Objective:To study the effect of milrinone on the cardiac function and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with senile refractory heart failure. Methods:90 patients with senile refr...Objective:To study the effect of milrinone on the cardiac function and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with senile refractory heart failure. Methods:90 patients with senile refractory heart failure who were treated in our hospital between August 2013 and August 2016 were collected and divided into control group (n=45) and observation group (n=45) according to the random number table. The control group received regular clinical treatment, and the observation group received regular + milrinone treatment. The cardiac function and serum NT-proBN contents were compared between two groups of patients before and after treatment.Results: Before treatment, the differences in ultrasound and serum cardiac function indexes and serum NT-proBN levels were not statistically significant between two groups of patients. After treatment, ultrasound serum cardiac function parameter LVEDD level in observation group was lower than that in control group while CI and SV levels were higher than those in control group;serum cardiac function indexes Cys-C, GDF-15, sST2 and H-FABP contents were lower than those in control group;serum NT-proBNP content was lower than that in control group.Conclusion: Milrinone therapy can optimize the cardiac function and reduce the serum NT-proBN levels in patients with senile refractory heart failure.展开更多
Background Myocardial damage often occurs after burns. Previously, cardiac enzyme profile was often measured to determine myocardial injury, but was hardly specific. In this study, we investigated early changes of pla...Background Myocardial damage often occurs after burns. Previously, cardiac enzyme profile was often measured to determine myocardial injury, but was hardly specific. In this study, we investigated early changes of plasma N-terminal pro-brain natriuretic peptide （NT-proBNP） over time and its diagnostic value in burned patients. Methods 39 patients with heat burned were assigned to heart failure group （n = 9）, control group （n = 30）. Plasma NT-ProBNP and troponin Ⅰ（cTnT） were measured at 1st, 3rd, 5th days and 7th day, and patients were subdivided into 2 groups according to their cardiac function. Results Nine patients had heart failure （27.7%） and their NT-proBNP was 1676.03 ± 2190.41 pg/L. Significant difference was found between the heart failure group and control group （P 〈 0.01 ）. Conclusion NT-proBNP is related to the severity of burning and can well reflect the status of myocardial injury in patients with severe burn, and can be used as an ideal marker for myocardial injury in burned patients.展开更多
文摘Objective:To study the effect of milrinone on the cardiac function and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with senile refractory heart failure. Methods:90 patients with senile refractory heart failure who were treated in our hospital between August 2013 and August 2016 were collected and divided into control group (n=45) and observation group (n=45) according to the random number table. The control group received regular clinical treatment, and the observation group received regular + milrinone treatment. The cardiac function and serum NT-proBN contents were compared between two groups of patients before and after treatment.Results: Before treatment, the differences in ultrasound and serum cardiac function indexes and serum NT-proBN levels were not statistically significant between two groups of patients. After treatment, ultrasound serum cardiac function parameter LVEDD level in observation group was lower than that in control group while CI and SV levels were higher than those in control group;serum cardiac function indexes Cys-C, GDF-15, sST2 and H-FABP contents were lower than those in control group;serum NT-proBNP content was lower than that in control group.Conclusion: Milrinone therapy can optimize the cardiac function and reduce the serum NT-proBN levels in patients with senile refractory heart failure.
基金supported by Guangdong Province Medical Research Foundation(A2009039)
文摘Background Myocardial damage often occurs after burns. Previously, cardiac enzyme profile was often measured to determine myocardial injury, but was hardly specific. In this study, we investigated early changes of plasma N-terminal pro-brain natriuretic peptide （NT-proBNP） over time and its diagnostic value in burned patients. Methods 39 patients with heat burned were assigned to heart failure group （n = 9）, control group （n = 30）. Plasma NT-ProBNP and troponin Ⅰ（cTnT） were measured at 1st, 3rd, 5th days and 7th day, and patients were subdivided into 2 groups according to their cardiac function. Results Nine patients had heart failure （27.7%） and their NT-proBNP was 1676.03 ± 2190.41 pg/L. Significant difference was found between the heart failure group and control group （P 〈 0.01 ）. Conclusion NT-proBNP is related to the severity of burning and can well reflect the status of myocardial injury in patients with severe burn, and can be used as an ideal marker for myocardial injury in burned patients.
