BACKGROUND Endoscopic submucosal dissection(ESD)and surgical resection are the standard of care for cT1N0M0 esophageal cancer(EC),whereas definitive chemoradiotherapy(d-CRT)is a treatment option.Nevertheless,the compa...BACKGROUND Endoscopic submucosal dissection(ESD)and surgical resection are the standard of care for cT1N0M0 esophageal cancer(EC),whereas definitive chemoradiotherapy(d-CRT)is a treatment option.Nevertheless,the comparative efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC remain unclear.AIM To compare the efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC.METHODS We retrospectively analyzed the hospitalized data of a total of 472 consecutive patients with cT1N0M0 EC treated at Sun Yat-sen University Cancer center between 2017-2019 and followed up until October 30th,2022.We analyzed demographic,medical recorded,histopathologic characteristics,imaging and endoscopic,and follow-up data.The Kaplan-Meier method and Cox proportional hazards modeling were used to analyze the difference of survival outcome by treatments.Inverse probability of treatment weighting(IPTW)was used to minimize potential confounding factors.RESULTS We retrospectively analyzed patients who underwent ESD(n=99)or surgery(n=220)or d-CRT(n=16)at the Sun Yat-sen University Cancer Center from 2017 to 2019.The median follow-up time for the ESD group,the surgery group,and the d-CRT group was 42.0 mo(95%CI:35.0-60.2),45.0 mo(95%CI:34.0-61.75)and 32.5 mo(95%CI:28.3-40.0),respectively.After adjusting for background factors using IPTW,the highest 3-year overall survival(OS)rate and 3-year recurrence-free survival(RFS)rate were observed in the ESD group(3-year OS:99.7% and 94.7% and 79.1%;and 3-year RFS:98.3%,87.4% and 79.1%,in the ESD,surgical,and d-CRT groups,respectively).There was no difference of severe complications occurring between the three groups(P≥0.05).Multivariate analysis showed that treatment method,histology and depth of infiltration were independently associated with OS and RFS.CONCLUSION For cT1N0M0 EC,ESD had better long-term survival and lower hospitalization costs than those who underwent d-CRT and surgery,with a similar rate of severe complications occurring.展开更多
Applying man-machine-environment system engineering(MMESE)in vessels is a method to improve the effectiveness of the interaction between equipment, environment, and humans for the purpose of advancing operating effici...Applying man-machine-environment system engineering(MMESE)in vessels is a method to improve the effectiveness of the interaction between equipment, environment, and humans for the purpose of advancing operating efficiency, performance, safety, and habitability of a vessel and its subsystems. In the following research, the life cycle of vessels was divided into 9 phases, and 15 research subjects were also identified from among these phases. The 15 subjects were systemized, and then the man-machine-environment engineering system application model for vessels was developed using the ICAM definition method 0 (IDEF0), which is a systematical modeling method. This system model bridges the gap between the data and information flow of every two associated subjects with the major basic research methods and approaches included, which brings the formerly relatively independent subjects together as a whole. The application of this systematic model should facilitate the application of man-machine-environment system engineering in vessels, especially at the conceptual and embodiment design phases. The managers and designers can deal with detailed tasks quickly and efficiently while reducing repetitive work.展开更多
We shall give natural generalized solutions of Hadamard and tensor products equations for matrices by the concept of the Tikhonov regularization combined with the theory of reproducing kernels.
基金Supported by the Guangdong Esophageal Cancer Institute Science and Technology Program,No.M202013Guangdong Medical Research Foundation,No.A2021369.
文摘BACKGROUND Endoscopic submucosal dissection(ESD)and surgical resection are the standard of care for cT1N0M0 esophageal cancer(EC),whereas definitive chemoradiotherapy(d-CRT)is a treatment option.Nevertheless,the comparative efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC remain unclear.AIM To compare the efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC.METHODS We retrospectively analyzed the hospitalized data of a total of 472 consecutive patients with cT1N0M0 EC treated at Sun Yat-sen University Cancer center between 2017-2019 and followed up until October 30th,2022.We analyzed demographic,medical recorded,histopathologic characteristics,imaging and endoscopic,and follow-up data.The Kaplan-Meier method and Cox proportional hazards modeling were used to analyze the difference of survival outcome by treatments.Inverse probability of treatment weighting(IPTW)was used to minimize potential confounding factors.RESULTS We retrospectively analyzed patients who underwent ESD(n=99)or surgery(n=220)or d-CRT(n=16)at the Sun Yat-sen University Cancer Center from 2017 to 2019.The median follow-up time for the ESD group,the surgery group,and the d-CRT group was 42.0 mo(95%CI:35.0-60.2),45.0 mo(95%CI:34.0-61.75)and 32.5 mo(95%CI:28.3-40.0),respectively.After adjusting for background factors using IPTW,the highest 3-year overall survival(OS)rate and 3-year recurrence-free survival(RFS)rate were observed in the ESD group(3-year OS:99.7% and 94.7% and 79.1%;and 3-year RFS:98.3%,87.4% and 79.1%,in the ESD,surgical,and d-CRT groups,respectively).There was no difference of severe complications occurring between the three groups(P≥0.05).Multivariate analysis showed that treatment method,histology and depth of infiltration were independently associated with OS and RFS.CONCLUSION For cT1N0M0 EC,ESD had better long-term survival and lower hospitalization costs than those who underwent d-CRT and surgery,with a similar rate of severe complications occurring.
基金Supported by the Fundamental Research Program of CSTIND under Grant No.GF2007004Harbin Engineering University Central Foundation under Grant No.HEUCF100718
文摘Applying man-machine-environment system engineering(MMESE)in vessels is a method to improve the effectiveness of the interaction between equipment, environment, and humans for the purpose of advancing operating efficiency, performance, safety, and habitability of a vessel and its subsystems. In the following research, the life cycle of vessels was divided into 9 phases, and 15 research subjects were also identified from among these phases. The 15 subjects were systemized, and then the man-machine-environment engineering system application model for vessels was developed using the ICAM definition method 0 (IDEF0), which is a systematical modeling method. This system model bridges the gap between the data and information flow of every two associated subjects with the major basic research methods and approaches included, which brings the formerly relatively independent subjects together as a whole. The application of this systematic model should facilitate the application of man-machine-environment system engineering in vessels, especially at the conceptual and embodiment design phases. The managers and designers can deal with detailed tasks quickly and efficiently while reducing repetitive work.
文摘We shall give natural generalized solutions of Hadamard and tensor products equations for matrices by the concept of the Tikhonov regularization combined with the theory of reproducing kernels.
