Computer science continues to grow at a rapid pace,raising the issue of how universities can best adapt to this trend.At the third Global Forum on the Development of Computer Science(GFDCS),five heads of departments o...Computer science continues to grow at a rapid pace,raising the issue of how universities can best adapt to this trend.At the third Global Forum on the Development of Computer Science(GFDCS),five heads of departments of computer science from Asia,Europe,and North America came together to exchange ideas under the theme Challenges and Opportunities of Computer Science in the New Era.Through the discussions,a number of new challenges were explored,including how to meet the growing demand for computer science education,how to manage increased teaching loads,how to foster collaboration between computer science and other disciplines,how to raise ethical awareness,and how to support new“transdisciplinary”modes of education and research.At the same time,there was a consensus on the need to strengthen the role of computer science in other departments,the importance of industrial collaboration,and the need for more scalable approaches to teaching.The evolving role of computer science within the context of broader science was also discussed.展开更多
Instead of relying on the erroneous principles of Special Relativity, this paper proposes a new theory based on the emission of photons by a source and their re-emission by a transparent medium. Through over 60 articl...Instead of relying on the erroneous principles of Special Relativity, this paper proposes a new theory based on the emission of photons by a source and their re-emission by a transparent medium. Through over 60 articles, we have demonstrated that Special Relativity is based on optical experiments and observations that have been incorrectly explained by the theory of a non-existent ether. Our findings show that all known experiments can be explained using classical concepts of space and time, thereby refuting the theory of relativity. This article also addresses the fallacy of the widely accepted etheric Doppler effects and its significant role in the history of science.展开更多
Punched steel sheets (metal sheets or foils) as thi n as 0.1mm are quite useful in the field of filters and various precision instrume nts. Thus, we have to develop more accurate and speedy techniques for punching t h...Punched steel sheets (metal sheets or foils) as thi n as 0.1mm are quite useful in the field of filters and various precision instrume nts. Thus, we have to develop more accurate and speedy techniques for punching t hin sheets. The traditional punching method uses an up-down pressing motion of a punch or a die on a strip of metal. The efficiency of this method is determine d by the speed of the motion. In the case of punching a sequence of tiny holes w ith a few millimeters’ interval, the speed of feeding a strip of metal to the p unching machine cannot exceed only a couple of meters per minute. We have de veloped a new technique for punching tiny holes with a pair of rotating bodies i n order to increase the feeding speed up to 100 meters per minute. Our proposed technique is shown in Fig.1 where the female tool has a round blade and the male tool has an M-shape boss. In addition, the setting of two tools i s alternating. The interference between them cannot occur because the clearance between the front and the back edge of the male tool and the female tool in the rotating direction becomes infinite in this configuration. An appropriate cleara nce is given for the thickness of the sheet between the side edge of the male to ol and the female tool. The punching itself is done by shearing. The side edge o f the male tool does contact with the female tool, but they cannot be interferin g. Our technique has another advantage to the traditional up-down pressing mach ine where the stamped out chips are hard to be discharged. It is quite easy in o ur proposed technique. Fig.2, 3 show a sample of punched material [TPP116A,+39mm88mm,Y,PZ#]Fig.1 The configuration of the punching parts using the sequential punching system.[TPP116B,+43mm155mm,X,BP#]Fig.2 A sample of punched material using the continuous punch ing lineFig.3 A exterior picture of a piece of punched steel foil(coi l) using the continuous punching For our developed high speed punching system, it is shown for (1) the configurat ion of punching tool and the punching mechanism, (2) the influence of male shape on punched hole quality, (3) the outline of continuous punching system, (4) the relation between punching speed and accuracy of hole pitch and hole dimensi on, (5) the mechanical property of punched metal sheet and (6) capability of hig her punching.展开更多
A fluorescence polarization immunoassay (FPIA) was developed for the analysis ofaflatoxins (AFs) using an anti-aflatoxin B1 (AFB1) monoclonal antibody and a novel fluorescein-labeled AFB1 tracer. The FPIA showed...A fluorescence polarization immunoassay (FPIA) was developed for the analysis ofaflatoxins (AFs) using an anti-aflatoxin B1 (AFB1) monoclonal antibody and a novel fluorescein-labeled AFB1 tracer. The FPIA showed an IC50 value of 23.33 ng/mL with a limit of detection of 13.12 ng/mL for AFB1. The cross-reactivities of AFB1, AFB2, AFG1, AFG2, AFM1, and AFM2 with the antibody were 100%, 65.7%, 143%, 23.5%, 111.4%, and 2%, respectively. The group-specificity of anti-AFB1mAb indicated that the FPIA could potentially be used in a screening method for the detection of total AFs, albeit not AFG2 and AFM2. The total time required for analyzing 96 samples in one microplate was less than 5 rain. This study demonstrates the potential usefulness of the FPIA as a rapid and simple technique for monitoring AFs.展开更多
Target of research in subarachnoid hemorrhage(SAH):The outcome of aneurysmal SAH remains poor despite advances in the diagnosis and treatment.Although many factors related to patients,aneurysms,and institutions,as ...Target of research in subarachnoid hemorrhage(SAH):The outcome of aneurysmal SAH remains poor despite advances in the diagnosis and treatment.Although many factors related to patients,aneurysms,and institutions,as well as physiological parameters and medical complications were reported as prognostic factors,展开更多
Objective The production of coal fines is very common in the development of coalbed methane(CBM)in the eastern margin of the Ordos Basin,China.A large amount of produced coal fines seriously affect the productivity ...Objective The production of coal fines is very common in the development of coalbed methane(CBM)in the eastern margin of the Ordos Basin,China.A large amount of produced coal fines seriously affect the productivity of CBM wells(Wei Yingchun et al.,2013).Therefore,the production problems of CBM wells caused by coal fines have attracted extensive attention.展开更多
Several groups in the USA have been working to de-velop a low chill apricot that would ripen its fruits veryearly in the season. Unfortunately, the cultivatcd apricothas been developed mainly from the high chilling Eu...Several groups in the USA have been working to de-velop a low chill apricot that would ripen its fruits veryearly in the season. Unfortunately, the cultivatcd apricothas been developed mainly from the high chilling Euro-pean group within the species Prunus armeniaca. Amongthe five groups within the apricot species, this is the mostrecently evolved and least variable (Bailey and展开更多
Dear Editor: I would like to congratulate Zhou et al.[1] on their study of the correlation between expression of lysyl oxidase-like 1 (LOX-1) and fibulin-5 (F5) in the car- dinal ligament tissue and pelvic organ ...Dear Editor: I would like to congratulate Zhou et al.[1] on their study of the correlation between expression of lysyl oxidase-like 1 (LOX-1) and fibulin-5 (F5) in the car- dinal ligament tissue and pelvic organ prolapse (POP). In their elegant work, they evaluated the levels of LOX-1 and F5 in connective tissue of the cardinal ligament in order to demonstrate signs of elastinopa- thy in women with POP. They stress the concept that several environmental risk factors could cause qualitative and quantitative changes in the connective tissue promoting POP. The above authors conclude that the specific mechanism of LOXL1 and F5 involved in the development of POP is unclear.展开更多
The use of exogenous carbon monoxide releasing molecules(CORMs)provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 w...The use of exogenous carbon monoxide releasing molecules(CORMs)provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to400μmol/L during 4-144 h post fertilization.Toxicity endpoints of mortality,spontaneous movement,heart rate,hatching rate,malformation,body length,and larval behavior were measured.展开更多
By using non-static atmosphere equations including basic current, heating force and friction, we discuss the balance amplitude of vertical motion in the conditions of constant heating force, linear and non-linear inte...By using non-static atmosphere equations including basic current, heating force and friction, we discuss the balance amplitude of vertical motion in the conditions of constant heating force, linear and non-linear interaction between large-scale ascending motion and diabatic heating force. In the non-linear condition, the multiple equilibrium feature of the tropical cyclone development is discussed and the reason of the sudden varying of tropical cyclone intensity is studied preliminarily.展开更多
The Philippines was in the 1960s a model of development in Asia and second to Japan,but occupies presently only the 11th position under South-East and East Asian countries in terms of GDP-per capita.The article explor...The Philippines was in the 1960s a model of development in Asia and second to Japan,but occupies presently only the 11th position under South-East and East Asian countries in terms of GDP-per capita.The article explores why this important Asian country with a long colonial past and enormous economic potential still ranks under lower-income countries and has in the last decades let pass by many other Asian countries.In answering this question,the approach of external triggers for accelerated development is being applied.In stark contrast to the success stories of the strongly outward-looking Asian countries like the four Tigers,later of Thailand and Vietnam the Philippines never developed a vision of an open economy connecting pro-actively to the world markets.Trade is hampered by a non-competitive and highly protected national economy.The existing FDI is more oriented to the profitable local markets.Foreign debts were never effectively used and international tourism was never well promoted.Linking these failures to the existing power structures in the country,it seems very much that the backward forces like the big landowners,the local producers and industrialists never wanted and continue not to want to open up the economy to international competition and governments are complacent with these groups.Various indicators demonstrate the long-term decline of the Philippines:Among them the slow growth of the GDP and the continuously high poverty rates.As the alliance of big business and policy holds firm no change in the failing nationalistic economic model can be detected leaving the bleak outlook that the economic decline will continue.展开更多
Schwann cells are the myelinating glial cells of the peripheral nervous system(PNS).By establishing lipid-rich myelin sheaths around large-caliber axons,they ensure that electrical signal transmission is accelerated...Schwann cells are the myelinating glial cells of the peripheral nervous system(PNS).By establishing lipid-rich myelin sheaths around large-caliber axons,they ensure that electrical signal transmission is accelerated-a process referred to as saltatory signal propagation.Apart from this prominent physiological function,these cells also exert important pathophysiological roles in PNS injuries or dis- eases. In contrast to the central nervous system (CNS), the adult PNS retains a remarkably high degree of intrinsic re- generation. As a consequence, transected axons and dam- aged myelin sheaths can be repaired and nerve functional- ity can be restored. This spontaneous regenerative capacity depends on (inter) actions of macrophages, neurons, and Schwann cells.展开更多
This article discusses the important role of mathematical and physical sciences in, and their influence on, the development of natural science and modern technology, as well as social science and the humanities. On th...This article discusses the important role of mathematical and physical sciences in, and their influence on, the development of natural science and modern technology, as well as social science and the humanities. On the basis of the present situation in China, it calls for accelerating the development of the mathematical and physical sciences.展开更多
Quality of Life (QOL) is a multiphase conception, including physical, mental and social factors, and can overall reflect health status of the human. At present, QOL has become a relevant measure of efficacy of treatme...Quality of Life (QOL) is a multiphase conception, including physical, mental and social factors, and can overall reflect health status of the human. At present, QOL has become a relevant measure of efficacy of treatment in clinical trials. Its use is spreading, and its importance is growing as a valid indicator of whether or not a medical treatment is展开更多
In order to compete in the global manufacturing mar ke t, agility is the only possible solution to response to the fragmented market se gments and frequently changed customer requirements. However, manufacturing agil ...In order to compete in the global manufacturing mar ke t, agility is the only possible solution to response to the fragmented market se gments and frequently changed customer requirements. However, manufacturing agil ity can only be attained through the deployment of knowledge. To embed knowledge into a CAD system to form a knowledge intensive CAD (KIC) system is one of way to enhance the design compatibility of a manufacturing company. The most difficu lt phase to develop a KIC system is to capitalize a huge amount of legacy data t o form a knowledge database. In the past, such capitalization process could only be done solely manually or semi-automatic. In this paper, a five step model fo r automatic design knowledge capitalization through the use of data mining is pr oposed whilst details of how to select, verify and performance benchmarking an a ppropriate data mining algorithm for a specific design task will also be discuss ed. A case study concerning the design of a plastic toaster casing was used as an illustration for the proposed methodology and it was found that the avera ge absolute error of the predictions for the most appropriate algorithm is withi n 17%.展开更多
Nowadays, many kinds of software, which have succes sf ully created the integration of CAD, CAPP and CAM, find their disadvantages in p ractical manufacturing. As a result, it is welcomed to develop small CAD/CAPP sy ...Nowadays, many kinds of software, which have succes sf ully created the integration of CAD, CAPP and CAM, find their disadvantages in p ractical manufacturing. As a result, it is welcomed to develop small CAD/CAPP sy stems on a proper CAD platform, which aim at requirements of factories. Based on the one of the most popular three-dimensional design software SolidWorks, we successfully developed a set of gear pump CAD /CAPP software for Huaiyin Gene ral Factory of Mechanics. 1 The architecture and function of the software According to the need of the enterprises, the general structure of the software contain two subsystems, which are detailed as follows: · The gear pump CAD subsystem contains four main modules, including the optiona l design module of gear pump, module of part design, the module of entity modeli ng and the module of drawing which creates 2 D drawings of parts and assembly c orresponding 3 D modals. · The gear pump CAPP subsystem, which is a combination of creative mode and der ivate mode, also includes four modules, they are the module of access to feature s, the module of planning process route, the module of designing process sheets and the module of generating process documents. 2 The developing environment of the system Basing on Windows 98 and SolidWorks2001 platform, this system creates all functi ons by using Visual C++ 6.0 as developing tools. 3 The keys to the CAD/CAPP integration 3.1 The establishment of product information modal The information of parts is the basis of process planning. In this system, we us e feature modeling to describe the information of parts and assembly of gear pum p, and set up a fundamental basis for the whole system. The information module o f gear pump includes the information of both the assembly and the parts; the par t-describing module uses four-layer structure that is subassembly layer, part layer, feature layer and geometric layer. 3.2 The operation of the information on feature modeling After establishment of information mode of gear pump, the next key problem is ho w to transmit information of product to CAPP subsystem. In order to integrate pe rfectly, connecting CAD with CAPP directly can be a good method. In this system, all information of parts is store in the part drawing files, and the CAPP syste m can load these files to get information. The gear pumps, which are produced by Huaiyin General Factory of Mechanics, are usually belong to several similar typ es, and this means that most products possess large number of similar feature. T herefore, we can easily establish a specific feature for gear pump CAD/CAPP syst em. All parts are created by selecting these features and/or adding few special features. In the module of access to feature of CAPP subsystem, the main task is to find the features and the information will be easily got. 4 Conclusion This system successfully creates gear pump CAD/CAPP integration based on SolidWo rks. 3D CAD software provide more convenient platform for integration and will i nevitably become the mainstream of product design. By developing this system, we clearly realize the promising future of SolidWorks.展开更多
The possible role of submandiblular glands (SMG) in the development of obesity was studied in two types of genetically obese mice, ob/ob and yellow Ay: Obesity is caused by hyperplasia followed by hypertrophy in ob/ob...The possible role of submandiblular glands (SMG) in the development of obesity was studied in two types of genetically obese mice, ob/ob and yellow Ay: Obesity is caused by hyperplasia followed by hypertrophy in ob/ob mice and mainly by hypertrophy in Ay mice.The histological features of SMGs exhibited clear sexual dimorphism in both mice similarto lean controls. The SMGs of ob/ob mice was smaller in size and had smaller granular convoluted tubular portions than lean controls, while the SMGs of Ay mice did not differ from lean controls. Sialoadenectomy before and after development of obesity gCnerally reduced the gain of body weights in both sexes of Ay mice but not in ob/ob mice. The content of epidermal growth factor (EGF) in the SMGs was higher in Ay mice and lower in ob/ob mice than their controls. The possible role of EGF in the SMGs in the development of obesity is discussed展开更多
The prevalence of obesity and type 2 diabetes mellitus(T2DM)has been increasing throughout the world over the past 20 years.Environmental chemicals known to regulate the endocrine system have been considered as a ri...The prevalence of obesity and type 2 diabetes mellitus(T2DM)has been increasing throughout the world over the past 20 years.Environmental chemicals known to regulate the endocrine system have been considered as a risk factor for the development of metabolic diseases.Several people are exposed to environmental chemicals during their lives.展开更多
文摘Computer science continues to grow at a rapid pace,raising the issue of how universities can best adapt to this trend.At the third Global Forum on the Development of Computer Science(GFDCS),five heads of departments of computer science from Asia,Europe,and North America came together to exchange ideas under the theme Challenges and Opportunities of Computer Science in the New Era.Through the discussions,a number of new challenges were explored,including how to meet the growing demand for computer science education,how to manage increased teaching loads,how to foster collaboration between computer science and other disciplines,how to raise ethical awareness,and how to support new“transdisciplinary”modes of education and research.At the same time,there was a consensus on the need to strengthen the role of computer science in other departments,the importance of industrial collaboration,and the need for more scalable approaches to teaching.The evolving role of computer science within the context of broader science was also discussed.
文摘Instead of relying on the erroneous principles of Special Relativity, this paper proposes a new theory based on the emission of photons by a source and their re-emission by a transparent medium. Through over 60 articles, we have demonstrated that Special Relativity is based on optical experiments and observations that have been incorrectly explained by the theory of a non-existent ether. Our findings show that all known experiments can be explained using classical concepts of space and time, thereby refuting the theory of relativity. This article also addresses the fallacy of the widely accepted etheric Doppler effects and its significant role in the history of science.
文摘Punched steel sheets (metal sheets or foils) as thi n as 0.1mm are quite useful in the field of filters and various precision instrume nts. Thus, we have to develop more accurate and speedy techniques for punching t hin sheets. The traditional punching method uses an up-down pressing motion of a punch or a die on a strip of metal. The efficiency of this method is determine d by the speed of the motion. In the case of punching a sequence of tiny holes w ith a few millimeters’ interval, the speed of feeding a strip of metal to the p unching machine cannot exceed only a couple of meters per minute. We have de veloped a new technique for punching tiny holes with a pair of rotating bodies i n order to increase the feeding speed up to 100 meters per minute. Our proposed technique is shown in Fig.1 where the female tool has a round blade and the male tool has an M-shape boss. In addition, the setting of two tools i s alternating. The interference between them cannot occur because the clearance between the front and the back edge of the male tool and the female tool in the rotating direction becomes infinite in this configuration. An appropriate cleara nce is given for the thickness of the sheet between the side edge of the male to ol and the female tool. The punching itself is done by shearing. The side edge o f the male tool does contact with the female tool, but they cannot be interferin g. Our technique has another advantage to the traditional up-down pressing mach ine where the stamped out chips are hard to be discharged. It is quite easy in o ur proposed technique. Fig.2, 3 show a sample of punched material [TPP116A,+39mm88mm,Y,PZ#]Fig.1 The configuration of the punching parts using the sequential punching system.[TPP116B,+43mm155mm,X,BP#]Fig.2 A sample of punched material using the continuous punch ing lineFig.3 A exterior picture of a piece of punched steel foil(coi l) using the continuous punching For our developed high speed punching system, it is shown for (1) the configurat ion of punching tool and the punching mechanism, (2) the influence of male shape on punched hole quality, (3) the outline of continuous punching system, (4) the relation between punching speed and accuracy of hole pitch and hole dimensi on, (5) the mechanical property of punched metal sheet and (6) capability of hig her punching.
基金supported by grants from the International Science&Technology Cooperation Program of China(2009DFA32330)the Special Fund for Agro-scientific Research in the Public Interest(No.201203040)
文摘A fluorescence polarization immunoassay (FPIA) was developed for the analysis ofaflatoxins (AFs) using an anti-aflatoxin B1 (AFB1) monoclonal antibody and a novel fluorescein-labeled AFB1 tracer. The FPIA showed an IC50 value of 23.33 ng/mL with a limit of detection of 13.12 ng/mL for AFB1. The cross-reactivities of AFB1, AFB2, AFG1, AFG2, AFM1, and AFM2 with the antibody were 100%, 65.7%, 143%, 23.5%, 111.4%, and 2%, respectively. The group-specificity of anti-AFB1mAb indicated that the FPIA could potentially be used in a screening method for the detection of total AFs, albeit not AFG2 and AFM2. The total time required for analyzing 96 samples in one microplate was less than 5 rain. This study demonstrates the potential usefulness of the FPIA as a rapid and simple technique for monitoring AFs.
基金supported by a Grant-in-Aid for Scientific Research from Mie Medical Research Foundation to HS
文摘Target of research in subarachnoid hemorrhage(SAH):The outcome of aneurysmal SAH remains poor despite advances in the diagnosis and treatment.Although many factors related to patients,aneurysms,and institutions,as well as physiological parameters and medical complications were reported as prognostic factors,
基金financially supported by the National Natural Science Foundation of China(grants No.41402134 and 41272181)
文摘Objective The production of coal fines is very common in the development of coalbed methane(CBM)in the eastern margin of the Ordos Basin,China.A large amount of produced coal fines seriously affect the productivity of CBM wells(Wei Yingchun et al.,2013).Therefore,the production problems of CBM wells caused by coal fines have attracted extensive attention.
文摘Several groups in the USA have been working to de-velop a low chill apricot that would ripen its fruits veryearly in the season. Unfortunately, the cultivatcd apricothas been developed mainly from the high chilling Euro-pean group within the species Prunus armeniaca. Amongthe five groups within the apricot species, this is the mostrecently evolved and least variable (Bailey and
文摘Dear Editor: I would like to congratulate Zhou et al.[1] on their study of the correlation between expression of lysyl oxidase-like 1 (LOX-1) and fibulin-5 (F5) in the car- dinal ligament tissue and pelvic organ prolapse (POP). In their elegant work, they evaluated the levels of LOX-1 and F5 in connective tissue of the cardinal ligament in order to demonstrate signs of elastinopa- thy in women with POP. They stress the concept that several environmental risk factors could cause qualitative and quantitative changes in the connective tissue promoting POP. The above authors conclude that the specific mechanism of LOXL1 and F5 involved in the development of POP is unclear.
基金supported by National Basic Research Program of China(2010CB834202)the National Natural Science Foundation of China(11305226,11175222)+1 种基金the Scientific Technology Research Projects of Lanzhou City(2015-3-75)the Western Talent Program of Chinese Academy of Sciences(Y460030XB0)
文摘The use of exogenous carbon monoxide releasing molecules(CORMs)provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to400μmol/L during 4-144 h post fertilization.Toxicity endpoints of mortality,spontaneous movement,heart rate,hatching rate,malformation,body length,and larval behavior were measured.
文摘By using non-static atmosphere equations including basic current, heating force and friction, we discuss the balance amplitude of vertical motion in the conditions of constant heating force, linear and non-linear interaction between large-scale ascending motion and diabatic heating force. In the non-linear condition, the multiple equilibrium feature of the tropical cyclone development is discussed and the reason of the sudden varying of tropical cyclone intensity is studied preliminarily.
文摘The Philippines was in the 1960s a model of development in Asia and second to Japan,but occupies presently only the 11th position under South-East and East Asian countries in terms of GDP-per capita.The article explores why this important Asian country with a long colonial past and enormous economic potential still ranks under lower-income countries and has in the last decades let pass by many other Asian countries.In answering this question,the approach of external triggers for accelerated development is being applied.In stark contrast to the success stories of the strongly outward-looking Asian countries like the four Tigers,later of Thailand and Vietnam the Philippines never developed a vision of an open economy connecting pro-actively to the world markets.Trade is hampered by a non-competitive and highly protected national economy.The existing FDI is more oriented to the profitable local markets.Foreign debts were never effectively used and international tourism was never well promoted.Linking these failures to the existing power structures in the country,it seems very much that the backward forces like the big landowners,the local producers and industrialists never wanted and continue not to want to open up the economy to international competition and governments are complacent with these groups.Various indicators demonstrate the long-term decline of the Philippines:Among them the slow growth of the GDP and the continuously high poverty rates.As the alliance of big business and policy holds firm no change in the failing nationalistic economic model can be detected leaving the bleak outlook that the economic decline will continue.
基金supported by grants from the DFG(German Research Council)Novartis Pharma Gmb H(Nürnberg+2 种基金Germany)Baxter Innovations Gmb H(ViennaGermany)
文摘Schwann cells are the myelinating glial cells of the peripheral nervous system(PNS).By establishing lipid-rich myelin sheaths around large-caliber axons,they ensure that electrical signal transmission is accelerated-a process referred to as saltatory signal propagation.Apart from this prominent physiological function,these cells also exert important pathophysiological roles in PNS injuries or dis- eases. In contrast to the central nervous system (CNS), the adult PNS retains a remarkably high degree of intrinsic re- generation. As a consequence, transected axons and dam- aged myelin sheaths can be repaired and nerve functional- ity can be restored. This spontaneous regenerative capacity depends on (inter) actions of macrophages, neurons, and Schwann cells.
文摘This article discusses the important role of mathematical and physical sciences in, and their influence on, the development of natural science and modern technology, as well as social science and the humanities. On the basis of the present situation in China, it calls for accelerating the development of the mathematical and physical sciences.
文摘Quality of Life (QOL) is a multiphase conception, including physical, mental and social factors, and can overall reflect health status of the human. At present, QOL has become a relevant measure of efficacy of treatment in clinical trials. Its use is spreading, and its importance is growing as a valid indicator of whether or not a medical treatment is
文摘In order to compete in the global manufacturing mar ke t, agility is the only possible solution to response to the fragmented market se gments and frequently changed customer requirements. However, manufacturing agil ity can only be attained through the deployment of knowledge. To embed knowledge into a CAD system to form a knowledge intensive CAD (KIC) system is one of way to enhance the design compatibility of a manufacturing company. The most difficu lt phase to develop a KIC system is to capitalize a huge amount of legacy data t o form a knowledge database. In the past, such capitalization process could only be done solely manually or semi-automatic. In this paper, a five step model fo r automatic design knowledge capitalization through the use of data mining is pr oposed whilst details of how to select, verify and performance benchmarking an a ppropriate data mining algorithm for a specific design task will also be discuss ed. A case study concerning the design of a plastic toaster casing was used as an illustration for the proposed methodology and it was found that the avera ge absolute error of the predictions for the most appropriate algorithm is withi n 17%.
文摘Nowadays, many kinds of software, which have succes sf ully created the integration of CAD, CAPP and CAM, find their disadvantages in p ractical manufacturing. As a result, it is welcomed to develop small CAD/CAPP sy stems on a proper CAD platform, which aim at requirements of factories. Based on the one of the most popular three-dimensional design software SolidWorks, we successfully developed a set of gear pump CAD /CAPP software for Huaiyin Gene ral Factory of Mechanics. 1 The architecture and function of the software According to the need of the enterprises, the general structure of the software contain two subsystems, which are detailed as follows: · The gear pump CAD subsystem contains four main modules, including the optiona l design module of gear pump, module of part design, the module of entity modeli ng and the module of drawing which creates 2 D drawings of parts and assembly c orresponding 3 D modals. · The gear pump CAPP subsystem, which is a combination of creative mode and der ivate mode, also includes four modules, they are the module of access to feature s, the module of planning process route, the module of designing process sheets and the module of generating process documents. 2 The developing environment of the system Basing on Windows 98 and SolidWorks2001 platform, this system creates all functi ons by using Visual C++ 6.0 as developing tools. 3 The keys to the CAD/CAPP integration 3.1 The establishment of product information modal The information of parts is the basis of process planning. In this system, we us e feature modeling to describe the information of parts and assembly of gear pum p, and set up a fundamental basis for the whole system. The information module o f gear pump includes the information of both the assembly and the parts; the par t-describing module uses four-layer structure that is subassembly layer, part layer, feature layer and geometric layer. 3.2 The operation of the information on feature modeling After establishment of information mode of gear pump, the next key problem is ho w to transmit information of product to CAPP subsystem. In order to integrate pe rfectly, connecting CAD with CAPP directly can be a good method. In this system, all information of parts is store in the part drawing files, and the CAPP syste m can load these files to get information. The gear pumps, which are produced by Huaiyin General Factory of Mechanics, are usually belong to several similar typ es, and this means that most products possess large number of similar feature. T herefore, we can easily establish a specific feature for gear pump CAD/CAPP syst em. All parts are created by selecting these features and/or adding few special features. In the module of access to feature of CAPP subsystem, the main task is to find the features and the information will be easily got. 4 Conclusion This system successfully creates gear pump CAD/CAPP integration based on SolidWo rks. 3D CAD software provide more convenient platform for integration and will i nevitably become the mainstream of product design. By developing this system, we clearly realize the promising future of SolidWorks.
文摘The possible role of submandiblular glands (SMG) in the development of obesity was studied in two types of genetically obese mice, ob/ob and yellow Ay: Obesity is caused by hyperplasia followed by hypertrophy in ob/ob mice and mainly by hypertrophy in Ay mice.The histological features of SMGs exhibited clear sexual dimorphism in both mice similarto lean controls. The SMGs of ob/ob mice was smaller in size and had smaller granular convoluted tubular portions than lean controls, while the SMGs of Ay mice did not differ from lean controls. Sialoadenectomy before and after development of obesity gCnerally reduced the gain of body weights in both sexes of Ay mice but not in ob/ob mice. The content of epidermal growth factor (EGF) in the SMGs was higher in Ay mice and lower in ob/ob mice than their controls. The possible role of EGF in the SMGs in the development of obesity is discussed
文摘The prevalence of obesity and type 2 diabetes mellitus(T2DM)has been increasing throughout the world over the past 20 years.Environmental chemicals known to regulate the endocrine system have been considered as a risk factor for the development of metabolic diseases.Several people are exposed to environmental chemicals during their lives.