Low‑Temperature Trigger Nitric Oxide Nanogenerators for Anti‑biofilm and Wound Healing

Infected wounds pose a significant global health challenge due to the persistence of bacterial biofilms and limited tissue self-repair.Nitric oxide(NO)functions as a potent antimicrobial agent,demonstrating a dual capacity for both antimicrobial action and tissue rejuvenation across varying concentrations.However,achieving controlled NO release at distinct stages of infected wound progression,simultaneously targeting biofilm removal and wound recovery,remains a formidable challenge.In this work,we introduce a smart electrospun fibrous membrane,featuring an interior laden with NO-loaded HKUST-1 particles and a porous external surface.Notably,the results reveal the photothermal property of HKUST-1 when exposed to near-infrared(NIR)light,enabling precise management of NO release contingent upon light conditions.During the initial phase of infection treatment,a significant NO release is triggered by near-infrared photothermal stimulation,synergistically complementing photothermal therapy to effectively eliminate bacterial biofilms.Subsequently,in the wound-healing phase,NO is released from the degrading fibrous membrane in a controlled and gradual manner,synergizing with trace amounts of copper ions released during MOF degradation.This collaborative mechanism accelerates the formation of blood vessels within the wound,thereby facilitating the healing process.This study suggests a promising and innovative approach for the effective treatment of infected wounds.

Benefits of multidisciplinary collaborative care team-based nursing services in treating pressure injury wounds in cerebral infarction patients

BACKGROUND Cerebral infarction patients need to be bedridden for long periods of time often resulting in pressure injuries,which may represent a serious threat to patients'life and health.An effective nursing program should be adopted for timely intervention in patients with pressure wounds.AIM To explore the value of nursing services based on a multidisciplinary collaborative treatment team in patients with pressure injury wounds following cerebral infarction.METHODS Patients with cerebral infarction pressure injury wounds in our hospital from December 2016 to January 2021 were selected and divided into one study group and one control group based on the simple random number table method.The control group was treated with conventional nursing care(CNC),and the study group was treated with care services based on multidisciplinary collaborative care(MDCC).The Pressure Ulcer Scale for Healing(PUSH),healing effect,Self-Perceived Burden Score(SPBS),and satisfaction with the intervention were calculated before and after 2 and 4 wk of intervention in both groups.RESULTS Sixty-two patients were enrolled,and 31 patients were assigned to each group.The results of the interventions were as follows:(1)There was no significant difference between the PUSH scores of the MDCC group(11.19±2.46)and CNC group(12.01±2.79)before the intervention(P>0.05),and the PUSH scores were lower after 2 and 4 wk of intervention in the MDCC group(6.63±1.97 and 3.11±1.04)than in the CNC group(8.78±2.13 and 4.96±1.35 points)(P<0.05);(2)The rate of wound healing in the MDCC group(96.77%)was higher than that in the CNC group(80.65%)(P<0.05);(3)There was no significant difference between the SPBS scores of emotional factors(21.15±3.11),economic factors(9.88±2.15),and physical factors(8.19±2.23)in the two groups before the intervention.The scores of emotional factors(13.51±1.88),economic factors(6.38±1.44),and physical factors(5.37±1.08)were lower in the MDCC group than in the CNC group(16.89±2.05,7.99±1.68 and 7.06±1.19)after 4 wk of intervention(P<0.05);and(4)Satisfaction with the intervention was higher in the MDCC group(93.55%)than in the CNC group(74.19%)(P<0.05).CONCLUSION Interventions for patients with cerebral infarction pressure wounds based on an MDCC treatment team can effectively reduce patients'self-perceived burden,improve pressure wound conditions,facilitate wound healing,and increase patient satisfaction with the intervention.

Ferroelectric catalytic BaTiO_(3)-based composite insoles to promote healing of infected wounds:Analysis of antibacterial efficacy and angiogenesis

Our feet are often subjected to moist and warm environments,which can promote the growth of harmful bacteria and the development of severe infection in wounds located in the foot.As a result,there is a need for new and innovative strategies to safely sterilize feet,when shoes are worn,to prevent any potential foot-related diseases.In this paper,we have produced a non-destructive,biocompatible and convenient-to-use insole by embedding a BaTiO_(3)(BT)ferroel ectric material into a conventional polydimethylsilane(PDMS)insole material to exploit a ferroelectric catalytic effect to promote the antibacterial and healing of infected wounds via the ferroelectric charges generated during walking.The formation of reactive oxygen species generated through a ferroelectric catalytic effect in the PDMS-BT composite is shown to increase the oxidative stress on bacteria and decrease both the activity of bacteria and the rate of formation of bacterial biofilms.In addition,the ferroelectric field generated by the PDMS-BT insole can enhance the level of transforming growth factor-beta and CD31 by influencing the endogenous electric field of a wound,thereby promoting the proliferation,differentiation of fibroblasts and angiogenesis.This work therefore provides a new route for antimicrobial and tissue reconstruction by integrating a ferroelectric biomaterial into a shoe insole,with significant potential for health-related applications.

A Mg^(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing

Bacterial infection is a vital factor to delay the wound healing process.The antibiotics abuse leads to drug resistance of some pathogenic bacteria.Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired.Herein,we reported a composite antibacterial hydrogel PDA-PAM/Mg^(2+)that shows excellent self-healing and tissue adhesive property,and photothermal antibacterial functions for accelerating wound healing.The gel was composed of polyacrylamide(PAM),polydopamine(PDA),and magnesium(Mg^(2+))and prepared via a two-step procedure:an alkali-induced dopamine pre-polymerization and followed radical polymerization process.The composite gel shows excellent tissue adhesiveness and Mg^(2+)-synergized photothermal antibacterial activity,inducing a survival rate of 5.29% for S.aureus and 7.06%for E.coli after near infrared light irradiation.The composite hydrogel further demonstrated efficient bacteria inhibition,enhanced wound healing and collagen deposition in a full-thickness skin defect rat model.Together,the PDA-PAM/Mg^(2+) hydrogel presents an excellent wound dressing with excellent tissue adhesion,wound healing,and antibacterial functions.

Synthesis of graphene oxide-quaternary ammonium nanocomposite with synergistic antibacterial activity to promote infected wound healing

Background: Bacterial infection is one of the most common complications in burn, trauma, and chronic refractory wounds and is an impediment to healing. The frequent occurrence of antimicrobial-resistant bacteria due to irrational application of antibiotics increases treatment cost and mortality. Graphene oxide (GO) has been generally reported to possess high antimicrobial activity against a wide range of bacteria in vitro. In this study, a graphene oxide-quaternary ammonium salt (GO-QAS) nanocomposite was synthesized and thoroughly investigated for synergistic antibacterial activity, underlying antibacterial mechanisms and biocompatibility in vitro and in vivo. Methods: The GO-QAS nanocomposite was synthesized through amidation reactions of carboxylic group end-capped QAS polymers with primary amine-decorated GO to achieve high QAS loading ratios on nanosheets. Next, we investigated the antibacterial activity and biocompatibility of GO-QAS in vitro and in vivo. Results: GO-QAS exhibited synergistic antibacterial activity against bacteria through not only mechanical membrane perturbation, including wrapping, bacterial membrane insertion, and bacterial membrane perforation, but also oxidative stress induction. In addition, it was found that GO-QAS could eradicate multidrug-resistant bacteria more effectively than conventional antibiotics. The in vitro and in vivo toxicity tests indicated that GO-QAS did not exhibit obvious toxicity towards mammalian cel s or organs at low concentrations. Notably, GO-QAS topically applied on infected wounds maintained highly efficient antibacterial activity and promoted infected wound healing in vivo. Conclusions: The GO-QAS nanocomposite exhibits excellent synergistic antibacterial activity and good biocompatibility both in vitro and in vivo. The antibacterial mechanisms involve both mechanical membrane perturbation and oxidative stress induction. In addition, GO-QAS accelerated the healing process of infected wounds by promoting re-epithelialization and granulation tissue formation. Overall, the results indicated that the GO-QAS nanocomposite could be applied as a promising antimicrobial agent for infected wound management and antibacterial wound dressing synthesis.

Design of Collagen-Based Hemostatic Material for Use in Plastic and Reconstructive Surgery

This study aims to develop collagen-based hemostatic materials. The sheet-shaped collagen sponge was manufactured by freeze-vacuum drying the aqueous solution of collagen (Col) and heat-denatured collagen (Col’) at a composition ratio of 2/1. The both sides or one side of sponge was treated with ultraviolet (UV) irradiation for 15 minutes to introduce intermolecular crosslinks between collagen molecules. The elution behavior of collagen sponge was investigated by immersing the sponge in water for a predetermined time and then by measuring the weight change. The double-sided UV-irradiated sponge showed very slow elution properties. On the other hand, the single-sided UV-irradiated sponge showed initially fast elution and subsequent very slow elution properties. Such initially fast elution of collagen molecules from the surface without UV-irradiation allows an adhesion of collagen sponge to the wound surface and results in hemostatic effect. In addition, the water absorption and retention properties of sponge were investigated by placing the hydrated sponge on a mesh for a predetermined time and then by measuring the weight change. The double-sided UV-irradiated sponge absorbed 81 times more water than own weight and showed a value of 45 times even after 7 days. The single-sided UV-irradiated sponge absorbed 80 times more water than own weight and showed a value of 39 times even after 7 days. The sponge with high water absorption and retention properties allows a wound healing effect because such sponge can absorb large amounts of blood plasma and exudates containing various cell growth factors. The double-sided UV-irradiated sponge is a good candidate for the wound dressing. On the other hand, the single-sided UV-irradiated sponge is a good candidate for the hemostatic material.

拔脓生肌软膏的药效学及皮肤安全性评价

目的 考察拔脓生肌软膏(BNO)治疗皮肤感染性创面的药理学作用,并初步评价其皮肤安全性,为进一步研发和安全应用提供参考。方法 采用无特定病原体(SPF)级小鼠和大鼠建立金黄色葡萄球菌诱导的细菌性感染皮肤创面模型,随机分为基质组,BNO小、中、大剂量组,龙珠组,百多邦组,给予相应药物涂抹后,考察BNO对大、小鼠细菌性皮肤感染创面的治疗作用,主要观察创面愈合率、创面病理形态、皮肤细菌逆培养细菌含量、皮肤创面组织中羟脯氨酸,以及大鼠皮肤创面组织中白细胞介素-10(IL-10)及肿瘤坏死因子-α(TNF-α)的含量;采用小鼠扭体及耳肿胀实验考察BNO的抗炎镇痛作用;采用皮肤刺激性实验和过敏性实验考察BNO对新西兰兔、豚鼠皮肤给药的安全性。结果 与基质组比较,BNO治疗后能显著促进皮肤创面愈合,改善创面组织病理形态,显著增加皮肤组织中羟脯氨酸含量,抑制创面感染部位的细菌生长,抑制炎症,降低IL-10、TNF-α的含量(P<0.05或P<0.01);BNO大剂量能显著抑制小鼠耳肿胀(P<0.01),中、大剂量均能显著减少扭体次数(P<0.05或P<0.01);BNO对新西兰兔、豚鼠皮肤实验结果显示没有明显的刺激性和过敏性,安全性良好。结论 BNO具有一定的抗炎镇痛及促进皮肤创面愈合作用,该制剂符合中药外用软膏的安全性要求。

Ultrasmall Fe-doped carbon dots nanozymes for photoenhanced antibacterial therapy and wound healing

Pathogenic bacteria pose a devastating threat to public health.However,because of the growing bacterial antibiotic resistance,there is an urgent need to develop alternative antibacterial strategies to the established antibiotics.Herein,iron-doped carbon dots(Fe-CDs,~3 nm)nanozymes with excellent photothermal conversion and photoenhanced enzyme-like properties are developed through a facile one-pot pyrolysis approach for synergistic efficient antibacterial therapy and wound healing.In particular,Fe doping endows CDs with photoenhanced peroxidase(POD)-like activity,which lead to the generation of heat and reactive oxygen species(ROS)for Gram-positive and Gram-negative bacteria killing.This study demonstrates Fe-CDs have significant wound healing efficiency of Fe-CDs by preventing infection,promoting fibroblast proliferation,angiogenesis,and collagen deposition.Furthermore,the ultrasmall size of Fe-CDs possesses good biocompatibility favoring clinical translation.We believe that the nanozyme-mediated therapeutic platform presented here is expected to show promising applications in antibacterial.

Bilayer hydrogel dressing with lysozymeenhanced photothermal therapy for biofilm eradication and accelerated chronic wound repair

Biofilms are closely associated with the tough healing and dysfunctional inflammation of chronic wounds.Photothermal therapy(PTT)emerged as a suitable alternative which could destroy the structure of biofilms with local physical heat.However,the efficacy of PTT is limited because the excessive hyperthermia could damage surrounding tissues.Besides,the difficult reserve and delivery of photothermal agents makes PTT hard to eradicate biofilms as expectation.Herein,we present a GelMA-EGF/Gelatin-MPDA-LZM bilayer hydrogel dressing to perform lysozyme-enhanced PTT for biofilms eradication and a further acceleration to the repair of chronic wounds.Gelatin was used as inner layer hydrogel to reserve lysozyme(LZM)loaded mesoporous polydopamine(MPDA)(MPDA-LZM)nanoparticles,which could rapidly liquefy while temperature rising so as to achieve a bulk release of nanoparticles.MPDA-LZM nanoparticles serve as photothermal agents with antibacterial capability,could deeply penetrate and destroy biofilms.In addition,the outer layer hydrogel consisted of gelatin methacryloyl(GelMA)and epidermal growth factor(EGF)promoted wound healing and tissue regeneration.It displayed remarkable efficacy on alleviating infection and accelerating wound healing in vivo.Overall,the innovative therapeutic strategy we came up with has significant effect on biofilms eradication and shows promising application in promoting the repair of clinical chronic wounds.

异体输血诱发巨噬细胞分化失调对糖尿病足溃疡患者创面愈合的影响分析

目的探讨异体输血诱发巨噬细胞分化失调对糖尿病足溃疡患者创面愈合的影响。方法90例异体输血诱发巨噬细胞分化失调患者,按照溃疡原因分为糖尿病足溃疡组和足部外伤溃疡组,各45例。所有患者均在入院后进行细菌培养+药敏试验,根据细菌培养结果对患者进行抗生素治疗,同时反复清创,直到创面新鲜,肉芽组织生长良好。比较两组患者干预前后足功能、创面组织炎症浸润细胞计数及创面组织白细胞介素-12β(IL-12β)、一氧化氮合成酶(iNOS)、肿瘤坏死因子-α(TNF-α)的信使核糖核酸(mRNA)相对表达量。结果糖尿病足溃疡组和足部外伤溃疡组干预前美国足与踝关节协会(AOFAS)评分、AOFAS功能评分对比,统计学结果无显著差异(P>0.05);糖尿病足溃疡组和足部外伤溃疡组干预后AOFAS评分、AOFAS功能评分均高于干预前,统计学结果有显著差异(P<0.05);糖尿病足溃疡组干预后AOFAS评分(62.53±4.21)分、AOFAS功能评分(42.14±3.21)分均低于足部外伤溃疡组的(89.68±6.51)、(48.37±4.59)分,统计学结果有显著差异(P<0.05)。糖尿病足溃疡组和足部外伤溃疡组干预前创面组织炎症浸润细胞计数对比,统计学结果无显著差异(P>0.05);糖尿病足溃疡组和足部外伤溃疡组干预后创面组织炎症浸润细胞计数均低于干预前,统计学结果有显著差异(P<0.05);糖尿病足溃疡组干预后创面组织炎症浸润细胞计数(41.33±4.09)个/高倍镜视野高于足部外伤溃疡组的(33.21±1.75)个/高倍镜视野,统计学结果有显著差异(P<0.05)。糖尿病足溃疡组和足部外伤溃疡组干预前创面组织IL-12β、iNOS、TNF-α的mRNA相对表达量对比,统计学结果无显著差异(P>0.05);糖尿病足溃疡组和足部外伤溃疡组干预后创面组织IL-12β、iNOS、TNF-α的mRNA相对表达量均低于干预前,统计学结果有显著差异(P<0.05);糖尿病足溃疡组干预后创面组织IL-12β、iNOS、TNF-α的mRNA相对表达量分别为(0.068±0.012)、(56.822±12.116)、(1.812±0.246),均高于足部外伤溃疡组的(0.025±0.011)、(33.032±11.005)、(0.833±0.115),统计学结果有显著差异(P<0.05)。结论异体输血诱发巨噬细胞分化失调会影响糖尿病足溃疡患者的足功能、创面组织炎症浸润细胞计数及创面组织IL-12β、iNOS、TNF-α的mRNA相对表达量,临床需引起足够的重视。

生肌玉红膏联合脐带间充质干细胞外泌体治疗糖尿病足创面的临床研究

目的探讨生肌玉红膏联合脐带间充质干细胞来源的外泌体(HUC-MSC-Ex)治疗糖尿病足创面的疗效。方法收集2022年1月至2023年2月就诊于平顶山市中医医院的64例糖尿病足患者的临床资料,根据治疗方法的不同分为观察组和对照组,每组32例。对照组采用凡士林纱布联合HUC-MSC-Ex进行治疗,观察组采用生肌玉红膏联合HUC-MSC-Ex进行治疗。比较两组患者的临床疗效,创面面积,创面症状、体征积分及创面愈合时间。结果治疗28 d后,观察组患者的临床疗效优于对照组患者,差异有统计学意义(P﹤0.05)。治疗28 d后,两组患者的创面面积均较本组治疗前缩小,创面症状、体征积分均较本组治疗前减少,且观察组患者的创面面积小于对照组患者,创面症状、体征积分低于对照组患者,创面愈合时间短于对照组患者,差异均有统计学意义(P﹤0.05)。结论生肌玉红膏联合脐带间充质干细胞外泌体治疗糖尿病足创面的效果明显,能够提高创面愈合率,缩小创面面积,改善创面症状,缩短创面愈合时间,值得临床推广应用。

湿性愈合新型敷料在外伤难愈合伤口中的应用及护理要点

目的:分析在外伤难愈合伤口中应用湿性愈合新型敷料的临床效果及护理要点。方法:选取本院2019年3月—2021年9月接诊的72例外伤难愈合伤口患者,按照电脑随机排序均分为参照组与研究组,各36例。参照组治疗过程中使用传统敷料,研究组使用湿性愈合新型敷料,比较2组的效果。结果:治疗前,2组患者的疼痛程度比较,差异无统计学意义(P>0.05);治疗后,研究组的疼痛程度低于治疗前及参照组,差异有统计学意义(P<0.05);参照组治疗前后的疼痛程度比较,差异无统计学意义(P>0.05)。研究组患者的换药次数少于参照组,愈合用时短于参照组,组间差异有统计学意义(P<0.05)。研究组的总有效率高于对照组,组间差异有统计学意义(P<0.05)。结论:湿性愈合新型敷料应用于外伤难愈合伤口中能够缩短伤口痊愈用时,提高治疗效果,适合于临床应用推广。

分层换药法在大面积深度烧伤后残余创面患者康复中的价值探讨

目的:探讨分层换药法在大面积深度烧伤后残余创面愈合患者康复中的价值。方法:选择2020年1月—2023年12月南开大学附属医院诊治的89例大面积深度烧伤后残余创面患者作为研究对象,根据随机信封抽签原则将其分为研究组(n=45)与对照组(n=44)。对照组采用常规换药法,研究组采用分层换药法,比较两组创面愈合时间、疗效、疼痛程度及生活质量评分。结果:研究组四肢、躯干、颜面部的创面愈合时间均短于对照组,差异有统计学意义(P<0.05)。治疗3、6、9 d后,研究组疼痛视觉模拟评分均低于对照组,差异均有统计学意义(P<0.05)。治疗第14天,研究组的治疗优良率为97.78%,高于对照组的84.09%,研究组健康调查简表各维度评分均高于对照组,差异均有统计学意义(P<0.05)。结论:分层换药法应用于大面积深度烧伤后残余创面患者康复中的应用,有助于缓解疼痛,缩短创面愈合时间,改善疗效,提高生活质量。

中药汤剂联合湿润烧伤膏治疗臁疮的临床疗效及对创面愈合的影响

目的研究中药汤剂联合湿润烧伤膏对臁疮的应用价值。方法非随机选取2021年1月—2023年9月南京市江宁中医院101例臁疮患者为研究对象,根据治疗方法不同分为两组,对照组50例,采用湿润烧伤膏治疗,研究组51例,在对照组基础上结合中药汤剂治疗。对比两组临床疗效、创面面积、疼痛程度及生活质量。结果研究组治疗总有效率为100%,高于对照组,差异有统计学意义(χ^(2)=4.326,P<0.05)。治疗后,研究组创面面积更小,疼痛评分更低,生活质量评分更高,差异有统计学意义(P均<0.05)。结论臁疮采用中药汤剂联合湿润烧伤膏治疗,可提高治疗效果,促进创面愈合,减轻疼痛,提高生活质量。

中药浸浴联合重组表皮细胞在压疮患者中的应用效果

目的探究中药浸浴联合重组表皮细胞在压疮患者中的应用效果。方法选取2022年1月至2023年6月贵溪市中医院收治的60例压疮患者作为研究对象,采用随机数字表法将其分为对照组与观察组,每组各30例。对照组采用重组表皮细胞生长因子方法,观察组在对照组基础上使用中药浸浴,分析两组干预后的创面愈合有效率、炎症因子水平、症状缓解时间、转化生长因子(TGF-β1)、血管内皮生长因子(VEGF)表达水平以及不良反应发生率。结果治疗前两组的TGF-β1、VEGF表达水平、炎症因子水平比较,差异无统计学意义(P>0.05)。观察组治疗后TGF-β1、VEGF表达水平以及炎症因子水平均低于对照组,差异有统计学意义(P<0.05)。观察组症状缓解时间、不良反应发生率低于对照组,差异有统计学意义(P<0.05)。观察组创面愈合总有效率高于对照组,差异有统计学意义(P<0.05)。结论在临床上对压疮创面修复中采用重组表皮细胞生长因子联合中药浸浴效果更好,患者创面愈合有效率提高,症状缓解时间缩短,不良反应发生率少,安全性高且效果显著,临床应用价值高。

祛腐生肌法对肛周脓肿及肛瘘患者术后创面愈合的效果研究

目的:分析祛腐生肌法对肛周脓肿及肛瘘患者术后创面愈合的效果。方法:选取2022年3月—2024年3月天津市东丽区中医医院收治的60例肛周脓肿及肛瘘术患者为研究对象,根据随机数字表法将其随机分为对照组和研究组,各30例。对照组采用康复新液纱条外敷治疗,研究组采用中医祛腐生肌法治疗。比较两组的创面相关指标、创面面积减情况、临床指标、疼痛指标。结果:研究组治疗有效率为96.67%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,研究组创面腐肉脱落、愈合和新生皮出现时间均短于对照组,研究组创面面积减小率为(67.52±20.45)%,高于对照组的(50.69±19.14)%,差异有统计学意义(P<0.05)。治疗后,研究组分泌物、肉芽形态和切口红肿评分、去甲肾上腺素水平和肛周疼痛数字评分法评分均低于对照组,差异均有统计学意义(P<0.05)。结论:祛腐生肌法治疗肛周脓肿及肛瘘术后创面,有助于缩短创面腐肉脱落时间、愈合时间和新生皮出现时间,降低创面面积减小率,改善患者临床指标,降低去甲肾上腺素水平,缓解肛周疼痛。

专项护理方案在皮肤软组织扩张术中的临床观察

目的探讨专项护理方案在皮肤软组织扩张术中的临床效果。方法选取2018年1月至2023年12月于郑州市骨科医院在收治的42例行皮肤软组织扩张术治疗的患者,按护理方法不同将其分为两组,每组21例,对照组实施常规护理,观察组在此基础之上实施专项护理,分析两组患者术后恢复的效果。结果观察组患者创口愈合时间(10.25±2.12)d,少于对照组患者的(11.85±2.14)d,观察组患者伤口拆线时间(7.25±1.24)d,少于对照组患者的(8.62±1.21)d,观察组患者温哥华瘢痕量表评分为(6.25±1.12)分,少于对照组患者的(8.89±1.43)分,上述结果差异有统计学意义(P<0.05)。观察组患者护理干预后的SAS、SDS评分低于对照组,差异有统计学意义(P<0.05)。结论皮肤软组织扩张术后采用专项护理可以显著提高创口愈合的速度,改善瘢痕评分,可以降低患者的焦虑和抑郁情绪。

负压伤口护理在普通外科患者术后伤口愈合中作用

目的 分析负压伤口护理措施在普通外科患者术后伤口愈合中作用。方法 选取2022年5月—2023年4月本院普通外科收治的80例患者作为研究对象,使用随机数字表法分为对照组和观察组,每组40例。对照组使用常规护理方案,观察组采取负压伤口护理,比较两组患者伤口愈合时间、疼痛感、术后感染率、护理满意度。结果 观察组经过负压伤口护理干预后,伤口愈合时间、出血量、疼痛数字评分(NRS)均低于对照组,组间差异有统计学意义(P<0.05);观察组术后感染发生率低于对照组,组间差异有统计学意义(P<0.05);观察组护理满意度明显高于对照组,组间差异有统计学意义(P<0.05)。结论 在普通外科患者术后护理中,采取负压伤口护理措施效果明显,可缩短患者伤口愈合时间,并且有利于降低疼痛感,使得患者术后伤口感染发生率降低,最终可提升患者对护理的满意度。

压疮愈合计分量表评价不同类型伤口的治疗效果

量化评价伤口治疗效果已成为伤口治疗领域的新趋势,美国压疮专家咨询组研制的压疮愈合计分量表(PUSH)最初用于量化评价压疮的治疗效果,后被引入用于评价不同类型的伤口治疗效果。文章从PUSH跨专业应用的信效度研究和临床应用进展进行综述,旨在为临床正确应用该工具提供参考。

同源异体血小板凝胶治疗糖尿病性难愈合创面的研究

目的评价同源异体血小板凝胶促进糖尿病性难治创面愈合的疗效。方法采用同源异体单采血小板为原料制备血小板凝胶(platelet gel,PG)。32例患者分为皮肤溃疡型和窦道型2类,各类分别设立对照组与实验组,皮肤溃疡型各10例,窦道型各6例,对照组采用临床常规方法,实验组采用PG治疗,观察并记录创面愈合情况,测量愈合面积或体积,进行统计学分析。结果 32例糖尿病性溃疡患者综合疗效评价统计结果显示,糖尿病性皮肤表面溃疡型和窦道型溃疡种类型的PG治疗效果明显优于对照组,实验组12周痊愈率达到87.5%,而对照组仅为12.5%。皮肤溃疡型和窦道型创面治疗第3、6、12周时的愈合率实验组高于对照组。实验组具有疗程短、换药间隔时间长、愈合质量好等优势。结论同源异体血小板凝胶用于治疗糖尿病性难治性溃疡效果明显优于常规治疗方法,无不良反应,是一种简单易行、安全有效的治疗糖尿病性难治性创面愈合的方法。