Investment of information technology (IT) in the government sector in Indonesia continues to increase every year. However, this increase has not been followed by good governance due to the lack of attention to good IT...Investment of information technology (IT) in the government sector in Indonesia continues to increase every year. However, this increase has not been followed by good governance due to the lack of attention to good IT management. Measurement of IT governance is therefore required as a basis for the continuous improvement of the IT services to government agencies. This study is aimed at producing an application to measure the maturity level of IT governance in government institutions, thus facilitating the process of improvement of IT services. The application developed is based on COBIT 4.1 framework and the design used is Unified Modeling Language. Through stages of information system development, this research results in an application for measuring the maturity level of IT governance that can be used by government agencies in assessing existing IT governance.展开更多
Thermal buckling behavior of cylindrical shell made of functionally graded material（FGM） is studied. The material constituents are composed of ceramic and metal.The material properties across the shell thickness are...Thermal buckling behavior of cylindrical shell made of functionally graded material（FGM） is studied. The material constituents are composed of ceramic and metal.The material properties across the shell thickness are assumed to be graded according to a simple power law distribution in terms of the volume fraction rule of mixtures. Based on the Donnell shell theory, a system of dimensionless partial differential equations of buckling in terms of displacement components is derived. The method of separation of variables is used to transform the governing equations to ordinary differential equations（ODEs）. A shooting method is used to search for the numerical solutions of the differential equations under two types of boundary conditions. Effects of the power law index, the dimensionless geometrical parameters, and the temperature ratio on the critical buckling temperature are discussed in detail.展开更多
Background: The degree of adipose tissue development at birth may influence neonatal survival and subsequent health outcomes. Despite their lower birth weights, piglets from Meishan sows(a fat breed with excellent mat...Background: The degree of adipose tissue development at birth may influence neonatal survival and subsequent health outcomes. Despite their lower birth weights, piglets from Meishan sows(a fat breed with excellent maternal ability) have a higher survival rate than piglets from Large White sows(a lean breed). To identify the main pathways involved in subcutaneous adipose tissue maturation during the last month of gestation, we compared the proteome and the expression levels of some genes at d 90 and d 110 of gestation in purebred and crossbred Large White or Meishan fetuses gestated by sows of either breed.Results: A total of 52 proteins in fetal subcutaneous adipose tissue were identified as differential y expressed over the course of gestation. Many proteins involved in energy metabolism were more abundant, whereas some proteins participating in cytoskeleton organization were reduced in abundance on d 110 compared with d 90. Irrespective of age,24 proteins differed in abundance between fetal genotypes, and an interaction effect between fetal age and genotype was observed for 13 proteins. The abundance levels of proteins known to be responsive to nutrient levels such as aldolase and fatty acid binding proteins, as wel as the expression levels of FASN, a key lipogenic enzyme, and MLXIPL, a pivotal transcriptional mediator of glucose-related stimulation of lipogenic genes, were elevated in the adipose tissue of pure and crossbred fetuses from Meishan sows. These data suggested that the adipose tissue of these fetuses had superior metabolic functionality, whatever their paternal genes. Conversely, proteins participating in redox homeostasis and apoptotic cel clearance had a lower abundance in Meishan than in Large White fetuses. Time-course differences in adipose tissue protein abundance were revealed between fetal genotypes for a few secreted proteins participating in responses to organic substances, such as alpha-2-HS-glycoprotein, transferrin and albumin.Conclusions: These results underline the importance of not only fetal age but also maternal intrauterine environment in the regulation of several proteins in subcutaneous adipose tissue. These proteins may be used to estimate the maturity grade of piglet neonates.展开更多
State-owned enterprises are important pillars of socialism with Chinese characteristics,and the modernization of their governance system and governance capacity is an important part of the modernization of the nationa...State-owned enterprises are important pillars of socialism with Chinese characteristics,and the modernization of their governance system and governance capacity is an important part of the modernization of the national governance system and governance capacity.Through case study and specific practice,this paper carries out an in-depth thinking and serious analysis on how to promote the modernization of the governance system and governance capacity of state-owned enterprises under the new situation and requirements.This paper puts forward three kinds of management and control mechanism to enhance core competence in addition to the specific implementation path by using digital governance means.展开更多
文摘Investment of information technology (IT) in the government sector in Indonesia continues to increase every year. However, this increase has not been followed by good governance due to the lack of attention to good IT management. Measurement of IT governance is therefore required as a basis for the continuous improvement of the IT services to government agencies. This study is aimed at producing an application to measure the maturity level of IT governance in government institutions, thus facilitating the process of improvement of IT services. The application developed is based on COBIT 4.1 framework and the design used is Unified Modeling Language. Through stages of information system development, this research results in an application for measuring the maturity level of IT governance that can be used by government agencies in assessing existing IT governance.
基金Project supported by the National Natural Science Foundation of China(Nos.11272278 and11672260)
文摘Thermal buckling behavior of cylindrical shell made of functionally graded material（FGM） is studied. The material constituents are composed of ceramic and metal.The material properties across the shell thickness are assumed to be graded according to a simple power law distribution in terms of the volume fraction rule of mixtures. Based on the Donnell shell theory, a system of dimensionless partial differential equations of buckling in terms of displacement components is derived. The method of separation of variables is used to transform the governing equations to ordinary differential equations（ODEs）. A shooting method is used to search for the numerical solutions of the differential equations under two types of boundary conditions. Effects of the power law index, the dimensionless geometrical parameters, and the temperature ratio on the critical buckling temperature are discussed in detail.
基金financial support from the French National Agency for Research(PORCINET project,ANR-09-GENMOO5)supported by grants from Biogenouest,IBi SA and Conseil Regional de Bretagne(France)
文摘Background: The degree of adipose tissue development at birth may influence neonatal survival and subsequent health outcomes. Despite their lower birth weights, piglets from Meishan sows(a fat breed with excellent maternal ability) have a higher survival rate than piglets from Large White sows(a lean breed). To identify the main pathways involved in subcutaneous adipose tissue maturation during the last month of gestation, we compared the proteome and the expression levels of some genes at d 90 and d 110 of gestation in purebred and crossbred Large White or Meishan fetuses gestated by sows of either breed.Results: A total of 52 proteins in fetal subcutaneous adipose tissue were identified as differential y expressed over the course of gestation. Many proteins involved in energy metabolism were more abundant, whereas some proteins participating in cytoskeleton organization were reduced in abundance on d 110 compared with d 90. Irrespective of age,24 proteins differed in abundance between fetal genotypes, and an interaction effect between fetal age and genotype was observed for 13 proteins. The abundance levels of proteins known to be responsive to nutrient levels such as aldolase and fatty acid binding proteins, as wel as the expression levels of FASN, a key lipogenic enzyme, and MLXIPL, a pivotal transcriptional mediator of glucose-related stimulation of lipogenic genes, were elevated in the adipose tissue of pure and crossbred fetuses from Meishan sows. These data suggested that the adipose tissue of these fetuses had superior metabolic functionality, whatever their paternal genes. Conversely, proteins participating in redox homeostasis and apoptotic cel clearance had a lower abundance in Meishan than in Large White fetuses. Time-course differences in adipose tissue protein abundance were revealed between fetal genotypes for a few secreted proteins participating in responses to organic substances, such as alpha-2-HS-glycoprotein, transferrin and albumin.Conclusions: These results underline the importance of not only fetal age but also maternal intrauterine environment in the regulation of several proteins in subcutaneous adipose tissue. These proteins may be used to estimate the maturity grade of piglet neonates.
文摘State-owned enterprises are important pillars of socialism with Chinese characteristics,and the modernization of their governance system and governance capacity is an important part of the modernization of the national governance system and governance capacity.Through case study and specific practice,this paper carries out an in-depth thinking and serious analysis on how to promote the modernization of the governance system and governance capacity of state-owned enterprises under the new situation and requirements.This paper puts forward three kinds of management and control mechanism to enhance core competence in addition to the specific implementation path by using digital governance means.
