By applying a global high-resolution （0.1°） OGCM, the influence of the island chains in the Luzon Strait （LS） on the Kuroshio intrusion is studied systematically. The island chains in the LS are separated int...By applying a global high-resolution （0.1°） OGCM, the influence of the island chains in the Luzon Strait （LS） on the Kuroshio intrusion is studied systematically. The island chains in the LS are separated into three parts： the south island chain, the middle and north island chain, and Babuyan Island. One control and three sensitivity experiments are conducted by adding these three parts of the topography gradually. From comparisons of the circulation, temperature, and salinity structures, it is found that the south island chain decreases the westward bending of the main Kuroshio path, the middle and north island chain increases the westward bending, and Babuyan Island also increases the westward bending. These results are extremely clear in winter. Dynamic diagnoses suggest that the westward bending increases with an increase in the incidence angle of the Kuroshio and an increase in the Kuroshio east branch transport. Moreover, the middle and north island chain can split the Kuroshio into two parts, the Kuroshio west and east branches, which can be seen clearly in the satellite altimeter maps.展开更多
The stationary probability vectors of a second order Markov chain on the(n-1)-dimensional standard simplex are considered.In 2015,Li and Zhang gave a characterization of the second order Markov chain such that every v...The stationary probability vectors of a second order Markov chain on the(n-1)-dimensional standard simplex are considered.In 2015,Li and Zhang gave a characterization of the second order Markov chain such that every vector in the simplex is a stationary vector.A modification of the characterization is presented in the paper.Some sufficient conditions are derived for any facet of the simplex such that every vector of the facet is a stationary vector.展开更多
In theoretical chemistry, the researchers use graph models to express the structure of molecular, and the Zagreb indices and multiplicative Zagreb indices defined on molecular graph G are applied to measure the chemic...In theoretical chemistry, the researchers use graph models to express the structure of molecular, and the Zagreb indices and multiplicative Zagreb indices defined on molecular graph G are applied to measure the chemical characteristics of compounds and drugs. In this paper, we present the exact expressions of multiplicative Zagreb indices for certain important chemical structures like nanotube, nanostar and polyomino chain.展开更多
AIM:To evaluate the in vitro effect of amoxicillin and clarithromycin on the cag pathogenicity island(cag PAI).METHODS:One hundred and forty-nine clinical isolates of Helicobacter pylori(H.pylori)cultured from gastric...AIM:To evaluate the in vitro effect of amoxicillin and clarithromycin on the cag pathogenicity island(cag PAI).METHODS:One hundred and forty-nine clinical isolates of Helicobacter pylori(H.pylori)cultured from gastric biopsies from 206 Colombian patients with dyspeptic symptoms from a high-risk area for gastric cancer were included as study material.Antimicrobial susceptibility was determined by the agar dilution method.Resistant isolates at baseline and in amoxicillin and clarithromycin serial dilutions were subjected to genotyping(cagA,vacA alleles s and m),Glu-Pro-Ile-Tyr-Ala(EPIYA)polymerase chain reaction and random amplified polymorphic DNA(RAPD).Images of the RAPD amplicons were analyzed by Gel-Pro Analyzer 4.5program.Cluster analyses was done using SPSS 15.0statistical package,where each of the fingerprint bands were denoted as variables.Dendrograms were designed by following Ward’s clustering method and the estimation of distances between each pair of H.pylori isolates was calculated with the squared Euclidean distance.RESULTS:Resistance rates were 4%for amoxicillin and 2.7%for clarithromycin with 2%double resistances.Genotyping evidenced a high prevalence of the genotype cagA-positive/vacA s1m1.The 3’region of cagA gene was successfully amplified in 92.3%(12/13)of the baseline resistant isolates and in 60%(36/60)of the resistant isolates growing in antibiotic dilutions.Upon observing the distribution of the number of EPIYA repetitions in each dilution with respect to baseline isolates,it was found that in 61.5%(8/13)of the baseline isolates,a change in the number of EPIYA repetitions lowered antibiotic pressure.The gain and loss of EPIYA motifs resulted in a diversity of H.pylori subclones after bacterial adjustment to changing conditions product of antibiotic pressure.RAPD PCR evidenced the close clonal relationship between baseline isolates and isolates growing in antibiotic dilutions.CONCLUSION:Antibiotic pressure does not induce loss of the cag pathogenicity island,but it can leadin most cases-to genetic rearrangements within the3’region cagA of the founding bacteria that can affect the level of tyrosine phosphorylation impacting on its cellular effects and lead to divergence of cagA-positive subclones.展开更多
基金supported by the National Basic Research Program of China(Grant Nos.2015CB954004 and 2013CB956204)the Strategic Priority Research Program(Grant No.XDA11010304) entitled "Western Pacific Ocean System:Structure,Dynamics and Consequences" of the Chinese Academy of Sciencesthe National Natural Science Foundation of China(Grant Nos.41276006,U1405233,41576025 and 41576026)
文摘By applying a global high-resolution （0.1°） OGCM, the influence of the island chains in the Luzon Strait （LS） on the Kuroshio intrusion is studied systematically. The island chains in the LS are separated into three parts： the south island chain, the middle and north island chain, and Babuyan Island. One control and three sensitivity experiments are conducted by adding these three parts of the topography gradually. From comparisons of the circulation, temperature, and salinity structures, it is found that the south island chain decreases the westward bending of the main Kuroshio path, the middle and north island chain increases the westward bending, and Babuyan Island also increases the westward bending. These results are extremely clear in winter. Dynamic diagnoses suggest that the westward bending increases with an increase in the incidence angle of the Kuroshio and an increase in the Kuroshio east branch transport. Moreover, the middle and north island chain can split the Kuroshio into two parts, the Kuroshio west and east branches, which can be seen clearly in the satellite altimeter maps.
基金National Natural Science Foundation of China(Nos.1167125811371086)
文摘The stationary probability vectors of a second order Markov chain on the(n-1)-dimensional standard simplex are considered.In 2015,Li and Zhang gave a characterization of the second order Markov chain such that every vector in the simplex is a stationary vector.A modification of the characterization is presented in the paper.Some sufficient conditions are derived for any facet of the simplex such that every vector of the facet is a stationary vector.
文摘In theoretical chemistry, the researchers use graph models to express the structure of molecular, and the Zagreb indices and multiplicative Zagreb indices defined on molecular graph G are applied to measure the chemical characteristics of compounds and drugs. In this paper, we present the exact expressions of multiplicative Zagreb indices for certain important chemical structures like nanotube, nanostar and polyomino chain.
基金Supported by The Administrative Department on Science and Innovation of the Republic of Colombia-COLCIENCIAS,No.RC-1106-408-20549,RC-1106-493-26237its program:Jóvenes Investigadores e Innovadores"Virginia Gutiérrez de Pineda",and by the Universidad del Valle,Cali,Colombia
文摘AIM:To evaluate the in vitro effect of amoxicillin and clarithromycin on the cag pathogenicity island(cag PAI).METHODS:One hundred and forty-nine clinical isolates of Helicobacter pylori(H.pylori)cultured from gastric biopsies from 206 Colombian patients with dyspeptic symptoms from a high-risk area for gastric cancer were included as study material.Antimicrobial susceptibility was determined by the agar dilution method.Resistant isolates at baseline and in amoxicillin and clarithromycin serial dilutions were subjected to genotyping(cagA,vacA alleles s and m),Glu-Pro-Ile-Tyr-Ala(EPIYA)polymerase chain reaction and random amplified polymorphic DNA(RAPD).Images of the RAPD amplicons were analyzed by Gel-Pro Analyzer 4.5program.Cluster analyses was done using SPSS 15.0statistical package,where each of the fingerprint bands were denoted as variables.Dendrograms were designed by following Ward’s clustering method and the estimation of distances between each pair of H.pylori isolates was calculated with the squared Euclidean distance.RESULTS:Resistance rates were 4%for amoxicillin and 2.7%for clarithromycin with 2%double resistances.Genotyping evidenced a high prevalence of the genotype cagA-positive/vacA s1m1.The 3’region of cagA gene was successfully amplified in 92.3%(12/13)of the baseline resistant isolates and in 60%(36/60)of the resistant isolates growing in antibiotic dilutions.Upon observing the distribution of the number of EPIYA repetitions in each dilution with respect to baseline isolates,it was found that in 61.5%(8/13)of the baseline isolates,a change in the number of EPIYA repetitions lowered antibiotic pressure.The gain and loss of EPIYA motifs resulted in a diversity of H.pylori subclones after bacterial adjustment to changing conditions product of antibiotic pressure.RAPD PCR evidenced the close clonal relationship between baseline isolates and isolates growing in antibiotic dilutions.CONCLUSION:Antibiotic pressure does not induce loss of the cag pathogenicity island,but it can leadin most cases-to genetic rearrangements within the3’region cagA of the founding bacteria that can affect the level of tyrosine phosphorylation impacting on its cellular effects and lead to divergence of cagA-positive subclones.
