Let x 1,x 2,… be independent identically distributed (i.i.d.) random variables, in which x n=0 or 1 and the probability of {x n=1} is p. Here p is unknown. Let τ be any finite stopping ...Let x 1,x 2,… be independent identically distributed (i.i.d.) random variables, in which x n=0 or 1 and the probability of {x n=1} is p. Here p is unknown. Let τ be any finite stopping time for (x n,n1). For any sequential sample (x 1,x 2,…,x τ ) and γ∈(0,1), we have given an optimal confidence limit of p with confidence level γ . Some related problems are also discussed.展开更多
On the basis of strict mathematical description about Failure_Free Period Life Test (FFPLT), the statistical properties of the tests and optimal confidence limit of the parameter are discussed in detail and correspond...On the basis of strict mathematical description about Failure_Free Period Life Test (FFPLT), the statistical properties of the tests and optimal confidence limit of the parameter are discussed in detail and corresponding calculating formulae are found out.展开更多
Based on the zero-failure data of 30 Chinese 1. 5 MW wind turbine gearboxes( WTGs),the optimal confidence limit method was developed to predict the reliability and reliability lifetime of WTG. Firstly,Bayesian method ...Based on the zero-failure data of 30 Chinese 1. 5 MW wind turbine gearboxes( WTGs),the optimal confidence limit method was developed to predict the reliability and reliability lifetime of WTG. Firstly,Bayesian method and classical probability estimation method were introduced to estimate the value interval of shape parameter considering the engineering practice. Secondly,taking this value interval into the optimal confidence limit method,the reliability and reliability lifetime of WTG could be obtained under different confidence levels. Finally,the results of optimal confidence limit method and Bayesian method were compared. And the comparison results show that the rationality of this estimated range.Meantime, the rule of confidence level selection in the optimal confidence limit method is provided, and the reliability and reliability lifetime prediction of WTG can be acquired.展开更多
AIM:To describe confidence interval calculation for antidotal potency ratios using bootstrap method.METHODS:We can easily adapt the nonparametric bootstrap method which was invented by Efron to construct confidence in...AIM:To describe confidence interval calculation for antidotal potency ratios using bootstrap method.METHODS:We can easily adapt the nonparametric bootstrap method which was invented by Efron to construct confidence intervals in such situations like this.The bootstrap method is a resampling method in which the bootstrap samples are obtained by resampling from the original sample.RESULTS:The described confidence interval calculation using bootstrap method does not require the sampling distribution antidotal potency ratio.This can serve as a substantial help for toxicologists,who are directed to employ the Dixon up-and-down method with the application of lower number of animals to determine lethal dose 50 values for characterizing the investigated toxic molecules and eventually for characterizing the antidotal protections by the test antidotal systems.CONCLUSION:The described method can serve as a useful tool in various other applications.Simplicity ofthe method makes it easier to do the calculation using most of the programming software packages.展开更多
This article deals with correlating two variables that have values that fall below the known limit of detection (LOD) of the measuring device;these values are known as non-detects (NDs). We use simulation to compare s...This article deals with correlating two variables that have values that fall below the known limit of detection (LOD) of the measuring device;these values are known as non-detects (NDs). We use simulation to compare several methods for estimating the association between two such variables. The most commonly used method, simple substitution, consists of replacing each ND with some representative value such as LOD/2. Spearman’s correlation, in which all NDs are assumed to be tied at some value just smaller than the LOD, is also used. We evaluate each method under several scenarios, including small to moderate sample size, moderate to large censoring proportions, extr</span><span style="font-family:Verdana;">eme imbalance in censoring proportions, and non-bivariate nor</span><span style="font-family:Verdana;">mal (BVN) data. In this article, we focus on the coverage probability of 95% confidence intervals obtained using each method. Confidence intervals using a maximum likelihood approach based on the assumption of BVN data have acceptable performance under most scenarios, even with non-BVN data. Intervals based on Spearman’s coefficient also perform well under many conditions. The methods are illustrated using real data taken from the biomarker literature.展开更多
鉴于科技的进步和实验经验,ISO/TC 209出台ISO14644-1:2015《按粒子浓度划出空气洁净度等级》Classification of air cleanliness by particle concentration比ISO14644-1:1999《空气洁净度等级》Classification of air cleanliness技...鉴于科技的进步和实验经验,ISO/TC 209出台ISO14644-1:2015《按粒子浓度划出空气洁净度等级》Classification of air cleanliness by particle concentration比ISO14644-1:1999《空气洁净度等级》Classification of air cleanliness技术概念更清晰,使用更方便;实事求是,更赋灵活性:分级表中,所有浓度值都是累积,包括所有大于等于关注粒径(Considered particle size)的粒子的最大允许浓度值(Maximun allowable concentration siae),浓度限值。区域粒子浓度太高,浓度限值不适用;或者由于低浓度时采样和统计方法的局限性区域分级不适用。按统计学技术概念,决定检测洁净度最少采样点数N_(L);N_(L)值与洁净度无直接关联。作为标准应用的补充,超净环境检测需关注超高过滤器滤材最易穿透粒径MPPS,Most penetrating particle size。展开更多
This article develops a new method, named M-Bayesian credible limit method, to estimate reliability parameter. In the article, the M-Bayesian credible limit method of failure rate is derived for zero-failure data from...This article develops a new method, named M-Bayesian credible limit method, to estimate reliability parameter. In the article, the M-Bayesian credible limit method of failure rate is derived for zero-failure data from products with exponential distribution. Relations between M-Bayesian credible limit and other classical confidence limits are discussed. Finally, the new method is applied to a real zero-failure data set, and as can be seen, it is both efficient and easy to operate.展开更多
In medicine and industry, small sample size often arises owing to the high test cost. Then exact confidence inference is important. Buehler confidence limit is a kind of exact confidence limit for the function of para...In medicine and industry, small sample size often arises owing to the high test cost. Then exact confidence inference is important. Buehler confidence limit is a kind of exact confidence limit for the function of parameters in a model. It can be always defined if the order in sample space is given. But the computing problem is often difficult, especially for the cases with high dimension parameter or with incomplete data. This paper presents an algorithm to compute the Buehler confidence limits by EM algorithm. This is the firsttime usage of EM algorithm on Buehler confidence limits, but the algorithm is often used for maximum likelihood estimate in literatures. Three computation examples are given to illustrate the method.展开更多
We present the general results determining confidence limits for the mean of exponential distribution in any time-sequential samples, which are obtained in any sequential life tests with replacement or without replace...We present the general results determining confidence limits for the mean of exponential distribution in any time-sequential samples, which are obtained in any sequential life tests with replacement or without replacement. Especially, we give the best lower confidence limits in the case of no failure data.展开更多
The normal distribution, which has a symmetric and middle-tailed profile, is one of the most important distributions in probability theory, parametric inference, and description of quantitative variables. However, the...The normal distribution, which has a symmetric and middle-tailed profile, is one of the most important distributions in probability theory, parametric inference, and description of quantitative variables. However, there are many non-normal distributions and knowledge of a non-zero bias allows their identification and decision making regarding the use of techniques and corrections. Pearson’s skewness coefficient defined as the standardized signed distance from the arithmetic mean to the median is very simple to calculate and clear to interpret from the normal distribution model, making it an excellent measure to evaluate this assumption, complemented with the visual inspection by means of a histogram and a box-and-whisker plot. From its variant without tripling the numerator or Yule’s skewness coefficient, the objective of this methodological article is to facilitate the use of this latter measure, presenting how to obtain asymptotic and bootstrap confidence intervals for its interpretation. Not only are the formulas shown, but they are applied with an example using R program. A general rule of interpretation of ∓0.1 has been suggested, but this can only become relevant when contextualized in relation to sample size and a measure of skewness with a population or parametric value of zero. For this purpose, intervals with confidence levels of 90%, 95% and 99% were estimated with 10,000 draws at random with replacement from 57 normally distributed samples-population with different sample sizes. The article closes with suggestions for the use of this measure of skewness.展开更多
文摘Let x 1,x 2,… be independent identically distributed (i.i.d.) random variables, in which x n=0 or 1 and the probability of {x n=1} is p. Here p is unknown. Let τ be any finite stopping time for (x n,n1). For any sequential sample (x 1,x 2,…,x τ ) and γ∈(0,1), we have given an optimal confidence limit of p with confidence level γ . Some related problems are also discussed.
文摘On the basis of strict mathematical description about Failure_Free Period Life Test (FFPLT), the statistical properties of the tests and optimal confidence limit of the parameter are discussed in detail and corresponding calculating formulae are found out.
基金National Natural Science Foundation of China(No.51265025)
文摘Based on the zero-failure data of 30 Chinese 1. 5 MW wind turbine gearboxes( WTGs),the optimal confidence limit method was developed to predict the reliability and reliability lifetime of WTG. Firstly,Bayesian method and classical probability estimation method were introduced to estimate the value interval of shape parameter considering the engineering practice. Secondly,taking this value interval into the optimal confidence limit method,the reliability and reliability lifetime of WTG could be obtained under different confidence levels. Finally,the results of optimal confidence limit method and Bayesian method were compared. And the comparison results show that the rationality of this estimated range.Meantime, the rule of confidence level selection in the optimal confidence limit method is provided, and the reliability and reliability lifetime prediction of WTG can be acquired.
文摘AIM:To describe confidence interval calculation for antidotal potency ratios using bootstrap method.METHODS:We can easily adapt the nonparametric bootstrap method which was invented by Efron to construct confidence intervals in such situations like this.The bootstrap method is a resampling method in which the bootstrap samples are obtained by resampling from the original sample.RESULTS:The described confidence interval calculation using bootstrap method does not require the sampling distribution antidotal potency ratio.This can serve as a substantial help for toxicologists,who are directed to employ the Dixon up-and-down method with the application of lower number of animals to determine lethal dose 50 values for characterizing the investigated toxic molecules and eventually for characterizing the antidotal protections by the test antidotal systems.CONCLUSION:The described method can serve as a useful tool in various other applications.Simplicity ofthe method makes it easier to do the calculation using most of the programming software packages.
文摘This article deals with correlating two variables that have values that fall below the known limit of detection (LOD) of the measuring device;these values are known as non-detects (NDs). We use simulation to compare several methods for estimating the association between two such variables. The most commonly used method, simple substitution, consists of replacing each ND with some representative value such as LOD/2. Spearman’s correlation, in which all NDs are assumed to be tied at some value just smaller than the LOD, is also used. We evaluate each method under several scenarios, including small to moderate sample size, moderate to large censoring proportions, extr</span><span style="font-family:Verdana;">eme imbalance in censoring proportions, and non-bivariate nor</span><span style="font-family:Verdana;">mal (BVN) data. In this article, we focus on the coverage probability of 95% confidence intervals obtained using each method. Confidence intervals using a maximum likelihood approach based on the assumption of BVN data have acceptable performance under most scenarios, even with non-BVN data. Intervals based on Spearman’s coefficient also perform well under many conditions. The methods are illustrated using real data taken from the biomarker literature.
文摘鉴于科技的进步和实验经验,ISO/TC 209出台ISO14644-1:2015《按粒子浓度划出空气洁净度等级》Classification of air cleanliness by particle concentration比ISO14644-1:1999《空气洁净度等级》Classification of air cleanliness技术概念更清晰,使用更方便;实事求是,更赋灵活性:分级表中,所有浓度值都是累积,包括所有大于等于关注粒径(Considered particle size)的粒子的最大允许浓度值(Maximun allowable concentration siae),浓度限值。区域粒子浓度太高,浓度限值不适用;或者由于低浓度时采样和统计方法的局限性区域分级不适用。按统计学技术概念,决定检测洁净度最少采样点数N_(L);N_(L)值与洁净度无直接关联。作为标准应用的补充,超净环境检测需关注超高过滤器滤材最易穿透粒径MPPS,Most penetrating particle size。
基金This work was supported partly by the Fujian Province Natural Science Foundation of Chinapartly by the Fujian University of Technology of China
文摘This article develops a new method, named M-Bayesian credible limit method, to estimate reliability parameter. In the article, the M-Bayesian credible limit method of failure rate is derived for zero-failure data from products with exponential distribution. Relations between M-Bayesian credible limit and other classical confidence limits are discussed. Finally, the new method is applied to a real zero-failure data set, and as can be seen, it is both efficient and easy to operate.
基金supposed by the National Natural Science Foundation of China(Grant Nos.90209001&10471007).
文摘In medicine and industry, small sample size often arises owing to the high test cost. Then exact confidence inference is important. Buehler confidence limit is a kind of exact confidence limit for the function of parameters in a model. It can be always defined if the order in sample space is given. But the computing problem is often difficult, especially for the cases with high dimension parameter or with incomplete data. This paper presents an algorithm to compute the Buehler confidence limits by EM algorithm. This is the firsttime usage of EM algorithm on Buehler confidence limits, but the algorithm is often used for maximum likelihood estimate in literatures. Three computation examples are given to illustrate the method.
基金the National Natural Science Foundation of China(Grant No.10471007)and MCSEC grant.
文摘We present the general results determining confidence limits for the mean of exponential distribution in any time-sequential samples, which are obtained in any sequential life tests with replacement or without replacement. Especially, we give the best lower confidence limits in the case of no failure data.
文摘The normal distribution, which has a symmetric and middle-tailed profile, is one of the most important distributions in probability theory, parametric inference, and description of quantitative variables. However, there are many non-normal distributions and knowledge of a non-zero bias allows their identification and decision making regarding the use of techniques and corrections. Pearson’s skewness coefficient defined as the standardized signed distance from the arithmetic mean to the median is very simple to calculate and clear to interpret from the normal distribution model, making it an excellent measure to evaluate this assumption, complemented with the visual inspection by means of a histogram and a box-and-whisker plot. From its variant without tripling the numerator or Yule’s skewness coefficient, the objective of this methodological article is to facilitate the use of this latter measure, presenting how to obtain asymptotic and bootstrap confidence intervals for its interpretation. Not only are the formulas shown, but they are applied with an example using R program. A general rule of interpretation of ∓0.1 has been suggested, but this can only become relevant when contextualized in relation to sample size and a measure of skewness with a population or parametric value of zero. For this purpose, intervals with confidence levels of 90%, 95% and 99% were estimated with 10,000 draws at random with replacement from 57 normally distributed samples-population with different sample sizes. The article closes with suggestions for the use of this measure of skewness.