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Static and Thermal Analysis of Aluminium (413,390,384 and 332) Piston Using Finite Element Method
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作者 Offei David Inusah Jacob Kwaku Nkrumah Vincent Akolbire Atindana 《Modeling and Numerical Simulation of Material Science》 2024年第1期1-38,共38页
The main objective of this research was to examine the suitability of aluminium alloy to design a piston of an internal combustion engine for improvement in weight and cost reduction. The piston was modelled using Aut... The main objective of this research was to examine the suitability of aluminium alloy to design a piston of an internal combustion engine for improvement in weight and cost reduction. The piston was modelled using Autodesk Inventor 2017 software. The modelled piston was then imported into Ansys for further analysis. Static structural and thermal analysis were carried out on the pistons of the four different materials namely: Al 413 alloy, Al 384 alloy, Al 390 alloy and Al332 alloy to determine the total deformation, equivalent Von Mises stress, maximum shear stress, and the safety factor. The results of the study revealed that, aluminium 332 alloy piston deformed less compared to the deformations of aluminium 390 alloy piston, aluminium 384 alloy piston and aluminium 413 alloy piston. The induced Von Mises stresses in the pistons of the four different materials were found to be far lower than the yield strengths of all the materials. Hence, all the selected materials including the implementing material have equal properties to withstand the maximum gas load. All the selected materials were observed to have high thermal conductivity enough to be able to withstand the operating temperature in the engine cylinders. 展开更多
关键词 Von Mise stress total deformation Aluminium alloy thermal analysis. PISTON Static structural Heat fux
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A time-domain nonlinear effective-stress non-Masing approach of ground response analysis of Guwahati city, India 被引量:2
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作者 Devdeep Basu Madhulatha Boga Arindam Dey 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2019年第1期61-75,共15页
The response of subsoil strata subjected to seismic excitations plays an important role in governing the response of the overlying superstructures at any site. Ground response analysis(GRA) helps to assess the influen... The response of subsoil strata subjected to seismic excitations plays an important role in governing the response of the overlying superstructures at any site. Ground response analysis(GRA) helps to assess the influence of soil characteristics on the propagating seismic stress waves from the bedrock level to the ground surface during an earthquake. For the northeastern region of India, located in the highest seismic zone in the country, conducting an extensive GRA study is of prime importance. Conventionally, most of the GRA studies are carried out using the equivalent linear method, which, being a simplistic approach, cannot capture the nonlinear behavior of soil during seismic shaking. This paper presents the outcomes of a one-dimensional effective stress based nonlinear GRA conducted for Guwahati city(located in northeast India) incorporating the non-Masing load/unload/reload characteristics. The various ground response parameters evaluated from this study help in assessing the ground shaking, soil amplification, and site responses expected in this region. 2D contour maps, which are representative of the distribution of some of these parameters throughout Guwahati city, are also developed. The results presented herein can serve as guidelines for the design of foundations and superstructures in this region. 展开更多
关键词 GROUND RESPONSE analysis nonlinear effective stress APPROACH non-masing criteria GROUND RESPONSE parameters soil amplification
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Size dependent free vibration analysis of functionally graded piezoelectric micro/nano shell based on modified couple stress theory with considering thickness stretching effect 被引量:5
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作者 Maryam Lori Dehsaraji Mohammad Arefi Abbas Loghman 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2021年第1期119-134,共16页
Higher-order shear and normal deformation theory is used in this paper to account thickness stretching effect for free vibration analysis of the cylindrical micro/nano shell subjected to an applied voltage and uniform... Higher-order shear and normal deformation theory is used in this paper to account thickness stretching effect for free vibration analysis of the cylindrical micro/nano shell subjected to an applied voltage and uniform temperature rising.Size dependency is included in governing equations based on the modified couple stress theory.Hamilton’s principle is used to derive governing equations of the cylindrical micro/nano shell.Solution procedure is developed using Navier technique for simply-supported boundary conditions.The numerical results are presented to investigate the effect of significant parameters such as some dimensionless geometric parameters,material properties,applied voltages and temperature rising on the free vibration responses. 展开更多
关键词 Thickness stretching effect Shear and normal deformation theory Vibration analysis Length scale parameter Modified couple stress theory
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Size-dependent effect on biaxial and shear nonlinear buckling analysis of nonlocal isotropic and orthotropic micro-plate based on surface stress and modified couple stress theories using differential quadrature method 被引量:2
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作者 M.MOHAMMADIMEHR M.A.MOHAMMADIMEHR P.DASHTI 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2016年第4期529-554,共26页
The size-dependent effect on the biaxial and shear nonlinear buckling analysis of an isotropic and orthotropic micro-plate based on the surface stress, the modified couple stress theory (MCST), and the nonlocal elas... The size-dependent effect on the biaxial and shear nonlinear buckling analysis of an isotropic and orthotropic micro-plate based on the surface stress, the modified couple stress theory (MCST), and the nonlocal elasticity theories using the differential quadrature method (DQM) is presented. Main advantages of the MCST over the classical theory (CT) are the inclusion of the asymmetric couple stress tensor and the consideration of only one material length scale parameter. Based on the nonlinear von Karman assumption, the governing equations of equilibrium for the micro-classical plate consid- ering midplane displacements are derived based on the minimum principle of potential energy. Using the DQM, the biaxial and shear critical buckling loads of the micro-plate for various boundary conditions are obtained. Accuracy of the obtained results is validated by comparing the solutions with those reported in the literature. A parametric study is conducted to show the effects of the aspect ratio, the side-to-thickness ratio, Eringen's nonlocal parameter, the material length scale parameter, Young's modulus of the surface layer, the surface residual stress, the polymer matrix coefficients, and various boundary conditions on the dimensionless uniaxial, biaxial, and shear critical buckling loads. The results indicate that the critical buckling loads are strongly sensitive to Eringen's nonlocal parameter, the material length scale parameter, and the surface residual stress effects, while the effect of Young's modulus of the surface layer on the critical buckling load is negligible. Also, considering the size dependent effect causes the increase in the stiffness of the orthotropic micro-plate. The results show that the critical biaxial buckling load increases with an increase in G12/E2 and vice versa for E1/E2. It is shown that the nonlinear biaxial buckling ratio decreases as the aspect ratio increases and vice versa for the buckling amplitude. Because of the most lightweight micro-composite materials with high strength/weight and stiffness/weight ratios, it is anticipated that the results of the present work are useful in experimental characterization of the mechanical properties of micro-composite plates in the aircraft industry and other engineering applications. 展开更多
关键词 biaxial and shear nonlinear buckling analysis nonlocal isotropic and orthotropic micro-plate modified couple stress theory (MCST) surface stress effect differential quadrature method (DQM)
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Effective stress analysis method of seismic response for high tailings dam 被引量:3
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作者 柳厚祥 李宁 +2 位作者 廖雪 吴从师 潘旭东 《Journal of Central South University of Technology》 EI 2007年第1期129-134,共6页
Based on the analysis method for tailings dam in upstream raising method presently used in metallurgy and nonferrous metals tailings depository in the world, an effective stress analysis method of seismic response for... Based on the analysis method for tailings dam in upstream raising method presently used in metallurgy and nonferrous metals tailings depository in the world, an effective stress analysis method of seismic response for high tailings dam was developed according to the results of engineering geological exploration, static and dynamic test and stability analysis on Baizhishan tailing dam 113.5 m high. The law of generation, diffusion and dissipation of seismic pore water pressure during and after earthquake was investigated, and the results of tailings dam’s acceleration, seismic dynamic stress and pore water pressure were obtained. The results show that the seismic stability and liquefaction resistance of high tailings dam are strengthened remarkably, and the scope and depth of liquefaction area at the top of dam are reduced greatly. The interior stress is compressive stress, the stress level of every element is less than 1.0 and the safety coefficient of every element is greater than 1.0. The safety coefficient against liquefaction of every element of tailing dam is greater than 1.5 according to the effective stress analysis of seismic response by finite element method. The calculated results prove that liquefaction is the main reason of seismic failure of high tailing dams, and the effect of seismic inertia forces on high tailing dams’ stability during earthquake is secondary reason. 展开更多
关键词 tailings dam seismic response effective stress nonlinear analysis against liquefaction upstream raising method
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Effect of boundary conditions on shakedown analysis of heterogeneous materials
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作者 Xiuchen GONG Yinghao NIE +1 位作者 Gengdong CHENG Kai LI 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第1期39-68,共30页
The determination of the ultimate load-bearing capacity of structures made of elastoplastic heterogeneous materials under varying loads is of great importance for engineering analysis and design. Therefore, it is nece... The determination of the ultimate load-bearing capacity of structures made of elastoplastic heterogeneous materials under varying loads is of great importance for engineering analysis and design. Therefore, it is necessary to accurately predict the shakedown domains of these materials. The static shakedown theorem, also known as Melan's theorem, is a fundamental method used to predict the shakedown domains of structures and materials. Within this method, a key aspect lies in the construction and application of an appropriate self-equilibrium stress field(SSF). In the structural shakedown analysis, the SSF is typically constructed by governing equations that satisfy no external force(NEF) boundary conditions. However, we discover that directly applying these governing equations is not suitable for the shakedown analysis of heterogeneous materials. Researchers must consider the requirements imposed by the Hill-Mandel condition for boundary conditions and the physical significance of representative volume elements(RVEs). This paper addresses this issue and demonstrates that the sizes of SSFs vary under different boundary conditions, such as uniform displacement boundary conditions(DBCs), uniform traction boundary conditions(TBCs), and periodic boundary conditions(PBCs). As a result, significant discrepancies arise in the predicted shakedown domain sizes of heterogeneous materials. Built on the demonstrated relationship between SSFs under different boundary conditions, this study explores the conservative relationships among different shakedown domains, and provides proof of the relationship between the elastic limit(EL) factors and the shakedown loading factors under the loading domain of two load vertices. By utilizing numerical examples, we highlight the conservatism present in certain results reported in the existing literature. Among the investigated boundary conditions, the obtained shakedown domain is the most conservative under TBCs.Conversely, utilizing PBCs to construct an SSF for the shakedown analysis leads to less conservative lower bounds, indicating that PBCs should be employed as the preferred boundary conditions for the shakedown analysis of heterogeneous materials. 展开更多
关键词 heterogeneous material self-equilibrium stress field(SSF) shakedown analysis effect of boundary conditions
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Investigation of the short-term stress distribution in stopes and drifts backfilled with cemented paste backfill 被引量:7
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作者 Pengyu Yang Li Li 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2015年第5期721-728,共8页
Cemented paste backfill(CPB) is largely used in underground mines worldwide.A key issue associated with application of CPB is to estimate the stresses in backfilled stopes and on barricades.Recent numerical and experi... Cemented paste backfill(CPB) is largely used in underground mines worldwide.A key issue associated with application of CPB is to estimate the stresses in backfilled stopes and on barricades.Recent numerical and experimental results show that arching effect is absent shortly after the placement of CPB in stopes.However,stress decreases in barricade drift with increasing distance between the measurement points and drawpoint have also been observed,demonstrating arching effect shortly after the pouring of CPB.To explain these paradoxes,CPB is considered as Bingham fluid having a yield shear stress.Three dimensional analytical solutions are proposed to evaluate the short-term total stresses in backfilled stopes and on barricades,accounting for the CPB's yield shear stress-induced arching effect.Stress diminution due to such arching effect in the backfilled stopes and on barricades is indeed obtained.But the reduction becomes insignificant using typical yield shear stress and stope geometry.More analyses indicate that the typical yield shear stress values do not fully correspond to field conditions where the yield shear stress would increase exponentially due to apparent consolidation(loss of water by drainage,a phenomenon similar to the desiccation of overly saturated fine-grained materials). 展开更多
关键词 Mines Cemented paste backfill Yield shear stress Short-term total stresses Arching effect Analytical solutions
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Finite element synthesized analysis of the forming process of spiral welded pipe 被引量:2
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作者 俞建荣 吴波 +3 位作者 赵增慧 凌星中 肖云峰 陈海洋 《China Welding》 EI CAS 2006年第4期71-74,共4页
Numerical simulation concerning the forming and welding process of spiral welded pipe was conducted, which included three steps : the first step was the stress analysis when the spiral was formed, and then the stress... Numerical simulation concerning the forming and welding process of spiral welded pipe was conducted, which included three steps : the first step was the stress analysis when the spiral was formed, and then the stress was regarded as initial condition of melding during the temperature field analysis in the process of welding, the last step was the thermal stress analysis of the weld seam after the welding was over. Moreover, when the steel strip was pushed, the stress was also calculated by non-linearity contact technology using Abaqus Software. By finite element modeling and calculating of the forming and welding process of the spiral welded pipe, the key points of the multi-fields synthetic simulating were studied and discussed. 展开更多
关键词 spiral welded pipe contact effect stress field temperature field finite element analysis
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Examination of effective stress in clay rock 被引量:1
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作者 Chun-Liang Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2017年第3期97-107,共11页
This paper examines the effective stress in indurated clay rock theoretically and experimentally.A stress concept is derived from the analysis of the microstructure and of the pore water in the highly-indurated Callov... This paper examines the effective stress in indurated clay rock theoretically and experimentally.A stress concept is derived from the analysis of the microstructure and of the pore water in the highly-indurated Callovo-Oxfordian and Opalinus clay rocks,and subsequently validated by various experiments performed on these claystones.The concept suggests that the interparticle or effective stress in a dense clay ewater system is transferred through both the adsorbed interparticle pore water in narrow pores and the solidesolid contact between non-clay mineral grains.The experiments show that the adsorbed pore water in the claystones is capable of bearing deviatoric effective stresses up to the failure strength.The applied stresses are for the most part or even totally transferred by the bound pore water,i.e.the swelling pressure in the interparticle bound pore water is almost equivalent to the effective stress.This stress concept provides a reasonable view to the nature of the effective stress in argillaceous rock and forms the fundamental basis for studies of the hydro-mechanical properties and processes in clay formations. 展开更多
关键词 Clay rock stress analysis effective stress Swelling pressure EXPERIMENT
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Evaluation of soil arching effect due to partially mobilized shear stress in piled and geosynthetic-reinforced embankment
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作者 LV Wei-hua WU Tao +1 位作者 GU Fan GAO Lei 《Journal of Central South University》 SCIE EI CAS CSCD 2020年第7期2094-2112,共19页
In piled and geosynthetic-reinforced(PGR) embankment, the arching behavior determines the overburden load on piles and subsoils. Placement of geosynthetic is effective in reducing the relative displacement between pil... In piled and geosynthetic-reinforced(PGR) embankment, the arching behavior determines the overburden load on piles and subsoils. Placement of geosynthetic is effective in reducing the relative displacement between pile and subsoil. When the mobilized shear stress is less than the shear strength, partially developed arching will occur. Consequently, existing analytical methods, adopting the ultimate shear strength failure criterion, need to be improved. This study developed a simplified 2 D analytical method, which is based on the developing arching effect, to evaluate the load redistribution of the PGR embankment. Then, the influences of embankment height and internal friction angle, subsoil depth, ratio of pile cap width to pile clear spacing(RPC) and geosynthetic tensile stiffness on the critical height ratio, stress concentration ratio, soil arching ratio, geosynthetic tension and axial strain were investigated. This study suggests that a RPC of 1:1.0 and a one-way of single-layer geosynthetic tensile stiffness of 2000 kN/m should be considered as the sensitivity thresholds for the PGR embankment. 展开更多
关键词 PILE GEOSYNtheTIC arching effect mobilized shear stress parametric analysis
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基于人工智能压力性损伤图片分析系统的精细干预在神经内科重症患者中的应用
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作者 李世玫 余爱华 +3 位作者 王苗苗 李敬 熊新荣 谢晓俭 《河北医药》 CAS 2024年第20期3194-3196,3200,共4页
目的探讨基于人工智能压力性损伤图片分析系统的精细干预在神经内科重症患者中的应用。方法选取2021年1月至2022年12月神经内科收治的重症患者120例,随机数字表法分为研究组(n=60)采用基于人工智能压力性损伤图片分析系统的精细干预,对... 目的探讨基于人工智能压力性损伤图片分析系统的精细干预在神经内科重症患者中的应用。方法选取2021年1月至2022年12月神经内科收治的重症患者120例,随机数字表法分为研究组(n=60)采用基于人工智能压力性损伤图片分析系统的精细干预,对照组(n=60)采用常规护理,比较2组患者护理效果。结果研究组压力性损伤发生率为6.67%(4/60)低于对照组12.67%(13/60)(P<0.05),研究组HAMA量表评分和HAMD量表评分均低于对照组(P<0.05);研究组压力性损伤相关知识掌握评分高于对照组(P<0.05)。结论基于人工智能压力性损伤图片分析系统的精细干预在神经内科重症患者中的应用效果显著,可显著减少患者压力性损伤发生率,改善患者负性情绪,提升护理人员压力性损伤相关知识掌握情况。 展开更多
关键词 人工智能压力性损伤图片分析系统 精细干预 神经内科 重症患者 治疗结果
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快速康复对全髋关节置换术患者功能恢复的临床效果分析
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作者 陈乔 刘兴邦 +4 位作者 喻斌 胡凌燕 李红林 许超 廉美阳 《中国医药科学》 2024年第16期160-163,共4页
目的 研究分析快速康复对全髋关节置换术患者功能恢复的临床效果。方法 选择2016年3月至2023年3月在潜江市中心医院治疗的200例老年股骨颈骨折患者(>65岁),均接受全髋关节置换术,采用以随机数表法将200例患者分为对照组和观察组,每组... 目的 研究分析快速康复对全髋关节置换术患者功能恢复的临床效果。方法 选择2016年3月至2023年3月在潜江市中心医院治疗的200例老年股骨颈骨折患者(>65岁),均接受全髋关节置换术,采用以随机数表法将200例患者分为对照组和观察组,每组各100例,围手术期,对照组患者接受常规康复,观察组患者接受快速康复,将对照组和观察组的患者术前、术后1周、术后1个月、术后3个月的日常生活活动能力评分(ADL)、Harris髋关节评分(HHS)、术后并发症的发生率、患者满意度进行比较,并进行统计学分析。结果观察组和对照组术前ADL评分、HHS比较,差异无统计学意义(P> 0.05),术后1周、术后1个月、术后3个月,观察组的ADL评分、HHS高于对照组,差异有统计学意义(P <0.05);观察组的并发症总发生率低于对照组,差异有统计学意义(P <0.05);观察组患者满意度高于对照组,差异有统计学意义(P <0.05)。结论 快速康复可使患者的髋关节功能恢复更好,更好地恢复日常生活能力,围手术期并发症发生率低,患者满意度更高。 展开更多
关键词 快速康复 日常生活活动能力评分 Harris髋关节评分 全髋关节置换 效果分析
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饱和岩土边坡的孔压增量强度折减极限分析方法
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作者 董天文 林小庆 赵同峰 《地下空间与工程学报》 CSCD 北大核心 2024年第5期1485-1490,1540,共7页
目前饱和边坡的强度折减法流固耦合分析是在总应力的静水压力差法基础上,通过调整浸润面位置、考虑材料浮力作用加以实现,未能解决强度折减过程孔隙水压力变化的情况。本文从岩土体固相介质强度参数(c、φ)与液相介质强度参数(孔隙水压... 目前饱和边坡的强度折减法流固耦合分析是在总应力的静水压力差法基础上,通过调整浸润面位置、考虑材料浮力作用加以实现,未能解决强度折减过程孔隙水压力变化的情况。本文从岩土体固相介质强度参数(c、φ)与液相介质强度参数(孔隙水压力)相互关系出发,解释了固体骨架、自由水不同步的荷载传递过程,提出了有效应力的强度折减法、孔压增量近似确定方法,并在总应力静水压力差方法基础上给出了孔压增量强度折减方法的实现过程。研究表明:孔压增量强度折减方法计算的饱和边坡零孔隙水压力面升高0.34~0.44 m(4%~5%),与目前在涉水边坡流固耦合分析中按经验选取0.5 m的浸润面抬升值较为一致。 展开更多
关键词 饱和边坡 强度折减方法 流固耦合分析 有效应力
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双向增强复合地基桩土应力比计算方法研究
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作者 张思峰 孙亚峰 +2 位作者 刘乾 范伟 龙关旭 《铁道工程学报》 EI CSCD 北大核心 2024年第9期7-14,共8页
研究目的:桩土应力比是反映双向增强复合地基工作特性的重要指标。由于路堤荷载下双向增强复合地基承载变形机理复杂,本文以双桩范围内的路堤与双向复合地基为研究对象,考虑路堤土拱效应、加筋层网兜效应、应力扩散效应等多重效应的共... 研究目的:桩土应力比是反映双向增强复合地基工作特性的重要指标。由于路堤荷载下双向增强复合地基承载变形机理复杂,本文以双桩范围内的路堤与双向复合地基为研究对象,考虑路堤土拱效应、加筋层网兜效应、应力扩散效应等多重效应的共同作用,建立路堤-水平加筋垫层-竖向桩体-桩间土协调变形的二维理论分析模型,探究各影响因素对桩土应力比的影响规律。研究结论:(1)桩土应力比随填土重度、桩间距的增加而减小,随填料内摩擦角的增大呈先增加后减小趋势,随路堤填筑高度、格栅层数、填料黏聚力的增加而增大;(2)桩土应力比对各参数的敏感性由高到低排序为:桩间距、路堤填筑高度、路堤填土重度、路堤填料黏聚力、格栅层数及路堤填料内摩擦角;(3)本研究成果可为类似工程的桩土应力比计算提供理论依据及工程借鉴。 展开更多
关键词 双向增强复合地基 多重效应 土工格栅 桩土应力比 影响因素 敏感性分析
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基于“三因制宜”理念的中医辨证护理在全髋关节置换术患者中的应用效果分析
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作者 褚俊链 郭容弟 《西部中医药》 2024年第3期126-130,共5页
目的:观察“三因制宜”理念的中医辨证护理在全髋关节置换术患者中的应用效果。方法:将88例全髋关节置换术(total hip arthroplasty,THA)患者按随机数字表法分为对照组和三因组各44例。对照组给予西医常规护理,三因组在对照组的基础上... 目的:观察“三因制宜”理念的中医辨证护理在全髋关节置换术患者中的应用效果。方法:将88例全髋关节置换术(total hip arthroplasty,THA)患者按随机数字表法分为对照组和三因组各44例。对照组给予西医常规护理,三因组在对照组的基础上给予“三因制宜”理念的中医辨证护理。观察两组患者术前及术后6天视觉模拟量表(visual analogue scale,VAS)和汉密尔顿焦虑量表(hamilton anxiety scale,HAMA)评分、术后7天炎症指标[白细胞介素6(interleukin-6,IL-6)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)]、术后5个月Harris髋关节评分、并发症及护理满意度。结果:术后6天两组患者VAS和HAMA评分均低于术前(P<0.05),三因组低于对照组(P<0.05);术后7天两组患者血清IL-6、TNF-α水平均高于术前(P<0.05),三因组低于对照组(P<0.05);术后5个月,三因组患者Harris髋关节疼痛评分低于对照组(P<0.05),活动度、功能评分均高于对照组(P<0.05),畸形评分与对照组比较差异无统计学意义(P>0.05);三因组患者并发症总发生率为2.27%(1/44),低于对照组的13.64%(6/44)(P<0.05);三因组患者总满意度为95.45%(42/44),高于对照组的79.55%(35/44)(P<0.05)。结论:基于“三因制宜”理念的中医辨证护理可有效缓解THA患者疼痛,抑制炎症反应、改善髋关节功能,降低术后并发症,提高护理满意度。 展开更多
关键词 全髋关节置换术 三因制宜 中医辨证护理 效果分析
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基于谱-效关系筛选菊茎叶总黄酮抗氧化物质基础及其机制探讨 被引量:2
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作者 巫梦莹 陈慧芳 +5 位作者 程冉冉 丁杨飞 熊俊伟 夏成凯 吴德玲 张伟 《天然产物研究与开发》 CAS CSCD 北大核心 2024年第3期464-477,共14页
为探讨菊茎叶总黄酮(total flavonoids from stems and leaves of Chrysanthemum morifolium,TFCSL)抗氧化应激的活性成分,阐明其药效物质基础和作用机制。采用HPLC建立不同批次TFCSL指纹图谱;以高浓度葡萄糖诱导人脐静脉内皮细胞建立... 为探讨菊茎叶总黄酮(total flavonoids from stems and leaves of Chrysanthemum morifolium,TFCSL)抗氧化应激的活性成分,阐明其药效物质基础和作用机制。采用HPLC建立不同批次TFCSL指纹图谱;以高浓度葡萄糖诱导人脐静脉内皮细胞建立氧化损伤模型,将丙二醛含量、乳酸脱氢酶含量和超氧化物歧化酶活性作为药效指标;采用灰色关联度和偏最小二乘法分析其谱-效关系确定抗氧化药效物质基础;基于网络药理学结合分子对接探究核心靶点及作用通路。从12批次TFCSL指纹图谱中确定12个共有峰,指认其中9个化学成分;各批次总黄酮样品均可减少细胞凋亡、降低丙二醛及乳酸脱氢酶含量、提高超氧化物歧化酶活性;综合2种数学模型确定峰5(芹菜素-7-O-β-D-葡萄糖苷)、峰6(异绿原酸C)、峰7(香叶木素-7-O-β-D-葡萄糖苷)为抗氧化物质基础;筛选出的3个活性成分作用于抗氧化应激的33个靶点;关键靶点为TNF、CASP3、EDNRA、XDH、PTGS2、MMP2,主要涉及脂质和动脉粥样硬化信号通路、IL-17信号通路、糖尿病并发症AGE-RAGE信号通路、TNF通路、MPKA通路等信号通路;分子对接结果显示活性成分与关键靶点之间均有较好的结合力。表明TFCSL抗氧化应激的物质基础可能为芹菜素-7-O-β-D-葡萄糖苷、异绿原酸C、香叶木素-7-O-β-D-葡萄糖苷,推测通过TNF、CASP3等靶点作用动脉粥样硬化信号通路、IL17信号通路发挥作用,体现菊茎叶多成分、多靶点抗氧化的作用特点。 展开更多
关键词 菊茎叶 总黄酮 氧化应激 谱效关系
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大跨连续梁拱组合体系桥拱脚结合段局部应力分析
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作者 赵堃 杨坤 +1 位作者 屈志英 张耀武 《特种结构》 2024年第5期94-100,110,共8页
大跨连续梁拱组合体系桥拱脚结合段的构造和受力复杂,需要对此处进行局部应力分析。结合工程实例,采用有限元法对拱脚结合段进行建模,提出了局部模型边界力的施加方法,并对其施加整体模型计算出的内力进行细部计算,分析局部应力状态。... 大跨连续梁拱组合体系桥拱脚结合段的构造和受力复杂,需要对此处进行局部应力分析。结合工程实例,采用有限元法对拱脚结合段进行建模,提出了局部模型边界力的施加方法,并对其施加整体模型计算出的内力进行细部计算,分析局部应力状态。计算和分析结果表明,拱脚结合段的应力总体上满足设计规范要求,横隔板分别与顶板、底板和腹板相连接的倒角位置出现应力集中现象,建议对倒角设置平顺过渡段;在拱肋插入处的顶板和支座位置处的底板存在应力集中现象,建议对这些位置加强布置构造钢筋。 展开更多
关键词 连续梁拱组合体系 有限元法 拱脚结合段 局部应力分析 剪力滞效应 应力集中
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Synergistic effect of pinellia total alkaloids and uncaria total alkaloids on anticonvulsant action in mice and rats 被引量:11
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作者 成银霞 王明正 +5 位作者 陈靖京 杨蓉 何欣嘏 马永刚 杨李华 张明升 《Journal of Chinese Pharmaceutical Sciences》 CAS 2007年第2期139-145,共7页
Aim To investigate the synergistic effect of the combination of pinellia total alkaloid (PTA) and uncaria total alkaloid (UTA), and explore the mechanism of anticonvulsant action. Methods Anticonvulsant and toxic ... Aim To investigate the synergistic effect of the combination of pinellia total alkaloid (PTA) and uncaria total alkaloid (UTA), and explore the mechanism of anticonvulsant action. Methods Anticonvulsant and toxic effect profiles of combinations of PTA with UTA, alone and at three fixed ratios of 1:4, 1 :1, 4:1, were evaluated in maximal electroshock (MES)-induced seizures and acute toxicity test in mice. Respective ED50 and LD50 were calculated with Bliss's method. Their synergistic effect were evaluated by isobolographic analysis and allowed the determination of benefit indices (BI) for respective combinations. The model of convulsive rats kindled by penicillin topically injected into cortex was used to investigated the content of Glu, Asp, Gly and GABA in hippocampus using high performance liquid chromatography (HPLC). Results Combinations of PTA and UTA at the ratio of 4:1 were synergistic in MES test and antagonistic in acute toxicity test, showing the best profile for combinations of PTA with UTA. In contrast, the ratios of 1 :4 and 1 : 1, despite synergistic in MES test, were additive in acute toxicity test. The 4:1 combination and two drugs alone significantly decreased Glu level and increased GABA level in the hippocampus, but the GABA level in the 4:1 combination group was higher than that in the two drugs alone groups. They did not have significant influence on the levels of ASp and Gly. Conclusion Combinations of PTA and UTA at 4:1 ratio demonstrated synergistic effect in anticonvulsant action and antagonistic effect in toxicity. The anticonvulsant mechanism might be related to decreasing the excitability of Glutamatergic neurons and increasing the inhibition of GABAergic neurons. 展开更多
关键词 Pinellia total alkaloids Uncaria total alkaloids Synergistic effect Anticonvulsant action Isobolographic analysis Maximal electroshock Penicillin kindling NEUROTRANSMITTERS
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正念减压疗法和正念认知疗法安全性的meta分析 被引量:3
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作者 谢静静 李丽霞 +1 位作者 柳学华 岳伟华 《中国心理卫生杂志》 CSCD 北大核心 2024年第1期73-83,共11页
目的:探讨正念减压疗法(MBSR)和正念认知疗法(MBCT)相关不良事件及影响因素。方法:检索PubMed、CINAHL、Embase、WebofScience、Scopus、Proquest、ScienceDirect、PsycINFO数据库及未发表的研究报告和灰色文献中有关MBSR和MBCT不良事... 目的:探讨正念减压疗法(MBSR)和正念认知疗法(MBCT)相关不良事件及影响因素。方法:检索PubMed、CINAHL、Embase、WebofScience、Scopus、Proquest、ScienceDirect、PsycINFO数据库及未发表的研究报告和灰色文献中有关MBSR和MBCT不良事件或不良反应的随机对照试验,并追溯纳入文献的参考文献和相关期刊,检索时限截止到2022年6月1日。采用RevMan5.4软件进行meta分析,计算合并OR(95%CI)值。结果:共纳入15篇文献,包含2841名研究对象。Meta分析结果显示,MBSR或MBCT干预组和对照组发生不良事件或不良反应的差异有统计学意义(0R=2.48,95%CI=1.09~1.61;P<0.05);使用的正念干预方法(单独使用MBSR,OR=9.04,95%CI=5.34~15.30)、参与者合并基础疾病(合并精神疾病,OR=1.49,95%CI=1.12~1.97;合并躯体疾病,OR=8.65,95%CI=5.17~14.45)、练习强度(每次>2h,OR=1.43,95%CI=1.04~1.96)及正念师资水平(未经过规范培训,OR=1.96,95%CI=1.20~3.23)是影响MBSR和MBCT治疗过程中可能会出现相关不良事件或不良反应的因素。结论:正念减压治疗或正念认知治疗过程中可能会出现不良事件或不良反应。 展开更多
关键词 正念减压疗法 正念认知疗法 不良事件 不良体验 不良反应 安全性 随机对照试验 META分析
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卸载状态下非均质圆形寒区隧道围岩弹塑性统一解 被引量:1
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作者 梁沈伟 王彬 +1 位作者 荣传新 于胜民 《冰川冻土》 CSCD 2024年第2期650-661,共12页
以统一强度理论作为卸载状态下寒区隧道冻结围岩屈服准则,综合考虑围岩非均质特性和中间主应力效应对冻结围岩强度影响,建立寒区隧道应力位移弹塑性力学模型,联合各区域边界条件,计算获得冻结围岩均质与非均质状态下,弹性解、塑性统一... 以统一强度理论作为卸载状态下寒区隧道冻结围岩屈服准则,综合考虑围岩非均质特性和中间主应力效应对冻结围岩强度影响,建立寒区隧道应力位移弹塑性力学模型,联合各区域边界条件,计算获得冻结围岩均质与非均质状态下,弹性解、塑性统一解以及塑性区半径的隐式方程,分别对其应力位移场讨论分析。研究表明:考虑冻结围岩的非均质特性,塑性区环向应力峰值增大40%,塑性区范围相对减少40.4%,内壁位移减少9.3%,弹性极限承载力提高41%,塑性极限承载力提高14%,影响显著。中间主应力效应能充分发挥非均质冻结围岩承载潜能,计算得到的承载力明显增大,塑性半径明显减小。所得结果可为寒区隧道开挖支护设计以及数值模拟,提供理论指导。 展开更多
关键词 寒区隧道 非均质冻结围岩 弹塑性分析 中间主应力效应 统一强度理论
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