Improved immunosuppression regimens have led to better survival for patients with renal transplant grafts and patients with immunological renal diseases worldwide. However, this is not the case in the Northern Territo...Improved immunosuppression regimens have led to better survival for patients with renal transplant grafts and patients with immunological renal diseases worldwide. However, this is not the case in the Northern Territory of Australia. Available limited published data from the Northern Territory of Australia have shown poor outcomes for renal transplantation with survival for both patients and grafts around 50% at 5 years suggesting death with a functioning graft as the commonest cause of graft loss. These studies have shown that the leading cause of death is infections. Achieving the right level of immunosuppression to prevent rejection in renal transplantation and achieve remission in immunological renal diseases can be a major challenge in areas with high prevalence of infections such as the Northern Territory. We present 2 cases of the challenges from infections of immunosuppression in renal transplantation and immunological renal diseases in the Northern Territory of Australia. A 57 year old Aboriginal woman received a deceased donor renal transplant in 2006. She has been plagued by recurrence of several life threatening infections including urinary tract, cytomegalovirus, and severe cryptococcocus infections. This resulted in immunosuppression reduction and failure of the transplant 5 years post transplantation. A 20 year old Aboriginal woman presented with a combination of severe lupus nephritis and severe sepsis. She fully recovered after treatment with antibiotics and careful immunosuppression. However, she has had recurrent hospital admissions with life threatening infections resulting in stopping the immunosuppression. She then had severe lupus nephritis flare leading to dialysis dependence and will need a renal transplant. The cases illustrate the need for tailored and robust immunosuppression and transplant work up protocols. To that effect, prospective studies to analyse outcomes in immunosuppressed individuals, pharmacokinetic studies assessing whether the conventionally recommended drug levels are appropriate for this population and culturally appropriate educational programmes need to be performed.展开更多
Imperialist Robert Baden-Powell’s Boy Scouts Association started in the Gold Coast Colony during the First World War and schooled boys for nationality during the 1920s.This paper uses archival documents to discuss ho...Imperialist Robert Baden-Powell’s Boy Scouts Association started in the Gold Coast Colony during the First World War and schooled boys for nationality during the 1920s.This paper uses archival documents to discuss how Chief Scout Governor Gordon Guggisberg,who was brigadier general during the First World War,reorganized the Boy Scouts Association in the Northern Province of the Northern Territories Protectorate.The scout officers at the Local Boy Scouts Associations had the power to fashion desire but were not supposed to have consequences on political power.As government officers and scout officers they had warrants to work at the government schools at Gambaga,Wa,and Lawra to attain money locally for kits to instruct and invent the identity,customs and nationalist categories of schoolboys performing the British Empire.展开更多
In 1907,military leader Robert Baden-Powell started the Boy Scouts Association in England as the British colonial government officers instituted Tamale village as the administrative centre of the Northern Territories ...In 1907,military leader Robert Baden-Powell started the Boy Scouts Association in England as the British colonial government officers instituted Tamale village as the administrative centre of the Northern Territories Protectorate.Sam Yarney worked with Frank Collyer the European bank cashier and scoutmaster who started the Boy Scouts in the Gold Coast Colony in 1914,the year the First World War started.In 1922,Governor Gordon Guggisberg,who was brigadier general during the war was the chief scout.He reorganized the Local Boy Scouts Association in the Tamale Government School that received select boys from various schools in the Northern Territories Protectorate.The schoolboys excelled in the Standard VII and Civil Service Examinations to work with the government institutions and train as teachers and telegraphists.Arthur James Philbrick the chief scout commissioner of the Northern Territories employed Yarney as the assistant scout commissioner in the Southern Province to take on the staff of the reorganized Tamale Local Boy Scouts Association and register the 1st Tamale Troop.The scout officers subscribed to a Scout Fund to buy kit,for the schoolboys who passed the Tenderfoot Tests to buy uniforms and perform at events.展开更多
Although ants are an ecologically dominant and extensively studied faunal group throughout the tropics, there is a poor understanding of tropical ant diversity and distribution at large spatial scales. Here we use a c...Although ants are an ecologically dominant and extensively studied faunal group throughout the tropics, there is a poor understanding of tropical ant diversity and distribution at large spatial scales. Here we use a collection developed from 3 decades of ant surveys to present the first analysis of ant diversity and biogeography of a large tropical region. Our objective was to document the species richness, composition, and biogeographic distributions of the ant fauna of the 400 000 km^2 ＂Top End＂ of Australia＇s Northern Territory. The known Top End ant fauna comprises 901 native species from 59 genera. The richest genera are Pheidole （90 species）, Melophorus （83）, Monomorium （83）, Camponotus （71）, Meranoplus （63）, Polyrhachis （57）, Rhytidoponera （50）, Tetramorium （43）, Cerapachys （32）, and Iridomyrmex （31）. The fauna is the center of diverse radiations within species-groups of genera such as Meranoplus, Rhytidoponera, and Leptogenys. It also includes IndoMalayan species that have likely bypassed the normal dispersal route into Australia through Cape York Peninsula in North Queensland. Faunistic similarity with other regions of far northern Australia is associated more with rainfall than with geographic proximity. Most （60%） of Top End ant species have not been recorded elsewhere, and, despite uncertainties relating to species delimitation and sampling intensity, this appears to be a credible estimate of the level of endemism. Such exceptionally high endemism can be attributed to the Top End＇s geographic isolation from other regions of northern Australia with comparably high rainfall.展开更多
文摘Improved immunosuppression regimens have led to better survival for patients with renal transplant grafts and patients with immunological renal diseases worldwide. However, this is not the case in the Northern Territory of Australia. Available limited published data from the Northern Territory of Australia have shown poor outcomes for renal transplantation with survival for both patients and grafts around 50% at 5 years suggesting death with a functioning graft as the commonest cause of graft loss. These studies have shown that the leading cause of death is infections. Achieving the right level of immunosuppression to prevent rejection in renal transplantation and achieve remission in immunological renal diseases can be a major challenge in areas with high prevalence of infections such as the Northern Territory. We present 2 cases of the challenges from infections of immunosuppression in renal transplantation and immunological renal diseases in the Northern Territory of Australia. A 57 year old Aboriginal woman received a deceased donor renal transplant in 2006. She has been plagued by recurrence of several life threatening infections including urinary tract, cytomegalovirus, and severe cryptococcocus infections. This resulted in immunosuppression reduction and failure of the transplant 5 years post transplantation. A 20 year old Aboriginal woman presented with a combination of severe lupus nephritis and severe sepsis. She fully recovered after treatment with antibiotics and careful immunosuppression. However, she has had recurrent hospital admissions with life threatening infections resulting in stopping the immunosuppression. She then had severe lupus nephritis flare leading to dialysis dependence and will need a renal transplant. The cases illustrate the need for tailored and robust immunosuppression and transplant work up protocols. To that effect, prospective studies to analyse outcomes in immunosuppressed individuals, pharmacokinetic studies assessing whether the conventionally recommended drug levels are appropriate for this population and culturally appropriate educational programmes need to be performed.
文摘Imperialist Robert Baden-Powell’s Boy Scouts Association started in the Gold Coast Colony during the First World War and schooled boys for nationality during the 1920s.This paper uses archival documents to discuss how Chief Scout Governor Gordon Guggisberg,who was brigadier general during the First World War,reorganized the Boy Scouts Association in the Northern Province of the Northern Territories Protectorate.The scout officers at the Local Boy Scouts Associations had the power to fashion desire but were not supposed to have consequences on political power.As government officers and scout officers they had warrants to work at the government schools at Gambaga,Wa,and Lawra to attain money locally for kits to instruct and invent the identity,customs and nationalist categories of schoolboys performing the British Empire.
文摘In 1907,military leader Robert Baden-Powell started the Boy Scouts Association in England as the British colonial government officers instituted Tamale village as the administrative centre of the Northern Territories Protectorate.Sam Yarney worked with Frank Collyer the European bank cashier and scoutmaster who started the Boy Scouts in the Gold Coast Colony in 1914,the year the First World War started.In 1922,Governor Gordon Guggisberg,who was brigadier general during the war was the chief scout.He reorganized the Local Boy Scouts Association in the Tamale Government School that received select boys from various schools in the Northern Territories Protectorate.The schoolboys excelled in the Standard VII and Civil Service Examinations to work with the government institutions and train as teachers and telegraphists.Arthur James Philbrick the chief scout commissioner of the Northern Territories employed Yarney as the assistant scout commissioner in the Southern Province to take on the staff of the reorganized Tamale Local Boy Scouts Association and register the 1st Tamale Troop.The scout officers subscribed to a Scout Fund to buy kit,for the schoolboys who passed the Tenderfoot Tests to buy uniforms and perform at events.
文摘Although ants are an ecologically dominant and extensively studied faunal group throughout the tropics, there is a poor understanding of tropical ant diversity and distribution at large spatial scales. Here we use a collection developed from 3 decades of ant surveys to present the first analysis of ant diversity and biogeography of a large tropical region. Our objective was to document the species richness, composition, and biogeographic distributions of the ant fauna of the 400 000 km^2 ＂Top End＂ of Australia＇s Northern Territory. The known Top End ant fauna comprises 901 native species from 59 genera. The richest genera are Pheidole （90 species）, Melophorus （83）, Monomorium （83）, Camponotus （71）, Meranoplus （63）, Polyrhachis （57）, Rhytidoponera （50）, Tetramorium （43）, Cerapachys （32）, and Iridomyrmex （31）. The fauna is the center of diverse radiations within species-groups of genera such as Meranoplus, Rhytidoponera, and Leptogenys. It also includes IndoMalayan species that have likely bypassed the normal dispersal route into Australia through Cape York Peninsula in North Queensland. Faunistic similarity with other regions of far northern Australia is associated more with rainfall than with geographic proximity. Most （60%） of Top End ant species have not been recorded elsewhere, and, despite uncertainties relating to species delimitation and sampling intensity, this appears to be a credible estimate of the level of endemism. Such exceptionally high endemism can be attributed to the Top End＇s geographic isolation from other regions of northern Australia with comparably high rainfall.
