In 2014,Huang Kaihong,a professor at School of Foreign Languages and Cultures,Southwest University of Science and Technology,interviewed the Doctoral advisor Professor Nie Zhenzhao during the period of his academic vi...In 2014,Huang Kaihong,a professor at School of Foreign Languages and Cultures,Southwest University of Science and Technology,interviewed the Doctoral advisor Professor Nie Zhenzhao during the period of his academic visiting to Central China Normal University.As early as in 2005,Huang Kaihong conducted an interview with Professor Nie Zhenzhao on the topic of the general introduction of ethical literary criticism.So around 11 years later,the second interview mainly covers not only the ethical literary criticism theory,but the game theory and the relationship between them as well.Professor Nie thinks whether the game theory can be applied to literature research is still under discussion.The theory of ethical literary criticism is a kind of methodology based on science and it can get the attention of literary critics at home and abroad,which is because it fits the practical needs of literary criticism,draws the literary criticism away from only emphasizing criticism genres and the research of criticism terms,and pays attention to the true nature of the literary text in literature research.After consulting Professor Nie Zhenzhao about some related questions from the perspective of game theory.Huang Kaihong gets some significant information concerning literature research and understands the latest core terms and the concrete application method of ethical literary criticism,especially the relationship between the instructing and aesthetic functions of literature.展开更多
Combined bodies of rock-like material and rock are widely encountered in geotechnical engineering,such as tunnels and mines.The existing theoretical models describing the stress-strain relationship of a combined body ...Combined bodies of rock-like material and rock are widely encountered in geotechnical engineering,such as tunnels and mines.The existing theoretical models describing the stress-strain relationship of a combined body lack a binary feature.Based on effective medium theory,this paper presents the governing equation of the“elastic modulus”for combined and single bodies under triaxial compressive tests.A binary effective medium model is then established.Based on the compressive experiment of concretegranite combined bodies,the feasibility of determining the stress threshold based on crack axial strain is discussed,and the model is verified.The model is further extended to coal-rock combined bodies of more diverse types,and the variation laws of the compressive mechanical parameters are then discussed.The results show that the fitting accuracy of the model with the experimental curves of the concretegranite combined bodies and various types of coal-rock combined bodies are over 95%.The crack axial strain method can replace the crack volumetric strain method,which clarifies the physical meanings of the model parameters.The variation laws of matrix parameters and crack parameters are discussed in depth and are expected to be more widely used in geotechnical engineering.展开更多
In postmodernist novel, the explanation of the relationship between fiction and reality is a distinctive feature, known as a playing game. In Continuity of Parks, the "game" is played through the application...In postmodernist novel, the explanation of the relationship between fiction and reality is a distinctive feature, known as a playing game. In Continuity of Parks, the "game" is played through the application of colors, settings, props, etc. with the plots' evolution. It is helpful to appreciate the postmodernist novel by analysing the relationship.展开更多
Objective To study the common pathogenesis of pneumonia and colitis using modern biological network analysis tools,and to explore the theory that the lung and large intestine are exteriorly and interiorly related.Meth...Objective To study the common pathogenesis of pneumonia and colitis using modern biological network analysis tools,and to explore the theory that the lung and large intestine are exteriorly and interiorly related.Methods The relevant target genes(hereinafter,“targets”)of pneumonia and colitis were separately queried on the GeneCards database.The main targets of the two diseases were then screened out according to their correlation scores and intersected to obtain those common to the two diseases.Metascape was used to analyze the main and common targets identified,and the Database for Annotation,Visualization and Integrated Discovery(DAVID)was used to enrich and analyze the common targets.Cytoscape 3.7.2 software was used to build the network diagram.Results In total,54 targets,such as TNF,IL-10,IL-6,IL-2,IL-4,TLR4,TLR2,CXCL8,IL-17A and IFNG,etc.,are common to pneumonia and colitis,which are mainly enriched in these processes such as cytokine–cytokine receptor interaction,the Tcell receptor signaling pathway,the Toll-like receptor signaling pathway and the Jak-STAT signaling pathway.The Metascape modular analysis identified 11 modules for pneumonia,six modules for colitis,and two modules for the common targets.Conclusions Pneumonia and colitis have the same pathogenic targets and mechanisms of action and finally interact with each other through inflammatory reactions and immune responses.This provides a probable molecular mechanism that explains the theory that the lung and large intestine are exteriorly and interiorly related.展开更多
Balance theory holds that when the subject is in the unbalanced state,there is two basic way to eliminate this situation.One is to change his attitude on the cognitive object;the other is to change the subject's a...Balance theory holds that when the subject is in the unbalanced state,there is two basic way to eliminate this situation.One is to change his attitude on the cognitive object;the other is to change the subject's attitude on reference person.To ex plain the relationship among teacher,students and teaching material by applying the Balance theory can help us find and solve problems during the education.It can generate motivation to restore a new balance to promote the development of education.展开更多
All theoires and rules for translation from Chinese into foreign languages or from foreign languages into Chinese are closely related to compartive linguistics. But, the relationship of the two can not be generalized ...All theoires and rules for translation from Chinese into foreign languages or from foreign languages into Chinese are closely related to compartive linguistics. But, the relationship of the two can not be generalized in the simple relation of theory and practice, for both of them there are theoretical and practical contents, the development of themselves plays a positive promoting role on the development of each other. Contrastive linguistics also exerting various influences on practice of translation.Contrastive linguistics and translation have a very close relationship, to apply the theory of comparative linguistics to translation studies will undoubtedly have to play a guiding role in the practice of translation, translation involves at least two languages, so it inevitably involve communication and transformation of two different cultures. This paper discusses the relationship between them from the perspective of vocabulary, grammar and discourse pragmatics to better direct the translation.展开更多
Density functional theory (DFT) was used to calculate molecular descriptors (properties) for 12 fluoro-quinolone with anti-S.pneumoniae activity. Principal component analysis (PCA) and hierarchical cluster analy...Density functional theory (DFT) was used to calculate molecular descriptors (properties) for 12 fluoro-quinolone with anti-S.pneumoniae activity. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were employed to reduce dimensionality and investigate in which variables should be more effective for classifying fluoroquinolones according to their degree of an-S.pneumoniae activity. The PCA results showed that the variables ELUMO, Q3, Q5, QA, logP, MR, VOL and △EHL of these compounds were responsible for the anti-S.pneumoniae activity. The HCA results were similar to those obtained with PCA.The methodologies of PCA and HCA provide a reliable rule for classifying new fluoroquinolones with antiS.pneumoniae activity. By using the chemometric results, 6 synthetic compounds were analyzed through the PCA and HCA and two of them are proposed as active molecules with anti-S.pneumoniae, which is consistent with the results of clinic experiments.展开更多
From the view of the ecological theory, this paper tries to analyze that Thoreau uses Chinese traditional philosophical thought--- the oneness of man and nature to deal with the relationship of human beings and the na...From the view of the ecological theory, this paper tries to analyze that Thoreau uses Chinese traditional philosophical thought--- the oneness of man and nature to deal with the relationship of human beings and the nature in Walden.展开更多
BACKGROUND Prostate cancer is a major disease impacting men’s health worldwide.Peplau,who is known as“the mother of psychiatric society,”developed an interpersonal relationship theory for nursing.Implementation of ...BACKGROUND Prostate cancer is a major disease impacting men’s health worldwide.Peplau,who is known as“the mother of psychiatric society,”developed an interpersonal relationship theory for nursing.Implementation of this theory in practice has been shown to positively impact patients’quality of life and reduce adverse symptoms after surgery.AIM To investigate the effects of a nursing model based on Peplau’s interpersonal relationship theory combined with bladder function training on patients with prostate cancer.METHODS Eighty-nine patients with prostate cancer who underwent transurethral resection of the prostate(TURP)participated in this study.These patients were admitted to The First Affiliated Hospital of Soochow University or Dushu Lake Hospital Affiliated to Soochow University between January 2020 and April 2021.Patients were randomized into either the Peplau nursing group(n=44)or a routine nursing group(n=45).The routine nursing group received routine care and bladder function training,while the Peplau care group received care that integrated concepts from the Peplau interpersonal relationship theory as well as bladder function training.The urinary incontinence symptoms of the two groups were recorded,and the respective International Prostate Symptom Scores(IPSS),Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being(FACIT-Sp)scores,and quality of life(QOL)scores for each group were compared before and after three months of nursing intervention.RESULTS During the intervention period,the duration of urinary incontinence,frequency,number and amount of urinary incontinence were significantly greater in the routine nursing group compared to the Peplau care group(P<0.05).The indicators of the routine nursing group were 7.13±2.42 days,8.23±2.75 times,and 1.24±0.42 L,while those of the Peplau care group were 4.74±1.85 d,4.21±1.26 times,and 0.56±0.11 L,respectively.After three months of intervention,the mean IPSS score of the routine nursing group was significantly reduced(P<0.05),while the mean FACIT-Sp and QOL scores were significantly increased(P<0.05).The mean IPSS score in the Peplau nursing group was significantly lower compared to the routine nursing group,while the FACIT-Sp and QOL scores were higher(P<0.05).CONCLUSION A nursing model based on Peplau’s interpersonal relationship theory combined with bladder function training can significantly improve prostate function and urinary symptoms,resulting in the restoration of physiological function and improvement in the QOL of patients with prostate cancer following TURP.展开更多
Einstein derived the energy-momentum relationship which holds in an isolated system in free space. However, this relationship is not applicable in the space inside a hydrogen atom where there is potential energy. Ther...Einstein derived the energy-momentum relationship which holds in an isolated system in free space. However, this relationship is not applicable in the space inside a hydrogen atom where there is potential energy. Therefore, in 2011, the author derived an energy-momentum relationship applicable to the electron constituting a hydrogen atom. This paper derives that relationship in a simpler way using another method. From this relationship, it is possible to derive the formula for the energy levels of a hydrogen atom. The energy values obtained from this formula almost match the theoretical values of Bohr. However, the relationship derived by the author includes a state that cannot be predicted with Bohr’s theory. In the hydrogen atom, there is an energy level with n = 0. Also, there are energy levels where the relativistic energy of the electron becomes negative. An electron with this negative energy (mass) exists near the atomic nucleus (proton). The name “dark hydrogen atom” is given to matter formed from one electron with this negative mass and one proton with positive mass. Dark hydrogen atoms, dark hydrogen molecules, other types of dark atoms, and aggregates made up of dark molecules are plausible candidates for dark matter, the mysterious type of matter whose true nature is currently unknown.展开更多
This paper presents a novel observer model that integrates quantum mechanics, relativity, idealism, and the simulation hypothesis to explain the quantum nature of the universe. The model posits a central server transm...This paper presents a novel observer model that integrates quantum mechanics, relativity, idealism, and the simulation hypothesis to explain the quantum nature of the universe. The model posits a central server transmitting multi-media frames to create observer-dependent realities. Key aspects include deriving frame rates, defining quantum reality, and establishing hierarchical observer structures. The model’s impact on quantum information theory and philosophical interpretations of reality are examined, with detailed discussions on information loss and recursive frame transmission in the appendices.展开更多
Encounters are celebrated experiences between persons with connectedness in human situations as expectation. While being in a human dynamic and rhythmic interaction, nursing encounters are dyadic relationships illumin...Encounters are celebrated experiences between persons with connectedness in human situations as expectation. While being in a human dynamic and rhythmic interaction, nursing encounters are dyadic relationships illuminated as patterns of an interconnected relationship moving between the nurse and the nursed, and reflecting person-and-otherness events. The purpose of this paper is to describe the theory of Encountering Nursing in a Nurse-Nursed Dyadic Relationship (ThENNDyR) and to illuminate the four nursing practice processes on which the theory is founded: <em>Knowing as appreciating relational moments</em>;<em>Reflecting as engaging moments</em>;<em>Realizing as patterns of living moments</em>;and <em>Transcending as celebrating moments</em>. Nursing practice occurs in moments in which dyadic relationships transpire as nursing encounters. As fleeting as moments are, the four processes of nursing simultaneously take place as understanding conditions that the <em>who</em> and <em>what</em> of the person warrants persons. “Encountering nursing” is a momentary co-existence of persons in a person-and-otherness situation communicating connectedness-interconnectedness in distinct patterning. Interactions in nursing exist as persons remain wholes and complete in the moment.展开更多
Optimized calculation of dibenzofuran (DF) and 135 polychlorinated dibenzofurans (PCDFs) was carried out at the B3LYP/6-31G* level in GAUSSIAN 98 program. Based on the theoretical linear solvation energy relation...Optimized calculation of dibenzofuran (DF) and 135 polychlorinated dibenzofurans (PCDFs) was carried out at the B3LYP/6-31G* level in GAUSSIAN 98 program. Based on the theoretical linear solvation energy relationship (TLSER) model, the obtained structural parameters were taken as theoretical descriptors to establish the novel quantitative structureproperty relationship (QSPR) model for predicting n-octanol/water partition coefficients (lgKow) of PCDFs. The new model of lgKow achieved in this work contains three variables: energy of the highest occupied molecular orbital (EHOMO), the most negative atomic partial charge (q^-) and average molecular polarizability (a), of which R^2= 0.9011 and SD = 0,17 with larger t values. In addition, the variation inflation factors (VIF) of variables in the present model are all less than 5.5, suggesting high accuracy of the lgKow model. And the results of cross-validation test (q^2 = 0.8688) and method validation also show this model exhibits optimum stability and better predictive power than semi-empirical method. At the same time, it is found that the aqueous solubility (-lgSw) has high relative correlation with constant volume molar heat capacity (Cv^0), of which R^2 = 0.9777 and SD = 0.22. Moreover, lgKow and -lgSw values of all PCDF congeners were predicted respectively.展开更多
Relevance Theory mainly emphasizes the transmission,utterance and inference of the communicative target.In this process,the communicators should create the best communication context according to communicative target ...Relevance Theory mainly emphasizes the transmission,utterance and inference of the communicative target.In this process,the communicators should create the best communication context according to communicative target and purpose to achieve the optimal relevance between the communication content and the background information of communicators.The basic conclusion to be drawn from this thesis is that the subtitle translator’s task is to guarantee the target-language audience able to enjoy the original dramatic experience as the source-language audience with the least processing efforts.展开更多
Density functional theory(DFT)-B3LYP level with the 6-311G**(d,p) basis set was used to calculate a set of molecular quantum chemical descriptors of 12 chloroanilines. Quantitative structure-activity relationshi...Density functional theory(DFT)-B3LYP level with the 6-311G**(d,p) basis set was used to calculate a set of molecular quantum chemical descriptors of 12 chloroanilines. Quantitative structure-activity relationship(QSAR) models of the bioconcentration factors(BCF) of the anilines in fish were established using some of the following calculated descriptors: EHOMO, ENHOMO, ELUMO, ENLUMO, ΔE1(= ELUMO- EHOMO), ΔE2(= ENLUMO- ENHOMO), dipole moment(μ), molecular volume(V), vibrational energy of 0 K(Ev), thermodynamic energy(E), heat capacity(Cv), entropy(Sm) and the charge of benzene ring(Qph). Using the variable selection and leaps-and-bounds regression, the quantum chemical descriptors derived directly from the molecular structures were employed to develop a linear QSAR model between the bioconcentration factors(BCF) and two descriptors(Sm, ENHOMO) of 12 chloroanilines. Statistically, the most significant one is a two-parameter linear equation with the correlation coefficient(R^2) of 0.981 and cross-validated correlation coefficient(Rcv^2) of 0.967. The established QSAR model has good stability and predictability based on the results from Rcv2 of leave-one-out cross-validation, AIC, FIT and tα/2. The quantum chemical analyses were performed from two aspects of frontier molecular orbital and entropy. The results show that two structural describers are crucial to the bioconcentration activity of chloroanilines.展开更多
Twenty eight alkyl(1-phenylsulfonyl) cycloalkane carboxylates were computed at the B3LYP/6-31G* level. Based on linear solvation energy theory, two quantitative correlation equations of the molecular structures of alk...Twenty eight alkyl(1-phenylsulfonyl) cycloalkane carboxylates were computed at the B3LYP/6-31G* level. Based on linear solvation energy theory, two quantitative correlation equations of the molecular structures of alkyl(1-phenylsulfonyl) cycloalkane carboxylate com- pounds to their chromatographic retention (capacity factor lgKW) and the toxicity for photo- bacterium phosphoreum (–lgEC50) were developed by using the molecular structural parameters as theoretical descriptors (r2 = 0.9501, 0.9488). The two quantitative correlation equations were consequently cross validated by leave-one-out (LOO) validation method with q2 of 0.9113 and 0.9281, respectively. The result showed that the two equations achieved in this work by B3LYP/6-31G* are both more advantageous than those from AM1, and can be used to predict the lgKW and –lgEC50 of congeneric organics.展开更多
Toxicities (-1gEC50) of 16 phenolic compounds against Q67 were determined, and structural parameters as well as thermodynamic parameters of these compounds were obtained through fully optimized calculations by using...Toxicities (-1gEC50) of 16 phenolic compounds against Q67 were determined, and structural parameters as well as thermodynamic parameters of these compounds were obtained through fully optimized calculations by using B3LYP method of density functional theory (DFT) at the 6-311G^** level. Moreover, a 3-parameter (molecular average polarizability (α), heat energy corrected value (Eth) and the most positive hydrogen atomic charge (qH^+)) correlation model with R^2 = 0.981 and q^2 = 0.967 to predict -1gEC50 was obtained from experimental data based on the above-mentioned parameters as theoretical descriptors. Therein a was the most significant on -1gEC50. Variance Inflation Factors (VIF), t-value and cross-validation were applied to verify the model, confirming that the resultant model has fairly better stability and predictive ability to predict -1gEC50 of similar compounds.展开更多
The research of the failure criterion and one-dimensional stress-strain relationship of deteriorated concrete were carried out. Based on the damage mechanics theory, the dsmage which reflects the alternation of intern...The research of the failure criterion and one-dimensional stress-strain relationship of deteriorated concrete were carried out. Based on the damage mechanics theory, the dsmage which reflects the alternation of internal state of material were introduced into the formula presented by Desayi and Krishman and the weighted twin-shear strength theory. As a nondestructive examination method in common use, the ultrasonic technique was adopted in the study, and the ultrasonic velocity was used to establish the damage variable. After that, the failure criterion and one-dimensional stress-strain relationship for deteriorated concrete were obtained. Eventually, tests were carried out to study the evolution laws on the damage. The results show that the more freezing and thawing cycles are, the more apparently the failure surface shrinks. Meanwhile, the comparison between theoretical data and experimental data verifies tile rationality of tile damage-based one-dimensional stress-strain relationship proposed.展开更多
It is well acknowledged that muscles that are elongated while activated(i.e.,eccentric muscle action)are stronger and require less energy(per unit of force)than muscles that are shortening(i.e.,concentric contraction)...It is well acknowledged that muscles that are elongated while activated(i.e.,eccentric muscle action)are stronger and require less energy(per unit of force)than muscles that are shortening(i.e.,concentric contraction)or that remain at a constant length(i.e.,isometric contraction).Although the cross-bridge theory of muscle contraction provides a good explanation for the increase in force in active muscle lengthening,it does not explain the residual increase in force following active lengthening(residual force enhancement),or except with additional assumptions,the reduced metabolic requirement of muscle during and following active stretch.Aside from the cross-bridge theory,2 other primary explanations for the mechanical properties of actively stretched muscles have emerged:(1)the so-called sarcomere length nonuniformity theory and(2)the engagement of a passive structural element theory.In this article,these theories are discussed,and it is shown that the last of these—the engagement of a passive structural element in eccentric muscle action—offers a simple and complete explanation for many hitherto unexplained observations in actively lengthening muscle.Although by no means fully proven,the theory has great appeal for its simplicity and beauty,and even if over time it is shown to be wrong,it nevertheless forms a useful framework for direct hypothesis testing.展开更多
文摘In 2014,Huang Kaihong,a professor at School of Foreign Languages and Cultures,Southwest University of Science and Technology,interviewed the Doctoral advisor Professor Nie Zhenzhao during the period of his academic visiting to Central China Normal University.As early as in 2005,Huang Kaihong conducted an interview with Professor Nie Zhenzhao on the topic of the general introduction of ethical literary criticism.So around 11 years later,the second interview mainly covers not only the ethical literary criticism theory,but the game theory and the relationship between them as well.Professor Nie thinks whether the game theory can be applied to literature research is still under discussion.The theory of ethical literary criticism is a kind of methodology based on science and it can get the attention of literary critics at home and abroad,which is because it fits the practical needs of literary criticism,draws the literary criticism away from only emphasizing criticism genres and the research of criticism terms,and pays attention to the true nature of the literary text in literature research.After consulting Professor Nie Zhenzhao about some related questions from the perspective of game theory.Huang Kaihong gets some significant information concerning literature research and understands the latest core terms and the concrete application method of ethical literary criticism,especially the relationship between the instructing and aesthetic functions of literature.
基金the Major Program of National Natural Science Foundation of China(No.41941019)Shaanxi Province Innovative Talent Promotion Plan-Science and Technology Innovation Team(No.2021TD-55)Central University Natural Science Innovation Team(No.300102262402)。
文摘Combined bodies of rock-like material and rock are widely encountered in geotechnical engineering,such as tunnels and mines.The existing theoretical models describing the stress-strain relationship of a combined body lack a binary feature.Based on effective medium theory,this paper presents the governing equation of the“elastic modulus”for combined and single bodies under triaxial compressive tests.A binary effective medium model is then established.Based on the compressive experiment of concretegranite combined bodies,the feasibility of determining the stress threshold based on crack axial strain is discussed,and the model is verified.The model is further extended to coal-rock combined bodies of more diverse types,and the variation laws of the compressive mechanical parameters are then discussed.The results show that the fitting accuracy of the model with the experimental curves of the concretegranite combined bodies and various types of coal-rock combined bodies are over 95%.The crack axial strain method can replace the crack volumetric strain method,which clarifies the physical meanings of the model parameters.The variation laws of matrix parameters and crack parameters are discussed in depth and are expected to be more widely used in geotechnical engineering.
文摘In postmodernist novel, the explanation of the relationship between fiction and reality is a distinctive feature, known as a playing game. In Continuity of Parks, the "game" is played through the application of colors, settings, props, etc. with the plots' evolution. It is helpful to appreciate the postmodernist novel by analysing the relationship.
基金funding support from the Guangdong Provincial Key Construction Unit Project of Traditional Chinese Medicine Pediatrics (Guangdong Traditional Chinese Medicine Office Letter [2018] No. 202)。
文摘Objective To study the common pathogenesis of pneumonia and colitis using modern biological network analysis tools,and to explore the theory that the lung and large intestine are exteriorly and interiorly related.Methods The relevant target genes(hereinafter,“targets”)of pneumonia and colitis were separately queried on the GeneCards database.The main targets of the two diseases were then screened out according to their correlation scores and intersected to obtain those common to the two diseases.Metascape was used to analyze the main and common targets identified,and the Database for Annotation,Visualization and Integrated Discovery(DAVID)was used to enrich and analyze the common targets.Cytoscape 3.7.2 software was used to build the network diagram.Results In total,54 targets,such as TNF,IL-10,IL-6,IL-2,IL-4,TLR4,TLR2,CXCL8,IL-17A and IFNG,etc.,are common to pneumonia and colitis,which are mainly enriched in these processes such as cytokine–cytokine receptor interaction,the Tcell receptor signaling pathway,the Toll-like receptor signaling pathway and the Jak-STAT signaling pathway.The Metascape modular analysis identified 11 modules for pneumonia,six modules for colitis,and two modules for the common targets.Conclusions Pneumonia and colitis have the same pathogenic targets and mechanisms of action and finally interact with each other through inflammatory reactions and immune responses.This provides a probable molecular mechanism that explains the theory that the lung and large intestine are exteriorly and interiorly related.
文摘Balance theory holds that when the subject is in the unbalanced state,there is two basic way to eliminate this situation.One is to change his attitude on the cognitive object;the other is to change the subject's attitude on reference person.To ex plain the relationship among teacher,students and teaching material by applying the Balance theory can help us find and solve problems during the education.It can generate motivation to restore a new balance to promote the development of education.
文摘All theoires and rules for translation from Chinese into foreign languages or from foreign languages into Chinese are closely related to compartive linguistics. But, the relationship of the two can not be generalized in the simple relation of theory and practice, for both of them there are theoretical and practical contents, the development of themselves plays a positive promoting role on the development of each other. Contrastive linguistics also exerting various influences on practice of translation.Contrastive linguistics and translation have a very close relationship, to apply the theory of comparative linguistics to translation studies will undoubtedly have to play a guiding role in the practice of translation, translation involves at least two languages, so it inevitably involve communication and transformation of two different cultures. This paper discusses the relationship between them from the perspective of vocabulary, grammar and discourse pragmatics to better direct the translation.
基金This work was supported by National Nature Science Foundation of China and China Academy of Engineering Physics (No. 10376021) Provincial National Science Foundation of He'nan (No. 2004601107).
文摘Density functional theory (DFT) was used to calculate molecular descriptors (properties) for 12 fluoro-quinolone with anti-S.pneumoniae activity. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were employed to reduce dimensionality and investigate in which variables should be more effective for classifying fluoroquinolones according to their degree of an-S.pneumoniae activity. The PCA results showed that the variables ELUMO, Q3, Q5, QA, logP, MR, VOL and △EHL of these compounds were responsible for the anti-S.pneumoniae activity. The HCA results were similar to those obtained with PCA.The methodologies of PCA and HCA provide a reliable rule for classifying new fluoroquinolones with antiS.pneumoniae activity. By using the chemometric results, 6 synthetic compounds were analyzed through the PCA and HCA and two of them are proposed as active molecules with anti-S.pneumoniae, which is consistent with the results of clinic experiments.
文摘From the view of the ecological theory, this paper tries to analyze that Thoreau uses Chinese traditional philosophical thought--- the oneness of man and nature to deal with the relationship of human beings and the nature in Walden.
文摘BACKGROUND Prostate cancer is a major disease impacting men’s health worldwide.Peplau,who is known as“the mother of psychiatric society,”developed an interpersonal relationship theory for nursing.Implementation of this theory in practice has been shown to positively impact patients’quality of life and reduce adverse symptoms after surgery.AIM To investigate the effects of a nursing model based on Peplau’s interpersonal relationship theory combined with bladder function training on patients with prostate cancer.METHODS Eighty-nine patients with prostate cancer who underwent transurethral resection of the prostate(TURP)participated in this study.These patients were admitted to The First Affiliated Hospital of Soochow University or Dushu Lake Hospital Affiliated to Soochow University between January 2020 and April 2021.Patients were randomized into either the Peplau nursing group(n=44)or a routine nursing group(n=45).The routine nursing group received routine care and bladder function training,while the Peplau care group received care that integrated concepts from the Peplau interpersonal relationship theory as well as bladder function training.The urinary incontinence symptoms of the two groups were recorded,and the respective International Prostate Symptom Scores(IPSS),Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being(FACIT-Sp)scores,and quality of life(QOL)scores for each group were compared before and after three months of nursing intervention.RESULTS During the intervention period,the duration of urinary incontinence,frequency,number and amount of urinary incontinence were significantly greater in the routine nursing group compared to the Peplau care group(P<0.05).The indicators of the routine nursing group were 7.13±2.42 days,8.23±2.75 times,and 1.24±0.42 L,while those of the Peplau care group were 4.74±1.85 d,4.21±1.26 times,and 0.56±0.11 L,respectively.After three months of intervention,the mean IPSS score of the routine nursing group was significantly reduced(P<0.05),while the mean FACIT-Sp and QOL scores were significantly increased(P<0.05).The mean IPSS score in the Peplau nursing group was significantly lower compared to the routine nursing group,while the FACIT-Sp and QOL scores were higher(P<0.05).CONCLUSION A nursing model based on Peplau’s interpersonal relationship theory combined with bladder function training can significantly improve prostate function and urinary symptoms,resulting in the restoration of physiological function and improvement in the QOL of patients with prostate cancer following TURP.
文摘Einstein derived the energy-momentum relationship which holds in an isolated system in free space. However, this relationship is not applicable in the space inside a hydrogen atom where there is potential energy. Therefore, in 2011, the author derived an energy-momentum relationship applicable to the electron constituting a hydrogen atom. This paper derives that relationship in a simpler way using another method. From this relationship, it is possible to derive the formula for the energy levels of a hydrogen atom. The energy values obtained from this formula almost match the theoretical values of Bohr. However, the relationship derived by the author includes a state that cannot be predicted with Bohr’s theory. In the hydrogen atom, there is an energy level with n = 0. Also, there are energy levels where the relativistic energy of the electron becomes negative. An electron with this negative energy (mass) exists near the atomic nucleus (proton). The name “dark hydrogen atom” is given to matter formed from one electron with this negative mass and one proton with positive mass. Dark hydrogen atoms, dark hydrogen molecules, other types of dark atoms, and aggregates made up of dark molecules are plausible candidates for dark matter, the mysterious type of matter whose true nature is currently unknown.
文摘This paper presents a novel observer model that integrates quantum mechanics, relativity, idealism, and the simulation hypothesis to explain the quantum nature of the universe. The model posits a central server transmitting multi-media frames to create observer-dependent realities. Key aspects include deriving frame rates, defining quantum reality, and establishing hierarchical observer structures. The model’s impact on quantum information theory and philosophical interpretations of reality are examined, with detailed discussions on information loss and recursive frame transmission in the appendices.
文摘Encounters are celebrated experiences between persons with connectedness in human situations as expectation. While being in a human dynamic and rhythmic interaction, nursing encounters are dyadic relationships illuminated as patterns of an interconnected relationship moving between the nurse and the nursed, and reflecting person-and-otherness events. The purpose of this paper is to describe the theory of Encountering Nursing in a Nurse-Nursed Dyadic Relationship (ThENNDyR) and to illuminate the four nursing practice processes on which the theory is founded: <em>Knowing as appreciating relational moments</em>;<em>Reflecting as engaging moments</em>;<em>Realizing as patterns of living moments</em>;and <em>Transcending as celebrating moments</em>. Nursing practice occurs in moments in which dyadic relationships transpire as nursing encounters. As fleeting as moments are, the four processes of nursing simultaneously take place as understanding conditions that the <em>who</em> and <em>what</em> of the person warrants persons. “Encountering nursing” is a momentary co-existence of persons in a person-and-otherness situation communicating connectedness-interconnectedness in distinct patterning. Interactions in nursing exist as persons remain wholes and complete in the moment.
基金This work was supported by the China Postdoctoral Science Foundation (No. 2003033486)
文摘Optimized calculation of dibenzofuran (DF) and 135 polychlorinated dibenzofurans (PCDFs) was carried out at the B3LYP/6-31G* level in GAUSSIAN 98 program. Based on the theoretical linear solvation energy relationship (TLSER) model, the obtained structural parameters were taken as theoretical descriptors to establish the novel quantitative structureproperty relationship (QSPR) model for predicting n-octanol/water partition coefficients (lgKow) of PCDFs. The new model of lgKow achieved in this work contains three variables: energy of the highest occupied molecular orbital (EHOMO), the most negative atomic partial charge (q^-) and average molecular polarizability (a), of which R^2= 0.9011 and SD = 0,17 with larger t values. In addition, the variation inflation factors (VIF) of variables in the present model are all less than 5.5, suggesting high accuracy of the lgKow model. And the results of cross-validation test (q^2 = 0.8688) and method validation also show this model exhibits optimum stability and better predictive power than semi-empirical method. At the same time, it is found that the aqueous solubility (-lgSw) has high relative correlation with constant volume molar heat capacity (Cv^0), of which R^2 = 0.9777 and SD = 0.22. Moreover, lgKow and -lgSw values of all PCDF congeners were predicted respectively.
文摘Relevance Theory mainly emphasizes the transmission,utterance and inference of the communicative target.In this process,the communicators should create the best communication context according to communicative target and purpose to achieve the optimal relevance between the communication content and the background information of communicators.The basic conclusion to be drawn from this thesis is that the subtitle translator’s task is to guarantee the target-language audience able to enjoy the original dramatic experience as the source-language audience with the least processing efforts.
基金co-financed by the National Natural Science Foundation of China(21075138)special fund of State Key Joint Laboratory of Environment Simulation and Pollution Control(13K02ESPCT)
文摘Density functional theory(DFT)-B3LYP level with the 6-311G**(d,p) basis set was used to calculate a set of molecular quantum chemical descriptors of 12 chloroanilines. Quantitative structure-activity relationship(QSAR) models of the bioconcentration factors(BCF) of the anilines in fish were established using some of the following calculated descriptors: EHOMO, ENHOMO, ELUMO, ENLUMO, ΔE1(= ELUMO- EHOMO), ΔE2(= ENLUMO- ENHOMO), dipole moment(μ), molecular volume(V), vibrational energy of 0 K(Ev), thermodynamic energy(E), heat capacity(Cv), entropy(Sm) and the charge of benzene ring(Qph). Using the variable selection and leaps-and-bounds regression, the quantum chemical descriptors derived directly from the molecular structures were employed to develop a linear QSAR model between the bioconcentration factors(BCF) and two descriptors(Sm, ENHOMO) of 12 chloroanilines. Statistically, the most significant one is a two-parameter linear equation with the correlation coefficient(R^2) of 0.981 and cross-validated correlation coefficient(Rcv^2) of 0.967. The established QSAR model has good stability and predictability based on the results from Rcv2 of leave-one-out cross-validation, AIC, FIT and tα/2. The quantum chemical analyses were performed from two aspects of frontier molecular orbital and entropy. The results show that two structural describers are crucial to the bioconcentration activity of chloroanilines.
基金This work was financially supported by the National Basic Research Program of China (2003CB415002), the China Postdoctoral Science Foundation (No. 2003033486) and the Natural Science Research Fund of University in Jiangsu (04KJB150149)
文摘Twenty eight alkyl(1-phenylsulfonyl) cycloalkane carboxylates were computed at the B3LYP/6-31G* level. Based on linear solvation energy theory, two quantitative correlation equations of the molecular structures of alkyl(1-phenylsulfonyl) cycloalkane carboxylate com- pounds to their chromatographic retention (capacity factor lgKW) and the toxicity for photo- bacterium phosphoreum (–lgEC50) were developed by using the molecular structural parameters as theoretical descriptors (r2 = 0.9501, 0.9488). The two quantitative correlation equations were consequently cross validated by leave-one-out (LOO) validation method with q2 of 0.9113 and 0.9281, respectively. The result showed that the two equations achieved in this work by B3LYP/6-31G* are both more advantageous than those from AM1, and can be used to predict the lgKW and –lgEC50 of congeneric organics.
基金supported by the Natural Science Foundation of Zhejiang Province (No. 2008Y507280)
文摘Toxicities (-1gEC50) of 16 phenolic compounds against Q67 were determined, and structural parameters as well as thermodynamic parameters of these compounds were obtained through fully optimized calculations by using B3LYP method of density functional theory (DFT) at the 6-311G^** level. Moreover, a 3-parameter (molecular average polarizability (α), heat energy corrected value (Eth) and the most positive hydrogen atomic charge (qH^+)) correlation model with R^2 = 0.981 and q^2 = 0.967 to predict -1gEC50 was obtained from experimental data based on the above-mentioned parameters as theoretical descriptors. Therein a was the most significant on -1gEC50. Variance Inflation Factors (VIF), t-value and cross-validation were applied to verify the model, confirming that the resultant model has fairly better stability and predictive ability to predict -1gEC50 of similar compounds.
文摘The research of the failure criterion and one-dimensional stress-strain relationship of deteriorated concrete were carried out. Based on the damage mechanics theory, the dsmage which reflects the alternation of internal state of material were introduced into the formula presented by Desayi and Krishman and the weighted twin-shear strength theory. As a nondestructive examination method in common use, the ultrasonic technique was adopted in the study, and the ultrasonic velocity was used to establish the damage variable. After that, the failure criterion and one-dimensional stress-strain relationship for deteriorated concrete were obtained. Eventually, tests were carried out to study the evolution laws on the damage. The results show that the more freezing and thawing cycles are, the more apparently the failure surface shrinks. Meanwhile, the comparison between theoretical data and experimental data verifies tile rationality of tile damage-based one-dimensional stress-strain relationship proposed.
文摘It is well acknowledged that muscles that are elongated while activated(i.e.,eccentric muscle action)are stronger and require less energy(per unit of force)than muscles that are shortening(i.e.,concentric contraction)or that remain at a constant length(i.e.,isometric contraction).Although the cross-bridge theory of muscle contraction provides a good explanation for the increase in force in active muscle lengthening,it does not explain the residual increase in force following active lengthening(residual force enhancement),or except with additional assumptions,the reduced metabolic requirement of muscle during and following active stretch.Aside from the cross-bridge theory,2 other primary explanations for the mechanical properties of actively stretched muscles have emerged:(1)the so-called sarcomere length nonuniformity theory and(2)the engagement of a passive structural element theory.In this article,these theories are discussed,and it is shown that the last of these—the engagement of a passive structural element in eccentric muscle action—offers a simple and complete explanation for many hitherto unexplained observations in actively lengthening muscle.Although by no means fully proven,the theory has great appeal for its simplicity and beauty,and even if over time it is shown to be wrong,it nevertheless forms a useful framework for direct hypothesis testing.