Analysis of the Effectiveness of Clopidogrel Combined with Aspirin in the Treatment of Coronary Heart Disease in Community-Dwelling Elderly

Objective:To analyze the combined therapeutic effect of clopidogrel(CLO)and aspirin(ASP)on coronary heart disease(CHD)in community-dwelling elderly.Methods:Thirty elderly patients with CHD who were admitted to the Xinxin Community Health Service Station,Pangzhuang Street,Quanshan District,Xuzhou City,from November 2020 to November 2022 were selected and randomly grouped into an observation group and a control group,with 15 cases in each group.The observation group was given the combination of CLO and ASP and the reference group was given only ASP.The total effective rate and other treatment indicators between the two groups were compared.Results:The total effective rate of the observation group(93.33%)was higher than that of the reference group(60.00%)(P<0.05).The adverse drug reaction rate(13.33%)and long-term cardiovascular adverse event rate(6.67%)of the observation group were lower than those of the reference group at 46.67%and 40.00%respectively,(P<0.05).Before treatment,the two groups had no difference in the quality-of-life scores(P>0.05).After treatment,the quality-of-life scores of the observation group were higher than those of the reference group(P<0.05).Conclusion:CLO combined with ASP improved the therapeutic effect of community-dwelling elderly patients with CHD,reduced adverse reactions during medication,prevented adverse cardiovascular events,and comprehensively improved the patient’s quality of life.

Host plant traits play a crucial role in shaping the composition of epiphytic microbiota in the arid desert,Northwest China

Phyllosphere microorganisms are a crucial component of environmental microorganisms,highly influenced by host characteristics,and play a significant role in plant health and productivity.Nonetheless,the impact of host characteristics on shaping phyllosphere microbial communities of plants with different life forms remains ambiguous.Utilizing high-throughput sequencing technology,this study analyzed the diversity and community composition of phyllosphere epiphytic microorganisms(e.g.,bacteria and fungi)of various plant life forms in the hinterland of the Gurbantunggut Desert,Northwest China.Functional annotation of prokaryotic taxa(FAPROTAX)and fungi function guild(FUNGuild)were employed to assess the ecological functions of microorganisms and to investigate the role of stochastic and deterministic processes in shaping phyllosphere microbial communities.Result showed a diverse array of phyllosphere epiphytic microorganisms in the desert plants,with Proteobacteria,Cyanobacteria,and Actinobacteriota dominating bacterial community,while Ascomycota and Basidiomycota were prevalent in fungal community.Comparison across different plant life forms highlighted distinct microbial communities,indicating strong filtering effects by plant characteristics.FAPROTAX prediction identified intracellular parasites(accounting for 27.44%of bacterial community abundance),chemoheterotrophy(10.12%),and phototrophy(17.41%)as the main functions of epiphytic bacteria on leaves of different life form plants.FUNGuild prediction indicated that phyllosphere epiphytic fungi primarily served as Saprotrophs(81.77%),Pathotrophs(17.41%),and Symbiotrophs(0.82%).Co-occurrence network analysis demonstrated a predominance of positive correlations among different microbial taxa.Raup-Crick dissimilarity index analysis revealed that deterministic processes predominantly influenced phyllosphere bacterial and fungal community assembly.Variance partitioning analysis and random forest modeling suggested that plant leaf functional traits significantly impacted both bacterial and fungal community composition,with fungal community composition showing a closer association with leaf nutrients and physiology compared with bacterial community composition.The distinct responses of bacterial and fungal communities to plant traits were attributed to the differing properties of bacteria and fungi,such as bacteria having higher potential dispersal rates and broader ecological niches than fungi.Overall,the results indicate that phyllosphere bacterial and fungal communities undergo similar community assembly processes,with fungi being more influenced by plant characteristics than bacteria.These findings offer novel insights into the ecology of phyllosphere microbial communities of desert plants.

Identification and Optimisation of Cycling Life Circle in High Density Communities with Public Health Support: A Case Study of Tiantongyuan in Beijing

In recent years,the compact development of high-density cities has sparked ongoing interest in healthy urban environments and public well-being.This study examines the relationship between cycling behaviors and the built environment of streets in Tiantongyuan Community,a typical high-density area in Beijing,China.By observing street spaces and summarizing residents’travel modes and behaviors,the study evaluates the impact of street design on cycling habits.In order to reveal the riding behavior characteristics of residents in different time periods and different street spaces,tools such as track recording APPs and the Gopro Motion Camera are employed to collect street view pictures and riding track data comprehensively,analyzing the various travel purposes of residents in Tiantongyuan community and the riding OD activity tracks of the main entrances and exits of the community.Meanwhile,by conducting the questionnaire survey of residents’travel demands and OD data of Baidu,and utilizing geographic information system(GIS)for data visualization,this study further investigates the distribution characteristics of cycling hotspots,cycling paths and cycling space,accurately identifies the cycling life circle of this community based on the spatial and temporal scales,and further puts forward the optimization strategy of the cycling network.Some cycling-friendly street space optimization strategies are suggested to deeply analyze the mechanism of the built environment of street space in high-density communities on the cycling activities and health of urban residents,with a view to provide accurate data support for the renewal of street cycling space.

Happy Life at the Foot of the Imperial City Wall——A Glimpse of Community Life in Dongcheng District, Beijing

Grandpa Qin, now 74, has returned to where he had lived for more than six decades in the company of his daughter. In front of him, the old dilapidated scenes have all disappeared. The former nine 1.9-meter-wide lanes have become 12 six-meter-wide roads. The former crowded courtyards, 11 stairs down the lanes, have completely changed their outlook. The only things that seem to have not changed are the old Beijing style of blue tiles and gray bricks and the imperial city walls nearby that are the witnesses to all these changes. Grandpa Qin is among the 300 households who have returned after the rebuilding project was completed. Qin’s family lived in the Nanchizi community for five generations. The big

The naked planet Earth:Most essential pre-requisite for the origin and evolution of life

Our blue planet Earth has long been regarded to carry full of nutrients for hosting life since the birth of the planet.Here we speculate the processes that led to the birth of early life on Earth and its aftermath, finally leading to the evolution of metazoans.We evaluate：（1） the source of nutrients,（2） the chemistry of primordial ocean,（3） the initial mass of ocean,and（4） the size of planet.Among the life-building nutrients,phosphorus and potassium play a key role.Only three types of rocks can serve as an adequate source of nutrients：（a） continent-forming TTG（granite）,enabling the evolution of primitive life to metazoans;（b） primordial continents carrying anorthosite with KREEP（Potassium,Rare Earth Elements, and Phosphorus） basalts,which is a key to bear life;（c） carbonatite magma,enriched in radiogenic elements such as U and Th,which can cause mutation to speed up evolution and promote the birth of new species in continental rift settings.The second important factor is ocean chemistry.The primordial ocean was extremely acidic（pH = 1-2） and enriched in halogens（CI,F and others）,S,N and metallic elements（Cd,Cu,Zn,and others）,inhibiting the birth of life.Plate tectonics cleaned up these elements which interfered with RNA.Blue ocean finally appeared in the Phanerozoic with pH = 7 through extensive interaction with surface continental crust by weathering,erosion and transportation into ocean.The initial ocean mass was also important.The birth of life and aftermath of evolution was possible in the habitable zone with 3-5 km deep ocean which was able to supply sufficient nutrients. Without a huge landmass,nutrients cannot be supplied into the ocean only by ridge-hydrothermal circulation in the Hadean.Finally,the size of the planet plays a crucial role.Cooling of massive planets is less efficient than smaller ones,so that return-flow of seawater into mantle does not occur until central stars finish their main sequence.Due to the suitable size of Earth,the dawn of Phanerozoic witnessed the initiation of return-flow of seawater into the mantle,leading to the emergence of huge landmass above sea-level,and the distribution of nutrients on a global scale.Oxygen pump also played a critical role to keep high-PO_2 in atmosphere since then,leading to the emergence of ozone layer and enabling animals and plants to invade the land. To satisfy the tight conditions to make the Earth habitable,the formation mechanism of primordial Earth is an important factor.At first,a ＇dry Earth＇ must be made through giant impact,followed by magma ocean to float nutrient-enriched primordial continents（anorthosite ＋ KREEP）.Late bombardment from asteroid belt supplied water to make 3-5 km thick ocean,and not from icy meteorites from Kuiper belt beyond cool Jupiter.It was essential to meet the above conditions that enabled the Earth as a habitable planet with evolved life forms.The tight constraints that we evaluate for birth and evolution of life on Earth would provide important guidelines for planetary scientists hunting for life in the exosolar planets.

Study on the Layout of 15-Minute Community-Life Circle in Third-Tier Cities Based on POI: Baoding City of Hebei Province

At present, the planning of 15-minute community-life circle is being actively promoted in China. Taking Baoding City as an example, the status quo of service facilities layout was analyzed based on the POI data. Using the spatial accessibility algorithm, the ranges of 15-minute life circle of more than 1000 communities in Baoding were determined. By calculating the up-to-standard rates of public service facilities in each district, it is found that the allocation of medical facilities and commercial facilities in urban community life circle is relatively perfect, but the allocation of public cultural facilities and pension facilities is obviously inadequate. Based on this, optimization suggestions on the layout of public service facilities in the 15-minute life circle were put forward from three aspects: facilities sharing, function mixing and population structure and activity characteristics differentiation. It not only provides data and technical support for the planning and construction of community life circle in Baoding city, but also provides referable examples and promotable models for the community planning of third-tier cities.

A possible anorthositic continent of early Mars and the role of planetary size for the inception of Earth-like life

The Moon has an anorthositic primordial continental crust. Recently anorthosite has also been discovered on the Martian surface. Although the occurrence of anorthosite is observed to be very limited in Earth＇s extant geological record,both lunar and Martian surface geology suggest that anorthosite may have comprised a primordial continent on the early Earth during the first 600 million years after its formation. We hypothesized that differences in the presence of an anorthositic continent on an Earthlike planet are due to planetary size. Earth likely lost its primordial anorthositic continent by tectonic erosion through subduction associated with a kind of proto-plate tectonics（PPT）. In contrast, Mars and the Moon, as much smaller planetary bodies, did not lose much of their anorthositic continental crust because mantle convection had weakened and/or largely stopped, and with time, they had appropriately cooled down. Applying this same reasoning to a super-Earth exoplanet suggests that, while a primordial anorthositic continent may briefly form on its surface, such a continent will be likely transported into the deep mantle due to intense mantle convection immediately following its formation. The presence of a primordial continent on an Earth-like planet seems to be essential to whether the planet will be habitable to Earth-like life. The key role of the primordial continent is to provide the necessary and sufficient nutrients for the emergence and evolution of life. With the appearance of a ＂trinity＂ consisting of（1） an atmosphere,（2） an ocean, and（3） the primordial continental landmass, material circulation can be maintained to enable a ＂Habitable Trinity＂ environment that will permit the emergence of Earth-like life. Thus, with little likelihood of a persistent primordial continent, a super-Earth affords very little chance for Earth-like life to emerge.

From the Beginning of the World to the Beginning of Life on Earth

Hypersphere World-Universe Model (WUM) is, in fact, a Paradigm Shift in Cosmology [1]. In this paper, we provide seven Pillars of WUM: Medium of the World;Inter-Connectivity of Primary Cosmological Parameters;Creation of Matter;Multicomponent Dark Matter;Macroobjects;Volcanic Rotational Fission;Dark Matter Reactors. We describe the evolution of the World from the Beginning up to the birth of the Solar System and discuss the condition of the Early Earth before the beginning of life on it.

Magnetic Isotope Theory of the Origin of Life on Earth

The authors have proposed a new of magnetic isotope theory of life on Earth. According to this theory the initial impetus for the beginning of the synthesis of organic compounds is the impact of electromagnetic radiation from the sun and energy radioactive isotopes.

Research Progress on the Influence of Movement Instruction on Community Life in Patients with Coronary Heart Disease

The incidence of coronary heart disease increases year by year with the material level of our country.It has a harmful effect on the patient’s life health and quality of life.Movement Instruction is an important aspect of the secondary prevention project of cardiac rehabilitation in patients with coronary heart disease.Although it has a history of decades at inland and abroad,the present situation in China is not optimistic.Some studies have shown that the popularization and participation of cardiac rehabilitation is true and lacking.This paper sums up the relevant knowledge of coronary heart disease,coronary heart disease movement instruction and its impact on community life of patients at home and abroad,and reviews the research results of movement instruction on community rehabilitation of coronary heart disease in recent years,which provides a theoretical reference and prospect for the future research of community exercise rehabilitation of coronary heart disease.

Origin of the Earth:A proposal of new model called ABEL

The Earth was born as a dry planet without atmosphere and ocean components at 4.56 Ga,with subsequent secondary accretion of bio-elements,such as carbon（C）,hydrogen（H）,oxygen（O）,and nitrogen（N） which peaked at 4.37-4.20 Ga.This two-step formation model of the Earth we refer to as the advent of bio-elements model（ABEL Model） and the event of the advent of bio-elements（water component） as ABEL Bombardment.It is clear that the solid Earth originated from enstatite chondrite-like dry material based on the similarity in oxygen isotopic composition and among other isotopes.On the other hand,Earth＇s water derives primarily from carbonaceous chondrite material based on the hydrogen isotopic ratio.We present our ABEL model to explain this enigma between solid Earth and water,as well as secondary accretion of oxidizing bio-elements,which became a precursor to initiate metabolism to emerge life on a highly reductive planet.If ABEL Bombardment had not occurred,life never would have emerged on the Earth.Therefore,ABEL Bombardment is one of the most important events for this planet to evolve into a habitable planet.The chronology of ABEL Bombardment is informed through previous researches of the late heavy bombardment and the late veneer model.ABEL Bombardment is considered to have occurred during 4.37-4.20 Ga,which is the concept to redefine the standard late heavy bombardment and the late veneer models.Also,ABEL Bombardment is the trigger of the transition from stagnant lid tectonics to plate tectonics on this planet because of the injection of volatiles into the initial dry Earth.

Delineation of an Urban Community Life Circle Based on a Machine-Learning Estimation of Spatiotemporal Behavioral Demand

Delineating life circles is an essential prerequisite for urban community life circle planning. Recent studies combined the environmental contexts with residents’ global positioning system(GPS) data to delineate the life circles. This method, however, is constrained by GPS data, and it can only be applied in the GPS surveyed communities. To address this limitation, this study developed a generalizable delineation method without the constraint of behavioral data. According to previous research, the community life circle consists of the walking-accessible range and internal structure. The core task to develop the generalizable method was to estimate the spatiotemporal behavioral demand for each plot of land to acquire the internal structure of the life circle, as the range can be delineated primarily based on environmental data. Therefore, behavioral demand estimation models were established through logistic regression and machine learning techniques, including decision trees and ensemble learning. The model with the lowest error rate was chosen as the final estimation model for each type of land. Finally, we used a community without GPS data as an example to demonstrate the effectiveness of the estimation models and delineation method. This article extends the existing literature by introducing spatiotemporal behavioral demand estimation models, which learn the relationships between environmental contexts, population composition and the existing delineated results based on GPS data to delineate the internal structure of the community life circle without employing behavioral data. Furthermore, the proposed method and delineation results also contributes to facilities adjustments and location selections in life circle planning, people-oriented transformation in urban planning, and activity space estimation of the population in evaluating and improving the urban policies.

Effect of Rare Earths on Tensile Behavior of Hot Roller Steel 60CrMnMo and Estimation of Roll′s Fatigue Life

The effect of rare earth(RE) on tensile behavior of hot roller steel 60CrMnMo was investigated at the temperature when roll served The roll′s fatigue at 500 ℃ was estimated The results show that elongation δ of hot roller steel 60CrMnMo can be increased by adding RE It is possible to estimate the fatigue life with tensile behavior of hot roller steel 60CrMnMo

Major biological events and fossil energy formation: On the development of energy science under the earth system framework

In geological history, one major life explosion and five mass extinction events occurred. These major biological and environmental events affected the evolution of the Earth ecosystem and controlled the formation of organic-rich strata. The life explosion occurred in Cambrian and the five mass extinction events happened at the end of Ordovician, Late Devonian, end of Permian, end of Triassic, and end of Cretaceous, respectively. They are corresponded to the formation of multiple suites of organic-rich strata globally, which are crucial to the formation, evolution and distribution of the fossil energy on Earth. China’s energy is characterized by "unlimited new energy, rich in coal but insufficient in oil and gas ", and it is determined to rely on new energy sources to achieve " energy independence " and carbon neutrality. From the perspective of the Earth system evolution, we investigate the multiple relationships between energy and Earth, energy and environment, as well as energy and human beings, and carry out comprehensive research on energy. Energy science refers to the science of studying the various energy sources formation and distribution, evaluation and selection, production and utilization, orderly replacement, development prospects, etc. in temporal and spatial scales based on the evolution of the Earth system. The connotation of energy science includes three core contents:(1) The relationship between the Earth and energy, including the formation of energy in the Earth system and the feedback of energy consumption to the Earth’s climate and environment;(2) The relationship between the Earth environment and the human beings, including the Earth environment breeding human beings and human activities transforming the earth environment;(3) The relationship between the energy and the human beings, including the development of energy technology by human beings and the progress of human society driven by energy utilization. The energy science focuses on the formation and development of fossil energy, development and orderly replacement of new energy, exploration and utilization of energy in deep earth and deep space, and energy development strategy and planning. The proposal of energy science is of great significance for improving the discipline system, promoting energy development, clarifying the development direction of energy transition, driving the carbon neutral geology research and constructing a habitable Earth.

China Seismic Experimental Site(CSES): Challenges of Deep Earth Exploration and Practice(DEEP)

Since May 2018,the planning,construction and functioning of China Seismic Experimental Site(CSES)has attracted much attention in earthquake science(CSES,2020 a,b,c;Wu,2020;Li et al.,2021).Different from traditional earthquake prediction experiment projects,such as the Parkfield earthquake prediction experiment(Roeloffs,2000).

Life on Earth Originated Where Later Microbial Oxygenic Photosynthesis Precipitated Banded Iron Formation, Suppressing Life Diversification for 1.4 Ga

The earliest Precambrian microbial structures appear in successions with banded iron formations (BIF) suggesting genetic relationships. The hypothesis of the deep ocean origin of BIFs associated with Mid-Ocean Ridge (MOR) like features seems to have been recently supported by the discovery of peculiar microbial ecosystems with unique faunal assemblages restricted to these volcanic vents. However, new sedimentological evidence points to the accumulation of varved BIF in huge, very shallow lakes of hydrothermal-water situated on continental plates while passing through thePolar Regions, where UV radiation is minimal. The mineral-rich solutions seeped from numerous fumaroles, providing suitable conditions for chemical reactions between inorganic components, incidentally creating organic-like self-multiplying molecules long before the biologically-initiated BIF deposition. Some of these early chemoautotrophic prokaryotes developed oxygenic photosynthesis during half a year of solar illumination. The released oxygen formed iron oxides and carbonates deposited with amorphous silica (geyserite) in laminae as BIF during 3.8 - 1.9 Ga. BIF deposition consumed most of the photosynthetic oxygen for 1.4 billion years. Intensified cyanobacteria oxygenic photosynthesis during 2.4 - 2.2 Ga raised the atmospheric oxygen content (Great Oxidation Event) over the Polar Regions, forming an oxygen-ozone shield against UV radiation. It gradually extended to lower latitudes, enabling prokaryotes to leave their ecologically stable habitat and acclimatize in new ecosystems, where they diversified, leading to eukaryote evolution. The 231/2° inclination of Earth’s rotation axis differentiated the solar effect on the Polar Regions, which controlled life evolution on Earth, as well as on planet Mars (25° inclination), where life probably did not evolve beyond early prokaryotes.

Roles of mutual help of local community networks in community health activities: Improvement for the quality of life of older people in Thailand

Objectives: This study aimed to describe work and activities of community networks focusing on the improvement of the quality of life (QOL) of older people in Thailand.The understanding of the work can help enhancing the community development and strengthening of local communities and their networks.Methods: Qualitative methods including in-depth interview,observation,and focus group discussion were employed to the study.64 participants participated to the study and were recruited from 4 key actors within the community.Content analysis was used to analyze the obtained data.This study was conducted in 6 local administrative organizations (LAOs) which selected from the outstanding areas of the project.Each LAO represents one sub-district of the regions of Thailand namely;(1) the upper north,(2) the lower north,(3)the upper eastern,(4) the lower eastern,(5) the central and (6) the south.Results: The findings of this study were categorized into three main themes: (1) Social capital including people in the community,social groups,and organizations,(2) Mutual help/collaboration activities composed of six sets of activities related to social capitals working on the improvement of QOL of older people,and (3) Impacts of the mutual help/collaboration activities on older people and local communities who help to improve of QOL of older people.Conclusion: The findings are important features for the community development.These themes should be recommended for community nurses,health related groups and organizations for the improvement of QOL of older people in the community.

Age-trends in Cognitive Function and Quality of Life: Sex Differences in a Community Population in Taiwan region,China

Population aging has developed into a significant area of concern in developed countries, especially in relation to thepreservation of functional independence and the quality of life (QoL). However, information on the contribution ofsex differences in quality of life and cognitive function is scarce. Therefore, this study aimed to investigate potentialdifferences in cognitive function and QoL between males and females. For this study, we recruited 382 healthy subjectsaged 19–79 years from communities in Southern Taiwan region,China. Cognitive function and QoL were assessed using the UCSD Performance-based Skills Assessment, Brief Version (UPSA-B) and World Health Organization Quality ofLife Instruments (WHOQOL-BREF), respectively. The effects of sex, age groups, and interaction of sex and ageon the UPSA-B and WHOQOL-BREF scores were examined. We found that the financial and communicationdomains of the UPSA-B showed declining trends with age in both sexes, although these trends were more obviousin females than in males. In the domain of Physical Capacity, QoL showed an age-increased trend in males, whileQoL in the Environment domain showed an age-increased trend in females. Regarding the relationships betweencognitive function and QoL, we found that the financial skill and communication skill of UPSA-B was positivelycorrelated to the psychological well-being domain of WHOQOL-BREF, in males of age <40 years. In conclusion,our findings demonstrate differential relationships between cognitive function and QoL between males and females,which could serve as a basis for further study between cognitive function and quality of life in communities.

Study on the quality of life and its related factors for older adults in communities in Beijing,China

Objectives:To describe the quality of life(QOL)of adults≥60 years of age in communities in Beijing and explore demographic,clinical,and psychological factors associated with QOL.Methods:This was a cross-sectional study.A total of 363 older adults were recruited,in which 313 completed the questionnaires.Depressive symptoms were measured with the Self-Rating Depression Scale(SDS)and QOL was analyzed with the 36-item short form(SF-36).The t-test and Mann-Whitney U tests were used to compare QOL by gender and age group.Factors associated with QOL were determined using multiple linear regression.Results:Among 313 older adults,depressive symptoms were observed to be prevalent to the extent of 16.6%.Overall,participants had higher QOL in the domains of social role functioning and emotional role functioning,with lower QOL in the domains of physical functioning and general health perceptions.There were no significant differences in QOL between women and men.However,there were significant differences between different age groups,with older adults having better mental QOL than younger adults.Better physical QOL was associated with less depressive symptoms,having a partner,and younger age(R2=28.7%).Better mental QOL was associated with less depressive symptoms,less chronic disease,and older age(R^(2)=34.7%).Conclusions:With aging,physical QOL was lower and mental QOL was better.Less depressive symptoms,having a spouse or partner,and young-old age assert positive influence on physical QOL of the older adults;and less depressive symptoms,no chronic disease,and older age assert positive influence on mental QOL.

Is Cognition a Determinant of Health Related Quality of Life in Community Dwelling Non Demented Elderly?

Quality of life (QOL) is an important topic in social and medical sciences, it has a multidimensional nature and is influenced by many factors. Aim of the Work: In this study we want to assess the impact of cognitive impairment on the health related quality of life (HR-QOL) of community dwelling non demented elderly. Subject and Method: 115 non demented elderly, 60 years and older recruited from outpatient geriatric clinic at Al Mansoura General Hospital, Dakahlia, Egypt. Each participant underwent, comprehensive geriatric assessment, assessing cognitive function using the mini-mental state examination (MMSE) and montreal cognitive function test, assessing the health related quality of life (HR-QOL) by the RAND-36 health survey. Results: We found that the elderly with impaired cognition by both MMSE and Montreal test were significantly older;the ones with lower education, with more depressive symptoms, had more functional impairment and had lower HR-QOL scores than the elderly with normal cognitive function, after controlling for confounders still cognition was a determinant of HR-QOL. Also by linear correlation coefficient a significant correlation between HR-QOL and age, function, cognition and depression was found. Conclusion: Cognition affects significantly HR-QOL of the elderly, so we can say that interventions targeting cognition in the elderly can significantly improve their QOL.