Promoting Sickle Cell Trait Awareness and Education: A Typology of Interventions in the United States to Inform Ongoing Efforts to Patients and Providers

Research Background: Sickle cell trait has no treatment or cure and predominantly affects people who are Black, but can affect anyone of any race or ethnicity. While commonly incorrectly considered benign by providers and the public, people with a sickle cell trait experience life-threatening outcomes that are exacerbated by extreme conditions. There is a severe lack of awareness and understanding of sickle cell trait and the associated health complications among sickle cell trait carriers and healthcare providers. Purpose/Aim: Interventions that aim to improve awareness of sickle cell trait differ in approaches and are not well documented in the literature. This typology aims to highlight current efforts to inform targeted interventions that raise awareness through consistent messaging, educate people and providers on sickle cell trait and the related health complications, and support the design and implementation of comprehensive sickle cell trait awareness initiatives. Methods: We conducted a scoping review of United States-based sickle cell trait interventions and performed a content analysis to identify the categories and characteristics of these efforts. We then organized the results into a typology according to established protocols. Results: Among 164 interventions, twenty-five (15%) met the typology inclusion criteria described above and were grouped into categories: Seven of twenty-five interventions were Educational Interventions (28%), three of twenty-five interventions (12%) were Combined Screening and Educational-Based Interventions, eight of twenty-five interventions (32%) were Policy and Guideline-Based Intervention, and six of twenty-five interventions (24%) were Sickle Cell Trait Organization-Led Interventions. Conclusions: There is a lack of consistency in messaging across interventions whether delivered by credible healthcare institutions or national organizations, which can result in lack of education and awareness and confusion around sickle cell trait. Categorizing interventions through a typology allows clarity and informs consistency in messaging, which should be at the forefront of future sickle cell trait efforts.

Breast cancer awareness in reproductive women in the low-and middle-income countries:a scoping review

Objective:This study aimed to assess breast cancer(BC)awareness among reproductive women in low-and middle-income countries(LMICs),identify influencing factors,and propose feasible interventions or programs.Methods:We followed a 5-step process using a modified version of Arksey and O’Malley framework methodology.A comprehensive search was conducted on the Embase,PubMed,and CINAHL electronic databases for literature published within 10 years(from 2012 to 2022).Results:Thirty-three papers published between 2012 and 2020,spanning 18 countries,were included.Of these,45.6%described a good level of knowledge,while 24.2%reported that women at reproductive ages had good awareness.Twelve influencing factors were identified in 3 categories:socio-demographic(family history,personal history,marital status,age,religion,income status,living place,and occupation),personal(self-efficacy,education,and perceived level),and external(advertisements promoting awareness).Educational programs were recommended in most(>72%)of the included studies.Conclusions:While most studies reported high levels of knowledge and awareness,some found low prevalence among certain groups.Factors affecting knowledge and awareness were classified into socio-demographic,personal,and external categories,with socio-demographic factors such as age,education,income,and marital status being the most frequently cited.The studies recommended implementing educational programs,health prevention strategies,and social interventions to increase BC knowledge and awareness.

Vitamin E in the management of pancreatic cancer: A scoping review

Pancreatic cancer is the leading cause of cancer mortality worldwide.Research investigating effective management strategies for pancreatic cancer is ongoing.Vitamin E,consisting of both tocopherol and tocotrienol,has demonstrated debatable effects on pancreatic cancer cells.Therefore,this scoping review aims to summarize the effects of vitamin E on pancreatic cancer.In October 2022,a literature search was conducted using PubMed and Scopus since their inception.Original studies on the effects of vitamin E on pancreatic cancer,including cell cultures,animal models and human clinical trials,were considered for this review.The literature search found 75 articles on this topic,but only 24 articles met the inclusion criteria.The available evidence showed that vitamin E modulated proliferation,cell death,angiogenesis,metastasis and inflammation in pancreatic cancer cells.However,the safety and bioavailability concerns remain to be answered with more extensive preclinical and clinical studies.More in-depth analysis is necessary to investigate further the role of vitamin E in the management of pancreatic cancers.

The effect of painting therapy in cancer patients:a scoping review

Objective:To analyze the effect of drawing therapy in cancer patients and to explore the effect of drawing therapy on negative emotions and quality of life of cancer patients,in order to provide reference for future related research.Methods:A computer search of Embase,Web of Science,Cochrane Library,PubMed,China Knowledge Network,Wanfang database,Vipshop database and China Biomedical Literature Service was conducted to retrieve relevant studies on the application of painting therapy in cancer patients from the database to December 2022,using the scoping review method as a guide.Results:A total of 15 publications were included,including 10 randomized controlled trials,4 class experimental studies and 1 cohort study,with full text summarizing the type of painting therapy,painting duration,intervention period,interventionist and treatment adherence.The main indicators of outcome included physiological indicators such as nausea and vomiting,negative emotions such as anxiety and depression and quality of life such as fatigue status and sleep quality in cancer patients.Conclusions:Painting therapy can reduce the degree of nausea,reduce negative emotions such as anxiety and depression,reduce fatigue,improve sleep quality and improve quality of life in cancer patients,but the degree of vomiting in cancer patients still needs to be further explored.In the future,we need to extend the follow-up period of painting therapy and explore the long-term effect of painting therapy applied in cancer patients.

The eligibility criteria,training content,and scope of practice for prescriptive authority for midwives:a modified Delphi study

Objective:To investigate the necessary eligibility criteria for prescriptive authority for midwives,gather suggestions from experts on training content for prescriptive authority for midwives,and explore the scope of practice of their prescriptive authority in certain circumstances.The results of this study could serve as a reference for the development of policies on prescriptive authority for midwives.Methods:Based on a literature search and semistructured interviews,a modified Delphi method was first used to conduct 2 rounds of expert consultation on eligibility criteria and training content for prescriptive authority for midwives.This stage included nursing experts(20)and medical experts(16)engaged in midwifery in many tertiary Grade A hospitals in China.Subsequently,consultation on the scope of practice of prescriptive authority for midwives was conducted with nursing experts(18)and medical experts(14)engaged in midwifery in many tertiary Grade A hospitals in China.The suggestions from the experts were analyzed using statistical methods to confirm the eligibility criteria for prescriptive authority,training content,circumstances,scope of practice for prescriptive authority,and the prescription forms.Results:Among the consulted experts,70.59%(the highest acceptance rate)considered an undergraduate degree to be the minimum educational requirement for midwives to be eligible for prescriptive authority,85.29%(the highest acceptance rate)considered the supervisor nurse to be the minimum technical position experience necessary for midwives to be eligible for having prescriptive authority,and 50%(the highest acceptance rate)considered 5 years to be the minimum number of years of experience in the specialty for midwives to be eligible for prescriptive authority.The applicants should at least be practicing at Grade C hospitals,which was the consensus among 91.18%of the consulted experts.Among the consulted experts,100%,100%,97.06%,94.12%,and 94.12%agreed that the applicants should have knowledge in pharmacology,laws and ethics,nursing,diagnostics,and midwifery,respectively.The consulted experts confirmed 22 related course topics and identified 6 specific circumstances in which the midwives could partially practice prescriptive authority,including uterine atony,excessive uterine contraction,postpartum hemorrhage,premature rupture of fetal membranes,normal labor,and neonatal asphyxia.Under these 6 circumstances,the consulted experts commonly agreed that there were 20 medication prescriptions and 13 auxiliary examination prescriptions that could be prescribed by midwives.Of these prescriptions,51.5%were independent prescriptions,30.3%were protocol prescriptions,and the remaining 18.2%were both independent and protocol prescriptions.Conclusions:Midwives who have an undergraduate degree,supervisor nurse position,and 5 years of practice in Grade C hospitals are considered eligible to apply for prescriptive authority.Partial prescriptive authority could be granted after regulated training in fundamental theories and practices,which could improve the independence and professionalism of midwifery.

Observations on the Efficacy of Various Forms of Selenium for Livestock: A Review

Since 1957, selenium has found extensive use in livestock production to maintain an adequate selenium status in animals in areas of soil and feed/forage deficiency. Selenium may be given directly to livestock, or applied as a fertilizer amendment to increase selenium content of their feeds. This paper addresses the area of direct supplementation, which includes oral and parenteral supplementation, and with ruminant animals the use of slow-release boluses. Various chemical forms of selenium have been examined as supplemental sources, with sodium selenite being the earliest compound of choice. Comnbination of selenium supplementation with other livestock managernent practices led to use of selenium dioxide, which avoided solubility problems with selenite but produced effective responses. Barium salts have been used with some success as supplemental selenium sources. Experience with ruminal boluses has shown that high pressure pelleting of increased grain size selenium, in hollow pellets, has prolonged their useful life. Attention has been paid recently to residual selenium returned to the soil from livestock supplementation practices and the resulting opinion is that currently approved practices are acceptable from the point of view of environmental quality

Factors influencing the belongingness of nursing students in clinical nursing: a scope overview

This paper reviews the published literature according to the Arksey and O’Malley’framework in order to determine the factors that influencing factors of nursing interns'belongingness in clinical nursing.Five influencing factors were extracted from 11 included studies:nursing students themselves,clinical teacher,clinical placement environment,relationships with patients and their families.

The competence of nursing students to prevent pressure injury - ascoping review

Objective: The purpose of the present study is to review the existing literatures to understand the competency ofnursing students to prevent the pressure injury. Methods: Arksey and O'Malley’s scoping review framework havebeen applied to understand the competency of nursing students on pressure injury prevention. A variety ofdatabases have been searched in this study, including PubMed, EMBASE, Web of Science, Cochrane Library,CNKI, Wanfang databases. Results: A total of 17 articles were selected and three main themes were summarized:“Knowledge and Attitude”, “Preparation” and “Educational situation and needs”. Conclusion: Although theattitudes towards pressure injuries were positive, the knowledge of nursing students on preventing pressure injurywas insufficient and their consciousness was weak. The controversy of the readiness of nursing students to preventpressure injuries has existed for a long time. Nursing students were severely lacking in pressure sore educationcourses and needed better education methods and more clinical practice opportunities.

Contemporary Development in College Grammar Instruction—The Application of Focus on Form Approach

Based on the theoretical presentations of a contemporary development in grammar instruction named focus on form as well as the analysis of the need for such grammar instructional approach utilized in Chinese college classrooms, this paper attempts to make a tentative proposal to apply focus on form approach to grammar teaching in colleges through recommending practicable instructional reflections.

Advances in the Study on"Simmering Pus and Forming Flesh"in Treating Anorectal Diseases by External Treatment in Traditional Chinese Medicine

Due to the special perianal location,anorectal diseases are prone to form chronic refractory wounds after surgery,with Qi(气)deficiency and blood stasis as the main cause.As a classical theory in TCM medicine,"simmering pus and forming flesh"attaches great importance to harmonizing Qi and blood in the wound healing period,which gradually achieves significant efficacy in clinical application after anorectal disease surgery.Literatures in recent years on"simmering pus and forming flesh"method being applied to postoperative wound healing in all kinds of anorectal diseases(such as anal fistula,perianal abscess,anal fissure,mixed hemorrhoid,etc.)were reviewed,and advantages and characteristics of its clinical efficacy in anorectal diseases were summarized,so as to provide reference for postoperative wound healing and repair treatment in anorectal diseases.

Invitation of EFL Learners for the Classroom Assessment

Among the two commonly identified ways of assessment,summative assessment aims to measure,or summarize,what a student has grasped,and typically occurs at the end of a course or unit of instruction.While the formative assessment,which is characterized by the needs of insiders,is distinct in that it focuses on learning through assessment and the role of the learners in this process.As is well known,teachers' role in the classroom assessment is geared to formulating and scaffolding learning on the basis of on-going feedback from internal and external assessment sources.Peer review,on the other hand,is also an important component of the process of developing assessment.During the formative assessment in the EFL classroom,classroom teachers' evaluation as well as students' active peer scaffolding in group works play important roles in the decision making process.Although the formative and for learning perspective is quite different from the summative and of learning perspective in terms of theoretical and educational orientation.Neither students nor teachers should be ignored in the whole process for formative assessment.

Non-pharmacological therapies for inflammatory bowel disease: Recommendations for self-care and physician guidance

We performed a scoping review on sought-after complementary therapies for patients with inflammatory bowel disease(IBD), specifically diet, physical activity and exercise(PA/E), and psychotherapy. We aim to update patients with IBD on therapies for self-care and provide physicians with guidance on how to direct their patients for the management of IBD. A search of MEDLINE, EMBASE, and PUBMED was completed in Sept 2016. Studies on diet, PA/E, or psychotherapy in patients with IBD were included. Medical Subject Heading terms and Boolean operators were used. The search was limited to full-text English articles describing an adult population. This review included 67 studies: Diet(n = 19); PA/E(n = 19); and psychotherapy(n = 29). We have made the following recommendations:(1) Diet: Consumption of diets rich in vegetables, fruit and soluble fiber may be beneficial in IBD. A trial of a low FODMAP diet can be considered in those patients with functional gastrointestinal symptoms. Restrictive diets are lacking in evidence and should be avoided;(2) PA/E: Regular lowmoderate intensity activity, including cardiovascular and resistance exercise, has been shown to improve quality of life(QOL) and may improve inflammation; and(3) psychotherapy: Therapies such as cognitive-behavioural interventions, mindfulness, hypnosis, and stress management have been shown to improve QOL, but evidence is limited on their impact on anxiety, depression, and disease activity. Overall, these complementary therapies are promising and should be used to treat patients with IBD from a more holistic perspective.

Vestibular migraine in low-and lower-middle-income countries:A scoping review

Background:Vestibular migraine(VM)is a common cause of dizziness that is underrecognized,underdiagnosed,and challenging to effectively treat.The prevalence,appropriate diagnostic workup,and therapies for VM in low-and lower-middle-income countries(LLMICs)remain understudied.The objective of this scoping review is to evaluate the current state of VM research in LLMICs.Methods:PubMed,Embase,and Web of Science databases were searched to execute a scoping review of VM.Keywords“vestibular diseases”and“vertigo”were used in combination with terms referring to LLMICs as defined by the World Bank.Title and abstract screening,full-text review,and data collection were conducted by two authors independently.Results:Twenty-six studies were included in the scoping review.Most studies were cross-sectional(57.7%)or case studies/series(23.1%)and were conducted in urban settings only(92.3%).Geographic distribution of studies was skewed,with 65.4%of articles originating from India.The prevalence of VM among clinic patients ranged from 0.3%to 33.3%.VM most frequently presented as headache,nausea and vomiting,and photophobia.Radiographic imaging,audiometry,and electronystagmography/videonystagmography were the three most commonly utilized diagnostic modalities in the dizziness workup.The most studied pharmacotherapies included calcium channel blockers,followed by beta-blockers and antiepileptics.Case studies and series discussed less common VM pharmacotherapies,such as ayurvedic medicine.Conclusions:There is a need for more VM research in LLMICs,including innovative diagnostic approaches and therapies that can improve VM care globally.Equitable partnerships between LLMIC and highincome country researchers must expand vestibular research capacity and productivity in LLMICs.

Clinical implications of single cell sequencing for bladder cancer

Bladder cancer(BC)is the 10th most common cancer worldwide,with about 0.5 million reported new cases and about 0.2 million deaths per year.In this scoping review,we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines.We searched PubMed,CENTRAL,Embase,and supplemented with manual searches through the Scopus,and Web of Science for published studies until February 2023.We included original studies that used at least one single-cell technology to study bladder cancer.Forty-one publications were included in the review.Twenty-nine studies showed that this technology can identify cell subtypes in the tumor microenvironment that may predict prognosis or response to immune checkpoint inhibition therapy.Two studies were able to diagnose BC by identifying neoplastic cells through single-cell sequencing urine samples.The remaining studies were mainly a preclinical exploration of tumor microenvironment at single cell level.Single-cell sequencing technology can discriminate heterogeneity in bladder tumor cells and determine the key molecular properties that can lead to the discovery of novel perspectives on cancer management.This nascent tool can advance the early diagnosis,prognosis judgment,and targeted therapy of bladder cancer.

The state of mountain research in Canada

Nearly a quarter of Canada’s landmass is covered by mountainous terrain,making mountains an important aspect of the physical and human geography of the country.Mountain areas in Canada have motivated a great deal of research activity,yet the state of mountain research in the country has never been systematically characterized,precluding a detailed understanding of what is being studied,when,where,how,and by whom.In response,we conducted a systematic scoping review to rigorously identify,collate,and critically examine existing peer-reviewed articles related to mountains in Canada.2,888 articles were included in our review,which reveals strong biases towards work in the natural sciences and in the mountain west,with little work to date in the social and health sciences or in other mountainous regions of the country.Our results demonstrate that Canada is among the most productive contributors to mountain research globally,but that topical and geographical biases in existing research effort leave important gaps that must be addressed to successfully navigate challenges and opportunities facing mountain areas in Canada.We provide a roadmap to guide future mountain-focused research activities in the country.

The Influence of Fat Mass and Obesity-Associated(FTO)Gene on the Effect of Physical Activity(PA)on Risk of Obesity:Scoping Review

Purpose We aimed to conduct a scoping review by reviewing studies that investigated the influence of the fat mass and obesity-associated(FTO)gene on the effect of physical activity(PA)on risk of obesity.The research questions of this review were:(1)“What is known from existing literature about the influence of the FTO gene on the effect of physical activity on obesity?”(2)“What are the gaps in existing literature in that area?”Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews(PRISMA-ScR)Checklist and the five-stage methodological framework outlined by Arksey and O’Malley were utilized to conduct this scoping review.Four online databases were searched for articles between July 2021 and August 2021.The articles were chosen to be included if they were:published in English;included male and/or female adult participants(ages 18-65);looked at the effect of FTO on overweight/obesity;and included PA/exercise/physical fitness intervention or examination.Excluded studies were studies with a population that had a diagnosis of any disorder or condition other than obesity.Results Nine articles were selected for this scoping review,one of which is a conference abstract.Based on the type,the articles were categorized into intervention(n=3),observational(n=5),and review article(n=1).All articles were sum-marized in terms of questions and main findings.Conclusion This scoping review presented evidence that the FTO gene could influence the effect of PA on obesity.The gaps in knowledge were evident in the limited number of intervention studies.

Application of horticulture therapy as a health intervention for elderly people in nursing homes:a scoping review

Objective:To review the scope of interventional studies on horticultural therapy(HT)applied to elderly people in nursing institutions to support the efficient implementation of HT among this target group.Methods:In accordance with the scoping review framework proposed by the Joanna Briggs Institute(JBI),the Pub Med,JSTOR,Web of Science,CNKI,and Wanfang databases were searched.Data from the retrieved literature were summarized and analyzed.Results:In all,18 studies were included in this review.The target population groups of interventions included self-supporting elderly people,cognitively impaired elderly people,elderly people with negative emotions,and elderly people with frailty living in nursing institutions.HT interventions,including planting,craft activities,derivative activities,and outdoor viewing activities,are implemented indoors,outdoors,or in mixed settings.The most common duration of the intervention was 8 weeks,the most common frequency was once per week,and the most common session duration was 60 min.Conclusions:The measurements used in HT interventions included assessments of physical,psycho-mental,and social health;quality of life;and activity effects.Future studies should include partially dependent groups and completely dependent groups of elderly individuals,interventions that last at least 6 months,scientifically designed activity intensity and safety-guarantee plans,and outcomeevaluation indicators such as compliance and intervention benefits.

Problem-Solving Based Intervention for Informal Caregivers: A Scoping Review

Background: Caregiving for someone is a huge task for informal caregivers. The caregiving role is often challenging and overwhelming for them. Stress, burden, and depression have been frequently identified as the negative caregiving experiences. This systematic review synthesized the available evidence for the problem-based intervention provided for caregivers as there is little insight about the effects of problem-based intervention on caregivers. Objectives: To describe: 1) the design of problem-solving intervention;2) the effects of problem-solving intervention for caregiver outcomes. Methods: This review followed Arksey and O’Malley’s methodological framework for conducting scoping reviews which entail setting research questions, selecting relevant studies, charting the data and synthesizing the results. FPRISMA guidelines were adopted and several databases were searched including MEDLINE;EMBASE;web of science. This review contains literature from 2012 to 2019 on problem-solving-based intervention which intended to caregivers. Results: 41 publications representing 27 unique problem-based interventions. Problem-solving-based intervention has different extent effects on caregiver emotion status, burden and quality of life. Conclusions: Problem-solving intervention is promising in caregiver intervention which could reduce caregiver depression, anxiety and burden.

Nursing Research during COVID-19 Pandemic: A Scoping Review

Purpose: This review paper aimed to provide an overview of the published nursing research related to the COVID-19 pandemic over the last six months. Method: Online Google Scholar database was searched for COVID-19 related articles published between the 1st of Jan 2020 and 15th of June 2020. Findings: The initial search found 1930 results from combining the search between the words “nurse” and “nursing” with COVID-19. Only 48 articles met the eligibility criteria. Most of the studies focused on psychological factors (33.3%), followed by clinical practices (29.2%). The majority of the authors have an academic affiliation (70.8%), only (12.5%) have a clinical affiliation. About (21%) of the articles were funded, (90%) of this fund came from China. Most of the authors utilized the quantitative approach (27.1%);the qualitative approach has been used by (4.2%);only one article (2.1%) utilized the mixed methodology. No study used a theoretical or conceptual framework. Mainly, the nurses conducted their research independently (52.1%), while (35.4%) has been done in a multidisciplinary team;35.3% of them were done in collaboration with physicians. Conclusion: The results indicate that the nurses responded immediately to the COVID-19 pandemic by conducting researches mainly by utilizing a quantitative approach and writing a lot of editorials. To enrich the research results, nurses worked in research in collaboration with other disciplines, especially physicians. Still, the nursing research funding is under the limit. Stress and psychological factors are the primary concern for the nurses during the COVID-19 pandemic.