Background: Acupoint herbal patching(AHP) alone or as an adjuvant therapy with conventional treatment(CT) has been widely used for prevention and treatment of chronic obstructive pulmonary disease(COPD). However, curr...Background: Acupoint herbal patching(AHP) alone or as an adjuvant therapy with conventional treatment(CT) has been widely used for prevention and treatment of chronic obstructive pulmonary disease(COPD). However, current clinical evidence from a systematic review of RCTs is lacking.Objective: To evaluate the effectiveness and safety of AHP with or without CT for people with COPD at stable stage.Methods: We searched randomized controlled trials comparing AHP(with or without CT) with no intervention, placebo, or CT from six databases. Two authors selected studies, extracted data and evaluated risk of bias of included trials. Rev Man 5.2 software was used to analysis data.Results: Twenty one RCTs(2327 participants) were included. AHP of non sanfu applied on no fixed dates with CT significantly decreased the mean frequency of acute exacerbation of COPD(times per year)(MD:-1.24; 95% CI:-2.02 to-0.46; 2 trials), and improved lung function parameters and quality of life. The AHP with CT showed no better effect in 6-minute walking distance(6 MWD) that CT alone. AHP applied at sanfu(specific dates based on lunar calendar) with CT had significant effect for 6 MWD(MD: 11.20; 95% CI: 0.83 to 21.56; I^2= 0%;3 trials). One trial reported skin irritation from AHP. Another trial reported two patients had eye discomfort, which was inferred as the adverse effects of seretide.Conclusion: AHP used as an adjunct to CT, appears to be more effective than CT alone in patients with stable COPD. However, further large,rigorously designed trials are warranted to confirm these potential effects.展开更多
目的:采用网状Meta分析方法评价中医外治法治疗失眠症的疗效。方法:检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、中国生物医学文献数据库(CBM)、Embase、Cochrane图书馆、Web of Science、P...目的:采用网状Meta分析方法评价中医外治法治疗失眠症的疗效。方法:检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、中国生物医学文献数据库(CBM)、Embase、Cochrane图书馆、Web of Science、PubMed,收集中医外治法治疗失眠症的随机对照研究,并对纳入的研究进行质量评价和数据提取,检索时间从建库至2020年9月2日,使用Revman5.3软件、Stata/SE 15.0软件及频率学方法进行数据分析。结果:最终纳入25篇文献,6种中医外治法,共1796例患者。网状Meta分析结果显示:推拿、电针、针刺、足浴、温针灸与口服艾司唑仑片比较,在改善失眠患者睡眠质量的效果方面差异有统计学意义,推拿与针刺比较、电针与温针灸比较、针刺与温针灸比较差异有统计学意义,其他比较均无统计学意义;累积排名曲线下面积由高到低排序为:温针灸、足浴、推拿、电针、耳穴压贴、针刺、艾司唑仑片。结论:中医外治法改善失眠症效果显著,温针灸成为最佳治疗方法的可能性最大,本研究因纳入文献的数量及质量的原因,结论仍需更多高质量、大样本、涵盖多种中医外治法的临床研究给予证实。展开更多
目的：借助循证医学的方法为1例急性痛风性关节炎患者制定循证治疗方案。方法：在充分评估患者的情况后,提出临床问题,检索Medline（1990年1月-2009年10月）、Cochrane图书馆（2009年第3期）及CBMWeb（1990年1月-2009年10月）。检索主...目的：借助循证医学的方法为1例急性痛风性关节炎患者制定循证治疗方案。方法：在充分评估患者的情况后,提出临床问题,检索Medline（1990年1月-2009年10月）、Cochrane图书馆（2009年第3期）及CBMWeb（1990年1月-2009年10月）。检索主题词：中西医结合疗法（TCM-WMtherapy）;急性（acute）;痛风性关节炎（Gouty arthritis）;治疗（treat ment ORtherapy）;随机对照试验（RCT）;Meta-分析（Meta-analysis）;系统评价（systematic review）;人类（human）。结果：检索发现,关于急性痛风型关节炎132篇RCT,0篇SR,通过分析检索结果、结合临床经验及患者实际情况,为患者制定了循证治疗方案。通过半年随访证实,该方案适合患者。结论：对急性痛风性关节炎患者,采用循证治疗的方法,可有效提高治疗效果,改善患者的预后。展开更多
基金supported by the Program for Innovative Research Team(2011-CXTD-09)of Beijing University of Chinese Medicinepartially supported by the Program for the Model of Building Clinical Research Capacity for Chinese Medicine(grant number201207007)from the State Administration of Traditional Chinese Medicine of China+2 种基金the program for Young Faculty Fellow Plan of Beijing University of Chinese Medicine(2012-QNJSZX012)young elite talent plan of Beijing Municipal Commission of Education(YETP0796)supported by Ba Gui Scholarship from Guangxi Zhuang Autonomous Region
文摘Background: Acupoint herbal patching(AHP) alone or as an adjuvant therapy with conventional treatment(CT) has been widely used for prevention and treatment of chronic obstructive pulmonary disease(COPD). However, current clinical evidence from a systematic review of RCTs is lacking.Objective: To evaluate the effectiveness and safety of AHP with or without CT for people with COPD at stable stage.Methods: We searched randomized controlled trials comparing AHP(with or without CT) with no intervention, placebo, or CT from six databases. Two authors selected studies, extracted data and evaluated risk of bias of included trials. Rev Man 5.2 software was used to analysis data.Results: Twenty one RCTs(2327 participants) were included. AHP of non sanfu applied on no fixed dates with CT significantly decreased the mean frequency of acute exacerbation of COPD(times per year)(MD:-1.24; 95% CI:-2.02 to-0.46; 2 trials), and improved lung function parameters and quality of life. The AHP with CT showed no better effect in 6-minute walking distance(6 MWD) that CT alone. AHP applied at sanfu(specific dates based on lunar calendar) with CT had significant effect for 6 MWD(MD: 11.20; 95% CI: 0.83 to 21.56; I^2= 0%;3 trials). One trial reported skin irritation from AHP. Another trial reported two patients had eye discomfort, which was inferred as the adverse effects of seretide.Conclusion: AHP used as an adjunct to CT, appears to be more effective than CT alone in patients with stable COPD. However, further large,rigorously designed trials are warranted to confirm these potential effects.
文摘目的:采用网状Meta分析方法评价中医外治法治疗失眠症的疗效。方法:检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、中国生物医学文献数据库(CBM)、Embase、Cochrane图书馆、Web of Science、PubMed,收集中医外治法治疗失眠症的随机对照研究,并对纳入的研究进行质量评价和数据提取,检索时间从建库至2020年9月2日,使用Revman5.3软件、Stata/SE 15.0软件及频率学方法进行数据分析。结果:最终纳入25篇文献,6种中医外治法,共1796例患者。网状Meta分析结果显示:推拿、电针、针刺、足浴、温针灸与口服艾司唑仑片比较,在改善失眠患者睡眠质量的效果方面差异有统计学意义,推拿与针刺比较、电针与温针灸比较、针刺与温针灸比较差异有统计学意义,其他比较均无统计学意义;累积排名曲线下面积由高到低排序为:温针灸、足浴、推拿、电针、耳穴压贴、针刺、艾司唑仑片。结论:中医外治法改善失眠症效果显著,温针灸成为最佳治疗方法的可能性最大,本研究因纳入文献的数量及质量的原因,结论仍需更多高质量、大样本、涵盖多种中医外治法的临床研究给予证实。
文摘目的评价辨证论治中药治疗糖尿病视网膜病变的的疗效与安全性。方法检索中国生物医学文献数据库、中国知网、维普网、万方数据库、Pub Med、Cochrane Library中的临床试验注册库,纳入从建库至2015年12月的辨证论治中药治疗糖尿病视网膜病变的随机对照临床试验。设计资料提取表进行资料提取,文献质量评价采用Cochrane手册推荐的"偏倚风险"评估工具,数据分析使用Rev Man 5.3软件。结果纳入16项试验3612名受试者。2个试验评价为低偏倚风险,其余均为高偏倚风险。中药加常规治疗对比西药加常规治疗中,2项辨证为瘀血阻络的试验(106人)在降低全血黏度低切上有统计学意义(MD:-1.88 m Pa.s,95%CI:[-2.13,-1.63])。中药加常规治疗对比安慰剂加常规治疗中,2项辨证为(气阴两虚、瘀血阻络)的试验(47人)在减少视网膜毛细血管无灌注区面积及毛细渗漏范围上有统计学差异(MD:-0.19 PD,95%CI:[-0.34,-0.04]、MD:-0.15 PD,95%CI:[-0.25,-0.06])。纳入试验没有报告严重不良事件。结论辨证为气阴两虚、瘀血阻络的患者使用芪灯明目胶囊和芪明颗粒在减小视网膜毛细血管无灌注区及毛细血管渗漏范围上有潜在疗效且无严重不良事件发生。但由于纳入试验的样本量较小和辨证治疗的异质性较大,需要慎重解释结果并在将来的研究中加以验证。
文摘目的：借助循证医学的方法为1例急性痛风性关节炎患者制定循证治疗方案。方法：在充分评估患者的情况后,提出临床问题,检索Medline（1990年1月-2009年10月）、Cochrane图书馆（2009年第3期）及CBMWeb（1990年1月-2009年10月）。检索主题词：中西医结合疗法（TCM-WMtherapy）;急性（acute）;痛风性关节炎（Gouty arthritis）;治疗（treat ment ORtherapy）;随机对照试验（RCT）;Meta-分析（Meta-analysis）;系统评价（systematic review）;人类（human）。结果：检索发现,关于急性痛风型关节炎132篇RCT,0篇SR,通过分析检索结果、结合临床经验及患者实际情况,为患者制定了循证治疗方案。通过半年随访证实,该方案适合患者。结论：对急性痛风性关节炎患者,采用循证治疗的方法,可有效提高治疗效果,改善患者的预后。
