Void Fraction Measurement in Oil-Gas Transportation Pipeline Using an Improved Electrical Capacitance Tomography System

To measure the void fraction online in oil-gas pipeline, an improved electrical capacitance tomography (ECT) system has been designed. The capacitance sensor with new structure has twelve internal electrodes and overcomes the influence of the pipe wall. The data collection system is improved by using high performance IC (integrated circuit). Static tests of bubble flow, stratified flow and annular flow regime are carried out. Measurements are taken on bubble flow, stratified flow and slug flow. Results show that the new ECT system performs well on void fraction measurement of bubble flow and stratified flow, but the error of measurement for slug flow is more than 10%.

Experimental Study and Simulation Principles of An Oil-Gas Multiphase Transportation System

Presented is an experimental study on the performance of an oil-gas multiphase transportation system, especially on the multiphase flow patterns, multiphase pumping and multiphase metering of the system. A dynamic simulation analysis is conducted to deduce simulation parameters of the system and similarity criteria under simplified conditions are obtained. The reliability and feasibility of two-phase flow experiment with oil and natural gas simulated by water and air are discussed by using the similarity criteria.

Transport Properties of Two Coupled Quantum Dots Under Optical Pumping

Using the Keldysh-Green function,we present a theoretical study on the electron transport properties of two coupled quantum dots under optical pumping. Plateaus in the I-V curve and resonant peaks in the transmission coefficient occur and can be explained by the local electron density of states in the quantum dots. The effects of the optical pumping frequency and intensity on the transport properties of the system are also discussed. The electron dynamical localization phenomenon occurs when the optical pumping frequency is equal to the discrete hole energy level. This result can be used to realize optical control switches.

Role of Ekman Transport Versus Ekman Pumping in Driving Summer Upwelling in the South China Sea

Relative roles of Ekman transport and Ekman pumping in driving summer upwelling in the South China Sea （SCS） are examined using QuikSCAT scatterometer wind data. The major upwelling regions in the SCS are the coastal regions east and south- east of Vietnam （UESEV）, east and southeast of Hainan Island （UESEH）, and southeast of Guangdong province （USEG）. It is shown that the Ekman transport due to alongshore winds and Ekman pumping due to offshore wind stress curl play different roles in the three upwelling systems. In UESEV, Ekman pumping and Ekman transport are equally important in generating upwelling. The Ek- man transport increases linearly from 0.49 Sv in May to 1.23 Sv in August, while the Ekman pumping increases from 0.36 to 1.22 Sv during the same period. In UESEH, the mean estimates of Ekman transport and Ekman pumping are 0.14 and 0.07 Sv, respectively, indicating that 33% of the total wind-driven upwelling is due to Ekman pumping. In USEC~ the mean Ekman transport is 0.041 Sv with the peak occurring in July, while Ekman pumping is much smaller （0.003 on average）, indicating that the upwelling in this area is primarily driven by Ekman transport. In the summers of 2003 and 2007 following E1 Nifio-Southern Oscillation （ENSO） events, both Ekman transport and Ekman pumping decrease in UESEV due to the abnormally weak southwest monsoon. During the same events, however, Ekman transport is slightly enhanced and Ekman pumping is weakened in UESEH and USEG.

Wave Effect on the Ocean Circulations Through Mass Transport and Wave-Induced Pumping

The wave Coriolis-Stokes-Force-modified ocean momentum equations are reviewed in this paper and the wave Stokes transport is pointed out to be part of the ocean circulations. Using the European Centre for Medium-Range Weather Forecasts 40-year reanalysis data(ERA-40 data) and the Simple Ocean Data Assimilation(SODA) version 2.2.4 data, the magnitude of this transport is compared with that of wind-driven Sverdrup transport and a 5-to-10-precent contribution by the wave Stokes transport is found. Both transports are stronger in boreal winter than in summers. The wave effect can be either contribution or cancellation in different seasons. Examination with Kuroshio transport verifies similar seasonal variations. The clarification of the efficient wave boundary condition helps to understand the role of waves in mass transport. It acts as surface wind stress and can be functional down to the bottom of the ageostrophic layer. The pumping velocities resulting from wave-induced stress are zonally distributed and are significant in relatively high latitudes. Further work will focus on the model performance of the wave-stress-changed-boundary and the role of swells in the eastern part of the oceans.

Investigation of impurity transport using laser blow-off technique in the HL-2A Ohmic and ECRH plasmas

Impurity transports in two neighboring discharges with and without electron cyclotron resonance heating（ECRH）are studied in the HL-2A tokamak by laser blow-off（LBO） technique.The progression of aluminium ions as the trace impurity is monitored by soft x-ray（SXR） and bolometer detector arrays with good temporal and spatial resolutions.Obvious difference in the time trace of the signal between the Ohmic and ECRH L-mode discharges is observed.Based on the numerical simulation with one-dimensional（1D） impurity transport code STRAHL,the radial profiles of impurity diffusion coefficient D and convective velocity V are obtained for each shot.The result shows that the diffusion coefficient D significantly increases throughout the plasma minor radius for the ECRH case with respect to the Ohmic case,and that the convection velocity V changes from negative（inward） for the Ohmic case to partially positive（outward） for the ECRH case.The result on HL-2A confirms the pump out effect of ECRH on impurity profile as reported on various other devices.

Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation

To investigate the relation of two different mutations to the outcome of partial external biliary diversion (PEBD) in severe bile salt export pump (BSEP) deficiency. METHODSMutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney (HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization. Bile acid profiles of patient and control bile samples were generated by ultra-performance liquid chromatography-tandem mass spectrometry. Wild-type and mutant BSEP transport of [3H]-labeled taurocholate (TC) and taurochenodeoxycholate (TCDC) was assessed by vesicular transport assays. RESULTSA girl (at 2 mo) presented with pruritus, jaundice and elevated serum bile salts (BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919del and the nonsense mutation p.R1235X. At the age of 17 years relative amounts of conjugated BS in her bile were normal, while total BS were less than 3% as compared to controls. An unrelated boy (age 1.5 years) presenting with severe pruritus and elevated serum BS was heterozygous for the same nonsense and another missense mutation, p.G1032R. PEBD failed to alleviate pruritus, eventually necessitating liver transplantation. BS concentration in bile was about 5% of controls. BS were mainly unconjugated with an unusual low amount of chenodeoxycholate derivatives (< 5%). The patients’ native liver biopsies showed canalicular BSEP expression. Both BSEP p.T919del and p.G1032R were localized in the plasma membrane in HEK293 cells. In vitro transport assays showed drastic reduction of transport by both mutations. Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively. CONCLUSIONIn summary, our findings suggest that residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of PEBD in progressive familial intrahepatic cholestasis type 2 (PFIC-2).

Valley-polarized pumping current in zigzag graphene nanoribbons with different spatial symmetries

We numerically investigate the valley-polarized current in symmetric and asymmetric zigzag graphene nanoribbons(ZGNRs) by the adiabatic pump, and the effect of spatial symmetry is considered by introducing different pumping regions. It is found that pumping potentials with the symmetry Vp(x,y) = Vp(-x,y)can generate the largest valleypolarized current. The valley-polarized currents I13~L with the pumping potential symmetry Vp(x,y) =Vp(x,-y,) and I14~L with Vp(x,y) = Vp(-x,-y) of symmetric ZGNRs are much smaller than those of asymmetric ZGNRs. We also find I13~L and I14~L of symmetric ZGNRs decrease and increase with the increasing pumping amplitude, respectively. Moreover, the dephasing effect from the electron-phonon coupling within the Buttiker dephasing scheme is introduced. The valley-polarized current of the symmetric ZGNRs with Vp(x,y)= Vp(x,-y) increases with the increase of the dephasing strength while that with Vp(x,y) = Vp(-x,-y) decreases as the dephasing strength increases.

Mechanisms Efflux Pumps of <i>Acinetobacter baumannii</i>(MDR): Increasing Resistance to Antibiotics

Acinetobacter baumannii has greatly increased its degree of resistance to become multidrug resistant (MDR) over the past 30 years and is on the red line of the most widely replicated bacteria according to World Health Organization (WHO). The efflux pumps are the main cause for the increasing antibiotic resistance of A. baumannii originated from nosocomial infection. The progressive resistance of A. baumannii even on the recent drugs (tigecycline and fosfomycin) reduces to very effective antibiotic scale. With attention focused on MDR and pan-drug-resistant (PDR) in A. baumannii multiple works on efflux pumps chemical inhibitor (NMP, PAβN, omeprazole, verapamil, reserpine, CCCP) are still in progress. Certain inhibitors from plants (Biricodar and timcodar, Falvone, Mahonia, Dalea versicolor, Lycopus europaeus, and Rosmarinus officinalis) have the capability to have such compounds according to their very significant synergistic effect with antibiotics. In this review we focused on the growth of antibiotic resistance to explain the mechanism of efflux pumps into these different super families and a comprehensive understanding of the extrusion, regulation and physiology role of drug efflux pumps in the essential development of anti-resistivity drugs. We recapitulated the evolution of the work carried out in these fields during the last years and in the course of elaboration, with the aim of increasing the chances of decreasing bacterial resistivity to antibiotics.

Emanuel Strehler’s work on calcium pumps and calcium signaling

Cells are equipped with mechanisms to control tightly the influx, efflux and resting level of free calcium (Ca 2+ ). Inappropriate Ca 2+ signaling and abnormal Ca 2+ levels are involved in many clinical disorders including heart disease, Alzheimer's disease and stroke. Ca 2+ also plays a major role in cell growth, differentiation and motility; disturbances in these processes underlie cell transformation and the progression of cancer. Accordingly, research in the Strehler laboratory is focused on a better understanding of the molecular "toolkit" needed to ensure proper Ca 2+ homeostasis in the cell, as well as on the mechanisms of localized Ca 2+ signaling. A longterm focus has been on the plasma membrane calcium pumps (PMCAs), which are linked to multiple disorders including hearing loss, neurodegeneration, and heart disease. Our work over the past 20 years or more has revealed a surprising complexity of PMCA isoforms with different functional characteristics, regulation, and cellular localization. Emerging evidence shows how specific PMCAs contribute not only to setting basal intracellular Ca 2+ levels, but also to local Ca 2+ signaling and vectorial Ca 2+ transport. A second major research arearevolves around the calcium sensor protein calmodulin and an enigmatic calmodulin-like protein (CALML3) that is linked to epithelial differentiation. One of the cellular targets of CALML3 is the unconventional motor protein myosin-10, which raises new questions about the role of CALML3 and myosin-10 in cell adhesion and migration in normal cell differentiation and cancer.

Temperature dependence of spin pumping in YIG/NiO(x)/W multilayer

We report the temperature dependence of the spin pumping effect for Y_(3)Fe_(5)O_(12)(YIG,0.9μm)/NiO(tNiO)/W(6 nm)(tNiO=0 nm,1 nm,2 nm,and 10 nm)heterostructures.All samples exhibit a strong temperature-dependent inverse spin Hall effect(ISHE)signal I_(c)and sensitivity to the NiO layer thickness.We observe a dramatic decrease of I_(c)with inserting thin NiO layer between YIG and W layers indicating that the inserting of NiO layer significantly suppresses the spin transport from YIG to W.In contrast to the noticeable enhancement in YIG/NiO(tNiO≈1-2 nm)/Pt,the suppression of spin transport may be closely related to the specific interface-dependent spin scattering,spin memory loss,and spin conductance at the NiO/W interface.Besides,the I_(c)of YIG/Ni O/W exhibits a maximum near the TNof the AF NiO layer because the spins are transported dominantly by incoherent thermal magnons.

一种挖泥船最小能耗工作点计算选取方法

[目的]为了解决挖泥船短排距工况下高能耗的问题,提出一种最小能耗工作点的计算选取方法。[方法]基于前期研究建立的泥泵排压、管道阻力、关键流速和泥泵汽蚀等相关模型,以单方能耗最小为目标,采用施工人员最为熟知并方便控制的泥泵转速为优化变量,运用输送系统最佳流速搜索和多泥泵转速优化相结合的双重优化方法,实现挖泥船多个泵串联最小能耗工作点的计算选取,并以配置有3台不同型号离心泵的“新海狼”号挖泥船在特定工况条件下施工为案例进行算法验证。[结果]结果显示,经所提算法模型优化后的工作点单方能耗比最大产量工作点的单方能耗降低了11.8%。[结论]研究成果的应用能有效弥补已有以施工能力(最大产量)为目标的优化施工方法,为疏浚工程的节能减排工作提供参考。

可见光抗菌的单向导湿自泵织物

具有湿度管理和抑菌性能的功能织物可以有效提高穿着舒适度。现有方法往往通过在亲水织物表面物理浸涂抗菌剂,虽然可起到短效抑菌作用,但会导致抗菌剂大量突释,引起皮肤不适,抗菌能力快速减弱。本文利用静电纺丝方法制备了一种掺杂可见光激发抗菌光敏剂的自泵织物(Self-pumping textile,SPT),实现了汗液的单向移除同时高效抗菌。自泵织物由疏水的聚偏二氟乙烯-六氟丙烯(PVDF-HFP)纤维和亲水的碱水解醋酸纤维素(CA)纤维组成,其中亲水纤维中掺杂了具有高活性氧产生能力的聚噻吩(PT2)光敏剂。在接触角导液模型中,我们证实了导液时间随疏水层厚度增加而延长,当疏水层电纺时间为60 s时,水分可以在10 s内从疏水层单向导出到亲水层。使用功率为25 mW/cm^(2)的氙灯光模拟日常太阳光进行抗菌,结果表明,10 min可以杀灭95%以上的金黄色葡萄球菌和大肠杆菌。本工作为功能性织物的设计提供了一种新的思路。

梯级泵站事故停机输水明渠水力过渡过程研究

为解决梯级泵站系统因超负荷、大流量、高水位运行出现垮渠、跳闸停机等事故,而导致水力过渡过程中出现进水前池被抽干或漫顶等问题,以甘肃省景泰川电力提灌二期工程长距离输水明渠为研究对象,在多梯级泵站事故停机产生溢流的工况下,基于Realizable k-ε和VOF模型进行数值模拟计算,分析景电二期工程1#~7#干渠在调蓄系统作用下,不同渠长、坡降的水面线以及水力振荡分布规律。结果表明:泵站停机后水位出现升降交替的水力振荡现象,影响各泵站波峰水位高度不一致的主要原因是渠道坡降;不同参数特征的渠道壅水波运动的回溯距离不同,溢流堰上发生溢流的时间主要在第一次水位振荡过程中。

原油管道顺序输送节能运行优化技术研究

为实现输油计划一定前提下原油管道顺序输送的运行优化,在离散时间表达式的基础上,建立了沿程外输泵电费和加热炉燃料费最低的目标函数,考虑不同时间步下的泵站特性约束、管道压力约束、流量约束和温度约束等,对于重要节点的时间步采用动态规划算法求解,对于其余常规时间步采用自适应遗传算法求解,结合实例进行算法验证和分析。结果表明,优化后,各站在不同时间步的开泵数量均降低,且有备用;部分站在部分时间步可以停运加热炉,实现热力越站;与原运行方案相比,月节约耗电量439.2×10^(4)kWh,月节约耗油量1605.6 t,月节约运行费用871.2万元,求解时间仅为0.21 h,满足计算精度和计算效率的要求。

长江口南槽悬沙纵向和横向输运过程与机制研究

河口悬沙输运对于最大浑浊带形成发育、地貌演变、港口航道安全、水质以及生态系统健康至关重要。本文基于2017年洪季长江口南槽拦门沙海域4站位同步观测的沉积动力数据,采用Scully和Sommerfield改进的通量机制分解法来获取垂向各层平流通量和潮泵通量及累积动态变化,以确定平流和潮汐泵送对悬沙净通量的相对贡献,探讨纵向和横向的水沙输运时空格局和动力机制,弥补了传统通量机制分解法仅限计算时空平均值的缺陷。研究发现:(1)洪季长江口南槽拦门沙海域大潮期间存在横向余环流,小潮期间出现表层向海、底层向陆的纵向余环流;(2)平流和潮泵作用是影响净输运的关键因素,南槽拦门沙海域由平流作用主导、悬沙向海净输运,横向上向西南边滩输运,为南汇边滩围垦区向海淤长提供物源,且靠近主槽区域横向悬沙通量对沉积过程的贡献与纵向通量相当;(3)潮泵输运在河口滞流点和拦门沙海域均较显著,泵送的大小和方向与径潮流相互作用和底床物源有关,纵向上由大潮期间向陆泵送占优转为小潮期间的向海净输运占优。综上,南槽拦门沙海域近底层悬沙呈现由浅滩向主槽辐聚的格局,浅滩区域的近底层悬沙净输运受潮泵作用控制,且对整个水柱悬沙输运贡献显著,可能是拦门沙形成和最大浑浊带发育的重要机制。

大倾角引水斜井TBM关键技术研究及应用

为解决传统抽水蓄能电站大倾角引水斜井施工安全风险高、环境影响大、施工效率低的问题,提出采用大倾角全断面斜井TBM掘进。首先,针对洛宁抽水蓄能电站工程和地质特点,论证采用全断面斜井TBM施工的技术优势,完成洛宁抽水蓄能电站全断面斜井TBM选型;其次,提出国产首台大倾角全断面斜井TBM关键技术,包括安全防溜及换步工艺、出渣及异常情况处理、整机物料运输、不良地质处理等多项关键技术;最后,通过实施上述技术,完成洛宁抽水蓄能电站斜井TBM设计制造及应用。实践证明:1)在抽水蓄能电站引水斜井采用全断面斜井TBM施工切实可行,且具有环境破坏小、绿色低碳等优点;2)采用敞开式主机并配置双重防溜撑靴适用于大倾角施工,具有安全系数高的特点;3)从斜井底部到TBM设备尾部采用液压绞车运输,TBM设备尾部至TBM前部采用单轨吊机运输,可满足高频次人员、物料的运输要求。

气动隔膜泵水力性能试验研究

为确定气动隔膜泵输送常温推进剂的工作性能,对气动隔膜泵的水力性能进行试验研究。气动隔膜泵首次应用于常温推进剂加注系统,用于加注后的管路内残存推进剂的输送,有必要对其工作性能进行详细研究。本文通过试验方法,对不同供气压力条件下气动隔膜泵输送流量、气体流量以及双泵并联输送液体流量进行了测量,并对影响气动隔膜泵水力性能的因素进行了详细分析。试验结果表明,随着供气压力的提高,气动隔膜泵输送液体的流量增加,输送气体的流量反而减小;两个减压阀供气时,双泵并联输送液体的流量是约单泵工作时的2倍。试验结果为隔膜泵抽吸常温液体推进剂的应用提供参考。

多相混输泵用超高压机械密封性能研究

针对超高压混输泵机械密封易磨损失效的问题,介绍了端面槽加工和涂层应用两种策略,用热流固耦合分析方法,分析了浅槽微接触式机械密封在实际应用中的温度分布和端面变形情况,阐述了表面涂层技术的应用,进行了一系列机械密封性能的试验研究。研究结果不仅证实了这些技术在提高机械密封寿命和可靠性方面的有效性,还证实了端面开槽和涂层技术在降低摩擦、改善耐磨性能方面的显著效果。为超高压混输泵机械密封系统的设计和优化提供了重要的理论依据及实践指导。

基于法尼醇X受体通路探讨壮药依山红对胆汁淤积大鼠的影响

目的探讨壮药依山红对α-萘异硫氰酸酯(alpha-naphtyl isothiocyanate,ANIT)诱导胆汁淤积大鼠的影响及其作用机制。方法采用120只SD大鼠,随机分成6组,分别为正常组、模型组、熊去氧胆酸组及壮药依山红高、中、低剂量组,每组20只。除正常组外,余用ANIT灌胃建立胆汁淤积大鼠模型。连续给药15天后,称量计算大鼠肝脾指数;血清生化法检测血清丙氨酸氨基转移酶(alanine aminotransferase,ALT)、门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、碱性磷酸酶(alkaline phosphatase,AKP)等转氨酶指标,测定总胆红素(total bilirubin,TBIL)、直接胆红素(direct bilirubin,DBIL)、总胆汁酸(total bile acids,TBA)等胆红素指标;苏木素—伊红(hematoxylin-Eosin,HE)染色法评估肝组织病理学变化,油红O染色评估肝脏脂滴代谢情况;蛋白免疫印迹法及实时荧光定量聚合酶链式反应检测法尼醇X受体(farnesoid X receptor,FXR)、钠牛磺胆酸共转运肽(Na+-taurocholate co-transporting polypeptide,NTCP)、多药耐药相关蛋白2(multidrug resistance-associated protein 2,MRP2)、胆汁盐转运蛋白(bile salt export pump,BSEP)蛋白和mRNA表达水平。结果与正常组比,模型组大鼠肝脾指数、血清转氨酶(ALT、AST、AKP)及胆红素(TBIL、DBIL、TBA)显著升高(P<0.05),肝组织受损。壮药依山红各剂量及熊去氧胆酸显著降低这些指标(P<0.05),改善肝组织学病变,减少脂滴沉积,效果呈剂量依赖性。同时,依山红各剂量组大鼠肝组织中NTCP、MRP2蛋白的表达量均明显升高(P<0.05);高剂量组大鼠肝组织中BSEP蛋白相对表达量显著下降(P<0.05)。与模型组相比,依山红高、中剂量组大鼠肝组织中Fxr、Ntcp、Mrp2 mRNA的相对表达量显著升高(P<0.05);依山红低剂量组大鼠仅Mrp2 mRNA表达量显著升高(P<0.05);依山红各剂量大鼠肝组织中Bsep mRNA表达水平显著下降(P<0.05)。结论壮药依山红可通过调节FXR及其调控的胆汁转运相关蛋白的表达,对ANIT诱导胆汁淤积模型大鼠起到保肝利胆的作用。