Irrigation uniformity and wind drift and evaporation losses (WDEL) are major concerns for the design and management of sprinkler irrigation systems under arid or semi-arid conditions. Field trials were carried out to ...Irrigation uniformity and wind drift and evaporation losses (WDEL) are major concerns for the design and management of sprinkler irrigation systems under arid or semi-arid conditions. Field trials were carried out to assess irrigation uniformity and WDEL under various wind velocities, sprinkler spacings and operating pressure heads. Based on experimental data, a frequency analysis was performed to infer the occurrence probability of a given uniformity coefficient (UC). In addition, statistical regressions were used to model WDEL as a function of different climatic variables. Increasing the operating pressure head improved uniformity at low wind speeds. It was shown that UC has been severely impaired at wind speeds above 4 m/s. In the prevailing wind conditions, the frequency analysis showed that a sprinkler spacing of 12 m × 12 m provided the best uniformity. In the local conditions, it is recommended to stop irrigation when wind velocity exceeds 4 m/s. Moreover, it was shown that wind speed and relative humidity were the main significant variables influencing WDEL.展开更多
Bone loss associated with musculoskeletal trauma or metabolic diseases often require bone grafting. The supply of allograft and auto-graft bones is limited. Hence, development of synthetic bone grafting materials is a...Bone loss associated with musculoskeletal trauma or metabolic diseases often require bone grafting. The supply of allograft and auto-graft bones is limited. Hence, development of synthetic bone grafting materials is an active area of research. Chitosan, extracted from chitin present in crawfish shells, was tested as a de-livery vehicle for osteoblasts in a 2-3 mm size defect model in rats. Twenty-seven male Lewis rats, divided into three groups with sacrifice intervals of 3, 6 &9 months were used. In the experimental samples, a critical size defect was filled with chitosan bone graft paste and fixed with a plate, while in the operated control group, a critical size defect was repaired only by a plate (no paste was applied). An unoperated control group was also included. Bone growth was evaluated histologically by examining undecal-cified and decalcified stained sections. The fe-murs were also examined non-destructively by micro-computed tomography (礐T). Defects filled with chitosan bone graft paste demon-strated superior healing across all time periods compared to unfilled defects as examined by histology and micro-computed tomography. Crawfish chitosan has successfully been used as a cell delivery system for osteoblasts for use as a synthetic bone graft material.展开更多
With the growth of Vehicular Ad-hoc Networks,many services delivery is gaining more attention from the intelligent transportation system.However,mobility characteristics of vehicular networks cause frequent disconnect...With the growth of Vehicular Ad-hoc Networks,many services delivery is gaining more attention from the intelligent transportation system.However,mobility characteristics of vehicular networks cause frequent disconnection of routes,especially during the delivery of data.In both developed and developing countries,a lot of time is consumed due to traffic congestion.This has significant negative consequences,including driver stress due to increased time demand,decreased productivity for various personalized and commercial vehicles,and increased emissions of hazardous gases especially air polluting gases are impacting public health in highly populated areas.Clustering is one of the most powerful strategies for achieving a consistent topological structure.Two algorithms are presented in this research work.First,a k-means clustering algorithm in which dynamic grouping by k-implies is performed that fits well with Vehicular network’s dynamic topology characteristics.The suggested clustering reduces overhead and traffic management.Second,for inter and intra-clustering routing,the dynamic routing protocol is proposed,which increases the overall Packet Delivery Ratio and decreases the End-to-End latency.Relative to the cluster-based approach,the proposed protocol achieves improved efficiency in terms of Throughput,Packet Delivery Ratio,and End-to-End delay parameters comparing the situations by taking different number of vehicular nodes in the network.展开更多
This paper proposes a semi-empirical model to predict a ship’s speed loss at arbitrary wave heading.In the model,the formulas that estimate a ship’s added resistance due to waves attacking from different heading ang...This paper proposes a semi-empirical model to predict a ship’s speed loss at arbitrary wave heading.In the model,the formulas that estimate a ship’s added resistance due to waves attacking from different heading angles have been further developed.A correction factor is proposed to consider the nonlinear effect due to large waves in power estimation.The formulas are developed and verified by model tests of 5 ships in regular waves with various heading angles.The full-scale measurements from three different types of ships,i.e.,a PCTC,a container ship,and a chemical tanker,are used to validate the proposed model for speed loss prediction in irregular waves.The effect of the improved model for speed loss prediction on a ship’s voyage optimization is also investigated.The results indicate that a ship’s voyage optimization solutions can be significantly affected by the prediction accuracy of speed loss caused by waves.展开更多
Boron neutron capture therapy(BNCT)is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope,boron-10,is irradiated with neutrons to produce high energ...Boron neutron capture therapy(BNCT)is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope,boron-10,is irradiated with neutrons to produce high energy alpha particles.This review will focus on tumor-targeting boron delivery agents that are an essential component of this binary system.Two low molecular weight boron-containing drugs currently are being used clinically,boronopheny-lalanine(BPA)and sodium borocaptate(BSH).Although they are far from being ideal,their therapeutic efficacy has been demonstrated in patients with high grade gliomas,recurrent tumors of the head and neck region,and a much smaller number with cutaneous and extra-cutaneous melanomas.Because of their limitations,great effort has been expended over the past 40 years to develop new boron delivery agents that have more favorable biodistribution and uptake for clinical use.These include boron-containing porphyrins,amino acids,polyamines,nucleosides,peptides,monoclonal antibodies,liposomes,nanoparticles of various types,boron cluster compounds and co-polymers.Cur-rently,however,none of these have reached the stage where there is enough convincing data to warrant clinical biodistribution studies.Therefore,at present the best way to further improve the clinical efficacy of BNCT would be to optimize the dosing paradigms and delivery of BPA and BSH,either alone or in combination,with the hope that future research will identify new and better boron delivery agents for clinical use.展开更多
Nanomaterials(NMs)have increasingly been used for the diagnosis and treatment of head and neck cancers(HNCs)over the past decade.HNCs can easily infiltrate surrounding tissues and form distant metastases,meaning that ...Nanomaterials(NMs)have increasingly been used for the diagnosis and treatment of head and neck cancers(HNCs)over the past decade.HNCs can easily infiltrate surrounding tissues and form distant metastases,meaning that most patients with HNC are diagnosed at an advanced stage and often have a poor prognosis.Since NMs can be used to deliver various agents,including imaging agents,drugs,genes,vaccines,radiosensitisers,and photosensitisers,they play a crucial role in the development of novel technologies for the diagnosis and treatment of HNCs.Indeed,NMs have been reported to enhance delivery efficiency and improve the prognosis of patients with HNC by allowing targeted delivery,controlled release,responses to stimuli,and the delivery of multiple agents.In this review,we consider recent advances in NMs that could be used to improve the diagnosis,treatment,and prognosis of patients with HNC and the potential for future research.展开更多
This paper considers the uniform parallel machine scheduling problem with unequal release dates and delivery times to minimize the maximum completion time.For this NP-hard problem,the largest sum of release date,proce...This paper considers the uniform parallel machine scheduling problem with unequal release dates and delivery times to minimize the maximum completion time.For this NP-hard problem,the largest sum of release date,processing time and delivery time first rule is designed to determine a certain machine for each job,and the largest difference between delivery time and release date first rule is designed to sequence the jobs scheduled on the same machine,and then a novel algorithm for the scheduling problem is built.To evaluate the performance of the proposed algorithm,a lower bound for the problem is proposed.The accuracy of the proposed algorithm is tested based on the data with problem size varying from 200 jobs to 600 jobs.The computational results indicate that the average relative error between the proposed algorithm and the lower bound is only 0.667%,therefore the solutions obtained by the proposed algorithm are very accurate.展开更多
Background: The one-step method was routine practices in China, scientific evidence to support this intervention is scarce. The purpose of this study was to observe the natural process of head-to-body delivery interv...Background: The one-step method was routine practices in China, scientific evidence to support this intervention is scarce. The purpose of this study was to observe the natural process of head-to-body delivery interval by waiting for at least one contraction (two-step) after head delivered in normal birth. Methods: From March 1 to March 30 in 2015 at Haikou Maternal and Child Hospital in China, normal vaginal birth with normal baby condition were recorded by video. Videotapes were transferred to computer then replayed and observed. Results: Ninety-two cases were enrolled in this study. The average head-to-body delivery interval by two-step delivery was 71.04± 61.02 s, (mean + 2 standard deviation - 193.07 s, 95% confidence interval [15.65-229.15] s). Fifty-one patients (51/92, 55.43%) were 〈60 s, 41 patients (41/92, 44.57%) were over 60 s. Shoulders delivered at the first contraction were 96.74% (89/92), 3.26% (3/92) had delivered by the second contraction. Shoulders emerged from perineum were 71.73% (66/92), 15.21% (14/92) transversely, and 13.04% (12/92) emerged from under pubic arch. Babies cried before the shoulder were 31.52% (29/92), cried after birth 52.17% (48/92), and 16.30% (15/92) did not cry after birth. Baby activities included as making faces, sucking, and bubbled from mouth and noses, and the lighter blue color of skin with good perfusion. Conclusions: The average time of head-to-body delivery interval was longer than 60 s by two-step delivery. Majority shoulders were delivered at the first contraction. Majority shoulders emerged from perineum rather from under pubic arch. The routine one-step method of shoulder delivery where the downward force applied is not necessary and is not the right direction. Baby's breath, making faces, sucking, bubble from noses and mouth, and the light blue color of the faces, all those signs during shoulder delivery indicated a normal live birth.展开更多
文摘Irrigation uniformity and wind drift and evaporation losses (WDEL) are major concerns for the design and management of sprinkler irrigation systems under arid or semi-arid conditions. Field trials were carried out to assess irrigation uniformity and WDEL under various wind velocities, sprinkler spacings and operating pressure heads. Based on experimental data, a frequency analysis was performed to infer the occurrence probability of a given uniformity coefficient (UC). In addition, statistical regressions were used to model WDEL as a function of different climatic variables. Increasing the operating pressure head improved uniformity at low wind speeds. It was shown that UC has been severely impaired at wind speeds above 4 m/s. In the prevailing wind conditions, the frequency analysis showed that a sprinkler spacing of 12 m × 12 m provided the best uniformity. In the local conditions, it is recommended to stop irrigation when wind velocity exceeds 4 m/s. Moreover, it was shown that wind speed and relative humidity were the main significant variables influencing WDEL.
文摘Bone loss associated with musculoskeletal trauma or metabolic diseases often require bone grafting. The supply of allograft and auto-graft bones is limited. Hence, development of synthetic bone grafting materials is an active area of research. Chitosan, extracted from chitin present in crawfish shells, was tested as a de-livery vehicle for osteoblasts in a 2-3 mm size defect model in rats. Twenty-seven male Lewis rats, divided into three groups with sacrifice intervals of 3, 6 &9 months were used. In the experimental samples, a critical size defect was filled with chitosan bone graft paste and fixed with a plate, while in the operated control group, a critical size defect was repaired only by a plate (no paste was applied). An unoperated control group was also included. Bone growth was evaluated histologically by examining undecal-cified and decalcified stained sections. The fe-murs were also examined non-destructively by micro-computed tomography (礐T). Defects filled with chitosan bone graft paste demon-strated superior healing across all time periods compared to unfilled defects as examined by histology and micro-computed tomography. Crawfish chitosan has successfully been used as a cell delivery system for osteoblasts for use as a synthetic bone graft material.
文摘With the growth of Vehicular Ad-hoc Networks,many services delivery is gaining more attention from the intelligent transportation system.However,mobility characteristics of vehicular networks cause frequent disconnection of routes,especially during the delivery of data.In both developed and developing countries,a lot of time is consumed due to traffic congestion.This has significant negative consequences,including driver stress due to increased time demand,decreased productivity for various personalized and commercial vehicles,and increased emissions of hazardous gases especially air polluting gases are impacting public health in highly populated areas.Clustering is one of the most powerful strategies for achieving a consistent topological structure.Two algorithms are presented in this research work.First,a k-means clustering algorithm in which dynamic grouping by k-implies is performed that fits well with Vehicular network’s dynamic topology characteristics.The suggested clustering reduces overhead and traffic management.Second,for inter and intra-clustering routing,the dynamic routing protocol is proposed,which increases the overall Packet Delivery Ratio and decreases the End-to-End latency.Relative to the cluster-based approach,the proposed protocol achieves improved efficiency in terms of Throughput,Packet Delivery Ratio,and End-to-End delay parameters comparing the situations by taking different number of vehicular nodes in the network.
基金Open access funding provided by Chalmers University of Technology.The authors acknowledge the financial support from the European Commission(Horizon 2020)project EcoSail(Grant Number 820593)We are also grateful to the support from the Swedish Foundation for International Cooperation in Research and Higher Education(CH2016-6673)+1 种基金National Natural Science Foundation of China(NSFC-51779202)The second author thanks the funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie(Grant Number 754412)and VGR MoRE2020.
文摘This paper proposes a semi-empirical model to predict a ship’s speed loss at arbitrary wave heading.In the model,the formulas that estimate a ship’s added resistance due to waves attacking from different heading angles have been further developed.A correction factor is proposed to consider the nonlinear effect due to large waves in power estimation.The formulas are developed and verified by model tests of 5 ships in regular waves with various heading angles.The full-scale measurements from three different types of ships,i.e.,a PCTC,a container ship,and a chemical tanker,are used to validate the proposed model for speed loss prediction in irregular waves.The effect of the improved model for speed loss prediction on a ship’s voyage optimization is also investigated.The results indicate that a ship’s voyage optimization solutions can be significantly affected by the prediction accuracy of speed loss caused by waves.
文摘Boron neutron capture therapy(BNCT)is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope,boron-10,is irradiated with neutrons to produce high energy alpha particles.This review will focus on tumor-targeting boron delivery agents that are an essential component of this binary system.Two low molecular weight boron-containing drugs currently are being used clinically,boronopheny-lalanine(BPA)and sodium borocaptate(BSH).Although they are far from being ideal,their therapeutic efficacy has been demonstrated in patients with high grade gliomas,recurrent tumors of the head and neck region,and a much smaller number with cutaneous and extra-cutaneous melanomas.Because of their limitations,great effort has been expended over the past 40 years to develop new boron delivery agents that have more favorable biodistribution and uptake for clinical use.These include boron-containing porphyrins,amino acids,polyamines,nucleosides,peptides,monoclonal antibodies,liposomes,nanoparticles of various types,boron cluster compounds and co-polymers.Cur-rently,however,none of these have reached the stage where there is enough convincing data to warrant clinical biodistribution studies.Therefore,at present the best way to further improve the clinical efficacy of BNCT would be to optimize the dosing paradigms and delivery of BPA and BSH,either alone or in combination,with the hope that future research will identify new and better boron delivery agents for clinical use.
基金This work was supported by the National Natural Science Foundation of China(grant numbers 62171193,81802710).
文摘Nanomaterials(NMs)have increasingly been used for the diagnosis and treatment of head and neck cancers(HNCs)over the past decade.HNCs can easily infiltrate surrounding tissues and form distant metastases,meaning that most patients with HNC are diagnosed at an advanced stage and often have a poor prognosis.Since NMs can be used to deliver various agents,including imaging agents,drugs,genes,vaccines,radiosensitisers,and photosensitisers,they play a crucial role in the development of novel technologies for the diagnosis and treatment of HNCs.Indeed,NMs have been reported to enhance delivery efficiency and improve the prognosis of patients with HNC by allowing targeted delivery,controlled release,responses to stimuli,and the delivery of multiple agents.In this review,we consider recent advances in NMs that could be used to improve the diagnosis,treatment,and prognosis of patients with HNC and the potential for future research.
基金supported by the National Natural Science Foundation of China (7087103290924021+2 种基金70971035)the National High Technology Research and Development Program of China (863 Program) (2008AA042901)Anhui Provincial Natural Science Foundation (11040606Q27)
文摘This paper considers the uniform parallel machine scheduling problem with unequal release dates and delivery times to minimize the maximum completion time.For this NP-hard problem,the largest sum of release date,processing time and delivery time first rule is designed to determine a certain machine for each job,and the largest difference between delivery time and release date first rule is designed to sequence the jobs scheduled on the same machine,and then a novel algorithm for the scheduling problem is built.To evaluate the performance of the proposed algorithm,a lower bound for the problem is proposed.The accuracy of the proposed algorithm is tested based on the data with problem size varying from 200 jobs to 600 jobs.The computational results indicate that the average relative error between the proposed algorithm and the lower bound is only 0.667%,therefore the solutions obtained by the proposed algorithm are very accurate.
文摘Background: The one-step method was routine practices in China, scientific evidence to support this intervention is scarce. The purpose of this study was to observe the natural process of head-to-body delivery interval by waiting for at least one contraction (two-step) after head delivered in normal birth. Methods: From March 1 to March 30 in 2015 at Haikou Maternal and Child Hospital in China, normal vaginal birth with normal baby condition were recorded by video. Videotapes were transferred to computer then replayed and observed. Results: Ninety-two cases were enrolled in this study. The average head-to-body delivery interval by two-step delivery was 71.04± 61.02 s, (mean + 2 standard deviation - 193.07 s, 95% confidence interval [15.65-229.15] s). Fifty-one patients (51/92, 55.43%) were 〈60 s, 41 patients (41/92, 44.57%) were over 60 s. Shoulders delivered at the first contraction were 96.74% (89/92), 3.26% (3/92) had delivered by the second contraction. Shoulders emerged from perineum were 71.73% (66/92), 15.21% (14/92) transversely, and 13.04% (12/92) emerged from under pubic arch. Babies cried before the shoulder were 31.52% (29/92), cried after birth 52.17% (48/92), and 16.30% (15/92) did not cry after birth. Baby activities included as making faces, sucking, and bubbled from mouth and noses, and the lighter blue color of skin with good perfusion. Conclusions: The average time of head-to-body delivery interval was longer than 60 s by two-step delivery. Majority shoulders were delivered at the first contraction. Majority shoulders emerged from perineum rather from under pubic arch. The routine one-step method of shoulder delivery where the downward force applied is not necessary and is not the right direction. Baby's breath, making faces, sucking, bubble from noses and mouth, and the light blue color of the faces, all those signs during shoulder delivery indicated a normal live birth.