maintaining the harmony, which is the also the inexorable trend of historical development. Reviewing the evolution history of human kind, the relationship between human beings and nature from harmony to imbalance, from imbalance to a new harmony was analyzed from the macro perspective, and it was pointed out that the present society is in the transitional phase from imbalance to a new harmony and also a phase that people are consciously coordinating their relationship with nature. It was found through the study that a harmonious society relies on the harmony between human beings and nature, and the latter is a necessary condition for a real harmonious society, however, people always forget such a principle. The imbalanced relationship between human beings and nature has seriously influenced many aspects of social harmony, and become instable factors in China and international society, even threatened the development and survival of human beings. Thus, all people should make joint efforts in creating win-win conditions for the development between human beings and nature, and ensuring offspring a healthy and green earth.展开更多
Universality is one of the essential characteristics of human rights, but there is a substantive difference between idealism and realism in understanding the concept of universality of human rights. The concepts of ra...Universality is one of the essential characteristics of human rights, but there is a substantive difference between idealism and realism in understanding the concept of universality of human rights. The concepts of radical universality and strong universality based on the concept of natural human rights are too idealistic and thus have a high risk of being alienated into a tool of international re-pression in practice. On the contrary, the theory on the subjectivity of human rights can effectively defuse this risk brought about by radical universality and strong universality. Advocating a transition from the universality of human rights to the subjectivity of human rights not only keeps in line with the actual construction process of international human rights, but can also effectively interpret the practical difficul-ties in the realization process of international human rights. Therefore, it can be used as another alternative theory on human rights beyond the theory of natural human rights.展开更多
The fourth new farming model Fenlong is identified as megascience for the first time. Fenlong can be directly applied to farming of farmland, remoulding of mortar black soil and saline alkali land and development of d...The fourth new farming model Fenlong is identified as megascience for the first time. Fenlong can be directly applied to farming of farmland, remoulding of mortar black soil and saline alkali land and development of degraded grassland. Deep loosening can create huge soil reservoirs, reduce fertilization, promote indi- rectly the improvement of river water fisheries and water sources and the upgrading of shaping and hydropower industry, thus making a new round of mobilization and pooling of natural resources. As a result, the nature is able to produce good food needed by human, the spatial dimension of the land is increased, the natural pre- cipitation storage is increased, the flood and drought disasters are reduced, the eco-environment is improved, and the economic benefits are increased. Fenlong is not restricted to global application by ecological region and crop variety and is not subject to the time-space constraints for a hundred thousand years. On the basis of utilizing the heaven and earth resources, it brings about a huge effect of mega- science. Compare with traditional farming, the depth under the mode of Fenlong is increased by 2-3 times, the contents of nutrient, water, oxygen and microorganism in the soil are increased by 10%-200%, the content of pale salt is increased by 20%-40%, the temperature is increased by 2-4 ~C, and the photosynthetic efficiency of crops is improved by 10%. Under the cultivation mode of Fenlong, the yield of crop applied with no fertilizers is increased by more than 10%, crop yield is still in- creased by more than 5% when the application amount of chemical fertilizer is re- duced by 10%-20%. Under the farming mode of Fenlong combined with no in- crease in fertilization, the crop yield, crop quality, farming efficiency, natural precipi- tation storage and air humidity are increased by 10%-50%, 5%, 15%, 100% and 5%, respectively, and the emissions of methane and other gases are reduced by more than 5%. Even in mortar black soil, saline alkali land and degraded grassland, the yield is still increased by 15%-50%. These improvement effects can last for many years, helping achieve the real harmonious coexistence between human and nature.展开更多
Investigating the spatiotemporal variation of human activity intensity and its determinants is a crucial basis for further revealing the mechanism of human-environment interaction and optimizing the human development ...Investigating the spatiotemporal variation of human activity intensity and its determinants is a crucial basis for further revealing the mechanism of human-environment interaction and optimizing the human development mode.In this study,the human activity intensity on the Qinghai-Tibet Plateau(QTP)from 1990 to 2020 was measured based on the quantitative model of land use data and the actual regional background,and the under-lying natural and socioeconomic determinants were investigated using spatial econometric methods.The results demonstrate that(1)the human activity intensity in QTP has increased by 11.96%,and there are differences in different spatial scales;the areas with high human activity intensity are distributed in the Hehuang Valley where Xining City and its surrounding areas are located,as well as the One-River and Two-River Area where Lhasa City and surrounding areas are located.(2)Human activity intensity has significant positive spatial spillover,suggesting that local changes will cause changes in the same direction in adjacent areas.(3)The human activ-ity intensity in QTP is affected by various determinants.Concerning socioeconomic factors,the economic level has no significant impact on the human activity intensity in QTP,which differs from the general regional law.Both urbanization and traffic conditions have a significant positive effect,and the impact intensity continues to increase.Concerning natural factors,topographic relief has a significant positive effect;the impacts of temper-ature and vegetation coverage have changed from insignificant to a significant positive effect;the impacts of precipitation and river network density have not been verified;there is no linear relationship between altitude and human activity intensity in the entire QTP,while it exists in local regions.Finally,this study proposes three policy implications for the realization of a more harmonious human-environment relationship in QTP.展开更多
The relationship between human beings and nature influences the expressions and manifestations of literature. Literature can spy on the nature exploration of human society and ideological values in the thinking and be...The relationship between human beings and nature influences the expressions and manifestations of literature. Literature can spy on the nature exploration of human society and ideological values in the thinking and behavior patterns,expressing the relationship between human beings and nature. Through expressions of literature in China and the West,we draw lessons from W estern literary expressions in the developing relationship between man and nature,and get inspiration for the development of Chinese literature.展开更多
The Call of the Wild,one of the most popular novels in the early twentieth-century America,is the first best-selling book of Jack London.As far as this novel is concerned,the main character Buck represents nature.He d...The Call of the Wild,one of the most popular novels in the early twentieth-century America,is the first best-selling book of Jack London.As far as this novel is concerned,the main character Buck represents nature.He deals with all kinds of peo⁃ple.The good treat Buck(nature)very well and live harmoniously with him.The evil treat Buck(nature)maliciously,just like fight⁃ing against their enemies.This novel shows the damages people did to nature and the imbalance between human being and nature.The author’s ecological awareness finds its full expression in the novel.The relationship between human and nature in the novel will be analyzed from the perspective of eco-criticism and the ecological theme of the novel will be discussed in a bid to arouse peo⁃ple’s ecological consciousness and environmental protection awareness.展开更多
Based on the landscape ecology theory,this paper analyzed the ecology concept and the existing misconceptions of landscape design from the perspective of ecology.The misconceptions included the excessive using of ecol...Based on the landscape ecology theory,this paper analyzed the ecology concept and the existing misconceptions of landscape design from the perspective of ecology.The misconceptions included the excessive using of ecological concepts,undue emphasis on the natural features of ecology,and endowing landscape with human cultural blindly.Taking Baoyan eco-tourism garden landscape renovation as an example,this study analyzed the superior natural conditions of this garden,the negative status in the current development process which included the conservative development and construction,singleness of entertainment,cultural educational and the other activities,disorder of landscape structure,lack of cultural landscape,weakness of landscape features and the unremarkable competitive advantages.To construct an ecological landscape with integration of humanistic and nature features,this paper proposed "ecological gardens" as the theme,following the design concept which made full integration of creating cultural landscape with the improvement and protection of natural ecological environment.Finally,the author elaborated such kind of ecological landscape from the following 4 aspects,including the integration,protection,restoration,and creation of landscape.展开更多
Promoting the unity of human nature and sociality in practice is a fundamental path dependence for achieving people's well-rounded development.Within the context of harmonious coexistence between humans and nature...Promoting the unity of human nature and sociality in practice is a fundamental path dependence for achieving people's well-rounded development.Within the context of harmonious coexistence between humans and nature,the practice of the unity of human nature and sociality is allowed to be truly implemented,and people's well-rounded development moves from possibility to reality.Strengthening the protection of human rights for people's well-rounded development in the harmonious coexistence between humans and nature not only requires the expansion of the connotations of environmental rights from“the right to a healthy environment”to“the right to a beautiful environment”,but also necessitates the formation of a collaborative framework between environmental rights and development rights.For legal responses to the expansion of the connotations of environmental rights,it is necessary to implement such expansions in environmental legislation,enhance the underlying principles,and make progress in the development of systematic environmental legislation simultaneously.Regarding the legal promotion of the synergy between environmental rights and development rights,it is essential to follow the guidance of the“Two Mountains Theory,”take the coordinated functions of environmental and traditional legal departments as the basis,and build a legal mechanism for the realization of the value of ecological products and services.展开更多
A set of universal loop-mediated isothermal amplification (LAMP) primers targeting the flo gene was designed to detect Borrelia burgdorferi sensu lato (B. burgdorferi s.I.) in human samples. The sensitivity of LAM...A set of universal loop-mediated isothermal amplification (LAMP) primers targeting the flo gene was designed to detect Borrelia burgdorferi sensu lato (B. burgdorferi s.I.) in human samples. The sensitivity of LAMP was 20 copies/reaction, and the assay did not detect false positives among 11 other related bacteria. A positive LAMP result was obtained for 9 of the 24 confirmed cases and for 12 of 94 suspected cases. The positive rate of LAMP was the same as that of nested PCR. The LAMP is a useful diagnostic method that can be developed for rapid detection of B. burgdorferi s.I. in human sera. Combination of the LAMP and nested PCR was more sensitive for detecting B. burgdorferi s.I. in human serum samples.展开更多
Marx's theory of humanity and nature is an indispensable part of Marx's theory of social development. The history of the development of human society is essentially a natural historical process. Human must sta...Marx's theory of humanity and nature is an indispensable part of Marx's theory of social development. The history of the development of human society is essentially a natural historical process. Human must start from certain natural premises and start from a combination of certain natural premises and human practices. This is the objective process and inevitable law of the development of human society. Grasping and understanding the scientific connotation of Marx's theory of humanity and nature has very important guiding significance for the development of human society.展开更多
BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line chemotherapy.The human epidermal growth factor receptor 2(HER-2)immunohistochemis...BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line chemotherapy.The human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in PDAC.CASE SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 month.She had not developed any grade 2 or above treatment-related adverse events at any point.Percentage of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no radiotherapy.CONCLUSION PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.展开更多
There are natural ethical debates in ecological ethics, namely whether nature has intrinsic value, whether the nature has its rights. Theoretical basis of argument is the opposite of anthropocentrism and non- anthropo...There are natural ethical debates in ecological ethics, namely whether nature has intrinsic value, whether the nature has its rights. Theoretical basis of argument is the opposite of anthropocentrism and non- anthropocentrism. Ecological ethics controversy concerns the core issue of the relationship between human and nature of the ecological ethics about nature, to correctly understand and deal with the relationship between mankind and nature, ecological ethics and ecological ethics is the starting point and destination debates.展开更多
The love is the topic of the abyss of time of mankind, but inhibits in the asceticism of western religion under, the love often takes a tragedy color. In the western literature work depiction concerning the love of cl...The love is the topic of the abyss of time of mankind, but inhibits in the asceticism of western religion under, the love often takes a tragedy color. In the western literature work depiction concerning the love of clergy, then there is the aggro of "human nature" and "divine nature". This text tries to explain west from three works religion bottom of love tragedy.展开更多
Famous for giving voice to Bertha, the marginalized mad woman in the attic in Jane Eyre, Wide Sargasso Sea is filled with vivid description of nature, which contributes to the successful characterization of main chara...Famous for giving voice to Bertha, the marginalized mad woman in the attic in Jane Eyre, Wide Sargasso Sea is filled with vivid description of nature, which contributes to the successful characterization of main characters and shows the theme of the relationship between nature and human beings. However few attention is paid to that theme. The mythological and archetypal approach is thus adopted to analyze three major characters and fill the gap. Antoinette is viewed as the daughter of nature. Christophine functions as the incarnation of nature. Rochester plays the role of the intruder who does harm to nature. To conclude, Wide Sargasso Sea is not only a criticism of anthropocentrism but also a warning bell to the stereotyped opposition in the western culture. After the successful shaking of the fixed order, Wide Sargasso Sea also drops a hint that there exists the hope to build a new world where human beings and nature, men and women keep a harmonious and balanced relationship.展开更多
In recent years,with the accelerating development of the socialist market economy and the process of globalization,corruption has appeared and become more and more serious,causing serious harm to the interests of the ...In recent years,with the accelerating development of the socialist market economy and the process of globalization,corruption has appeared and become more and more serious,causing serious harm to the interests of the state and people,so the construction of a clean and honest government draws people’s attention.The doctrine of evil human nature of Syun Zih explained profound theories concerning the nature of human beings and the view of interest with simple language,from which the origin of the construction of a clean and honest government could be found.As a result,we can have a right starting point,representing the fundamental interests of the overwhelming majority of people in the long-term exploration.The doctrine of evil human nature of Syun Zih plays an irreplaceable role in the correct understanding and analysis of the construction of a clean and honest government and the construction of the incorrupt government culture.展开更多
War has brought mankind a seething world,and the evil of war has brought western civilization and morality to a dead end.This paper discusses William Golding’s novel Lord of the Flies and Graham Greene’s The Destruc...War has brought mankind a seething world,and the evil of war has brought western civilization and morality to a dead end.This paper discusses William Golding’s novel Lord of the Flies and Graham Greene’s The Destructors.To have a better under⁃standing of the autho’s thought:war is rooted in the original evil of human nature.In the novel,there is no external binding force,such as ethical,moral,legal and religious control.The original evil of human nature is revealed,and the fierce conflict between civi⁃lization and barbarism is aroused,which are intertwined and manifest themselves through multiple symbolic meanings.Based on the theory of symbolism,the paper will classify the name,objects and characters with symbolic significance that appear in large numbers in two novels,and discuss its symbolic meaning and the function of these symbolic meanings to the development of the theme respectively.In order to better grasp the moral of the novel as a whole,ring the alarm bell for human beings,and cause peo-ple to ponder over the various evils of human beings.展开更多
Natural gas hydrate(NGH)is generally produced and accumulated together with the underlying conventional gas.Therefore,optimizing the production technology of these two gases should be seen as a relevant way to effecti...Natural gas hydrate(NGH)is generally produced and accumulated together with the underlying conventional gas.Therefore,optimizing the production technology of these two gases should be seen as a relevant way to effectively reduce the exploitation cost of the gas hydrate.In this study,three types of models accounting for the coexistence of these gases are considered.Type A considers the upper hydrate-bearing layer(HBL)adjacent to the lower conventional gas layer(CGL);with the Type B a permeable interlayer exists between the upper HBL and the lower CGL;with the type C there is an impermeable interlayer between the upper HBL and the lower CGL.The production performances associated with the above three models are calculated under different conditions,including only a depressurized HBL(only HBL DP);only a depressurized CGL(only CGL DP);and both the HBL and the CGL being depressurized(HBL+CGL DP).The results show that for Type A and Type B coexistence accumulation models,when only HBL or CGL is depressurized,the gas from the other layer will flow into the production layer due to the pressure difference between the two layers.In the coexistence accumulation model of type C,the cumulative gas production is much lower than that of Type A and Type B,regardless of whether only HBL DP,only CGL DP,or HBL+CGL DP are considered.This indicates that the impermeable interlayer restricts the cross-flow of gas between HBL and CGL.For three different coexistence accumulation models,CGL DP has the largest gas-to-water ratio.展开更多
Tracing the contamination origins in water sources and identifying the impacts of natural and human processes are essential for ecological safety and public health.However,current analysis approaches are not ideal,as ...Tracing the contamination origins in water sources and identifying the impacts of natural and human processes are essential for ecological safety and public health.However,current analysis approaches are not ideal,as they tend to be laborious,time-consuming,or technically difficult.Disinfection byproducts(DBPs)are a family of well-known secondary pollutants formed by the reactions of chemical disinfectants with DBP precursors during water disinfection treatment.Since DBP precursors have various origins(e.g.,natural,domestic,industrial,and agricultural sources),and since the formation of DBPs from different precursors in the presence of specific disinfectants is distinctive,we argue that DBPs and DBP precursors can serve as alternative indicators to assess the contamination in water sources and identify pollution origins.After providing a retrospective of the origins of DBPs and DBP precursors,as well as the specific formation patterns of DBPs from different precursors,this article presents an overview of the impacts of various natural and anthropogenic factors on DBPs and DBP precursors in drinking water sources.In practice,the DBPs(i.e.,their concentration and speciation)originally present in source water and the DBP precursors determined using DBP formation potential tests—in which water samples are dosed with a stoichiometric excess of specific disinfectants in order to maximize DBP formation under certain reaction conditions—can be considered as alternative metrics.When jointly used with other water quality parameters(e.g.,dissolved organic carbon,dissolved organic nitrogen,fluorescence,and molecular weight distribution)and specific contaminants of emerging concern(e.g.,certain pharmaceuticals and personal care products),DBPs and DBP precursors in drinking water sources can provide a more comprehensive picture of water pollution for better managing water resources and ensuring human health.展开更多
基金a phased achievement of the MOE’s key philosophy and social science research project“Research on General Secretary Xi Jinping’s Discourses on Respecting and Protecting Human Rights”(Project Approval Number 22JZD002)MOE Humanities and Social Sciences Key Research Base’s major project“Research on the Theoretical Structure and Legal Guarantee of Digital Human Rights Governance”(Project Approval Number 21JJD8200014)。
文摘Xi Jinping’s discourses on respecting and protect-ing human rights stand as a shining example of the sinicization and modernization of Marxist human rights theory,embodying profound theoretical,political,practical,and cultural logic.Existing research has conducted comprehensive and systematic theoretical analysis and academic extractions on the following contents:the core essence in-herent in these important discourses,including the“theory of human rights concepts,”the“theory of human rights paths,”the“theory of human rights practices,”the“theory of human rights protection,”and the“theory of human rights governance,”along with their profound theoretical significance,practical significance,and global signifi-cance.In the future,researchers should emphasize efforts on studying the original texts and understanding the original principles.While focusing on the precision of concepts,the scientific nature of the prop-ositions,the maturity of theoretical systems,and the rigor of internal logic related to Xi Jinping’s discourses on respecting and protecting human rights,researchers should also pay attention to constructing a discourse system on human rights from the dimensions of discourse power,discourse cluster,and discourse field.Researchers should be adept at drawing innovative insights into human rights theory from China’s vibrant human rights practices and the vast masses of people.This approach will facilitate the systematic unfolding,academic trans-formation,and innovative development of Xi Jinping’s discourses on respecting and protecting human rights.
文摘This study aimed to alert people that the harmony between human beings and nature has already become an urgent problem. All people are responsible for maintaining the harmony, which is the also the inexorable trend of historical development. Reviewing the evolution history of human kind, the relationship between human beings and nature from harmony to imbalance, from imbalance to a new harmony was analyzed from the macro perspective, and it was pointed out that the present society is in the transitional phase from imbalance to a new harmony and also a phase that people are consciously coordinating their relationship with nature. It was found through the study that a harmonious society relies on the harmony between human beings and nature, and the latter is a necessary condition for a real harmonious society, however, people always forget such a principle. The imbalanced relationship between human beings and nature has seriously influenced many aspects of social harmony, and become instable factors in China and international society, even threatened the development and survival of human beings. Thus, all people should make joint efforts in creating win-win conditions for the development between human beings and nature, and ensuring offspring a healthy and green earth.
文摘Universality is one of the essential characteristics of human rights, but there is a substantive difference between idealism and realism in understanding the concept of universality of human rights. The concepts of radical universality and strong universality based on the concept of natural human rights are too idealistic and thus have a high risk of being alienated into a tool of international re-pression in practice. On the contrary, the theory on the subjectivity of human rights can effectively defuse this risk brought about by radical universality and strong universality. Advocating a transition from the universality of human rights to the subjectivity of human rights not only keeps in line with the actual construction process of international human rights, but can also effectively interpret the practical difficul-ties in the realization process of international human rights. Therefore, it can be used as another alternative theory on human rights beyond the theory of natural human rights.
文摘The fourth new farming model Fenlong is identified as megascience for the first time. Fenlong can be directly applied to farming of farmland, remoulding of mortar black soil and saline alkali land and development of degraded grassland. Deep loosening can create huge soil reservoirs, reduce fertilization, promote indi- rectly the improvement of river water fisheries and water sources and the upgrading of shaping and hydropower industry, thus making a new round of mobilization and pooling of natural resources. As a result, the nature is able to produce good food needed by human, the spatial dimension of the land is increased, the natural pre- cipitation storage is increased, the flood and drought disasters are reduced, the eco-environment is improved, and the economic benefits are increased. Fenlong is not restricted to global application by ecological region and crop variety and is not subject to the time-space constraints for a hundred thousand years. On the basis of utilizing the heaven and earth resources, it brings about a huge effect of mega- science. Compare with traditional farming, the depth under the mode of Fenlong is increased by 2-3 times, the contents of nutrient, water, oxygen and microorganism in the soil are increased by 10%-200%, the content of pale salt is increased by 20%-40%, the temperature is increased by 2-4 ~C, and the photosynthetic efficiency of crops is improved by 10%. Under the cultivation mode of Fenlong, the yield of crop applied with no fertilizers is increased by more than 10%, crop yield is still in- creased by more than 5% when the application amount of chemical fertilizer is re- duced by 10%-20%. Under the farming mode of Fenlong combined with no in- crease in fertilization, the crop yield, crop quality, farming efficiency, natural precipi- tation storage and air humidity are increased by 10%-50%, 5%, 15%, 100% and 5%, respectively, and the emissions of methane and other gases are reduced by more than 5%. Even in mortar black soil, saline alkali land and degraded grassland, the yield is still increased by 15%-50%. These improvement effects can last for many years, helping achieve the real harmonious coexistence between human and nature.
基金the National Natural Sci-ence Foundation of China(Grant No.42001139)the Second Ti-betan Plateau Scientific Expedition and Research Program(Grant No.2019QZKK0406)+1 种基金the National Natural Science Foundation of China(Grant No.42230510)the China Postdoctoral Science Foundation(Grant No.2020M670472).
文摘Investigating the spatiotemporal variation of human activity intensity and its determinants is a crucial basis for further revealing the mechanism of human-environment interaction and optimizing the human development mode.In this study,the human activity intensity on the Qinghai-Tibet Plateau(QTP)from 1990 to 2020 was measured based on the quantitative model of land use data and the actual regional background,and the under-lying natural and socioeconomic determinants were investigated using spatial econometric methods.The results demonstrate that(1)the human activity intensity in QTP has increased by 11.96%,and there are differences in different spatial scales;the areas with high human activity intensity are distributed in the Hehuang Valley where Xining City and its surrounding areas are located,as well as the One-River and Two-River Area where Lhasa City and surrounding areas are located.(2)Human activity intensity has significant positive spatial spillover,suggesting that local changes will cause changes in the same direction in adjacent areas.(3)The human activ-ity intensity in QTP is affected by various determinants.Concerning socioeconomic factors,the economic level has no significant impact on the human activity intensity in QTP,which differs from the general regional law.Both urbanization and traffic conditions have a significant positive effect,and the impact intensity continues to increase.Concerning natural factors,topographic relief has a significant positive effect;the impacts of temper-ature and vegetation coverage have changed from insignificant to a significant positive effect;the impacts of precipitation and river network density have not been verified;there is no linear relationship between altitude and human activity intensity in the entire QTP,while it exists in local regions.Finally,this study proposes three policy implications for the realization of a more harmonious human-environment relationship in QTP.
文摘The relationship between human beings and nature influences the expressions and manifestations of literature. Literature can spy on the nature exploration of human society and ideological values in the thinking and behavior patterns,expressing the relationship between human beings and nature. Through expressions of literature in China and the West,we draw lessons from W estern literary expressions in the developing relationship between man and nature,and get inspiration for the development of Chinese literature.
文摘The Call of the Wild,one of the most popular novels in the early twentieth-century America,is the first best-selling book of Jack London.As far as this novel is concerned,the main character Buck represents nature.He deals with all kinds of peo⁃ple.The good treat Buck(nature)very well and live harmoniously with him.The evil treat Buck(nature)maliciously,just like fight⁃ing against their enemies.This novel shows the damages people did to nature and the imbalance between human being and nature.The author’s ecological awareness finds its full expression in the novel.The relationship between human and nature in the novel will be analyzed from the perspective of eco-criticism and the ecological theme of the novel will be discussed in a bid to arouse peo⁃ple’s ecological consciousness and environmental protection awareness.
文摘Based on the landscape ecology theory,this paper analyzed the ecology concept and the existing misconceptions of landscape design from the perspective of ecology.The misconceptions included the excessive using of ecological concepts,undue emphasis on the natural features of ecology,and endowing landscape with human cultural blindly.Taking Baoyan eco-tourism garden landscape renovation as an example,this study analyzed the superior natural conditions of this garden,the negative status in the current development process which included the conservative development and construction,singleness of entertainment,cultural educational and the other activities,disorder of landscape structure,lack of cultural landscape,weakness of landscape features and the unremarkable competitive advantages.To construct an ecological landscape with integration of humanistic and nature features,this paper proposed "ecological gardens" as the theme,following the design concept which made full integration of creating cultural landscape with the improvement and protection of natural ecological environment.Finally,the author elaborated such kind of ecological landscape from the following 4 aspects,including the integration,protection,restoration,and creation of landscape.
基金phased achievement of the National Social Sciences Fund’s Major Project titled“Research on Legal Regulation of Biodiversity Protection under the Perspective of Holistic System”(Project No.19ZDA162)。
文摘Promoting the unity of human nature and sociality in practice is a fundamental path dependence for achieving people's well-rounded development.Within the context of harmonious coexistence between humans and nature,the practice of the unity of human nature and sociality is allowed to be truly implemented,and people's well-rounded development moves from possibility to reality.Strengthening the protection of human rights for people's well-rounded development in the harmonious coexistence between humans and nature not only requires the expansion of the connotations of environmental rights from“the right to a healthy environment”to“the right to a beautiful environment”,but also necessitates the formation of a collaborative framework between environmental rights and development rights.For legal responses to the expansion of the connotations of environmental rights,it is necessary to implement such expansions in environmental legislation,enhance the underlying principles,and make progress in the development of systematic environmental legislation simultaneously.Regarding the legal promotion of the synergy between environmental rights and development rights,it is essential to follow the guidance of the“Two Mountains Theory,”take the coordinated functions of environmental and traditional legal departments as the basis,and build a legal mechanism for the realization of the value of ecological products and services.
基金funded by the National Key Science and Technology Projects of China(2012ZX10004219 and 2013ZX10004001)
文摘A set of universal loop-mediated isothermal amplification (LAMP) primers targeting the flo gene was designed to detect Borrelia burgdorferi sensu lato (B. burgdorferi s.I.) in human samples. The sensitivity of LAMP was 20 copies/reaction, and the assay did not detect false positives among 11 other related bacteria. A positive LAMP result was obtained for 9 of the 24 confirmed cases and for 12 of 94 suspected cases. The positive rate of LAMP was the same as that of nested PCR. The LAMP is a useful diagnostic method that can be developed for rapid detection of B. burgdorferi s.I. in human sera. Combination of the LAMP and nested PCR was more sensitive for detecting B. burgdorferi s.I. in human serum samples.
文摘Marx's theory of humanity and nature is an indispensable part of Marx's theory of social development. The history of the development of human society is essentially a natural historical process. Human must start from certain natural premises and start from a combination of certain natural premises and human practices. This is the objective process and inevitable law of the development of human society. Grasping and understanding the scientific connotation of Marx's theory of humanity and nature has very important guiding significance for the development of human society.
基金the Suzhou Medical Center,No.Szlcyxzx202103the National Natural Science Foundation of China,No.82171828+9 种基金the Key R&D Plan of Jiangsu Province(Social Development),No.BE2021652the Subject Construction Support Project of The Second Affiliated Hospital of Soochow University,No.XKTJHRC20210011Wu Jieping Medical Foundation,No.320.6750.2021-01-12the Special Project of“Technological Innovation”Project of CNNC Medical Industry Co.Ltd,No.ZHYLTD2021001Suzhou Science and Education Health Project,No.KJXW2021018Foundation of Chinese Society of Clinical Oncology,No.Y-pierrefabre202102-0113Beijing Bethune Charitable Foundation,No.STLKY0016Research Projects of China Baoyuan Investment Co.,No.270004Suzhou Gusu Health Talent Program,No.GSWS2022028Open Project of State Key Laboratory of Radiation Medicine and Protection of Soochow University,No.GZN1202302.
文摘BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line chemotherapy.The human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in PDAC.CASE SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 month.She had not developed any grade 2 or above treatment-related adverse events at any point.Percentage of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no radiotherapy.CONCLUSION PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.
文摘There are natural ethical debates in ecological ethics, namely whether nature has intrinsic value, whether the nature has its rights. Theoretical basis of argument is the opposite of anthropocentrism and non- anthropocentrism. Ecological ethics controversy concerns the core issue of the relationship between human and nature of the ecological ethics about nature, to correctly understand and deal with the relationship between mankind and nature, ecological ethics and ecological ethics is the starting point and destination debates.
文摘The love is the topic of the abyss of time of mankind, but inhibits in the asceticism of western religion under, the love often takes a tragedy color. In the western literature work depiction concerning the love of clergy, then there is the aggro of "human nature" and "divine nature". This text tries to explain west from three works religion bottom of love tragedy.
文摘Famous for giving voice to Bertha, the marginalized mad woman in the attic in Jane Eyre, Wide Sargasso Sea is filled with vivid description of nature, which contributes to the successful characterization of main characters and shows the theme of the relationship between nature and human beings. However few attention is paid to that theme. The mythological and archetypal approach is thus adopted to analyze three major characters and fill the gap. Antoinette is viewed as the daughter of nature. Christophine functions as the incarnation of nature. Rochester plays the role of the intruder who does harm to nature. To conclude, Wide Sargasso Sea is not only a criticism of anthropocentrism but also a warning bell to the stereotyped opposition in the western culture. After the successful shaking of the fixed order, Wide Sargasso Sea also drops a hint that there exists the hope to build a new world where human beings and nature, men and women keep a harmonious and balanced relationship.
文摘In recent years,with the accelerating development of the socialist market economy and the process of globalization,corruption has appeared and become more and more serious,causing serious harm to the interests of the state and people,so the construction of a clean and honest government draws people’s attention.The doctrine of evil human nature of Syun Zih explained profound theories concerning the nature of human beings and the view of interest with simple language,from which the origin of the construction of a clean and honest government could be found.As a result,we can have a right starting point,representing the fundamental interests of the overwhelming majority of people in the long-term exploration.The doctrine of evil human nature of Syun Zih plays an irreplaceable role in the correct understanding and analysis of the construction of a clean and honest government and the construction of the incorrupt government culture.
文摘War has brought mankind a seething world,and the evil of war has brought western civilization and morality to a dead end.This paper discusses William Golding’s novel Lord of the Flies and Graham Greene’s The Destructors.To have a better under⁃standing of the autho’s thought:war is rooted in the original evil of human nature.In the novel,there is no external binding force,such as ethical,moral,legal and religious control.The original evil of human nature is revealed,and the fierce conflict between civi⁃lization and barbarism is aroused,which are intertwined and manifest themselves through multiple symbolic meanings.Based on the theory of symbolism,the paper will classify the name,objects and characters with symbolic significance that appear in large numbers in two novels,and discuss its symbolic meaning and the function of these symbolic meanings to the development of the theme respectively.In order to better grasp the moral of the novel as a whole,ring the alarm bell for human beings,and cause peo-ple to ponder over the various evils of human beings.
基金supported by the National Natural Science Foundation of China (Nos.52074334,51991365)the National Key R&D Program of China (2021YFC2800903),which are gratefully acknowledged.
文摘Natural gas hydrate(NGH)is generally produced and accumulated together with the underlying conventional gas.Therefore,optimizing the production technology of these two gases should be seen as a relevant way to effectively reduce the exploitation cost of the gas hydrate.In this study,three types of models accounting for the coexistence of these gases are considered.Type A considers the upper hydrate-bearing layer(HBL)adjacent to the lower conventional gas layer(CGL);with the Type B a permeable interlayer exists between the upper HBL and the lower CGL;with the type C there is an impermeable interlayer between the upper HBL and the lower CGL.The production performances associated with the above three models are calculated under different conditions,including only a depressurized HBL(only HBL DP);only a depressurized CGL(only CGL DP);and both the HBL and the CGL being depressurized(HBL+CGL DP).The results show that for Type A and Type B coexistence accumulation models,when only HBL or CGL is depressurized,the gas from the other layer will flow into the production layer due to the pressure difference between the two layers.In the coexistence accumulation model of type C,the cumulative gas production is much lower than that of Type A and Type B,regardless of whether only HBL DP,only CGL DP,or HBL+CGL DP are considered.This indicates that the impermeable interlayer restricts the cross-flow of gas between HBL and CGL.For three different coexistence accumulation models,CGL DP has the largest gas-to-water ratio.
基金supported by the National Natural Science Foundation of China(52325001,52170009,and 52091542)the National Key Research and Development Program of China(2021YFC3200700)+3 种基金the Program of Shanghai Academic Research Leader,China(21XD1424000)the International Cooperation Project of Shanghai Science and Technology Commission(20230714100)the Key-Area Research and Development Program of Guangdong Province(2020B1111350001)Tongji University Youth 100 Program.
文摘Tracing the contamination origins in water sources and identifying the impacts of natural and human processes are essential for ecological safety and public health.However,current analysis approaches are not ideal,as they tend to be laborious,time-consuming,or technically difficult.Disinfection byproducts(DBPs)are a family of well-known secondary pollutants formed by the reactions of chemical disinfectants with DBP precursors during water disinfection treatment.Since DBP precursors have various origins(e.g.,natural,domestic,industrial,and agricultural sources),and since the formation of DBPs from different precursors in the presence of specific disinfectants is distinctive,we argue that DBPs and DBP precursors can serve as alternative indicators to assess the contamination in water sources and identify pollution origins.After providing a retrospective of the origins of DBPs and DBP precursors,as well as the specific formation patterns of DBPs from different precursors,this article presents an overview of the impacts of various natural and anthropogenic factors on DBPs and DBP precursors in drinking water sources.In practice,the DBPs(i.e.,their concentration and speciation)originally present in source water and the DBP precursors determined using DBP formation potential tests—in which water samples are dosed with a stoichiometric excess of specific disinfectants in order to maximize DBP formation under certain reaction conditions—can be considered as alternative metrics.When jointly used with other water quality parameters(e.g.,dissolved organic carbon,dissolved organic nitrogen,fluorescence,and molecular weight distribution)and specific contaminants of emerging concern(e.g.,certain pharmaceuticals and personal care products),DBPs and DBP precursors in drinking water sources can provide a more comprehensive picture of water pollution for better managing water resources and ensuring human health.