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Magma Mixing Genesis of the Mafic Enclaves and Related Granitoids in the Kan Granite-Gneiss Complex of Central Côte d’Ivoire: Evidence from Geology, Petrology and Geochemistry
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作者 Koffi Raoul Teha Koffi Kossonou Jean-Marie Pria +3 位作者 Koffi Joseph Brou Alain Nicaise Kouamelan Marc Ephrem Allialy Souad M’Rabet 《Open Journal of Geology》 CAS 2024年第8期760-786,共27页
The mafic enclaves from Paleoproterozoic domain are considered to be the results of large-scale crust-mantle interaction and magma mixing. In this paper, petrography, mineralogy and geochemistry were jointly used to d... The mafic enclaves from Paleoproterozoic domain are considered to be the results of large-scale crust-mantle interaction and magma mixing. In this paper, petrography, mineralogy and geochemistry were jointly used to determine the origin of the mafic enclaves and their relationship with the host granitoids of the Kan granite-gneiss complex. This study also provides new information on crust-mantle interactions. The mafic enclaves of the Kan vary in shape and size and have intermediate chemical compositions. The diagrams used show a number of similarities in the major elements (and often in the trace elements) between the mafic enclaves and the host granitoids. Geochemical show that the Kan rock are metaluminous, enriched in silica, medium to high-K calc-alkaline I-type granite. The similarities reflect a mixing of basic and acid magma. Mafic enclaves have a typical magmatic structure, which is characterized by magma mixing. The genesis of these rocks is associated with the context of subduction. They result from the mixing of a mafic magma originating from the mantle and linked to subduction, and a granitic magma (type I granite) that arises from the partial melting of the crust. 展开更多
关键词 Magma Mixing Mafic Microgranular Enclaves Host Granitoids Kan Granite-Gneiss Complex West Africa
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Design Method for Optimizing the Interactive Interface of Live Broadcasting Platform for the Elderly Users
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作者 WEI Bi-ze FAN Wei DUAN Ying-ke 《印刷与数字媒体技术研究》 CAS 北大核心 2024年第4期167-178,共12页
In the era of network live broadcasting for everyone,the development of live broadcasting platforms is also more intelligent and diversified.However,in the face of a large group of elderly users,the interface interact... In the era of network live broadcasting for everyone,the development of live broadcasting platforms is also more intelligent and diversified.However,in the face of a large group of elderly users,the interface interaction design mode used is still mainly based on the interaction mode for young groups,and is not designed for elderly users.Therefore,a design method for optimizing the interaction interface of live broadcasting platform for elderly users was proposed in this study.Firstly,the case study method and Delphi expert survey method were used to determine the design needs of elderly users and the design mode was analysed.Secondly,the orthogonal design principle was used to design a test sample of the interactive interface of live broadcasting platform applicable for the elderly users,and then a user evaluation system was established to calculate the weights of the design elements using hierarchical analysis,and then the predictive relationship between the design mode of the interactive interface of live broadcasting platform and the elderly users was established by Quantitative Theory I.Finally,Genetic Algorithm was applied to generate the optimized design scheme.The results showed that the design method based on the Genetic Algorithm and the combination of Quantitative Theory can scientifically and effectively optimize the design of the interactive interface of the live broadcasting platform for the elderly users,and improve the experience of the elderly users. 展开更多
关键词 Live broadcasting platform Interaction design Elderly users Genetic Algorithm Quantitative theory I
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Isolation of a feline-derived feline panleukopenia virus with an A300P substitution in the VP2 protein and confrmation of its pathogenicity in dogs
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作者 Jiakang Li Jiajia Peng +9 位作者 Yue Zeng Ying Wang Luying Li Yiran Cao Longlong Cao QingXiu Chen Zijun Ye Dengyuan Zhou Shengbo Cao Qiuyan Li 《Animal Diseases》 CAS 2024年第3期173-185,共13页
Feline panleukopenia virus(FPV)is a single-stranded DNA virus that can infect cats and cause feline panleukopenia,which is a highly contagious and fatal disease in felines.The sequence of FPV is highly variable,and mu... Feline panleukopenia virus(FPV)is a single-stranded DNA virus that can infect cats and cause feline panleukopenia,which is a highly contagious and fatal disease in felines.The sequence of FPV is highly variable,and mutations in the amino acids of its capsid protein play crucial roles in altering viral virulence,immunogenicity,host selection,and other abilities.In this study,the epidemiology of FPV was studied using 746 gastrointestinal swab samples derived from cats that presented gastrointestinal symptoms specifcally,diarrhea or vomiting during the period spanning from 2018 to 2022.The overall prevalence of FPV-positive patients among these samples was determined to be 45.4%.Capsid(virion)protein 2(VP2)gene of each FPV-positive sample was sequenced and amplifed,yielding 65 VP2 sequences.Among them,six VP2 gene sequences were detected in the majority of the samples test positive for FPV,and these positive samples originated from a diverse range of geographical locations.These isolates were named FPV-6,FPV-10,FPV-15,FPV-251,FPV-271 and FPV-S2.Additionally,the substitution of Ala300Pro(A300P)in VP2 was detected for the frst time in feline-derived FPV(FPV-251).FPV-251 isolate,with this substitution in VP2 protein,exhibited stable proliferative capacity in Madin-Darby canine kidney(MDCK)cells and A72 cells.FPV-271 was selected as the FPV control isolate due to its single amino acid diference from VP2 protein of FPV-251 at position 300(FPV-271 has alanine,while FPV-251 has proline).After oral infection,both FPV-251 and FPV-271 isolates caused feline panleukopenia,which is characterized by clinical signs of enterocolitis.However,FPV-251 can infect dogs through the oral route and cause gastrointestinal(GI)symptoms with lesions in the intestine and mesenteric lymph nodes(MLNs)of infected dogs.This is the frst report on the presence of an A300P substitution in VP2 protein of feline-derived FPV.Additionally,FPV isolate with a substitution of A300P at VP2 protein demonstrated efcient replication capabilities in canine cell lines and the ability to infect dogs. 展开更多
关键词 Feline panleukopenia virus FPV DOGS VP2 gene characteristic Host range
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Understanding host-graft crosstalk for predicting the outcome of stem cell transplantation
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作者 Luminita Labusca Florin Zugun-Eloae 《World Journal of Stem Cells》 SCIE 2024年第3期232-236,共5页
Mesenchymal stromal cells(MSCs)hold great promise for tissue regeneration in debilitating disorders.Despite reported improvements,the short-term outcomes of MSC transplantation,which is possibly linked to poor cell su... Mesenchymal stromal cells(MSCs)hold great promise for tissue regeneration in debilitating disorders.Despite reported improvements,the short-term outcomes of MSC transplantation,which is possibly linked to poor cell survival,demand extensive investigation.Disease-associated stress microenvironments further complicate outcomes.This debate underscores the need for a deeper understanding of the phenotypes of transplanted MSCs and their environment-induced fluctuations.Additionally,questions arise about how to predict,track,and comprehend cell fate post-transplantation.In vivo cellular imaging has emerged as a critical requirement for both short-and long-term safety and efficacy studies.However,translating preclinical imaging methods to clinical settings remains challenging.The fate and function of transplanted cells within the host environment present intricate challenges,including MSC engraftment,variability,and inconsistencies between preclinical and clinical data.The study explored the impact of high glucose concentrations on MSC survival in diabetic environments,emphasizing mitochondrial factors.Preserving these factors may enhance MSC survival,suggesting potential strategies involving genetic modification,biomaterials,and nanoparticles.Understanding stressors in diabetic patients is crucial for predicting the effects of MSC-based therapies.These multifaceted challenges call for a holistic approach involving the incorporation of large-scale data,computational disease modeling,and possibly artificial intelligence to enable deterministic insights. 展开更多
关键词 Mesenchymal stem cells PHENOTYPE Transplantation HOST MICROENVIRONMENT Cellular imaging Diabetes mellitus
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Behavioural Bioassays and Identification of Cashew Leaf and Stem Volatiles Mediating Attraction to the Stem Girdler, Analeptes trifasciata (Coleoptera: Cerambycidae)
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作者 Idongesit Umanah Mokwunye Olufemi Richard Pitan 《Advances in Entomology》 2024年第3期170-182,共13页
The cashew stem girdler, Analeptes trifasciata Fabricius (Coleoptera: Cerambycidae), damages cashew by its girdling activities in the stem thereby causing huge economic losses. The stem girdler is managed through cult... The cashew stem girdler, Analeptes trifasciata Fabricius (Coleoptera: Cerambycidae), damages cashew by its girdling activities in the stem thereby causing huge economic losses. The stem girdler is managed through cultural practice of burning girdled stems and beetles, though this has drawbacks. The objective of this study was to explore the cues mediating attraction to the cashew host plant;hence the role of olfaction in host plant location by A. trifasciata underlying the semio-chemical option for controlling this insect pest. A diffusional Y-tube olfactometer was used to study the behavioural response of A. trifasciata, to freshly cut cashew stem and leaves odour sources. Methanol-extract of these plant tissues was subjected to the coupled gas chromatography-mass spectrometry (GC-MS) analysis. Y-tube olfactometric assays demonstrated that both sexes oriented towards and spent significantly more time in stem odour arm compared to the leaf odour arm in both male (male: t = 2.228, d.f = 11, P = 0.040) and female (t = 2.341, d.f = 11, P = 0.040). A combination of fatty acids, amino acids and carbohydrates were detected in cashew stems. Some of these fatty acids are attractants to other insect pests. It is suspected that these fatty acid blends may possibly be responsible for facilitating host plant location by both sexes. In conclusion, both sexes were independently and strongly attracted to the stem volatiles;this study opens the possibility of utilizing cashew stem volatiles as surveillance and control tools. 展开更多
关键词 Analeptes trifasciata Behavioural Bioassay Host Plant Volatile Cues
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Theoretical Analysis and Design Implementation of FM Broadcast Receiving System based on SDR
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作者 Yalan Yin Qi Wang +1 位作者 Jianrui Li Chunliu He 《Journal of Electronic Research and Application》 2024年第6期118-123,共6页
ADALM Pluto is a software-defined radio product.Based on theoretical analysis,this paper designs a Frequency Modulation(FM)broadcast receiving system using ADALM Pluto as a wireless receiver on the Simulink platform.T... ADALM Pluto is a software-defined radio product.Based on theoretical analysis,this paper designs a Frequency Modulation(FM)broadcast receiving system using ADALM Pluto as a wireless receiver on the Simulink platform.The simulation results show that the theoretical analysis is correct and the parameter settings are reasonable,and the Software-Defined Radio(SDR)has the characteristics of high performance,high ease of use,and low cost. 展开更多
关键词 SDR FM broadcasting Modulation and demodulation SIMULINK
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Research on the Teaching Strategy of Broadcasting and Hosting Specialty in Colleges and Universities from the Perspective of New Media
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作者 Yuanyuan Wang 《Review of Educational Theory》 2019年第3期25-28,共4页
With the continuous development of science and technology and the comprehensive arrival of the information era, new media has gradually emerged and developed, which has had a serious impact on the original media form.... With the continuous development of science and technology and the comprehensive arrival of the information era, new media has gradually emerged and developed, which has had a serious impact on the original media form. Under the background of new media, higher requirements are put forward for the education and teaching activities of broadcasting and hosting specialty in colleges and universities, and the combination of new media technology and Chinese educational practice is the general trend in the current education field, which can effectively improve students’ learning quality and learning effects, and provide a broader space for the development of new media professions. This paper mainly explores the teaching strategies of broadcasting and hosting specialty in colleges and universities from the perspective of new media. 展开更多
关键词 the PERSPECTIVE of new media broadcasting and hosting SPECIALTY in COLLEGES and UNIVERSITIES Teaching strategy
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Reflection on Education of Broadcasting and Hosting Major in Today's Universities
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作者 Shimin Yang Qiaoling Dai 《International Journal of Technology Management》 2015年第7期83-85,共3页
According to the development trend in China' s radio and television industry, the requirements of the media for broadcasters and hosts are totally different from before, and they differ from each other. Good appearan... According to the development trend in China' s radio and television industry, the requirements of the media for broadcasters and hosts are totally different from before, and they differ from each other. Good appearance, elegant temperament and pleasant voice are no longer the sole criteria for being employed. This paper analyzes the problems with the education of broadcasting and hosting majors in China' s universities and proposes strategies and suggestions on this, so as to offer a guideline for its future development. 展开更多
关键词 broadcasting and hosting major PROBLEMS strategies
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Stable immobilization of lithium polysulfides using three-dimensional ordered mesoporous Mn_(2)O_(3) as the host material in lithium-sulfur batteries 被引量:1
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作者 Sung Joon Park Yun Jeong Choi +6 位作者 Hyun-seung Kim Min Joo Hong Hongjun Chang Janghyuk Moon Young-Jun Kim Junyoung Mun Ki Jae Kim 《Carbon Energy》 SCIE EI CAS CSCD 2024年第6期99-112,共14页
Lithium-sulfur batteries(LSBs)have drawn significant attention owing to their high theoretical discharge capacity and energy density.However,the dissolution of long-chain polysulfides into the electrolyte during the c... Lithium-sulfur batteries(LSBs)have drawn significant attention owing to their high theoretical discharge capacity and energy density.However,the dissolution of long-chain polysulfides into the electrolyte during the charge and discharge process(“shuttle effect”)results in fast capacity fading and inferior electrochemical performance.In this study,Mn_(2)O_(3)with an ordered mesoporous structure(OM-Mn_(2)O_(3))was designed as a cathode host for LSBs via KIT-6 hard templating,to effectively inhibit the polysulfide shuttle effect.OM-Mn_(2)O_(3)offers numerous pores to confine sulfur and tightly anchor the dissolved polysulfides through the combined effects of strong polar-polar interactions,polysulfides,and sulfur chain catenation.The OM-Mn_(2)O_(3)/S composite electrode delivered a discharge capacity of 561 mAh g^(-1) after 250 cycles at 0.5 C owing to the excellent performance of OM-Mn_(2)O_(3).Furthermore,it retained a discharge capacity of 628mA h g^(-1) even at a rate of 2 C,which was significantly higher than that of a pristine sulfur electrode(206mA h g^(-1)).These findings provide a prospective strategy for designing cathode materials for high-performance LSBs. 展开更多
关键词 host material lithium-sulfur battery ordered mesoporous structure shuttle effect transition-metal oxides
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The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production 被引量:2
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作者 Di Wu Linglong Fu +1 位作者 Weizhang Wen Na Dong 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2023年第2期501-514,共14页
Host defense peptides(HDPs)are small molecules with broad-spectrum antimicrobial activities against infectious bacteria,viruses,and fungi.Increasing evidence suggests that HDPs can also indirectly protect hosts by mod... Host defense peptides(HDPs)are small molecules with broad-spectrum antimicrobial activities against infectious bacteria,viruses,and fungi.Increasing evidence suggests that HDPs can also indirectly protect hosts by modulating their immune responses.Due to these dual roles,HDPs have been considered one of the most promising antibiotic substitutes to improve growth performance,intestinal health,and immunity in farm animals.This review describes the antimicrobial and immunomodulatory roles of host defense peptides and their recent applications in animal production. 展开更多
关键词 Antimicrobials Host defense peptides IMMUNOMODULATION POULTRY RUMINANTS SWINE
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Two intestinal microbiota-derived metabolites, deoxycholic acid and butyrate, synergize to enhance host defense peptide synthesis and alleviate necrotic enteritis
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作者 Dohyung M.Kim Jing Liu +3 位作者 Melanie A.Whitmore Isabel Tobin Zijun Zhao Guolong Zhang 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第3期1158-1172,共15页
Background Necrotic enteritis(NE)is a major enteric disease in poultry,yet effective mitigation strategies remain elusive.Deoxycholic acid(DCA)and butyrate,two major metabolites derived from the intestinal microbiota,... Background Necrotic enteritis(NE)is a major enteric disease in poultry,yet effective mitigation strategies remain elusive.Deoxycholic acid(DCA)and butyrate,two major metabolites derived from the intestinal microbiota,have independently been shown to induce host defense peptide(HDP)synthesis.However,the potential synergy between these two compounds remains unexplored.Methods To investigate the possible synergistic effect between DCA and butyrate in regulating HDP synthesis and barrier function,we treated chicken HD11 macrophage cells and jejunal explants with DCA and sodium butyrate(NaB),either individually or in combination,for 24 h.Subsequently,we performed RNA isolation and reverse transcrip-tion-quantitative PCR to analyze HDP genes as well as the major genes associated with barrier function.To further determine the synergy between DCA and NaB in enhancing NE resistance,we conducted two independent trials with Cobb broiler chicks.In each trial,the diet was supplemented with DCA or NaB on the day-of-hatch,followed by NE induction through sequential challenges with Eimeria maxima and Clostridium perfringens on d 10 and 14,respectively.We recorded animal mortality after infection and assessed intestinal lesions on d 17.The impact of DCA and NaB on the microbiota in the ileum and cecum was evaluated through bacterial 16S rRNA gene sequencing.Results We found that the combination of DCA and NaB synergistically induced multiple HDP genes in both chicken HD11 cells and jejunal explants.Additionally,the gene for claudin-1,a major tight junction protein,also exhibited synergistic induction in response to DCA and NaB.Furthermore,dietary supplementation with a combination of 0.75 g/kg DCA and 1 g/kg NaB led to a significant improvement in animal survival and a reduction in intestinal lesions compared to either compound alone in a chicken model of NE.Notably,the cecal microbiota of NE-infected chickens showed a marked decrease in SCFA-producing bacteria such as Bacteroides,Faecalibacterium,and Cuneatibacter,with lactobacilli becoming the most dominant species.However,supplementation with DCA and NaB largely restored the intestinal microbiota to healthy levels.Conclusions DCA synergizes with NaB to induce HDP and claudin-1 expression and enhance NE resistance,with potential for further development as cost-effective antibiotic alternatives. 展开更多
关键词 Bile acids Host defense peptides METABOLITES MICROBIOME Necrotic enteritis Short-chain fatty acids
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Characterization and screening of cotton(Gossypium hirsutum L.)germplasm for leafhopper(Amrasca biguttula biguttula(Ishida))resistance
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作者 Mawblei Chossterfield Premalatha Nallathambi +1 位作者 Manivannan Alagarsamy Senguttuvan Kannan 《Journal of Cotton Research》 CAS 2024年第2期188-195,共8页
Background Cotton(Gossypium hirsutum L.)is one of the most significant fibre and cash crops and plays an important role in Indian industrial and agricultural economies.However,over the years quantity and quality have ... Background Cotton(Gossypium hirsutum L.)is one of the most significant fibre and cash crops and plays an important role in Indian industrial and agricultural economies.However,over the years quantity and quality have been hampered by the pest leafhopper.Leafhopper alone has been shown to cause yield losses of up to 40%.In this study,screening and evaluation were performed to identify and categorize 100 cotton genotypes along with 5 checks as resistant,moderately resistant,sensitive and highly sensitive to leafhoppers.Results A total of hundred genotypes were evaluated along with five checks for leafhopper resistance.Based on the screening results,a total of 19 genotypes were resistant to leafhoppers,which was on par with the findings of the check KC 3.The contents of total soluble sugar,total soluble protein,and total free amino acids were significantly positively correlated with the mean grade,whereas total phenols content and trichome density were significantly negatively correlated with the susceptibility grade.However,based on screening and biochemical analysis,the genotypes KC 2,JR-23,Samaru-26-T,D 4,TCH 1728,RS 253,and B-61-1862 exhibited high resistance to leafhopper.Conclusion According to the findings of this study,choosing genotypes with high total phenolics content together with high trichome density and low contents of total soluble sugar,total soluble protein,and free amino acids may aid in the development of resistant genotypes. 展开更多
关键词 GOSSYPIUM Amrasca biguttula biguttula Field screening Host plant resistance Biochemical parameters
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Hatching and development of maize cyst nematode Heterodera zeae infecting different plant hosts
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作者 Jiangkuan Cui Haohao Ren +5 位作者 BoWang Fujie Chang Xuehai Zhang Haoguang Meng Shijun Jiang Jihua Tang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第5期1593-1603,共11页
The occurrence, distribution, and rapid molecular detection technology of Heterodera zeae Koshy et al. 1971, have been reported in China. We explored the biological characteristics of H. zeae sampled in Henan Province... The occurrence, distribution, and rapid molecular detection technology of Heterodera zeae Koshy et al. 1971, have been reported in China. We explored the biological characteristics of H. zeae sampled in Henan Province, China to understand its interaction with plants. Cysts and second-stage juveniles(J2s) were identified under an optical and scanning electron microscope, internal transcribed spacer(ITS) phylogenetic tree, and sequence characterized amplified region(SCAR)-PCR analyses. The optimum hatching temperatures of H. zeae were 30°C and 28°C, with cumulative hatching rates of 16.5 and 16.1%, respectively, at 30 days post-hatching(dph). The hatching rate of H. zeae eggs was improved by 20-and 50-time maize soil leachate and root juice, and 10-time root exudates. The hatching rate in 10-time root exudates was the highest(25.9%). The 10-time root exudates of maize and millet produced the highest hatching rate at 30 dph(25.9 and 22.9%, respectively), followed by wheat(19.9%), barley(18.3%), and rice(17.6%). Heterodera zeae developed faster in maize than in other crops. Fourth-stage juveniles(J4s) were detected in maize roots 8 days post-inoculation(dpi) at 28°C but not in other crops. Combined with hatching tests, the Huang–Huai–Hai summer maize region and the south and central-southwest mountainous maize areas are highly suitable for H. zeae in China. This is the first systematically study of the hatching and infection characteristics on different plant hosts of corn cyst nematode H. zeae in temperate regions. This study laid a theoretical foundation for the rapid spread and high environmental adaptability of corn cyst nematode. 展开更多
关键词 crop host resistance Heterodera zeae incubation fluid maize cyst nematode nematode development nematodehatching
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Large-scale interplant exchange of macromolecules between soybean and dodder under nutrient stresses
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作者 Jingxiong Zhang Shalan Li +9 位作者 Wenxing Li Zerui Feng Shuhan Zhang Xijie Zheng Yuxing Xu Guojing Shen Man Zhao Guoyan Cao Xuna Wu Jianqiang Wu 《Plant Diversity》 SCIE CAS CSCD 2024年第1期116-125,共10页
Parasitic plants and their hosts communicate through haustorial connections.Nutrient deficiency is a common stress for plants,yet little is known about whether and how host plants and parasites communicate during adap... Parasitic plants and their hosts communicate through haustorial connections.Nutrient deficiency is a common stress for plants,yet little is known about whether and how host plants and parasites communicate during adaptation to such nutrient stresses.In this study,we used transcriptomics and proteomics to analyze how soybean(Glycine max)and its parasitizing dodder(Cuscuta australis)respond to nitrate and phosphate deficiency(-N and-P).After-N and-P treatment,the soybean and dodder plants exhibited substantial changes of transcriptome and proteome,although soybean plants showed very few transcriptional responses to-P and dodder did not show any transcriptional changes to either-N or-P.Importantly,large-scale interplant transport of mRNAs and proteins was detected.Although the mobile mRNAs only comprised at most 0.2%of the transcriptomes,the foreign mobile proteins could reach 6.8%of the total proteins,suggesting that proteins may be the major forms of interplant communications.Furthermore,the interplant mobility of macromolecules was specifically affected by the nutrient regimes and the transport of these macromolecules was very likely independently regulated.This study provides new insight into the communication between host plants and parasites under stress conditions. 展开更多
关键词 CUSCUTA Mobile molecules Nutrient deficiency Host plant-parasitic plant interaction Interplant transport Systemic signaling
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Allergen degradation of bee pollen by lactic acid bacteria fermentation and its alleviatory effects on allergic reactions in BALB/c mice
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作者 Shuting Yin Qiangqiang Li +5 位作者 Yuxiao Tao Enning Zhou Kun Wang Wanwen Chen Xiangxin Li Liming Wu 《Food Science and Human Wellness》 SCIE CSCD 2024年第1期349-359,共11页
Food allergy as a global health problem threatens food industry.Bee pollen(BP)is a typical food with allergenic potentials,although it performs various nutritional/pharmacological functions to humans.In this study,lac... Food allergy as a global health problem threatens food industry.Bee pollen(BP)is a typical food with allergenic potentials,although it performs various nutritional/pharmacological functions to humans.In this study,lactic acid bacteria(LAB)were used to ferment Brassica napus BP for alleviating its allergenicity.Four novel allergens(glutaredoxin,oleosin-B2,catalase and lipase)were identified with significant decreases in LAB-fermented BP(FBP)than natural BP by proteomics.Meanwhile,metabolomics analysis showed significant increases of 28 characteristic oligopeptides and amino acids in FBP versus BP,indicating the degradation of LAB on allergens.Moreover,FBP showed alleviatory effects in BALB/c mice,which relieved pathological symptoms and lowered production of allergic mediators.Microbial high-throughput sequencing analysis showed that FBP could regulate gut microbiota and metabolism to strengthen immunity,which were closely correlated with the alleviation of allergic reactivity.These findings could contribute to the development and utilization of hypoallergenic BP products. 展开更多
关键词 Alleviatory effects Lactic acid bacteria fermentation Bee pollen allergen Gut microbiota Host metabolism
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Roles of host proteases in the entry of SARS-CoV-2
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作者 Alexandria Zabiegalal Yunjeong Kim Kyeong-Ok Chang 《Animal Diseases》 CAS 2024年第1期27-39,共13页
The spike protein(S)of SARS-CoV-2 is responsible for viral attachment and entry,thus a major factor for host suscep-tibility,tissue tropism,virulence and pathogenicity.The S is divided with S1 and S2 region,and the S1... The spike protein(S)of SARS-CoV-2 is responsible for viral attachment and entry,thus a major factor for host suscep-tibility,tissue tropism,virulence and pathogenicity.The S is divided with S1 and S2 region,and the S1 contains the receptor-binding domain(RBD),while the S2 contains the hydrophobic fusion domain for the entry into the host cell.Numerous host proteases have been implicated in the activation of SARS-CoV-2 S through various c leavage sites.In this article,we review host proteases including furin,trypsin,transmembrane protease serine 2(TMPRSS2)and cathepsins in the activation of SARS-CoV-2 S.Many betacoronaviruses including SARS-CoV-2 have polybasic residues at the S1/S2 site which is subjected to the cleavage by furin.The S1/S2 cleavage facilitates more assessable RBD to the receptor ACE2,and the binding triggers further conformational changes and exposure of the S2'site to proteases such as type Il transmembrane serine proteases(TTPRs)including TMPRSS2.In the presence of TMPRSS2 on the target cells,SARS-CoV-2 can utilize a direct entry route by fusion of the viral envelope to the cellular membrane.In the absence of TMPRSS2,SARS-CoV-2 enter target cells via endosomes where multiple cathepsins cleave the S for the successful entry.Additional host proteases involved in the cleavage of the S were discussed.This article also includes roles of 3C-like protease inhibitors which have inhibitory activity against cathepsin L in the entry of SARS-CoV-2,and discussed the dual roles of such inhibitors in virus replication. 展开更多
关键词 SARS-CoV-2 Spike protein(S) Host proteases Cleavage site Virus entry
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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury
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作者 Xinyu You Lin Niu +4 位作者 Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang 《Neural Regeneration Research》 SCIE CAS 2025年第8期2153-2168,共16页
Traumatic brain injury is a prevalent disorder of the central nervous system.In addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for pati... Traumatic brain injury is a prevalent disorder of the central nervous system.In addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are lacking.Intestinal dysfunction is a significant consequence of traumatic brain injury.Being the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous system.The gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated complications.We comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut microbiota.Additionally,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain injury.This review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effects of the“brain-gut-microbiota axis.” 展开更多
关键词 traumatic brain injury brain-gut-microbiome axis gut microbiota NEUROIMMUNE immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry
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Petrochemical eigenvalues and diagrams for the identification of metamorphic rocks'protolith,taking the host rocks of Dashuigou tellurium deposit in China as an example 被引量:1
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作者 Jianzhao Yin Shoupu Xiang +2 位作者 Yuhong Chao Yuhan Yin Hongyun Shi 《Acta Geochimica》 EI CAS CSCD 2023年第1期103-124,共22页
The Dashuigou tellurium deposit is the world’s only known independent tellurium deposit.By restoring metamorphic rocks’protolith,we seek to understand not only the development and evolution trajectory of the region ... The Dashuigou tellurium deposit is the world’s only known independent tellurium deposit.By restoring metamorphic rocks’protolith,we seek to understand not only the development and evolution trajectory of the region but also the origin of the relevant deposits.While there are many ways to restore metamorphic rocks’protolith,we take the host metamorphic rocks of Dashuigou tellurium deposit and leverage various petrochemical eigenvalues and related diagrams previously proposed to reveal the deposit’s host metamorphic rocks’protolith.The petrochemical eigenvalues include molecular number,Niggli’s value,REE parity ratio,CaO/Al_(2)O_(3)ratio,Fe^(3+) /(Fe^(3+) -+Fe^(2+) )ratio,chondrite-normalized REE value,logarithmic REE value,various REE eigenvalues including scandium,Eu/Sm ratio,total REE amount,light and heavy REEs,δEu,Eu anomaly,Sm/Nd ratio,and silicon isotope δ^(30) SiNBS-29‰,etc.The petrochemical plots include ACMs,100 mg-c-(al+alk),SiO_(2)-(Na_(2)O+K_(2)O),(al+fm)-(c+alk)versus Si,FeO+Fe_(2)O^(3+) TiO)-Al_(2)O_(3)-MgO,c-mg,Al_(2)O_(3)-(Na_(2)O+K_(2)O),chondrite-normalized REE model,La/Yb-REE,and Sm/Nd ratio,etc.On the basis of these comprehensive analyses,the following conclusions are drawn,starting from the many mantle-derived types of basalt developed in the study area of different geological ages,combined with the previously published research results on the deposit s fluid inclusions and sulfur and lead isotopes.The deposit is formed by mantle degassing in the form of a mantle plume in the late Yanshanian orogeny.The degassed fluids are rich in nano-sc ale substances including Fe,Te,S,As,Bi,Au,Se,H_(2),CO_(2),N_(2),H_(2)O,and CH_(4),which are enriched by nano-effect,and then rise to a certain part of the crust in the form of mantle plume along the lithospheric fault to form the deposit.The ultimate power for tellurium mineralization was from H_(2)flow with high energy,which was produced through radiation from the melted iron of the Earth’s outer core.The H,flow results in the Earth’s degassing,as well as the mantle and crust’s uplift. 展开更多
关键词 Petrochemical diagrams and eigenvalue PROTOLITH Metamorphic rock Independent tellurium deposit Host rock the mantle plume
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Inventory of Host Plants and Parasitoids of the Fall Armyworm (FAW), Spodoptera frugiperda (JE Smith), in the Southern Agricultural Zone of Niger
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作者 Ousmane Zakari Moussa Souleymane Laminou +2 位作者 Hamissou Zangui Laouali Amadou Ibrahim Baoua Boukari 《Journal of Agricultural Chemistry and Environment》 CAS 2023年第1期16-27,共12页
The fall armyworm, Spodoptera frugiperda (JE Smith), is a polyphagous pest reported in sub-Saharan Africa since 2016 and has expanded rapidly in almost Africa. In Niger, Spodoptera frugiperda (JE Smith) is considered ... The fall armyworm, Spodoptera frugiperda (JE Smith), is a polyphagous pest reported in sub-Saharan Africa since 2016 and has expanded rapidly in almost Africa. In Niger, Spodoptera frugiperda (JE Smith) is considered like a major pest of maize, to which it causes significant damage, in a context where proven control methods against this moth remain almost non-existent. The objective of the present study was to determine the economic importance of FAW through the damage caused to the different host plants and to identify the parasitoids of this caterpillar. The study was conducted in the southern agricultural zone of Niger, specifically in the regions of Dosso, Maradi, Tahoua and Zinder. FAW eggs and caterpillars were collected from six villages in each region and then incubated and reared in the entomology laboratory of INRAN in Maradi. The rate of infestation of the different crops by FAW was determined as well as the observation of the beneficiaries. The results obtained indicate the presence of FAW on millet with an attack rate varying from 45.7% to 68%, sorghum with 47.2% to 62.25% and sesame with 9.7%. This work also revealed an oophagous parasitoid, Telenomus remus with 138 ± 23 and larval parasitoids, Cotesia sp with 16 ± 1 maximum number of individuals emerged from the collected material. Also, it was identified the parasitoid Cotesia icipe with a rate of parasitism from 4.6% to 5.75%;the Charops ater whose rate of parasitism varies from 4.5% and 12.25% but for Chelonus insularis with 17.25% and Tachnidae with 53%. These very interesting results will constitute a basis for the development of biological control and a component of an agroecological management strategy of caterpillar. 展开更多
关键词 INVENTORY Host Plants Spodoptera frugiperda PARASITOIDS NIGER
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Formation and Properties of Organic Long Persistent Luminescence Crystals Containing Benzidine Derivatives by Melt Crystallization
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作者 Norihito Doki Kiyoka Maruyama Masaaki Yokota 《Advances in Chemical Engineering and Science》 CAS 2024年第1期1-7,共7页
Organic molecules that exhibit long persistent luminescence (LPL) are rapidly gaining attention for a variety of applications. In this study, organic molecules with simple structures were selected and organic long per... Organic molecules that exhibit long persistent luminescence (LPL) are rapidly gaining attention for a variety of applications. In this study, organic molecules with simple structures were selected and organic long persistent luminescence (OLPL) crystals were prepared. The crystal structure of the prepared OLPL crystal was elucidated and the guideline for the design of OLPL crystal was clarified. LPL was observed in OLPL crystals prepared with TMB as the guest molecule and 1,2-bis(diphenylphosphino)ethane as the host molecule. XRD measurements of the OLPL crystals suggest that the guest molecule is a solid solution substituted in the stable crystal structure of the host molecule in a lattice-shrinking direction. 展开更多
关键词 Melt Crystallization Host-Guest Chemistry
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