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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation
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作者 Xu Liang Ni-Hui Zhang +4 位作者 Zhi-Lai Zhan Guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao 《Traditional Medicine Research》 2025年第2期1-15,共15页
Background:Rosa chinensis Jacq.and Rosa rugosa Thunb.are not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional medicines.The two plants h... Background:Rosa chinensis Jacq.and Rosa rugosa Thunb.are not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional medicines.The two plants have some differences in efficacy,but the flower buds are easily confused for similar traits.In addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal roses.Therefore,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography fingerprints.Then,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large differences.Differential compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and Meigui.Results:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the samples.Through principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four groups.Partial least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavonoid glycosides,as well as phenolic acids.Eight differential components were screened out by orthogonal partial least-squares discriminant analysis and S-plot analysis.Quantitative analyses of the eight compounds,including gallic acid,ellagic acid,hyperoside,isoquercitrin,etc.,showed that Yueji was generally richer in phenolic acids and flavonoids than Meigui,and the quality of Yueji from Shandong and Hebei was better.It is worth noting that Xinjiang rose is rich in various components,which is worth focusing on more in-depth research.Conclusion:In this study,the fingerprints of Meigui and Yueji were established.The chemical components information of roses was further improved based on non-targeted metabolomics and mass spectrometry technology.At the same time,eight differential components of Meigui and Yueji were screened out and quantitatively analyzed.The research results provided a scientific basis for the quality control and rational development and utilization of Rosae Chinensis Flos and Rosae Rugosae Flos,and also laid a foundation for the study of their pharmacodynamic material basis. 展开更多
关键词 Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics CHEMOMETRICS multiple component quantification quality evaluation
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Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population 被引量:3
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作者 Muhammed Hadithi Marcel Cazemier +6 位作者 Gerrit A Meijer Elisabeth Bloemena Richel J Felt-Bersma Chris J Mulder Stephan GM Meuwissen Amado Salvador Pea Adriaan A van Bodegraven 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第20期3183-3187,共5页
AIM: To describe the characteristics of Dutch patients with chronic.inflammatory bowel disease (IBD) first diagnosed above 60 years of age-a disease also known as old-age colitis (OAC) and to highlight a conditio... AIM: To describe the characteristics of Dutch patients with chronic.inflammatory bowel disease (IBD) first diagnosed above 60 years of age-a disease also known as old-age colitis (OAC) and to highlight a condition that has a similar appearance to IBD, namely segmen- tal colitis associated with diverticular disease (SCAD). METHODS: A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years. RESULTS: Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 (50) [median age 82 years (range 64-101); 25 male (42%)] were identified. These patients were diagnosed with ulcerative colitis (n = 37, 61%), Crohn's disease (n = 14, 24%), and indeterminate colitis (n = 8, 15%). Remission was induced in 40 (68%) patients within a median interval of 6 mo (range 1-21) and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five (8%) patients. CONCLUSION: OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical features suggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli. 展开更多
关键词 Inflammatory bowel disease old-age colitis Segmental colitis
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Study of androgen and atherosclerosis in old-age male 被引量:2
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作者 杨云梅 吕雪英 +2 位作者 黄卫东 徐哲荣 吴灵娇 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2005年第9期931-935,共5页
Objective: To observe the difference of androgen and inflammatory cytokines level in atherosclerosis and analyse their relations. Method: Both carotid arteries and arteries of lower extremity were subjected to ultra... Objective: To observe the difference of androgen and inflammatory cytokines level in atherosclerosis and analyse their relations. Method: Both carotid arteries and arteries of lower extremity were subjected to ultrasonic examination by Doppier's method. Those with much atheromatous plaque formation were ranged into case group, and those with normal result formed control group. Total, free testosterone and estradiol were assayed by radioimmunoassay. C reactive protein (CRP) was assayed by nepheloturbidity. Tumor necrosis factor-α(TNF-α), lnterleukin-6 (IL-6), lnterleukin-8 (IL-8), lnterleukin-10 (IL-10), Interleukin-18 (IL-18), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were assayed by ELISA. The mean difference between two groups and the correlation between free testosterone and cytokines were analysed. Results: Free testosterone was (6.337±3.371) pg/L in case group and (11.375±4.733)pg/L in control group, P〈0.01. No differences were found in total testosterone and estradiol. CRP was (27.294±10.238)mg/L in case group and (12.843±6.318) mg/L in control group, P〈0.01. IL-6 was (41.700±31.385)pg/L in case group and (25.396±20.772)pg/L in control group, P〈0.05. IL-8 was (89.249±58.357)pg/L in case group and (67.873±31.227)pg/L in control group, P〈0.05. sICAM-1 was (470.491±134.078)pg/L in case group and (368.487±97.183)pg/L in control group, P〈0.01. sVCAM-1 was (537.808±213.172)pg/L in case group and (457.275±157.273)pg/L in control group, P〈0.05. There were no differences in TNF-α, IL-10 and IL-18. Correlation analysis showed that FT (free testosterone) had negative correlation with CRP, IL-6 and sICAM-1. Among them FT had well correlation with CRP, correlation index was -0.678. Conclusion: Free testosterone was in negative correlation with atherosclerosis in old-age male. Free testosterone may have the role of anti-atherosclerosis, and this effect was not achieved by its transformation to estradiol. Low tree testosterone level was followed by increased level of inflammatory cytokines. Low free testosterones coexist with inflammation and they both affect the process of atherosclerosis in old-age male. 展开更多
关键词 ATHEROSCLEROSIS old-age male ANDROGEN Free testosterone Inflammatory cytokine
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Rural migrants' participation in old-age insurance: a case study of the inter-provincial migrant workers from Sichuan, China 被引量:2
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作者 Yong Chen Yan Tan Qin Zhang 《Chinese Journal of Population,Resources and Environment》 2017年第2期120-131,共12页
Old-age pension, a fundamental part of the Chinese social security system, is perceived by the Chinese government as the last support for rural-to-urban migrant workers upon retreating from the labor market. Using sur... Old-age pension, a fundamental part of the Chinese social security system, is perceived by the Chinese government as the last support for rural-to-urban migrant workers upon retreating from the labor market. Using survey data collected by the authors, this paper examines a host of factors which influence migrant workers' participation in the old-age scheme. The result shows that individual characteristics, employment status, attitudes toward old-age support and perception of the old-age pension system significantly differentiate two groups of migrant workers between those that have participated in and their counterparts who have not participated in the old-age pension schemes. Among a number of factors, age, educational attainment, holding labor contract, etc. are found to be significant factors influencing migrants' behavior participating(or not participating) the available age-pension schemes. Policy implications for how to improve the rate of participation in existing old-age pension schemes among migrant workers are drawn from the findings. 展开更多
关键词 Inter-provincial rural migrant old-age pension participation in old-age pension factors
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Construction of Comprehensive Old-age Tourism Complex in Kunming City 被引量:1
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作者 HUAN Shaojun 《Journal of Landscape Research》 2016年第4期30-34,共5页
As the population aging becomes a global trend,old-age tounsm has gradually become a newly-emerging industry integrating tounsm industry and old-age support industry for such functions as leisure sightseeing,vacationi... As the population aging becomes a global trend,old-age tounsm has gradually become a newly-emerging industry integrating tounsm industry and old-age support industry for such functions as leisure sightseeing,vacationing and health care,learning and expenence,recuperation,soul comfort and so on.In face of the market opportunities of old-age tounsm,Kunming City owns many advantages such as climate,location,traffic and tounsm resources,but also shows deficiencies such as few and low-grade old-age tourism agencies,insufficient funds for old-age tourism,underdeveloped old-age service industry.To enhance the advantages and avoid disadvantages,this paper proposed the industrialized development mode of old-age tourism complex for Kunming City.On the basis of sorting out tourism resources in the city this paper first concluded 6 old-age tounsm resource spaces,integrated characteristic tounsm resources,cultural resources and social resources of each space into the 7 sub-systems of the old-age tounsm complex,proposed specific conceptions for the construction of old-age tounsm complex in Kunming,and finally gave suggestions in view of the development environment of local old-age tourism complex. 展开更多
关键词 Kunming City AGING old-age tounsm INDUSTRIALIZATION
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Aging Characteristics and Layout Planning of Old-age Care Facilities in the Downtown Area of Nanchang City 被引量:1
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作者 HU Siqi 《Journal of Landscape Research》 2016年第5期77-80,共4页
Compared to the situation of population aging and the elderly aging, the development of oldage undertaking in Nanchang is still undeveloped in that the old-age care industry lags behind the urban renewal speed and the... Compared to the situation of population aging and the elderly aging, the development of oldage undertaking in Nanchang is still undeveloped in that the old-age care industry lags behind the urban renewal speed and the objective needs of aging. Apart from discussions on the composition of elderly population and the status quo of aging, this paper took the institutional old-age care in the downtown area of Nanchang for example, explored problems in the current institutional old-age care facilities through field investigation, and proposed suggestions for the layout planning of old-age care facilities in the study area. 展开更多
关键词 Population aging old-age care facilities Layout Nanchang
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Design of Prefabricated Old-age Building Based on Modularization:A Case Study of Institutional Elderly Houses Design in Taigou Village,Xi'an City 被引量:3
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作者 SUN Qianqian 《Journal of Landscape Research》 2018年第5期84-87,共4页
Old-age building was designed in Ziwu Town,from the aspects of energy saving,environmental protection,full use of solar energy and characteristics of the local climate.In order to meet the requirements of energy conse... Old-age building was designed in Ziwu Town,from the aspects of energy saving,environmental protection,full use of solar energy and characteristics of the local climate.In order to meet the requirements of energy conservation,environmental protection and climate adaptability of residential buildings,this paper integrates the construction and design in the prefabricated building design,at the same time,with the consideration of the possibility of expansion and removal of the nursing home,the concept of "modular unit" is put forward.Considering the climatic adaptability of the base position,the utilization of solar energy and the organization of natural ventilation should be paid attention to,also,the rammed soil construction method is added in this design,which can improve the thermal insulation performance of the building enclosure and create a comfortable indoor thermal environment both in winter and summer.In order to realize the object of industrial building construction and design,the prefabricated construction method is used,which produces impact on the surrounding environment more environmentally friendly.The building will be easily built,less restricted,and low-cost.What's more,local material and the advantages of all dry work increase the operability of the project. 展开更多
关键词 PREFABRICATED assembly old-age BUILDING DESIGN Modular units
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Key Elements of “Family” Life Style of Old-age Residential Facilities
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作者 LIU Linggui LIANG Ying ZHOU Dian 《Journal of Landscape Research》 2019年第6期33-36,共4页
The problem of old-age care in China is more and more serious. Under the background of continuous promotion of community old-age, the importance of research on the"family" life style of oldage residential fa... The problem of old-age care in China is more and more serious. Under the background of continuous promotion of community old-age, the importance of research on the"family" life style of oldage residential facilities has become increasingly prominent. Through field survey of different types of oldage residential facilities and questionnaire interviews, the shortcomings of the old-age residential facilities in Xi’an were compared and summarized, and the key elements of "family" life style of the old-age residential facilities were concluded, which mainly include urban community embeddedness, family structure elements, indoor furnishings and accompanying care system. The "family" life style of the old-age residential facilities can not only maintain the "kinship" living needs, but also conform to the new direction of promoting the "community" of the old-age residential facilities in China. 展开更多
关键词 old-age facilities “Family” LIFE STYLE BUILDINGS for the aged
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Industrialization of Old-age Tourism in Yunnan
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作者 HUAN Shaojun NI Yan 《Journal of Landscape Research》 2019年第6期136-140,共5页
Faced with the supply-side reform of the tourism industry, the industrialization of Yunnan oldage tourism will be an inevitable attempt to subdivide the tourism market in Yunnan. Based on the concept of old-age touris... Faced with the supply-side reform of the tourism industry, the industrialization of Yunnan oldage tourism will be an inevitable attempt to subdivide the tourism market in Yunnan. Based on the concept of old-age tourism, this study put forward the regional structure of Yunnan’s old-age tourism industry, and pointed out the development direction for the "one center and six districts" of Yunnan old-age tourism. Then from the perspective of system theory, the concept of the old-age tourism complex in Yunnan Province was proposed. At the same time, from the perspective of operation management system, oldage tourism accommodation system, old-age tourism passenger transport system, ethnic cultural products, ecological health products, arts and crafts, health services and rural old-age tourism, the construction idea of the old-age tourism complex in Yunnan Province was proposed. 展开更多
关键词 old-age TOURISM INDUSTRIAL REGIONAL Structure Complex Construction
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A Study of Classification of Figures and Sizes for Middle-and Old-Aged Men
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作者 李兴刚 李元虹 《Journal of Donghua University(English Edition)》 EI CAS 2003年第3期129-133,共5页
The characteristics of human figures, variable laws and the basic sizes of each part of human body have been found by means of anthropomctric measurements of the middle-arid old-aged men and data analyses. Also, propo... The characteristics of human figures, variable laws and the basic sizes of each part of human body have been found by means of anthropomctric measurements of the middle-arid old-aged men and data analyses. Also, proposals of how to classify dimensions and sizes of the medium human figures among the middle-and old-aged men have been put forward. 展开更多
关键词 middle-and old-aged men human body measurement figure clothing size
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Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage 被引量:5
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作者 Jiatong Zhang Qi Zhu +4 位作者 Jie Wang Zheng Peng Zong Zhuang Chunhua Hang Wei Li 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第4期825-832,共8页
The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow.Mitochondria are directly affected by direct facto... The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow.Mitochondria are directly affected by direct factors such as ischemia,hypoxia,excitotoxicity,and toxicity of free hemoglobin and its degradation products,which trigger mitochondrial dysfunction.Dysfunctional mitochondria release large amounts of reactive oxygen species,inflammatory mediators,and apoptotic proteins that activate apoptotic pathways,further damaging cells.In response to this array of damage,cells have adopted multiple mitochondrial quality control mechanisms through evolution,including mitochondrial protein quality control,mitochondrial dynamics,mitophagy,mitochondrial biogenesis,and intercellular mitochondrial transfer,to maintain mitochondrial homeostasis under pathological conditions.Specific interventions targeting mitochondrial quality control mechanisms have emerged as promising therapeutic strategies for subarachnoid hemorrhage.This review provides an overview of recent research advances in mitochondrial pathophysiological processes after subarachnoid hemorrhage,particularly mitochondrial quality control mechanisms.It also presents potential therapeutic strategies to target mitochondrial quality control in subarachnoid hemorrhage. 展开更多
关键词 mitochondrial biogenesis mitochondrial dynamics mitochondrial dysfunction mitochondrial fission and fusion mitochondrial quality control MITOPHAGY subarachnoid hemorrhage
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Genome wide association analysis identifies candidate genes for fruit quality and yield in Actinidia eriantha 被引量:1
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作者 Yingzhen Wang Ying Wu +7 位作者 Xinlei Wang Wangmei Ren Qinyao Chen Sijia Zhang Feng Zhang Yunzhi Lin Junyang Yue Yongsheng Liu 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第6期1929-1939,共11页
Quality and yield are the primary concerns in kiwifruit breeding,but research on the genetic mechanisms of fruit size,shape,and ascorbic acid(ASA)content is currently very limited,which restricts the development of ki... Quality and yield are the primary concerns in kiwifruit breeding,but research on the genetic mechanisms of fruit size,shape,and ascorbic acid(ASA)content is currently very limited,which restricts the development of kiwifruit molecular breeding.In this study,we obtained a total of 8.88 million highly reliable single nucleotide polymorphism(SNP)markers from 140 individuals from the natural hybrid offspring of Actinidia eriantha cv.‘White’using whole genome resequencing technology.A genome-wide association study was conducted on eight key agronomic traits,including single fruit weight,fruit shape,ASA content,and the number of inflorescences per branch.A total of 59 genetic loci containing potential functional genes were located,and candidate genes related to single fruit weight,fruit length,ASA content,number of inflorescences per branch and other traits were identified within the candidate interval,such as AeWUSCHEL,AeCDK1(cell cycle dependent kinase),AeAO1(ascorbic oxidase)and AeCO1(CONSTANS-like 4).After constructing an RNAi vector for AeAO1 and injecting it into the fruit of cv.‘Midao 31’to interfere with the expression of the AeAO1 gene,the results showed that the activity of ascorbic oxidase in the fruit of‘Midao 31’significantly decreased,while the content of ASA significantly increased.This study provides valuable insights into the genetic basis of variation in A.eriantha fruit traits,which may benefit molecular marker-assisted breeding efforts. 展开更多
关键词 Actinidia eriantha GWAS SNP QTLS fruit quality
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Sleep quality in middle-aged and elderly hemodialysis patients:Impact of a structured nursing intervention program 被引量:1
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作者 Ling-Ling Tao Cai-Hua Zeng +1 位作者 Wen-Juan Mei Yan-Li Zou 《World Journal of Clinical Cases》 SCIE 2024年第25期5713-5719,共7页
BACKGROUND Poor sleep quality is common among hemodialysis patients and can significantly impact their well-being.This study aimed to evaluate the effectiveness of a structured nursing intervention program in improvin... BACKGROUND Poor sleep quality is common among hemodialysis patients and can significantly impact their well-being.This study aimed to evaluate the effectiveness of a structured nursing intervention program in improving sleep quality in middleaged and elderly hemodialysis patients.AIM To evaluate the impact of nursing intervention on sleep quality in hemodialysis patients.METHODS This cross-sectional study was conducted in a tertiary hospital,the First Affiliated Hospital of Nanchang University,in 2023.This study included 105 middle-aged and elderly hemodialysis patients aged≥45 years who underwent maintenance hemodialysis for at least 3 mo,utilizing the Pittsburgh Sleep Quality Index(PSQI)to identify poor sleepers.Those identified underwent a 12-wk nursing intervention program focusing on education,relaxation techniques,and counseling.Post-intervention,sleep quality was reassessed using the PSQI.RESULTS The study found that 68.6%of hemodialysis patients were poor sleepers.Following the 12-wk nursing intervention program,there was a significant decrease in the mean global PSQI score from 8.9±3.2 to 5.1±2.7(P<0.001),indicating improved sleep quality.This demonstrated the effectiveness of the structured nursing intervention in enhancing sleep quality for middle-aged and elderly hemodialysis patients.CONCLUSION The structured nursing intervention program focusing on sleep hygiene education,relaxation techniques,and counseling effectively improved sleep quality among middle-aged and elderly hemodialysis patients.The significant decrease in the mean global PSQI score post-intervention indicates the positive impact of tailored nursing interventions in addressing poor sleep quality in this patient population.These findings emphasize the importance of implementing targeted nursing interventions to enhance the quality of life for hemodialysis patients by addressing the prevalent issue of poor sleep quality. 展开更多
关键词 Hemodialysis patients Nursing intervention Sleep quality ELDERLY Pittsburgh Sleep quality Index Patient wellbeing
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Investigation of the quality of life,mental status in patients with gynecological cancer and its influencing factors 被引量:2
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作者 Hai-Xia Shang Wen-Ting Ning +5 位作者 Jin-Fen Sun Nan Guo Xin Guo Jan-Nan Zhang Hong-Xin Yu Su-Hui Wu 《World Journal of Psychiatry》 SCIE 2024年第7期1053-1061,共9页
BACKGROUND Having a gynecological tumor or undergoing treatment can be a traumatic experience for women,as it affects their self-image and sexual relationships and can lead to psychological reactions.Psychological adj... BACKGROUND Having a gynecological tumor or undergoing treatment can be a traumatic experience for women,as it affects their self-image and sexual relationships and can lead to psychological reactions.Psychological adjustment following cancer occurrence remains a key issue among the survivors.AIM To examine the current status of quality of life(QoL),anxiety,and depression in patients with gynecological cancer and to analyze the factors associated with it.METHODS Data for 160 patients with gynecological malignancies treated at Shanxi Bethune Hospital from June 2020 to June 2023 were collected and analyzed retrospectively.Patients’QoL was assessed using the European Organization for Research on Treatment of Cancer Quality of Life Questionnaire Core 30 and the Functional Assessment of Cancer Therapy-General Questionnaire.Their emotional status was evaluated using the Self-Rating Anxiety/Depression Scale.The associated factors of anxiety and depression were analyzed.RESULTS The overall QoL score of the patients 6 months after surgery was 76.39±3.63 points.This included low levels of social and emotional function and severe fatigue and pain.The scores for physiological,functional,emotional,social,and family well-being exhibited an upward trend following surgery compared with those before surgery.One month after surgery,some patients experienced anxiety and depression,with an incidence of 18.75%and 18.13%,respectively.Logistic analysis revealed that good sleep was a protective factor against anxiety and depression in patients with gynecological tumors,whereas physical pain was a risk factor.CONCLUSION Patients with gynecological malignancies often experience anxiety and depression.By analyzing the factors that affect patients’QoL,effective nursing measures can be administered. 展开更多
关键词 GYNECOLOGICAL TUMORS quality of life ANXIETY DEPRESSION
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Old-Age Support Facilities Under-Utilized
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《China Population Today》 2001年第6期17-17,共1页
关键词 old-age Support Facilities Under-Utilized HIGH
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Current status of magnetic resonance imaging radiomics in hepatocellular carcinoma:A quantitative review with Radiomics Quality Score 被引量:2
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作者 Valentina Brancato Marco Cerrone +2 位作者 Nunzia Garbino Marco Salvatore Carlo Cavaliere 《World Journal of Gastroenterology》 SCIE CAS 2024年第4期381-417,共37页
BACKGROUND Radiomics is a promising tool that may increase the value of magnetic resonance imaging(MRI)for different tasks related to the management of patients with hepatocellular carcinoma(HCC).However,its implement... BACKGROUND Radiomics is a promising tool that may increase the value of magnetic resonance imaging(MRI)for different tasks related to the management of patients with hepatocellular carcinoma(HCC).However,its implementation in clinical practice is still far,with many issues related to the methodological quality of radiomic studies.AIM To systematically review the current status of MRI radiomic studies concerning HCC using the Radiomics Quality Score(RQS).METHODS A systematic literature search of PubMed,Google Scholar,and Web of Science databases was performed to identify original articles focusing on the use of MRI radiomics for HCC management published between 2017 and 2023.The methodological quality of radiomic studies was assessed using the RQS tool.Spearman’s correlation(ρ)analysis was performed to explore if RQS was correlated with journal metrics and characteristics of the studies.The level of statistical significance was set at P<0.05.RESULTS One hundred and twenty-seven articles were included,of which 43 focused on HCC prognosis,39 on prediction of pathological findings,16 on prediction of the expression of molecular markers outcomes,18 had a diagnostic purpose,and 11 had multiple purposes.The mean RQS was 8±6.22,and the corresponding percentage was 24.15%±15.25%(ranging from 0.0% to 58.33%).RQS was positively correlated with journal impact factor(IF;ρ=0.36,P=2.98×10^(-5)),5-years IF(ρ=0.33,P=1.56×10^(-4)),number of patients included in the study(ρ=0.51,P<9.37×10^(-10))and number of radiomics features extracted in the study(ρ=0.59,P<4.59×10^(-13)),and time of publication(ρ=-0.23,P<0.0072).CONCLUSION Although MRI radiomics in HCC represents a promising tool to develop adequate personalized treatment as a noninvasive approach in HCC patients,our study revealed that studies in this field still lack the quality required to allow its introduction into clinical practice. 展开更多
关键词 Hepatocellular carcinoma Systematic review Magnetic resonance imaging Radiomics Radiomics quality score
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Dynamic changes of rumen microbiota and serum metabolome revealed increases in meat quality and growth performances of sheep fed bio‑fermented rice straw 被引量:1
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作者 Yin Yin Kyawt Min Aung +6 位作者 Yao Xu Zhanying Sun Yaqi Zhou Weiyun Zhu Varijakshapanicker Padmakumar Zhankun Tan Yanfen Cheng 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第3期1207-1226,共20页
Background Providing high-quality roughage is crucial for improvement of ruminant production because it is an essential component of their feed.Our previous study showed that feeding bio-fermented rice straw(BF)improv... Background Providing high-quality roughage is crucial for improvement of ruminant production because it is an essential component of their feed.Our previous study showed that feeding bio-fermented rice straw(BF)improved the feed intake and weight gain of sheep.However,it remains unclear why feeding BF to sheep increased their feed intake and weight gain.Therefore,the purposes of this research were to investigate how the rumen micro-biota and serum metabolome are dynamically changing after feeding BF,as well as how their changes influence the feed intake,digestibility,nutrient transport,meat quality and growth performances of sheep.Twelve growing Hu sheep were allocated into 3 groups:alfalfa hay fed group(AH:positive control),rice straw fed group(RS:negative control)and BF fed group(BF:treatment).Samples of rumen content,blood,rumen epithelium,muscle,feed offered and refusals were collected for the subsequent analysis.Results Feeding BF changed the microbial community and rumen fermentation,particularly increasing(P<0.05)relative abundance of Prevotella and propionate production,and decreasing(P<0.05)enteric methane yield.The histomorphology(height,width,area and thickness)of rumen papillae and gene expression for carbohydrate trans-port(MCT1),tight junction(claudin-1,claudin-4),and cell proliferation(CDK4,Cyclin A2,Cyclin E1)were improved(P<0.05)in sheep fed BF.Additionally,serum metabolome was also dynamically changed,which led to up-regulating(P<0.05)the primary bile acid biosynthesis and biosynthesis of unsaturated fatty acid in sheep fed BF.As a result,the higher(P<0.05)feed intake,digestibility,growth rate,feed efficiency,meat quality and mono-unsaturated fatty acid concentration in muscle,and the lower(P<0.05)feed cost per kg of live weight were achieved by feeding BF.Conclusions Feeding BF improved the growth performances and meat quality of sheep and reduced their feed cost.Therefore,bio-fermentation of rice straw could be an innovative way for improving ruminant production with mini-mizing production costs. 展开更多
关键词 Bio-fermentation Growth rate Meat quality METABOLOME MICROBIOTA Rice straw
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Product quality prediction based on RBF optimized by firefly algorithm 被引量:2
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作者 HAN Huihui WANG Jian +1 位作者 CHEN Sen YAN Manting 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2024年第1期105-117,共13页
With the development of information technology,a large number of product quality data in the entire manufacturing process is accumulated,but it is not explored and used effectively.The traditional product quality pred... With the development of information technology,a large number of product quality data in the entire manufacturing process is accumulated,but it is not explored and used effectively.The traditional product quality prediction models have many disadvantages,such as high complexity and low accuracy.To overcome the above problems,we propose an optimized data equalization method to pre-process dataset and design a simple but effective product quality prediction model:radial basis function model optimized by the firefly algorithm with Levy flight mechanism(RBFFALM).First,the new data equalization method is introduced to pre-process the dataset,which reduces the dimension of the data,removes redundant features,and improves the data distribution.Then the RBFFALFM is used to predict product quality.Comprehensive expe riments conducted on real-world product quality datasets validate that the new model RBFFALFM combining with the new data pre-processing method outperforms other previous me thods on predicting product quality. 展开更多
关键词 product quality prediction data pre-processing radial basis function swarm intelligence optimization algorithm
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The impact of Internet access on household dietary quality:Evidence from rural China 被引量:1
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作者 Yi Cui Qiran Zhao +1 位作者 Thomas Glauben Wei Si 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第2期374-383,共10页
Over the past few decades,the Internet has rapidly diffused across China.The spread of the Internet has had a profound economic and social impact on Chinese rural areas.Existing research shows that Internet access sig... Over the past few decades,the Internet has rapidly diffused across China.The spread of the Internet has had a profound economic and social impact on Chinese rural areas.Existing research shows that Internet access significantly impacts agricultural production and improves smallholder farmers’income.Beyond these,the Internet can affect other dimensions of social welfare.However,research about the impact of Internet access on dietary quality in rural China remains scarce.This study utilizes multi-period panel data from Fixed Observation Point in rural China from 2009 to 2015 to estimate the impact of Internet access on dietary quality and food consumption of rural households and conducts a causal analysis.Regression models with time and household fixed effects allow robust estimation while reducing potential issues of unobserved heterogeneity.The estimates show that Internet access has significantly increased rural household dietary quality(measured by the Chinese Diet Balance Index).Further research finds that Internet access has increased the consumption of animal products,such as aquatic and dairy products.We also examine the underlying mechanisms.Internet access improves dietary quality and food consumption mainly through increasing household income and food expenditure.These results encourage the promotion of Internet access as a valuable tool for nutritional improvements,especially in rural areas. 展开更多
关键词 dietary quality fixed effect model Internet access rural China
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Genome-wide identification of the pectate lyase(PEL)gene family members in Malvaceae,and their contribution to cotton fiber quality 被引量:1
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作者 Qian Deng Zeyu Dong +5 位作者 Zequan Chen Zhuolin Shi Ting Zhao Xueying Guan Yan Hu Lei Fang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第10期3264-3282,共19页
Pectin is a major constituent of the plant cell wall.Pectate lyase(PEL,EC 4.2.2.2)uses anti-β-elimination chemistry to cleave theα-1,4 glycosidic linkage in the homogalacturonan region of pectin.However,limited info... Pectin is a major constituent of the plant cell wall.Pectate lyase(PEL,EC 4.2.2.2)uses anti-β-elimination chemistry to cleave theα-1,4 glycosidic linkage in the homogalacturonan region of pectin.However,limited information is available on the comprehensive and evolutionary analysis of PELs in the Malvaceae.In this study,we identified 597PEL genes from 10 Malvaceae species.Phylogenetic and motif analyses revealed that these PELs are classified into six subfamilies:Clades I,II,III,IV,Va,and Vb.The two largest subfamilies,Clades I and II,contained 237 and222 PEL members,respectively.The members of Clades Va and Vb only contained four or five motifs,far fewer than the other subfamilies.Gene duplication analysis showed that segmental duplication played a crucial role in the expansion of the PEL gene family in Gossypium species.The PELs from Clades I,IV,Va,and Vb were expressed during the fiber elongation stage,but nearly all PEL genes from Clades II and III showed no expression in any of the investigated fiber developmental stages.We further performed single-gene haplotype association analysis in 2,001G.hirsutum accessions and 229 G.barbadense accessions.Interestingly,14 PELs were significantly associated with fiber length and strength traits in G.barbadense with superior fiber quality,while only eight GhPEL genes were found to be significantly associated with fiber quality traits in G.hirsutum.Our findings provide important information for further evolutionary and functional research on the PEL gene family members and their potential use for fiber quality improvement in cotton. 展开更多
关键词 MALVACEAE pectate lyase(PEL) Gossypium species fiber quality
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