AIM To evaluate the efficacy of peripheral blood concentrations of angiopoietins(Ang) as cirrhosis biomarkers of chronic hepatitis C(CHC).METHODS Ang1 and Ang2 serum levels were measured by enzyme-linked immunosorbent...AIM To evaluate the efficacy of peripheral blood concentrations of angiopoietins(Ang) as cirrhosis biomarkers of chronic hepatitis C(CHC).METHODS Ang1 and Ang2 serum levels were measured by enzyme-linked immunosorbent assays(ELISA) in samples from 179 cirrhotic and non-cirrhotic CHC patients, classified according to the METAVIR system.Groups were compared by non-parametric MannWhitney U test. Subsequently, the association of peripheral concentrations of angiopoietins with the stage of fibrosis was analyzed using Spearman correlation test. Finally, the accuracy, sensitivity and specificity of circulating angiopoietins for cirrhosis diagnosis were determined by the study of the respective area under the curve of receiver operator characteristics(AUC-ROC).RESULTS Peripheral blood concentrations of Ang1 and Ang2 in CHC patients were significantly related to fibrosis. While Ang1 was decreased in cirrhotic subjects compared to non-cirrhotic(P < 0.0001), Ang2 was significantly increased as CHC progressed to the end stage of liver disease(P < 0.0001). Consequently, Ang2/Ang1 ratio was notably amplified and significantly correlated with fibrosis(P < 0.0001). Interestingly, the individual performance of each angiopoietin for the diagnosis of cirrhosis reached notable AUC-ROC values(above 0.7, both), but the Ang2/Ang1 ratio was much better(AUC-ROC = 0.810) and displayed outstanding values of sensitivity(71%), specificity(84%) and accuracy(82.1%) at the optimal cut-off(10.33). Furthermore, Ang2/Ang1 ratio improved the performance of many other previously described biomarkers or scores of liver cirrhosis in CHC.CONCLUSION Ang2/Ang1 ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target.展开更多
Taking B2C E-commerce enterprises as the center, it can be divided into a set of logistics activities upstream supply chain logistics producer to B2C e-commerce enterprises, and the B2C e-commerce enterprise logistics...Taking B2C E-commerce enterprises as the center, it can be divided into a set of logistics activities upstream supply chain logistics producer to B2C e-commerce enterprises, and the B2C e-commerce enterprise logistics to client consumer, and the paper focuses on the study of self-supporting logistics for the E-commerce enterprise. According to the development status of current B2C electronic commerce enterprise in our country and logistics, the paper study B2C electric business enterprise how to correctly choose the logistics mode and how to promote the business logistics operation level.展开更多
In this paper, it is proved that for any C2-cofinite, simple, CFT-type vertex operator superalgebra V and a finite solvable group G consisting of automorphisms of V, the fixed point subalgebra Vc is a C2-cofinite vert...In this paper, it is proved that for any C2-cofinite, simple, CFT-type vertex operator superalgebra V and a finite solvable group G consisting of automorphisms of V, the fixed point subalgebra Vc is a C2-cofinite vertex operator superalgebra.展开更多
For any C2-cofinite vertex product and the P（z）-tensor product finite length are proved to exist, which operator superalgebra V, the tensor of any two admissible V-modules of are shown to be isomorphic, and their co...For any C2-cofinite vertex product and the P（z）-tensor product finite length are proved to exist, which operator superalgebra V, the tensor of any two admissible V-modules of are shown to be isomorphic, and their constructions are given explicitly in this paper.展开更多
基金Supported by the Ministerio de Ciencia e Innovación(SAF:2010/21805,partially)CIBERehd(Instituto de Salud CarlosⅢ,Madrid)+1 种基金Fundación Mutua Madrile■a(to Moreno-Otero R)a grant from Asociación Espa■ola Contra el Cáncer(AIO 2010,AECC,to Sanz-Cameno P)
文摘AIM To evaluate the efficacy of peripheral blood concentrations of angiopoietins(Ang) as cirrhosis biomarkers of chronic hepatitis C(CHC).METHODS Ang1 and Ang2 serum levels were measured by enzyme-linked immunosorbent assays(ELISA) in samples from 179 cirrhotic and non-cirrhotic CHC patients, classified according to the METAVIR system.Groups were compared by non-parametric MannWhitney U test. Subsequently, the association of peripheral concentrations of angiopoietins with the stage of fibrosis was analyzed using Spearman correlation test. Finally, the accuracy, sensitivity and specificity of circulating angiopoietins for cirrhosis diagnosis were determined by the study of the respective area under the curve of receiver operator characteristics(AUC-ROC).RESULTS Peripheral blood concentrations of Ang1 and Ang2 in CHC patients were significantly related to fibrosis. While Ang1 was decreased in cirrhotic subjects compared to non-cirrhotic(P < 0.0001), Ang2 was significantly increased as CHC progressed to the end stage of liver disease(P < 0.0001). Consequently, Ang2/Ang1 ratio was notably amplified and significantly correlated with fibrosis(P < 0.0001). Interestingly, the individual performance of each angiopoietin for the diagnosis of cirrhosis reached notable AUC-ROC values(above 0.7, both), but the Ang2/Ang1 ratio was much better(AUC-ROC = 0.810) and displayed outstanding values of sensitivity(71%), specificity(84%) and accuracy(82.1%) at the optimal cut-off(10.33). Furthermore, Ang2/Ang1 ratio improved the performance of many other previously described biomarkers or scores of liver cirrhosis in CHC.CONCLUSION Ang2/Ang1 ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target.
文摘Taking B2C E-commerce enterprises as the center, it can be divided into a set of logistics activities upstream supply chain logistics producer to B2C e-commerce enterprises, and the B2C e-commerce enterprise logistics to client consumer, and the paper focuses on the study of self-supporting logistics for the E-commerce enterprise. According to the development status of current B2C electronic commerce enterprise in our country and logistics, the paper study B2C electric business enterprise how to correctly choose the logistics mode and how to promote the business logistics operation level.
文摘In this paper, it is proved that for any C2-cofinite, simple, CFT-type vertex operator superalgebra V and a finite solvable group G consisting of automorphisms of V, the fixed point subalgebra Vc is a C2-cofinite vertex operator superalgebra.
基金Acknowledgements This work was supported by the China Postdoctoral Science Foundation （Grant No. 2013M540709）.
文摘For any C2-cofinite vertex product and the P（z）-tensor product finite length are proved to exist, which operator superalgebra V, the tensor of any two admissible V-modules of are shown to be isomorphic, and their constructions are given explicitly in this paper.
