AIM: To evaluate the ability of the time-signal intensity curve (TIC) of the pancreas obtained from dynamic contrast-enhanced magnetic resonance imaging (MRI) for differentiation of focal pancreatic masses, especially...AIM: To evaluate the ability of the time-signal intensity curve (TIC) of the pancreas obtained from dynamic contrast-enhanced magnetic resonance imaging (MRI) for differentiation of focal pancreatic masses, especially pancreatic carcinoma coexisting with chronic pancreatitis and tumor-forming pancreatitis. METHODS: Forty-eight consecutive patients who underwent surgery for a focal pancreatic mass, including pancreatic ductal carcinoma (n = 33), tumor-forming pancreatitis (n = 8), and islet cell tumor (n = 7), were reviewed. Five pancreatic carcinomas coexisted with longstanding chronic pancreatitis. The pancreatic TICs were obtained from the pancreatic mass and the pancreatic parenchyma both proximal and distal to the mass lesion in each patient, prior to surgery, and were classified into 4 types according to the time to a peak: 25 s and 1, 2, and 3 min after the bolus injection of contrast material, namely, type-Ⅰ, Ⅱ, Ⅲ, and Ⅳ, respectively, and were then compared to the corresponding histological pancreatic conditions. RESULTS: Pancreatic carcinomas demonstrated type-Ⅲ (n = 13) or Ⅳ (n = 20) TIC. Tumor-forming pancreatitis showed type-Ⅱ (n = 5) or Ⅲ (n = 3) TIC. All islet cell tumors revealed type-Ⅰ. The type-Ⅳ TIC was only recognized in pancreatic carcinoma, and the TIC of carcinoma always depicted the slowest rise to a peak among the 3 pancreatic TICs measured in each patient, even in patients with chronic pancreatitis.CONCLUSION: Pancreatic TIC from dynamic MRI provides reliable information for distinguishing pancreatic carcinoma from other pancreatic masses, and may enable us to avoid unnecessary pancreatic surgery and delays in making a correct diagnosis of pancreatic carcinoma, especially, in patients with longstanding chronic pancreatitis.展开更多
In this study the probable seismic behavior of skewed bridges with continuous decks under earthquake excitations from different directions is investigated. A 45° skewed bridge is studied. A suite of 20 records is...In this study the probable seismic behavior of skewed bridges with continuous decks under earthquake excitations from different directions is investigated. A 45° skewed bridge is studied. A suite of 20 records is used to perform an Incremental Dynamic Analysis (IDA) for fragility curves. Four different earthquake directions have been considered: -45°, 0°, 22.5, 45°. A sensitivity analysis on different spectral intensity measures is presented; efficiency and practicality of different intensity measures have been studied. The fragility curves obtained indicate that the critical direction for skewed bridges is the skew direction as well as the longitudinal direction. The study shows the importance of finding the most critical earthquake in understanding and predicting the behavior of skewed bridges.展开更多
The reliability and reliable indexes of q ua ntitative assessment of coronary flow reserve (CFR) by using time intensity cur ve (TIC) via myocardial contrast echocardiography were investigated. The TIC var iables wer...The reliability and reliable indexes of q ua ntitative assessment of coronary flow reserve (CFR) by using time intensity cur ve (TIC) via myocardial contrast echocardiography were investigated. The TIC var iables were obtained by employing acoustic densitometry (AD) technique before an d after acetylcholine (Ach) injection in 12 dogs. Meanwhile, the correlation be tween these variables and CFR was analyzed. Among the variables derived from TIC , peak intensity (PI), area under the curve (AUC) and descending slope (DS) were increased significantly ( P <0.05) with the increase of coronary blood flow a fter Ach injection. Conversely, time to peak (TP), half time of descent (HT) , and mean transit time (MTT) were decreased remarkably ( P <0.0001). Th e P I and AUC ratios from post to pre Ach injection were strongly associated with CFR with the correlation coefficient (r) being 0.8366 and 0.8824, respectively. It is reliable by using the variables derived from TIC with myocardial contrast echocardiography to quantitatively evaluate regional myocardial CFR. The PI an d AUC ratios from post to pre Ach injection are the reliable indexes for quan titative assessment of CFR.展开更多
Summary: To study reliability and reliable indices of quantitative assessment of right ventricular systolic function by time-intensity curve (TIC) with right ventricular contrast, 5 % sonicated human albumin was injec...Summary: To study reliability and reliable indices of quantitative assessment of right ventricular systolic function by time-intensity curve (TIC) with right ventricular contrast, 5 % sonicated human albumin was injected intravenously at a does of 0.08 ml/kg into 10 dogs at baseline status and cardiac insufficiency. Apical four-chamber view was observed for washin and washout of contrast agent from right ventricle. The parameters of TIC were obtained by curve fitting. The differences of parameters were analyzed in different states of cardiac functions. Among the parameters derived from TIC, the time constant (k) was decreased significantly with decline of cardiac function (P<0.001). But half-time of decent of peak intensity (HT) and mean-transit-time (MTT) of washout were increased significantly (P<0.001). The k was strongly related to cardiac output of right ventricle (CO) and ejection fraction (EF) of left ventricle and fractional shortening (FS) of left ventricle. Right ventricular systolic function could be assessed reliably by the parameters derived from TIC with right ventricular contrast echocardiography. The k, HT and MTT are reliable indices for quantitative assessment of right ventricular systolic function.展开更多
Objective: The aim of our study was to investigate the value of dynamic contrast-enhanced MRI for evaluating differential diagnosis of pulmonary isolated lesions. Methods: Twenty-nine consecutive patients enrolled i...Objective: The aim of our study was to investigate the value of dynamic contrast-enhanced MRI for evaluating differential diagnosis of pulmonary isolated lesions. Methods: Twenty-nine consecutive patients enrolled in this study, all of whom underwent DCE-MRI examinations and received a histologic and clinical diagnosis. Among these, lung tuberculoma 7 cases, harmatoma 3 cases, peripheral lung cancer 19 cases. DCE-MRI was acquired with 3D LAVA technique, total 18 phases were acquired, scanner time of per phase was 5-7″. After contrasting agent, twice successive scanning was acquired at 10″ and 50″. Then 1′30″, 2′, 2′30″, 3′, 3′30″, 4′, 5′, 6′, 7′, 8′, 9′, 10′, 11′, 12′ performed scanning. Region of interest was placed on the Maximum level in the tumors. According to Schaefer's standard, four types of time signal intensity curve (TIC) were classified, which were A, B, C and D. Compared the dynamic parameters between benign and malignant nodules. Results: Lung tuberculoma may display three curves: A type 1 case, ring-shaped enhancement 4 cases (periphery ring A type, central region D type), D type 2 cases. Harmatoma may display three curves: A type 1 case, C type 2 case. Peripheral lung cancer may display A type. Except 2 cases D type lung tuberculoma, we compared curve data of 8 cases benign nodules (including tuberculoma Atype and periphery ring Atype, harmatoma Atype and C type) and lung cancer. SlEP%: benign nodules 0.7885 ±0.5543, lung cancer 1.2623 ±0.3059, P 〈 0.05; MER: benign nodules 1.0007 ± 0.4251, lung cancer 1.3694 ±0.2740, P 〈 0.05; washout: P 〉 0.05. Conclusion: Lung MR imaging is helpful to diagnosis and differential diagnosis of isolated benign and malignant nodules. SIEP% and MER could offer valuable information. The evolution of global tuberculosis may be from A type to ring-shaped ennoblement to D type. It was easy to do right diagnosis to lung tuberculoma with ring-shaped ennoblement and D type. Peripheral lung cancer commonly displayed A type and needed identification with acute inflammation. So, it is important to anti-inflammatory follow-up for a few A type nodules.展开更多
The change in rainfall pattern and intensity is becoming a great concern for hydrologic engineers and planners. Many parts of the world are experiencing extreme rainfall events such as experienced on 26<sup>th&l...The change in rainfall pattern and intensity is becoming a great concern for hydrologic engineers and planners. Many parts of the world are experiencing extreme rainfall events such as experienced on 26<sup>th</sup> July 2005 in Mumbai, India. For the appropriate design and planning of urban drainage system in an area, Intensity Duration Frequency (IDF) curves for given rainfall conditions are required. The aim of the present study is to derive the IDF curves for the rainfall in the Mumbai city, Maharashtra, India. Observed rainfall data from 1901 pertaining to Colaba and from 1951 of the Santacruz rain gauge stations in Mumbai are used in the present study to derive the IDF curves. Initially, the proposed IDF curves are derived using an empirical equation (Kothyari and Garde), by using probability distribution for annual maximum rainfall and then IDF curves are derived by modifying the equation. IDF curves developed by the modified equation gives good results in the changing hydrologic conditions and are compatible even with the extreme rainfall of 26<sup>th</sup> July 2005 in Mumbai.展开更多
Objective/Background: Qualitative assessment of uncertain (type II) time-intensity curves (TICs) in breast DCE-MRI is problematic and operator dependent. The aim of this work is to evaluate if a semi-quantitative asse...Objective/Background: Qualitative assessment of uncertain (type II) time-intensity curves (TICs) in breast DCE-MRI is problematic and operator dependent. The aim of this work is to evaluate if a semi-quantitative assessment of uncertain TICs could improve overall diagnostic performance. Methods: In this study 49 lesions from 44 patients were retrospectively analysed. Per each lesion one region-of-interest (ROI)- averaged TIC was qualitatively evaluated by two radiologists in consensus: all the ROIs resulted in type II (uncertain) TIC. The same TICs were semi-quantitatively re-classified on the basis of the difference between the signal intensities of the last-time-point and of the peak: this difference was classified according to two different cut-off ranges (±5% and ±3%). All patients were cytological or histological biopsy proven. Fisher test and McNemar test were performed to evaluate if results were statistically significant (p < 0.05). Results: Using ±5% cut-off 16 TICs were reclassified as type III and 12 as type I while 21 were reclassified again as type II. Using ±3% 22 TICs were reclassified as type III and 16 as type I while 11 were reclassified again as type II. The semi-quantitative classification was compared to the histological-cytological results: the sensitivity, specificity, positive and negative predictive values obtained with ±3% were 77%, 91%, 91% and 78% respectively while using ±5% were 58%, 96%, 94% and 68% respectively. Using the ±5% cut-off 26/28 (93%) TICs were correctly reclassified while using the ±3% cut-off 34/38 (90%) TICs were correctly reclassified (p < 0.05). Conclusions: Semi-quantitative methods in kinetic curve assessment on DCE-MRI could improve classification of qualitatively uncertain TICs, leading to a more accurate classification of suspicious breast lesions.展开更多
Examinations with a visualisation of the anatomy and pathology of the gastrointestinal(GI) tract are often necessary for the diagnosis of GI diseases.Traditional radiology played a crucial role for many years.Endoscop...Examinations with a visualisation of the anatomy and pathology of the gastrointestinal(GI) tract are often necessary for the diagnosis of GI diseases.Traditional radiology played a crucial role for many years.Endoscopy,despite some limitations,remains the main technique in the differential diagnosis and treatment of GI diseases.In the last decades,the introduction of,and advances in,non-invasive cross-sectional imaging modalities,including ultrasound(US),computed tomography(CT),positron-emission tomography(PET),and magnetic resonance imaging,as well as improvements in the resolution of imaging data,the acquisition of 3D images,and the introduction of contrast-enhancement,have modified the approach to the examination of the GI tract.Moreover,additional co-registration techniques,such as PET-CT and PET-MRI,allow multimodal data acquisition with better sensitivity and specificity in the study of tissue pathology.US has had a growing role in the development and application of the techniques for diagnosis and management of GI diseases because it is inexpensive,non-invasive,and more comfortable for the patient,and it has sufficient diagnostic accuracy toprovide the clinician with image data of high temporal and spatial resolution.Moreover,Doppler and contrastenhanced ultrasound(CEUS) add important information about blood flow.This article provides a general review of the current literature regarding imaging modalities used for the evaluation of bowel diseases,highlighting the role of US and recent developments in CEUS.展开更多
The energy level shifts of hydrogen in the space curved by the intense short laser pulses are studied. It shows that for present power level of laser pulses, the magnitude of the energy level shifts in a highly ex...The energy level shifts of hydrogen in the space curved by the intense short laser pulses are studied. It shows that for present power level of laser pulses, the magnitude of the energy level shifts in a highly excited hydrogen atom is detectable.展开更多
Aim The general arbitrary cracked problem in an elastic plane was discussed. Methods For the purpose of acquiring the solution of the problem, a new formulation on the problem was proposed. Compared with the classic...Aim The general arbitrary cracked problem in an elastic plane was discussed. Methods For the purpose of acquiring the solution of the problem, a new formulation on the problem was proposed. Compared with the classical plane elastic crack model, only the known conditions were revised in the new formulation, which are greatly convenient to solve the problem, and no other new condition was given. Results and Conclusion The general exact analytic solution is given here based on the formulation though the problem is very complicated. Furthermore, the stress intensity factors K Ⅰ, K Ⅱ of the problem are also given.展开更多
The weakly singular integral equation sued to solve the problem ofthe curved crack crossing the boundary of the antiplane circularinclusion is presented. Using the principal part analysis method ofthe Cauchy type inte...The weakly singular integral equation sued to solve the problem ofthe curved crack crossing the boundary of the antiplane circularinclusion is presented. Using the principal part analysis method ofthe Cauchy type integral equation, the singular stress index at theintersection and the singular stress of angular Regions near theintersection are obtained. By using the singular stress obtained, thestress intensity factor at The intersection is defined. After thenumerical solution of the integral equation, the stress intensityfactors at The end points of the crack and intersection areobtainable.展开更多
The selection of optimal intensity measures(IMs)has been recommended for generating the seismic demand models with different probabilities by researchers since the seismic IMs are closely associated with earthquake ri...The selection of optimal intensity measures(IMs)has been recommended for generating the seismic demand models with different probabilities by researchers since the seismic IMs are closely associated with earthquake risks and structural safety.However,the seismic design code(mainly for aboveground structures)and dynamic analysis of underground structures conventionally employ the peak ground acceleration(PGA)as an optimal IM.In this paper,the research is to identify the optimal scalar and vector IMs in the fragility investigation of deep-buried hydraulic arched tunnels using the finite element method.A refinement process was performed to determine the optimal scalar IMs by comprehensively comparing their correlation,efficiency,practicality,proficiency,and sufficiency among the examined IMs.Furtherly,the optimum vector IMs were also developed,followed by the three different scalar IMs.Eventually,the dif-ferences between the fragility curves of the tunnel produced using the optimal scalar and vector IM were compared.The generated vector fragility surface can be used to estimate the seismic fragility of identical hydraulic tunnels in an approximative manner.展开更多
Tidal bore is a special and intensive form of flow movement induced by tidal effect in estuary areas, which has complex characteristics of profile, propagation and flow velocity. Although it has been widely studied fo...Tidal bore is a special and intensive form of flow movement induced by tidal effect in estuary areas, which has complex characteristics of profile, propagation and flow velocity. Although it has been widely studied for the generation mechanism, propagation features and influencing factors, the curved channel will complicate the characteristics of tidal bore propagation, which need further investigation compared with straight channel. In this study, the flume experiments for both undular and breaking bores’ propagation in curved channel are performed to measure the freesurface elevation and flow velocity by ultrasonic sensors and ADV respectively. The propagation characteristics,including tidal bore height, cross-section surface gradient, tidal bore propagation celerity, and flow velocity are obtained for both sides of the curved channel. And three bore intensities are set for each type of tidal bores. The freesurface gradients are consistently enlarged in high-curvature section for undular and breaking bores, but have distinct behaviors in low-curvature section. The spatial distributions of tidal bore propagation celerity and flow velocity are compared between concave and convex banks. This work will provide experimental reference for engineering design of beach and seawall protection, erosion reduction and siltation promotion in estuary areas with the existence of tidal bores.展开更多
目的:探讨经直肠超声造影(contrast-enhanced transrectal ultrasound)时间-强度曲线(time-intensity curve,TIC)参数评估前列腺癌(prostate cancer,PCa)患者对新辅助内分泌治疗(neoadjuvant hormonal therapy,NHT)的反应程度。方法:纳...目的:探讨经直肠超声造影(contrast-enhanced transrectal ultrasound)时间-强度曲线(time-intensity curve,TIC)参数评估前列腺癌(prostate cancer,PCa)患者对新辅助内分泌治疗(neoadjuvant hormonal therapy,NHT)的反应程度。方法:纳入27例接受NHT的PCa患者的临床资料,根据术后病理学检查结果分为有效组(n=16)和无效组(n=11)。对比两组患者临床病理学特征、治疗前后血清前列腺特异性抗原(prostate-specific antigen,PSA)和CETRUS检查指标及其变化率,以筛选与NHT反应性有关的潜在指标。进一步采用相关性分析评价其在评估患者对NHT反应方面的价值。结果:有效组和无效组在临床病理学特征、治疗前的血清PSA和C E T R U S检查指标方面的差异无统计学意义(均P>0.05)。治疗后,仅有效组的TIC曲线下面积(area under curve,AUC)低于无效组(560 dB·s vs 710 dB·s),其变化率大于无效组(-27.1%vs-5.3%)(均P<0.05)。相关性分析显示AUC变化率与组织学反应评分之间的相关性略高于治疗后AUC(r为-0.690 vs-0.630)。结论:CETRUS TIC参数中,NHT后的AUC及其变化率在评估PCa患者对NHT反应方面具有较好的价值。其中,AUC变化率可能与治疗反应程度更相关。展开更多
文摘AIM: To evaluate the ability of the time-signal intensity curve (TIC) of the pancreas obtained from dynamic contrast-enhanced magnetic resonance imaging (MRI) for differentiation of focal pancreatic masses, especially pancreatic carcinoma coexisting with chronic pancreatitis and tumor-forming pancreatitis. METHODS: Forty-eight consecutive patients who underwent surgery for a focal pancreatic mass, including pancreatic ductal carcinoma (n = 33), tumor-forming pancreatitis (n = 8), and islet cell tumor (n = 7), were reviewed. Five pancreatic carcinomas coexisted with longstanding chronic pancreatitis. The pancreatic TICs were obtained from the pancreatic mass and the pancreatic parenchyma both proximal and distal to the mass lesion in each patient, prior to surgery, and were classified into 4 types according to the time to a peak: 25 s and 1, 2, and 3 min after the bolus injection of contrast material, namely, type-Ⅰ, Ⅱ, Ⅲ, and Ⅳ, respectively, and were then compared to the corresponding histological pancreatic conditions. RESULTS: Pancreatic carcinomas demonstrated type-Ⅲ (n = 13) or Ⅳ (n = 20) TIC. Tumor-forming pancreatitis showed type-Ⅱ (n = 5) or Ⅲ (n = 3) TIC. All islet cell tumors revealed type-Ⅰ. The type-Ⅳ TIC was only recognized in pancreatic carcinoma, and the TIC of carcinoma always depicted the slowest rise to a peak among the 3 pancreatic TICs measured in each patient, even in patients with chronic pancreatitis.CONCLUSION: Pancreatic TIC from dynamic MRI provides reliable information for distinguishing pancreatic carcinoma from other pancreatic masses, and may enable us to avoid unnecessary pancreatic surgery and delays in making a correct diagnosis of pancreatic carcinoma, especially, in patients with longstanding chronic pancreatitis.
文摘In this study the probable seismic behavior of skewed bridges with continuous decks under earthquake excitations from different directions is investigated. A 45° skewed bridge is studied. A suite of 20 records is used to perform an Incremental Dynamic Analysis (IDA) for fragility curves. Four different earthquake directions have been considered: -45°, 0°, 22.5, 45°. A sensitivity analysis on different spectral intensity measures is presented; efficiency and practicality of different intensity measures have been studied. The fragility curves obtained indicate that the critical direction for skewed bridges is the skew direction as well as the longitudinal direction. The study shows the importance of finding the most critical earthquake in understanding and predicting the behavior of skewed bridges.
文摘The reliability and reliable indexes of q ua ntitative assessment of coronary flow reserve (CFR) by using time intensity cur ve (TIC) via myocardial contrast echocardiography were investigated. The TIC var iables were obtained by employing acoustic densitometry (AD) technique before an d after acetylcholine (Ach) injection in 12 dogs. Meanwhile, the correlation be tween these variables and CFR was analyzed. Among the variables derived from TIC , peak intensity (PI), area under the curve (AUC) and descending slope (DS) were increased significantly ( P <0.05) with the increase of coronary blood flow a fter Ach injection. Conversely, time to peak (TP), half time of descent (HT) , and mean transit time (MTT) were decreased remarkably ( P <0.0001). Th e P I and AUC ratios from post to pre Ach injection were strongly associated with CFR with the correlation coefficient (r) being 0.8366 and 0.8824, respectively. It is reliable by using the variables derived from TIC with myocardial contrast echocardiography to quantitatively evaluate regional myocardial CFR. The PI an d AUC ratios from post to pre Ach injection are the reliable indexes for quan titative assessment of CFR.
文摘Summary: To study reliability and reliable indices of quantitative assessment of right ventricular systolic function by time-intensity curve (TIC) with right ventricular contrast, 5 % sonicated human albumin was injected intravenously at a does of 0.08 ml/kg into 10 dogs at baseline status and cardiac insufficiency. Apical four-chamber view was observed for washin and washout of contrast agent from right ventricle. The parameters of TIC were obtained by curve fitting. The differences of parameters were analyzed in different states of cardiac functions. Among the parameters derived from TIC, the time constant (k) was decreased significantly with decline of cardiac function (P<0.001). But half-time of decent of peak intensity (HT) and mean-transit-time (MTT) of washout were increased significantly (P<0.001). The k was strongly related to cardiac output of right ventricle (CO) and ejection fraction (EF) of left ventricle and fractional shortening (FS) of left ventricle. Right ventricular systolic function could be assessed reliably by the parameters derived from TIC with right ventricular contrast echocardiography. The k, HT and MTT are reliable indices for quantitative assessment of right ventricular systolic function.
文摘Objective: The aim of our study was to investigate the value of dynamic contrast-enhanced MRI for evaluating differential diagnosis of pulmonary isolated lesions. Methods: Twenty-nine consecutive patients enrolled in this study, all of whom underwent DCE-MRI examinations and received a histologic and clinical diagnosis. Among these, lung tuberculoma 7 cases, harmatoma 3 cases, peripheral lung cancer 19 cases. DCE-MRI was acquired with 3D LAVA technique, total 18 phases were acquired, scanner time of per phase was 5-7″. After contrasting agent, twice successive scanning was acquired at 10″ and 50″. Then 1′30″, 2′, 2′30″, 3′, 3′30″, 4′, 5′, 6′, 7′, 8′, 9′, 10′, 11′, 12′ performed scanning. Region of interest was placed on the Maximum level in the tumors. According to Schaefer's standard, four types of time signal intensity curve (TIC) were classified, which were A, B, C and D. Compared the dynamic parameters between benign and malignant nodules. Results: Lung tuberculoma may display three curves: A type 1 case, ring-shaped enhancement 4 cases (periphery ring A type, central region D type), D type 2 cases. Harmatoma may display three curves: A type 1 case, C type 2 case. Peripheral lung cancer may display A type. Except 2 cases D type lung tuberculoma, we compared curve data of 8 cases benign nodules (including tuberculoma Atype and periphery ring Atype, harmatoma Atype and C type) and lung cancer. SlEP%: benign nodules 0.7885 ±0.5543, lung cancer 1.2623 ±0.3059, P 〈 0.05; MER: benign nodules 1.0007 ± 0.4251, lung cancer 1.3694 ±0.2740, P 〈 0.05; washout: P 〉 0.05. Conclusion: Lung MR imaging is helpful to diagnosis and differential diagnosis of isolated benign and malignant nodules. SIEP% and MER could offer valuable information. The evolution of global tuberculosis may be from A type to ring-shaped ennoblement to D type. It was easy to do right diagnosis to lung tuberculoma with ring-shaped ennoblement and D type. Peripheral lung cancer commonly displayed A type and needed identification with acute inflammation. So, it is important to anti-inflammatory follow-up for a few A type nodules.
文摘The change in rainfall pattern and intensity is becoming a great concern for hydrologic engineers and planners. Many parts of the world are experiencing extreme rainfall events such as experienced on 26<sup>th</sup> July 2005 in Mumbai, India. For the appropriate design and planning of urban drainage system in an area, Intensity Duration Frequency (IDF) curves for given rainfall conditions are required. The aim of the present study is to derive the IDF curves for the rainfall in the Mumbai city, Maharashtra, India. Observed rainfall data from 1901 pertaining to Colaba and from 1951 of the Santacruz rain gauge stations in Mumbai are used in the present study to derive the IDF curves. Initially, the proposed IDF curves are derived using an empirical equation (Kothyari and Garde), by using probability distribution for annual maximum rainfall and then IDF curves are derived by modifying the equation. IDF curves developed by the modified equation gives good results in the changing hydrologic conditions and are compatible even with the extreme rainfall of 26<sup>th</sup> July 2005 in Mumbai.
文摘Objective/Background: Qualitative assessment of uncertain (type II) time-intensity curves (TICs) in breast DCE-MRI is problematic and operator dependent. The aim of this work is to evaluate if a semi-quantitative assessment of uncertain TICs could improve overall diagnostic performance. Methods: In this study 49 lesions from 44 patients were retrospectively analysed. Per each lesion one region-of-interest (ROI)- averaged TIC was qualitatively evaluated by two radiologists in consensus: all the ROIs resulted in type II (uncertain) TIC. The same TICs were semi-quantitatively re-classified on the basis of the difference between the signal intensities of the last-time-point and of the peak: this difference was classified according to two different cut-off ranges (±5% and ±3%). All patients were cytological or histological biopsy proven. Fisher test and McNemar test were performed to evaluate if results were statistically significant (p < 0.05). Results: Using ±5% cut-off 16 TICs were reclassified as type III and 12 as type I while 21 were reclassified again as type II. Using ±3% 22 TICs were reclassified as type III and 16 as type I while 11 were reclassified again as type II. The semi-quantitative classification was compared to the histological-cytological results: the sensitivity, specificity, positive and negative predictive values obtained with ±3% were 77%, 91%, 91% and 78% respectively while using ±5% were 58%, 96%, 94% and 68% respectively. Using the ±5% cut-off 26/28 (93%) TICs were correctly reclassified while using the ±3% cut-off 34/38 (90%) TICs were correctly reclassified (p < 0.05). Conclusions: Semi-quantitative methods in kinetic curve assessment on DCE-MRI could improve classification of qualitatively uncertain TICs, leading to a more accurate classification of suspicious breast lesions.
文摘Examinations with a visualisation of the anatomy and pathology of the gastrointestinal(GI) tract are often necessary for the diagnosis of GI diseases.Traditional radiology played a crucial role for many years.Endoscopy,despite some limitations,remains the main technique in the differential diagnosis and treatment of GI diseases.In the last decades,the introduction of,and advances in,non-invasive cross-sectional imaging modalities,including ultrasound(US),computed tomography(CT),positron-emission tomography(PET),and magnetic resonance imaging,as well as improvements in the resolution of imaging data,the acquisition of 3D images,and the introduction of contrast-enhancement,have modified the approach to the examination of the GI tract.Moreover,additional co-registration techniques,such as PET-CT and PET-MRI,allow multimodal data acquisition with better sensitivity and specificity in the study of tissue pathology.US has had a growing role in the development and application of the techniques for diagnosis and management of GI diseases because it is inexpensive,non-invasive,and more comfortable for the patient,and it has sufficient diagnostic accuracy toprovide the clinician with image data of high temporal and spatial resolution.Moreover,Doppler and contrastenhanced ultrasound(CEUS) add important information about blood flow.This article provides a general review of the current literature regarding imaging modalities used for the evaluation of bowel diseases,highlighting the role of US and recent developments in CEUS.
文摘The energy level shifts of hydrogen in the space curved by the intense short laser pulses are studied. It shows that for present power level of laser pulses, the magnitude of the energy level shifts in a highly excited hydrogen atom is detectable.
文摘Aim The general arbitrary cracked problem in an elastic plane was discussed. Methods For the purpose of acquiring the solution of the problem, a new formulation on the problem was proposed. Compared with the classical plane elastic crack model, only the known conditions were revised in the new formulation, which are greatly convenient to solve the problem, and no other new condition was given. Results and Conclusion The general exact analytic solution is given here based on the formulation though the problem is very complicated. Furthermore, the stress intensity factors K Ⅰ, K Ⅱ of the problem are also given.
基金National Natural Science Foundation of China(No.59879012)the project of Chinese Foundation of State Education Commission(No.98024832)
文摘The weakly singular integral equation sued to solve the problem ofthe curved crack crossing the boundary of the antiplane circularinclusion is presented. Using the principal part analysis method ofthe Cauchy type integral equation, the singular stress index at theintersection and the singular stress of angular Regions near theintersection are obtained. By using the singular stress obtained, thestress intensity factor at The intersection is defined. After thenumerical solution of the integral equation, the stress intensityfactors at The end points of the crack and intersection areobtainable.
基金support from the National Natural Science Foundation of China(Grant No.52209169).
文摘The selection of optimal intensity measures(IMs)has been recommended for generating the seismic demand models with different probabilities by researchers since the seismic IMs are closely associated with earthquake risks and structural safety.However,the seismic design code(mainly for aboveground structures)and dynamic analysis of underground structures conventionally employ the peak ground acceleration(PGA)as an optimal IM.In this paper,the research is to identify the optimal scalar and vector IMs in the fragility investigation of deep-buried hydraulic arched tunnels using the finite element method.A refinement process was performed to determine the optimal scalar IMs by comprehensively comparing their correlation,efficiency,practicality,proficiency,and sufficiency among the examined IMs.Furtherly,the optimum vector IMs were also developed,followed by the three different scalar IMs.Eventually,the dif-ferences between the fragility curves of the tunnel produced using the optimal scalar and vector IM were compared.The generated vector fragility surface can be used to estimate the seismic fragility of identical hydraulic tunnels in an approximative manner.
基金supported by the National Key Research and Development Program of China (Grant No.2022YFE0104500)the National Natural Science Foundation of China (Grant No. 52271271)+2 种基金the National Natural Science Foundation of China (Grant No. 41906183)the National Natural Science Foundation of China (Grant No.52101308)the Fundamental Research Funds for the Central Universities (Grant No.B220202080)。
文摘Tidal bore is a special and intensive form of flow movement induced by tidal effect in estuary areas, which has complex characteristics of profile, propagation and flow velocity. Although it has been widely studied for the generation mechanism, propagation features and influencing factors, the curved channel will complicate the characteristics of tidal bore propagation, which need further investigation compared with straight channel. In this study, the flume experiments for both undular and breaking bores’ propagation in curved channel are performed to measure the freesurface elevation and flow velocity by ultrasonic sensors and ADV respectively. The propagation characteristics,including tidal bore height, cross-section surface gradient, tidal bore propagation celerity, and flow velocity are obtained for both sides of the curved channel. And three bore intensities are set for each type of tidal bores. The freesurface gradients are consistently enlarged in high-curvature section for undular and breaking bores, but have distinct behaviors in low-curvature section. The spatial distributions of tidal bore propagation celerity and flow velocity are compared between concave and convex banks. This work will provide experimental reference for engineering design of beach and seawall protection, erosion reduction and siltation promotion in estuary areas with the existence of tidal bores.
文摘目的:探讨经直肠超声造影(contrast-enhanced transrectal ultrasound)时间-强度曲线(time-intensity curve,TIC)参数评估前列腺癌(prostate cancer,PCa)患者对新辅助内分泌治疗(neoadjuvant hormonal therapy,NHT)的反应程度。方法:纳入27例接受NHT的PCa患者的临床资料,根据术后病理学检查结果分为有效组(n=16)和无效组(n=11)。对比两组患者临床病理学特征、治疗前后血清前列腺特异性抗原(prostate-specific antigen,PSA)和CETRUS检查指标及其变化率,以筛选与NHT反应性有关的潜在指标。进一步采用相关性分析评价其在评估患者对NHT反应方面的价值。结果:有效组和无效组在临床病理学特征、治疗前的血清PSA和C E T R U S检查指标方面的差异无统计学意义(均P>0.05)。治疗后,仅有效组的TIC曲线下面积(area under curve,AUC)低于无效组(560 dB·s vs 710 dB·s),其变化率大于无效组(-27.1%vs-5.3%)(均P<0.05)。相关性分析显示AUC变化率与组织学反应评分之间的相关性略高于治疗后AUC(r为-0.690 vs-0.630)。结论:CETRUS TIC参数中,NHT后的AUC及其变化率在评估PCa患者对NHT反应方面具有较好的价值。其中,AUC变化率可能与治疗反应程度更相关。