Manual Order Picking Route Optimization in Distribution Warehouse of Chain Furniture Retail Enterprise

Due to the effects of the COVID-19 pandemic and the rise of online shopping, the offline sales of IKEA Fuzhou have been declining since 2020. Because the cost of distribution warehouse is a major expense for offline chain furniture retailers, and the picking process is a key activity in distribution warehouse operations. To reduce the cost of distribution warehouse and alleviate the survival pressure of the offline chain furniture retailers, this paper focuses on optimizing the picking route of the IKEA Fuzhou distribution warehouse. It starts by creating a two-dimensional coordinate system for the storage location of the distribution warehouse using the traditional S-type picking strategy to calculate the distance and time of the sorting route. Then, the problem of optimizing the picking route is then transformed into the travelling salesman problem (TSP), and picking route optimization model is developed using a genetic algorithm to analyze the sorting efficiency and picking route optimization. Results show that the order-picking route using the genetic algorithm strategy is significantly better than the traditional S-type picking strategy, which can improve overall sorting efficiency and operations, reduce costs, and increase efficiency. Thus, this establishes an implementation process for the order-picking path based on genetic algorithm optimization to improve overall sorting efficiency and operations, reduce costs, increase efficiency, and alleviate the survival pressure of pandemic-affected enterprises.

Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s disease.Nanoscale perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory properties.However,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly understood.In this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s disease.Microglial suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in vitro.Consequently,the neurotoxic effects were mitigated,which alleviated neuronal degeneration.Additionally,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic reprogramming.We further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1αpathway.Collectively,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

Geographic Drone-based Route Optimization Approach for Emergency Area Ad-Hoc Network

Wireless sensor Mobile ad hoc networks have excellent potential in moving and monitoring disaster area networks on real-time basis.The recent challenges faced in Mobile Ad Hoc Networks(MANETs)include scalability,localization,heterogeneous network,self-organization,and self-sufficient operation.In this background,the current study focuses on specially-designed communication link establishment for high connection stability of wireless mobile sensor networks,especially in disaster area network.Existing protocols focus on location-dependent communications and use networks based on typically-used Internet Protocol(IP)architecture.However,IP-based communications have a few limitations such as inefficient bandwidth utilization,high processing,less transfer speeds,and excessive memory intake.To overcome these challenges,the number of neighbors(Node Density)is minimized and high Mobility Nodes(Node Speed)are avoided.The proposed Geographic Drone Based Route Optimization(GDRO)method reduces the entire overhead to a considerable level in an efficient manner and significantly improves the overall performance by identifying the disaster region.This drone communicates with anchor node periodically and shares the information to it so as to introduce a drone-based disaster network in an area.Geographic routing is a promising approach to enhance the routing efficiency in MANET.This algorithm helps in reaching the anchor(target)node with the help of Geographical Graph-Based Mapping(GGM).Global Positioning System(GPS)is enabled on mobile network of the anchor node which regularly broadcasts its location information that helps in finding the location.In first step,the node searches for local and remote anticipated Expected Transmission Count(ETX),thereby calculating the estimated distance.Received Signal Strength Indicator(RSSI)results are stored in the local memory of the node.Then,the node calculates the least remote anticipated ETX,Link Loss Rate,and information to the new location.Freeway Heuristic algorithm improves the data speed,efficiency and determines the path and optimization problem.In comparison with other models,the proposed method yielded an efficient communication,increased the throughput,and reduced the end-to-end delay,energy consumption and packet loss performance in disaster area networks.

Route Search Method for Railway Replacement Buses Adopting Ant Colony Optimization

In recent years, Japan, and especially rural areas have faced the growing problems of debt-ridden local railway lines along with the population decline and aging population. Therefore, it is best to consider the discontinuation of local railway lines and introduce replacement buses to secure the transportation methods of the local people especially in rural areas. Based on the above background, targeting local railway lines that may be discontinued in the near future, appropriate bus stops when provided with potential bus stops were selected, the present study proposed a method that introduces routes for railway replacement buses adopting ant colony optimization (ACO). The improved ACO was designed and developed based on the requirements set concerning the route length, number of turns, road width, accessibility of railway lines and zones without bus stops as well as the constraint conditions concerning the route length, number of turns and zones without bus stops. Original road network data were generated and processed adopting a geographic information systems (GIS), and these are used to search for the optimal route for railway replacement buses adopting the improved ACO concerning the 8 zones on the target railway line (JR Kakogawa line). By comparing the improved ACO with Dijkstra’s algorithm, its relevance was verified and areas needing further improvements were revealed.

基于熵的Mass函数算法及在液压泵故障诊断中的应用

如何确定Mass函数是D-S证据理论的棘手问题,本文从信息论的观点出发,提出一种新的计算Mass函数的算法。该算法依据证据体可信度因素和证据体与目标关联的相对熵来分配证据体的Mass函数,较全面反映证据体的不确定性。将方法应用于液压泵诊断中,结果表明它获取的Mass函数是符合实际情况的,具有较好的实用性,而且其算法容易实现。

基于IMO分级的MASS岸基操控人员法律地位探析

随着AI技术的发展,人工智能与传统设备的结合已深刻改变了人类的生产生活。MASS(Maritime Autonomous Surface Ships)全称为海上自主水面船舶,其作为人工智能的产物,代表着未来船舶的发展趋势,也推动MASS岸基操控人员这一新兴海事主体的产生。“自动化”并不意味着在MASS的操作过程中完全消除人员因素的干扰,在IMO所定义的MASS发展四阶段中,人在循环中的角色是不断变化的,其职能、责任、法律地位均有所不同,关于岸基操控人员法律地位的认定,具有基础性和高度优先性。L1级别MASS无需岸基操控人员;L2级别MASS岸基操控人员可视作L3级别岸基操控人员的实习或见习期;L3级别岸基操控人员可视为船长或“外部船长”;L4级别MASS系统的优先程度高于人,岸基操控人员仅具有“监督”与作出“降级”决定的职责,不排除其成为新兴海事主体的可能性。

Electrolytic Sampling from Pure Copper and Common Brasses Ⅰ: Calculation of the Mass Dissolved from the Samples according to Faraday's Law

In a procedure for electrolytic dissolving pure copper and common brasses, the approximate electrochemical mole mass(k) of the sample was determined in accordance with the brand of the sample, a stitable electrolyte was selected to make the current efficiency equal to 100%, and then the dissolved mass of samples was calculated according to Faraday's law(m=klt).Three representative samples were sampled by the electrolytic dissolution method and the calculated dissolved amounts were equal to the values by weighing the anode.The cxperimental results of zinc and copper in the anode liquor are in agreement with certified values.

An experiment evaluating how the tiny mass eccentricities in spinstabilized projectiles affect the position of impact points

This study investigates and quantifies some possible sources affecting the position of impact points of small caliber spin-stabilized projectiles(such as 12.7 mm bullets).A comparative experiment utilizing the control variable method was designed to figure out the influence of tiny eccentric centroids on the projectiles.The study critically analyzes data obtained from characteristic parameter measurements and precision trials.It also combines Sobol’s algorithm with an artificial intelligence algorithmdAdaptive Neuro-Fuzzy Inference Systems(ANFIS)ein order to conduct global sensitivity analysis and determine which parameters were most influential.The results indicate that the impact points of projectiles with an entry angle of 0°deflected to the left to that of projectiles with an entry angle of 90°.The difference of the mean coordinates of impact points was about 12.61 cm at a target range of 200 m.Variance analysis indicated that the entry angleei.e.the initial position of mass eccentricityehad a notable influence.After global sensitivity analysis,the significance of the effect of mass eccentricity was confirmed again and the most influential factors were determined to be the axial moment and transverse moment of inertia(Izz Iyy),the mass of a projectile(m),the distance between nose and center of mass along the symmetry axis for a projectile(Lm),and the eccentric distance of the centroid(Lr).The results imply that the control scheme by means of modifying mass center(moving mass or mass eccentricity)is promising for designing small-caliber spin-stabilized projectiles.

Diagnostic and surgical challenges of progressive neck and upper back painless masses in Madelung’s disease: A case report and review of literature

BACKGROUND Madelung’s disease(MD)is a chronic alcoholism-associated metabolic syndrome characterized by symmetrical subcutaneous deposition of adipose tissue in the head,neck,shoulders,back,trunk,and nerve roots of the upper and lower limbs.It is relatively rare in Asian individuals and is prone to misdiagnosis.Herein,we report a case of a patient with MD who had undergone surgical management at our hospital,and we discuss the pathogenesis,diagnosis,and treatment of MD.CASE SUMMARY We report a case of MD in a 65-year-old man of Han descent.The patient had multiple,painless progressive masses for more than five years in the neck and more than 30 years in the upper back.Because of neck mobility limitations and progressive cosmetic deformities caused by the masses,he was admitted to our hospital.He drank approximately 500 mL of liquor per day and smoked heavily for more than 30 years.Contrast-enhanced computed tomography of the neck and chest documented abundant unencapsulated,subcutaneous fatty deposits.We prepared a staged operation plan.The patient was diagnosed with MD;he was advised to abstain from alcohol and was followed up regularly.After a 3-month follow-up,no recurrence of fat accumulation was found in the surgical areas.CONCLUSION This report presents a case of surgical treatment for MD to improve clinicians'understanding of the disease.

First-principles investigation of electronic structure,effective carrier masses, and optical properties of ferromagnetic semiconductor CdCr_2S_4

The electronic structures, the effective masses, and optical properties of spinel CdCr_2S_4 are studied by using the fullpotential linearized augmented planewave method and a modified Becke–Johnson exchange functional within the densityfunctional theory. Most importantly, the effects of the spin–orbit coupling（SOC） on the electronic structures and carrier effective masses are investigated. The calculated band structure shows a direct band gap. The electronic effective mass and the hole effective mass are analytically determined by reproducing the calculated band structures near the BZ center.SOC substantially changes the valence band top and the hole effective masses. In addition, we calculated the corresponding optical properties of the spinel structure CdCr_2S_4. These should be useful to deeply understand spinel CdCr_2S_4 as a ferromagnetic semiconductor for possible semiconductor spintronic applications.

Joint Detection of Serum Vitamin D,Body Mass Index,and Tumor Necrosis Factor Alpha for the Diagnosis of Crohn’s Disease

Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD patients.This study investigated the role of serum VD,body mass index(BMI),and tumor necrosis factor alpha(TNF-α)in the diagnosis of Crohn’s disease.Methods CD patients(n=76)and healthy subjects(n=76)were enrolled between May 2019 and December 2020.The serum 25-hydroxyvitamin D[25(OH)D]levels,BMI,and TNF-αlevels,together with other biochemical parameters,were assessed before treatment.The diagnostic efficacy of the single and joint detection of serum 25(OH)D,BMI,and TNF-αwas determined using receiver operating characteristic(ROC)curves.Results The levels of 25(OH)D,BMI,and nutritional indicators,including hemoglobin,total protein,albumin,and high-density lipoprotein cholesterol,were much lower,and the TNF-αlevels were much higher in the CD patients than in the healthy subjects(P<0.05 for all).The areas under the ROC curve for the single detection of 25(OH)D,BMI,and TNF-αwere 0.887,0.896,and 0.838,respectively,with the optimal cutoff values being 20.64 ng/mL,19.77 kg/m^(2),and 6.85 fmol/mL,respectively.The diagnostic efficacy of the joint detection of 25(OH)D,BMI,and TNF-αwas the highest,with an area under the ROC curve of 0.988(95%CI:0.968–1.000).Conclusion The joint detection of 25(OH)D,TNF-α,and BMI showed high sensitivity,specificity,and accuracy in CD diagnosis;thus,it would be effective for the diagnosis of CD in clinical practice.

Classification and 3-D distribution of upper layer water masses in the northern South China Sea

Using the fuzzy cluster analysis and the temperature-salinity(T-S) similarity number analysis of cruise conductivity-temperature-depth(CTD) data in the upper layer(0–300 m) of the northern South China Sea(NSCS), we classify the upper layer water of the NSCS into six water masses: diluted water(D), surface water(SS),the SCS subsurface water mass(U_S), the Pacific Ocean subsurface water mass(U_P), surface-subsurface mixed water(SU) and subsurface-intermediate mixed water(UI). A new stacked stereogram is used to illustrate the water mass distribution, and to examine the source and the distribution of U_P, combining with the sea surface height data and geostrophic current field. The results show that water mass U_P exists in all four seasons with the maximum range in spring and the minimum range in summer. In spring and winter, the U_P intrudes into the Luzon Strait and the southwest of Taiwan Island via the northern Luzon Strait in the form of nonlinear Rossby eddies, and forms a high temperature and high salinity zone east of the Dongsha Islands. In summer, the U_P is sporadically distributed in the study area. In autumn, the U_P is located in the upper 200 m layer east of Hainan Island.

Mass Constituents of a Flat Lattice Multiverse: Conclusion from Similarity between Two Universal Numbers, the Rocksalt-Type 2<i>D</i>Madelung Constant and the Golden Mean

In fairly good agreement with the consensus range of dark energy to matter this ratio of the critical density is suggested to be connected with the golden mean &phi;=0.6180339887, yielding for dark energy to matter mass fractions .?Assuming the baryonic matter to be only 4.432%, the ratio of matter to baryonic matter would be , and further the ratio of dark matter to baryonic one . If one subtracts from the dark matter a contribution of antimatter with the same mass of baryonic matter, according to the antigravity theories of Villata respectively Hajdukovic, the remaining mass ratio would yield . Replacing the “Madelung” constant α of Villata’s “lattice universe” by &phi;, one reaches again 1 + &phi;as the ratio of the repulsive mass contribution to the attractive one. Assuming instead of a 3D lattice a flat 2D one of rocksalt type, the numerical similarity between the Madelung constant and φ&minus;1 could not be just coincidence. The proposed scaling of the cosmological mass fractions with the square of the most irrational universal number &phi;may indicate that the chaotic cosmological processes have reached a quite stable equilibrium. This may be confirmed by another, but similar representation of the mass constituents by the Archimedes’ constant &pi;, giving for respectively for the dark components . However, the intimate connection of φ with its reciprocal may ignite the discussion whether our universe is intertwined with another universe or even part of a multiverse with the dark constituents contributed from there.

Influences of C/S Mass Ratio and Kieserite Impregnation on Performance of 95-Grade Magnesia Bricks

The irfluences of C/S mass ratio and kieserite im-pregnation on performance of 95-grade magnesia bricks prepared using sintered magnesia DBM95 as main start-ing material, silica fi, me and limestone as additives were researched. The cold and hot physical properties were tested according to Chinese standards on refractories. The hydration resistance was determined in a high pres-sure autoclave with 0. 55 MPa of water vapor pressure for different holding times of 0. 5 h, 3 h, and 5 h. The tri-al results show （ 1 ） adding silica fume to decrease C/S ratio from 0. 84 to 0. 33 improves sintering property; addin,g limestone to increase C/S ratio J？om 0. 84 to 1.95 causes more pores and negatively influences physi-cal properties： BD decreases, AP increases, MOR and CCS decrease generally, but HMOR increases obviously; （2） for non-impregnated specimens, adjusting C/S mass ratio can not improve hydration resistance; （3） the impregnation with kieserite solution can improve hydra-tion resistance of magnesia bricks significantly.

Association between childhood obesity and gut microbiota:16S rRNA gene sequencing-based cohort study

BACKGROUND This study aimed to identify characteristic gut genera in obese and normal-weight children(8-12 years old)using 16S rDNA sequencing.The research aimed to provide insights for mechanistic studies and prevention strategies for childhood obesity.Thirty normal-weight and thirty age-and sex-matched obese children were included.Questionnaires and body measurements were collected,and fecal samples underwent 16S rDNA sequencing.Significant differences in body mass index(BMI)and body-fat percentage were observed between the groups.Analysis of gut microbiota diversity revealed lowerα-diversity in obese children.Differences in gut microbiota composition were found between the two groups.Prevotella and Firmicutes were more abundant in the obese group,while Bacteroides and Sanguibacteroides were more prevalent in the control group.AIM To identify the characteristic gut genera in obese and normal-weight children(8-12-year-old)using 16S rDNA sequencing,and provide a basis for subsequent mechanistic studies and prevention strategies for childhood obesity.METHODS Thirty each normal-weight,1:1 matched for age and sex,and obese children,with an obese status from 2020 to 2022,were included in the control and obese groups,respectively.Basic information was collected through questionnaires and body measurements were obtained from both obese and normal-weight children.Fecal samples were collected from both groups and subjected to 16S rDNA sequencing using an Illumina MiSeq sequencing platform for gut microbiota diversity analysis.RESULTS Significant differences in BMI and body-fat percentage were observed between the two groups.The Ace and Chao1 indices were significantly lower in the obese group than those in the control group,whereas differences were not significant in the Shannon and Simpson indices.Kruskal-Wallis tests indicated significant differences in unweighted and weighted UniFrac distances between the gut microbiota of normal-weight and obese children(P<0.01),suggesting substantial disparities in both the species and quantity of gut microbiota between the two groups.Prevotella,Firmicutes,Bacteroides,and Sanguibacteroides were more abundant in the obese and control groups,respectively.Heatmap results demonstrated significant differences in the gut microbiota composition between obese and normal-weight children.CONCLUSION Obese children exhibited lowerα-diversity in their gut microbiota than did the normal-weight children.Significant differences were observed in the composition of gut microbiota between obese and normal-weight children.

KANE’S EQUATIONS FOR PERCUSSION MOTION OF VARIABLE MASS NONHOLONOMIC MECHANICAL SYSTEMS

In this paper,the Kane’s equations for the Routh’s form of variable massnonholonomic systems are established.and the Kane’s equations for percussion motionof variable mass holonomic and nonholonomic systems are deduced from them. Secondly,the equivalence to Lagrange’s equations for percussion motion and Kane’sequations is obtained,and the application of the new equation is illustrated by anexample.

Neutrino Mass Generation in SO(4) Model

Generation of neutrino mass in SO（4） model is proposed here. The algebraic structure of SO （4） is same as to that ofSU（2）L x SU（2）R. It is shown that the spontaneous symmetry breaking results three massive as well as three massless gauge bosons. The standard model theory according to which there exist three massive gauge bosons and a massless one is emerged from this model. In the framework ofSU（2）L x SU（2）R a small Dirac neutrino mass is derived. It is also shown that such mass term may vanish with a special choice. The Majorana mass term is not considered here and thus in this model the neutrino mass does not follow seesaw structure.

Effects of thermodynamics parameters on mass transfer of volatile pollutants at air-water interface

A transient three-dimensional coupling model based on the compressible volume of fluid （VOF） method was developed to simulate the transport of volatile pollutants at the air-water interface. VOF is a numerical technique for locating and tracking the free surface of water flow. The relationships between Henry＇s constant, thermodynamics parameters, and the enlarged topological index were proposed for nonstandard conditions. A series of experiments and numerical simulations were performed to study the transport of benzene and carbinol. The simulation results agreed with the experimental results. Temperature had no effect on mass transfer of pollutants with low transfer free energy and high Henry＇s constant. The temporal and spatial distribution of pollutants with high transfer free energy and low Henry＇s constant was affected by temperature. The total enthalpy and total transfer free energy increased significantly with temperature, with significant fluctuations at low temperatures. The total enthalpy and total transfer free energy increased steadily without fluctuation at high temperatures.

Crohn’s Disease and Urinary Manifestations: A Crohn’s Intestinal Disease Mimicking a Bladder Mass

We report a rare mode of presentation of Crohn’s Disease (CD) in a 17-year-old boy, who was admitted at our hospital due to abdominal pain, dysuria, polyuria and fever. The ultrasound showed an increased wall thickness of the small bowel and cecum and a vegetating lesion adjoined into the bladder. The histology was not suggestive of CD and it excluded the bladder neoplasm. Based on the biochemical assessment and the imaging, we started the treatment specific for CD (nutritional therapy by Modulen, short courses of steroids, azathioprine and mesalazine during the follow up), These treatments improved the gastrointestinal symptoms and the nutritional status of our patient but also induced the disappearance of the mass adjoined into the bladder. In spite of the severe onset, in this patient, the clinical course of CD was mild and responder to conventional therapy.

Cerebrospinal fluid diagnostic markers for two-dimensional electrophoresis-mass spectrometry in Parkinson’s disease patients

BACKGROUND： Previous studies have confirmed the existence of specific proteins in body fluid of Parkinson＇s disease （PD） patients. However, the existing research has contained several interference factors with poor reproducibility and has not focused on patients grouped according to disease duration. OBJECTIVE： To verify differential expression of proteins in cerebrospinal fluid of PD patients grouped in order of disease severity through the use of two-dimensional electrophoresis-mass spectrometry methods. DESIGN, TIME AND SETTING： The proteomic-based, case-control study was performed between September 2008 and June 2009 at the Key Laboratory of Neurology in the First Affiliated Hospital of Chongqing Medical University. PARTICIPANTS： A total of 52 outpatients and/or inpatients, who were admitted to the Department of Neurology in the First Affiliated Hospital of Chongqing Medical University between 2008 and 2009, were randomized into the present study. Among them, 27 PD patients served as the PD group and were assigned to three subgroups according to modified Webster, Hoehn, and Yahr rating scales： 14 = mild, 8 = moderate, and 5 = severe; non-PD group of 16 patients included 5 cases of viral meningitis, 3 cases of acute myelitis, 1 case of Guillain-Barre syndrome, 2 cases of tuberculous meningitis, 2 cases of restless legs syndrome, and 3 cases of essential tremor; control group （n = 9） consisted of muscular tension headache in 6 cases, as well as syncope, trigeminal neuralgia, idiopathic orthostatic hypotension in 1 case. METHODS： Cerebrospinal fluid was collected from the involved patients using the lumbar puncture method. Proteins in the cerebrospinal fluid were separated by two-dimensional electrophoresis. MAIN OUTCOME MEASURES： Characteristics of protein electrophoresis patterns were analyzed, differentially expressed proteins were detected using matrix-assisted laser desorption ionization time of flight mass spectrometry, and protein data were analyzed in the Mascot database. RESULTS： Five protein electropherograms were analyzed by PDQuest 8.0, and （789 ± 32） protein spots were observed. There were significant differences in four protein spots in each of the PD sub-groups compared with the non-disease and control groups. Expression was down-regulated in three protein spots and up-regulated in one protein spot; 100% repetition rate was observed in four protein spots. According to the Mascot database, protein spots with down-regulated expression were as follows： DNA-guided RNA polymerase III subunit RPC5 （score： 50 points）; double serine, threonine, and tyrosine protein kinase （score： 64 points, P 〈 0.05）; activity-regulated cytoskeleton-associated protein （score： 58 points, P 〈 0.05）. However, G2 mitotic-specific cyclin was up-regulated （score： 84 points, P 〈 0.05）. CONCLUSION： Differential protein expression in the cerebrospinal fluid of PD patients was detected by two-dimensional electrophoresis-mass spectrometry, revealing changes in DNA-guided RNA polymerase III subunit RPC5, double serine, threonine, and tyrosine protein kinase, activity-regulated cytoskeleton-associated protein, and G2 mitotic cell cyclin, with good reproducibility.