For investigating the accelerated blood clearance(ABC) phenomenon of polyglycerin modified nanoemulsions upon cross administration with polyethylene glycol(PEG) covered nanoemulsion, we used the 1,2-distea-royl-sn-gly...For investigating the accelerated blood clearance(ABC) phenomenon of polyglycerin modified nanoemulsions upon cross administration with polyethylene glycol(PEG) covered nanoemulsion, we used the 1,2-distea-royl-sn-glycero-3-phosphoethanolamine-npolyglycerine-610 and the 1,2-distearoyl-n-glycero-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)-2000] as modify materials, the dialkylcarbocyanines as fluorescence indicator. Exhausted macrophages rat model was established and new material containing polycarboxyl structure was synthesized. The microplate reader and the in vivo optical imaging system were applied to measure the concentration of nanoemulsions in tissues.The results show that the first dose of polyglycerin modified nanoemulsion can induce the ABC phenomenon of the second dose of PEGylated nanoemulsion. With the increase in the amount of the surface polyglycerin, the extent of the ABC phenomenon decreases. Liver accumulation has positive relationship with the ABC phenomenon. Furthermore, kupffer cells in liver can get more immune information from polyhydroxy structure than polycarboxyl group in the modify compound. The results of our work imply that the polycarboxyl structure has advantages to eliminate the ABC phenomenon.展开更多
Accumulation occurs widely in fluvial processes.Accurately accounting for the effects of previous water and sediment conditions on accumulation is essential for studying riverbed evolution.In this study,to reveal the ...Accumulation occurs widely in fluvial processes.Accurately accounting for the effects of previous water and sediment conditions on accumulation is essential for studying riverbed evolution.In this study,to reveal the physical mechanisms of accumulation,various geometric observations of both the upstream and downstream reaches of dams on several typical fluvial channels were analyzed.The changes in water and sediment conditions were defined as external disturbances.Assuming that the probability of an external disturbance conforms to a Poisson distribution,and that the response intensity induced by an individual disturbance decays exponentially over time,a mathematical description of the accumulation of internal responses to external disturbances is given.Furthermore,a corresponding theoretical model for simulating the spatiotemporal readjustments of characteristic river variables is proposed based on stochastic theory.The proposed models are then applied to investigate spatiotemporal readjustment in the upper and lower reaches of dams following their construction.The results indicate that temporally,the vertical,lateral,and overall readjustment rates of the reaches are relatively fast in the early period following dam construction but then decrease rapidly over time.Accumulated riverbed degradation,channel width,and sedimentation continuously increase until a new dynamic equilibrium is reached.These phenomena reflect the representative accumulation characteristics of fluvial processes.Spatially,the erosion intensities in downstream reaches decrease nonlinearly along the channel until eventually diminishing.The unbalanced spatial distribution of erosion intensity arises from the system response characterized by propagation in space but decay over time,which is characteristic of accumulation phenomena after disturbances.The results of the developed model show that the spatiotemporal readjustments of the studied cross-sections and channel reaches can be accurately described by the unified theoretical formula derived herein.The model predictions show good agreement with observed field data with determination coefficients of 0.92,0.93,0.76,and 0.95 for vertical,lateral,longitudinal,and overall readjustments,respectively.The proposed theoretical models account for both the accumulation characteristics of fluvial processes and their spatial distributions.In demonstrating the proposed ap-proach,this study provides a theoretical basis and new calculation method for quantitatively describing the spatiotemporal readjustments of non-equilibrium fluvial channels following external disturbances.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos.81072602,81373334)
文摘For investigating the accelerated blood clearance(ABC) phenomenon of polyglycerin modified nanoemulsions upon cross administration with polyethylene glycol(PEG) covered nanoemulsion, we used the 1,2-distea-royl-sn-glycero-3-phosphoethanolamine-npolyglycerine-610 and the 1,2-distearoyl-n-glycero-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)-2000] as modify materials, the dialkylcarbocyanines as fluorescence indicator. Exhausted macrophages rat model was established and new material containing polycarboxyl structure was synthesized. The microplate reader and the in vivo optical imaging system were applied to measure the concentration of nanoemulsions in tissues.The results show that the first dose of polyglycerin modified nanoemulsion can induce the ABC phenomenon of the second dose of PEGylated nanoemulsion. With the increase in the amount of the surface polyglycerin, the extent of the ABC phenomenon decreases. Liver accumulation has positive relationship with the ABC phenomenon. Furthermore, kupffer cells in liver can get more immune information from polyhydroxy structure than polycarboxyl group in the modify compound. The results of our work imply that the polycarboxyl structure has advantages to eliminate the ABC phenomenon.
基金National Natural Science Foundation of China,No.91547204National Key Resarch and Development Program of China,No.2016YFC0402500,No 2017YFC0404303。
文摘Accumulation occurs widely in fluvial processes.Accurately accounting for the effects of previous water and sediment conditions on accumulation is essential for studying riverbed evolution.In this study,to reveal the physical mechanisms of accumulation,various geometric observations of both the upstream and downstream reaches of dams on several typical fluvial channels were analyzed.The changes in water and sediment conditions were defined as external disturbances.Assuming that the probability of an external disturbance conforms to a Poisson distribution,and that the response intensity induced by an individual disturbance decays exponentially over time,a mathematical description of the accumulation of internal responses to external disturbances is given.Furthermore,a corresponding theoretical model for simulating the spatiotemporal readjustments of characteristic river variables is proposed based on stochastic theory.The proposed models are then applied to investigate spatiotemporal readjustment in the upper and lower reaches of dams following their construction.The results indicate that temporally,the vertical,lateral,and overall readjustment rates of the reaches are relatively fast in the early period following dam construction but then decrease rapidly over time.Accumulated riverbed degradation,channel width,and sedimentation continuously increase until a new dynamic equilibrium is reached.These phenomena reflect the representative accumulation characteristics of fluvial processes.Spatially,the erosion intensities in downstream reaches decrease nonlinearly along the channel until eventually diminishing.The unbalanced spatial distribution of erosion intensity arises from the system response characterized by propagation in space but decay over time,which is characteristic of accumulation phenomena after disturbances.The results of the developed model show that the spatiotemporal readjustments of the studied cross-sections and channel reaches can be accurately described by the unified theoretical formula derived herein.The model predictions show good agreement with observed field data with determination coefficients of 0.92,0.93,0.76,and 0.95 for vertical,lateral,longitudinal,and overall readjustments,respectively.The proposed theoretical models account for both the accumulation characteristics of fluvial processes and their spatial distributions.In demonstrating the proposed ap-proach,this study provides a theoretical basis and new calculation method for quantitatively describing the spatiotemporal readjustments of non-equilibrium fluvial channels following external disturbances.
