Lingo-1: a novel target in therapy for Alzheimer's disease?

Unraveling the causes underlying Alzheimer’s disease（AD）is certainly one of the greatest challenges of this century for researchers.With advances in medicine and technology,the world is experiencing a demographic shift towards a growing elderly population.With this increasingly ageing population,the number of individuals being affected by AD is booming.AD has a significant negative impact on the lives of the individuals with the disorder,as well as creating a significant social andeconomic burden for society.

Effect of Seed Size, Suspension Recycling and Substrate Pre-Treatment on the CVD Growth of Diamond Coatings

CVD growth of uniform conformal polycrystalline diamond (PCD) coatings over complex three dimensional structures is very important material processing technique. It has been found that the nucleation and subsequent growth period is very critical for successful development of CVD diamond based technologies. There are many methods of enhancing diamond nucleation on foreign substrates-ultrasonic treatment with diamond seed suspension being the best among them. A combination of ultrasonic seeding (US) technique with prior treatment (PT) of the substrate under CVD diamond growth conditions for brief period of time, has found to be very effective in enhancing the diamond nucleation during CVD growth—together they are known as NNP. But successive usage of the same seeding suspension up to ten cycles deteriorates the seeding efficiency. 6th seeding cycle onwards the silicon substrates are barely get covered by diamond crystallites. Five different diamond micron grits were used for seeding the silicon substrates and it is observed that US with the sub-micron particles (0.25 μm) is very effective in efficient nucleation of PCD on Si substrates. PT of the substrate somewhat negates the effect of successive use of the same seeding slurry but it is best to avoid recycling of the same seeding suspension using micron size diamond grits.

Biotoxicity dynamic change and key toxic organics identification of coal chemical wastewater along a novel full-scale treatment process

It is particularly important to comprehensively assess the biotoxicity variation of industrial wastewater along the treatment process for ensuring the water environment security.However,intensive studies on the biotoxicity reduction of industrial wastewater are still limited.In this study,the toxic organics removal and biotoxicity reduction of coal chemical wastewater(CCW)along a novel full-scale treatment process based on the pretreatment process-anaerobic process-biological enhanced(BE)process-anoxic/oxic(A/O)process-advanced treatment process was evaluated.This process performed great removal efficiency of COD,total phenol,NH_(4)^(+)-N and total nitrogen.And the biotoxicity variation along the treatment units was analyzed from the perspective of acute biotoxicity,genotixicity and oxidative damage.The results indicated that the effluent of pretreatment process presented relatively high acute biotoxicity to Tetrahymena thermophila.But the acute biotoxicity was significantly reduced in BE-A/O process.And the genotoxicity and oxidative damage to Tetrahymena thermophila were significantly decreased after advanced treatment.The polar organics in CCW were identified as the main biotoxicity contributors.Phenols were positively correlated with acute biotoxicity,while the nitrogenous heterocyclic compounds and polycyclic aromatic hydrocarbons were positively correlated with genotoxicity.Although the biotoxicity was effectively reduced in the novel full-scale treatment process,the effluent still performed potential biotoxicity,which need to be further explored in order to reduce environmental risk.

Researching the Research: Applying Machine Learning Techniques to Dissertation Classification

This research examines industry-based dissertation research in a doctoralcomputing program through the lens of machine learning algorithms todetermine if natural language processing-based categorization on abstractsalone is adequate for classification. This research categorizes dissertationby both their abstracts and by their full-text using the GraphLabCreate library from Apple’s Turi to identify if abstract analysis is anadequate measure of content categorization, which we found was not. Wealso compare the dissertation categorizations using IBM’s Watson Discoverydeep machine learning tool. Our research provides perspectiveson the practicality of the manual classification of technical documents;and, it provides insights into the: (1) categories of academic work createdby experienced fulltime working professionals in a Computing doctoralprogram, (2) viability and performance of automated categorization of theabstract analysis against the fulltext dissertation analysis, and (3) natuallanguage processing versus human manual text classification abstraction.

烷基水杨酸盐清净剂合成工艺研究进展

近年来,随着节约能源和保护环境的要求逐渐提高,发动机设计日益向小型化,大功率和高速度方向发展,因此对内燃机油的高温清净性能提出了越来越苛刻的要求,低硫低磷及低灰分型内燃机油将是未来发展的方向。烷基水杨酸盐具有优异的清净作用及酸中和性能,且具备一定的抗氧化和抗腐蚀能力,是内燃机油的主要添加剂之一,可满足内燃机油低硫低磷及低灰分的要求。对烷基水杨酸盐的传统及改进的合成工艺进行了综述。传统合成工艺严重制约了烷基水杨酸盐的应用和发展,探索新的合成工艺是烷基水杨酸盐发展的主要方向。

天津市乡村振兴示范村创建进程及发展模式研究

乡村振兴示范村创建是天津市落实中央开展“百县千乡万村”乡村振兴示范创建任务的具体实践。本文在总结归纳天津市推进乡村振兴示范村创建主要做法基础上,依据广泛实地调研,按全市10个涉农区每个区各选1个取得初步成效的典型村,进行发展模式分析。结果表明:示范村创建过程中存在的规划方案的科学性需提升、产业融合发展不充分、要素制约瓶颈亟待破解、示范带动和可复制性任重道远等问题。为有利、有序、有效推进乡村振兴示范村创建工作,笔者提出4个方面的对策建议:科学规划布局,注重远近结合;培育特色产业,推进融合发展;破解要素瓶颈,夯实发展基础;加强示范带动,实现区域共富。

2-己基癸酸改性的全溶液制备的CsPbBr_(3)量子点发光二极管

钙钛矿量子点发光二极管是极具发展潜力的新型显示技术。全无机CsPbX3(X=Cl,Br,I)钙钛矿量子点具有优异的光电性能,然而合成CsPbX3量子点时往往需要油酸(OA)和油胺(OAm)等配体的参与,这些配体和量子点之间的动态结合方式使其极易从量子点表面脱落,进而引发量子点的不稳定性现象。此外,油酸油胺的绝缘特性会阻碍发光二极管中载流子的传输并恶化器件性能。鉴于此,本文以CsPbBr_(3)量子点为研究对象,采用短链配体2-己基癸酸(DA)部分取代长链OA配体,系统探究了不同DA/OA摩尔比对CsPbBr_(3)量子点光学性能的影响。结果表明,经DA修饰的CsPbBr_(3)量子点表现出高达88.64%的光致发光量子产率。随后,将优化后的CsPbBr_(3)量子点应用到全溶液制备的发光二极管中,器件的最高亮度和最大外量子效率分别从9 cd·m^(-2)和0.04%提升至155 cd·m^(-2)和0.14%。接着,通过优化钙钛矿发光层和空穴传输层之间的能级匹配,进一步将器件的亮度和外量子效率提升至436 cd·m^(-2)和0.20%。

清代小说批评家的“主体意识”研究

主体意识是理解主体作用的一个关键介质。以清代小说批评家们的“主体意识”为考察对象,探寻其在小说评点文本中的投射,发现清代小说评点家们在小说审美、小说形式、小说理论方面表现出我自为美、我有我形、我画我像的独立精神和创造精神。这种主体精神使他们在小说评点中既坚持自觉继承,又主动另辟蹊径,完成了对传统小说评点方式的超越,对于新时期文艺批评主体话语的建构意义非凡。

Stunning evenness in filament yarns

Heberlein AG,Wattwil,Switzerland,May 14,2024-Unique technology for creating advanced technical textiles with exquisite characteristics was featured at ITM in Turkey.Heberlein,the leading supplier of air interlacing and air texturing jets,plans to amaze visitors to the event with critical components-such as the latest Poly-Jet-TG-3-that can influence both yarn properties and processes.

常压多色同浴染色新技术在机织物上的应用

从纱线选择、组织结构、色彩搭配、染色工艺、性能测评等方面验证常压多色同浴染色新技术在机织物上应用的可行性。按预期设计要求进行小样试织试染,并对染后机织物的透气性、耐摩擦色牢度和耐皂洗色牢度性能进行了测试。结果表明:不同结构的阳离子改性涤纶和其他纤维交织的机织物能够实现常压多色同浴染色,染料上染率高,染色残液清澈透明,可重复使用;织物的耐摩擦色牢度和耐皂洗色牢度均在4级及以上,样布具有良好的染色牢度;织物透气性好,含有三角形横截面微观结构的新型常压阳离子染料可染涤纶织物比圆形横截面的常规涤纶织物更有利于空气的流通。

节能降碳的丙烯酸吸收精制工艺

简述了丙烯酸工艺、尤其是丙烯酸吸收精制工艺;在此基础上,通过对丙烯酸吸收精制新工艺与经典工艺的对比分析,得出结论:在节能降耗方面,丙烯酸吸收精制新工艺优于经典工艺。在“双碳”背景下,丙烯酸吸收精制新工艺更具竞争力。

采用新编码GA的工艺规划与车间调度集成优化

为了实现以完工时间最短为目标的工艺规划与车间调度集成优化,提出了基于新编码遗传算法(Genetic Algorithm,GA)的集成优化方法。对工艺规划与车间调度集成优化(Integrated Process Planning and Scheduling optimization,IPPS)问题进行了描述,并建立了完工时间最短的集成优化模型;设计一种具有最大柔性空间的染色体编码方法,从编码角度保证了集成优化问题的最大柔性度;根据IPPS问题特定约束改进了交叉变异方法,保证遗传操作前后均为可行解,使算法迭代均为有效迭代;进而制定了基于新编码遗传算法的IPPS问题求解流程。经Kim算例验证可知,与现有先进算法两阶段混合算法(Two-stage Hybrid Algorithm,THA)、改进蚁群算法(Enhanced Ant Colony Algorithm,EACA)和混合遗传算法(Hybrid Genetic Algorithm,HGA)相比,新编码GA在小规模、大规模生产情况下集成优化方案的完工时间均最小(分别为343、344、372、320、427及432 min),实验结果验证了新编码GA在IPPS问题求解中的可行性和先进性。

基于深度强化学习的新型电力系统无功电压优化控制

新型电力系统框架下可再生能源的随机性和波动性、负荷的主动性以及电网的电力电子化使得电网的运行方式和实时控制面临着新的挑战。无功电压优化控制是保证电网安全稳定运行的基础,针对可再生能源系统的大规模接入、储能系统的灵活配置带来的无功电压控制问题,提出了基于深度强化学习的电网无功电压优化控制方法,综合考虑运行效率、经济性和安全性建立电网无功优化模型,利用马尔可夫决策过程将无功优化问题转化为强化学习序贯决策优化,充分考虑无功调压设备时间、空间耦合特性,利用深度确定性梯度算法(deep deterministic policy gradient,DDPG)进行模型求解。最后,在改进的IEEE 33算例上进行仿真验证,通过对比验证了文中所提方法在无功优化决策过程中的有效性和可靠性。

NOVELL网络管理与故障处理

本文对网络管理技术进行了探讨，给出了NOVELL网络故障处理的基本方法。

REVIEW ON RESEARCH AND DEVELOPMENT OF MAGNESIUM ALLOYS

The current research and development of magnesium alloys is summarized. Several aspects of magnesium alloys are described： cast Mg alloy, wrought Mg alloy, and novel processing. The subjects are discussed individually and recommendations for further study are listed in the final section.

Clinical Research of Pre-Hospital Emergency Care, Nursing, Infection Prevention and Control for Senile Osteoporotic Vertebral Compression Fracture during Epidemic Period

Background: Novel coronavirus pneumonia (NCP) and osteoporotic vertebral compression fractures (OVCF) are the high incidences of diseases in the elderly. During the epidemic period, if not treated in time, the complications are high and the mortality is high. If we do not pay attention to infection prevention and control in pre-hospital emergency care, it will lead to the first time infection of medical staff and in-hospital cross infection in emergency outpatient receiving area. The correct consideration of both and the establishment of perfect pre-hospital emergency treatment and infection prevention and control synchronous strategy is an important premise to ensure the stable, orderly and safe medical treatment. Objective: To explore the effect of synchronous implementation of pre-hospital emergency care, nursing and infection pre-vention and control for senile OVCF during the epidemic. In order to improve the efficiency of pre-hospital emergency care and prevent the spread of infection. Method: A total of 92 elderly patients with OVCF who received pre-hospital treatment in 18 hospitals in Zhangjiakou City during the epidemic prevention and control period from January 2020 to November 2022 and met the inclusion criteria were selected as research objects, including 24 males and 68 females, aged 65 - 82 (74.2 ± 2.2) years. All patients were associated with concomitant injuries and underlying diseases. All patients in this group underwent predictive pre-hospital rescue and infection prevention and control procedures. Results: All the 92 elderly patients with OVCF received timely pre-hospital treatment during the epidemic period, and no aggravation occurred of the 92 patients, 35 were in the high risk area, 10 were in the medium risk area, and 47 were in the low risk area. Exclude OVCF for NCP Patients were treated according to the conventional diagnosis and treatment principles. Suspected and confirmed cases are transferred to designated surgical hospitals for treatment. All patients were followed up 3 months, 6 months and 12 months after treatment. There was no death rate, high satisfaction of pre-hospital first aid, high diagnostic accuracy, and good curative effect. None of the rescue personnel had any infection rate, and no hospital infection transmission and nosocomial cross infection occurred. Conclusion: It is the first step to safely treat patients and prevent cross infection to establish a perfect synchronous strategy of pre-hospital first aid and infection prevention and control.

Efficient perovskite solar cells based on the novel low-temperature processed electron transport layer

With the support by the National Natural Science Foundation of China,the research team led by Prof.Hou Yu(侯宇)and Prof.Yang Huagui(杨化桂)at the Key Laboratory for Ultrafine Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science

川东地区凉高山组致密砂岩压裂工艺优选研究

为了提高川东地区凉高山组致密砂岩气藏工业产量,针对凉高山组致密砂岩气藏物性较差,前期开展大型体积压裂效果较差的问题,从体积压裂可行性分析、造长缝大型压裂可行性分析以及目标储层压裂方式3个方面开展了研究工作。研究表明:1)凉高山组储层物性差且脆性高,但天然裂缝欠发育,水平应力差异系数(0.18)较大,缝网形成难度大;储隔层应力差较小(2 MPa),缝高极易失控,不适合采用体积压裂模式。2)模拟发现,储隔层应力差、排量、压裂规模和压裂液黏度对凉高山组裂缝参数影响较大,需要适度控制排量(5 m^(3)/min以内)、压裂规模以及减小黏度(50 mPa·s以内)以控制缝高而造长缝,优选控缝高造长缝的压裂工艺作为凉高山组压裂工艺。3)提出了采用变排量(排量由2 m^(3)/min起步逐步提至5 m^(3)/min)、一级段塞停泵(停泵15 min)、控制排量和控制规模(单段液量为280~300 m^(3))等措施控缝高,推荐了典型施工泵注程序。以上成果认识为凉高山组储层后续开发具有指导价值。

浅述我校Novell网及其在教学上的应用

通过对我校Novell网络机房与单机房使用对比，阐述了Novell网络的优点；对Novell网的拓扑结构、系统组成、运行机制及应用中的一些问题进行了阐述；对今后机房的建设提出了建议。

综合SEIR-FAHP的城市疫情防控评价

新型冠状病毒感染疫情防控已成为各国各级政府重要任务之一,为掌握疫情对城市公共卫生系统的影响程度,对疫情发展变化趋势进行预测并评判防控措施实施效果。以政府公开数据为信息源,建立评价对象城市的SEIR传染动力学模型,通过模型参数的灵敏度分析,以累计感染者人数为标准,确定模型各参数的重要程度序列,进而综合模糊层次分析法进行评价,最终建立综合SEIR-FAHP的城市疫情防控系统评价模型。然后以2019年武汉市疫情为实例,应用该模型对武汉市疫情防控系统进行评价。将疫情发展划分为疫情早期、中期和后期3个阶段,应用该评价模型进行评价,得到结果R_(1)·V_(1)=[0.0253846160.0792307690.250.3946150.250769];R_(2)·V_(2)=[0.01350.04960.20130.40670.3290];R_(3)·V_(3)=[000.15870.36450.4767]。根据最大隶属度原则,武汉疫情早期、中期及后期公共卫生系统评价结果依次为“良好”、“良好”、“优秀”。研究表明该方法能够客观反映城市疫情防控系统现状,可为政府进一步制定疫情防控政策提供合理参考。