目的探讨β胶原特殊序列(β-crosslaps,β-CTX)、总1型胶原氨基端延长肽(t-P1NP)及N端中段骨钙素(N-MID-OT)在绝经后女性骨质疏松性骨折风险评估中的应用价值。方法回顾性分析2020年2月至2022年12月解放军总医院第六医学中心收治的102...目的探讨β胶原特殊序列(β-crosslaps,β-CTX)、总1型胶原氨基端延长肽(t-P1NP)及N端中段骨钙素(N-MID-OT)在绝经后女性骨质疏松性骨折风险评估中的应用价值。方法回顾性分析2020年2月至2022年12月解放军总医院第六医学中心收治的102例绝经后骨质疏松(postmenopausal osteoporosis,PMOP)患者的临床资料,将其作为研究组,并根据是否发生骨折将其分为PMOP骨折组(39例)与PMOP未骨折组(63例),另选100名健康体检者作为对照组。记录所有研究对象的β-CTX、t-P1NP及N-MID-OT水平并进行比较,用ROC曲线评价β-CTX、t-P1NP及N-MID-OT在绝经后女性骨质疏松性骨折风险评估中的应用价值。结果研究组的平均体重、体质量指数、股骨颈骨密度(bone mineral density,BMD)、左髋总和BMD及L 1~4总和BMD均明显低于对照组(P<0.05);而两组研究对象的平均年龄、平均身高及绝经年龄等比较差异均无统计学意义(P>0.05)。研究组的β-CTX、t-P1NP及N-MID-OT均明显高于对照组(t值依次为12.688、37.430、26.599,P<0.05)。β-CTX+t-P1NP+N-MID-OT联合检测用于预测PMOP的AUC值为0.978,敏感度为98.04%,特异度为97.00%,表明β-CTX+t-P1NP+N-MID-OT三指标联合检测用于预测PMOP的效能更高。PMOP骨折组的β-CTX、t-P1NP及N-MID-OT均明显高于PMOP未骨折组(t值依次为6.078、16.363、12.227,P<0.05)。β-CTX+t-P1NP+N-MID-OT联合检测用于评估PMOP骨折风险的AUC值为0.939,敏感度为94.87%,特异度为95.24%,表明β-CTX+t-P1NP+N-MID-OT联合检测用于评估PMOP骨折风险的效能更高。结论PMOP患者β-CTX、t-P1NP及N-MID-OT水平均明显升高,而PMOP骨折患者β-CTX、t-P1NP及N-MID-OT水平升高更为明显,且β-CTX+t-P1NP+N-MID-OT联合检测可显著提高对PMOP预测及骨折风险评估效能,值得借鉴。展开更多
目的:检测慢性心力衰竭(CHF)患者血清Ⅲ型前胶原氨基末端前肽(N-terminal peptide of typeⅢprocollagen,PⅢNP)、高迁移率族蛋白B1(high mobility group box-1,HMGB1)的表达水平,探讨二者与左室射血分数(LVEF)的相关性以及对CHF的诊断...目的:检测慢性心力衰竭(CHF)患者血清Ⅲ型前胶原氨基末端前肽(N-terminal peptide of typeⅢprocollagen,PⅢNP)、高迁移率族蛋白B1(high mobility group box-1,HMGB1)的表达水平,探讨二者与左室射血分数(LVEF)的相关性以及对CHF的诊断价值。方法:收集2021年12月至2022年11月期间于佳木斯大学附属第一医院心内科住院治疗的慢性心力衰竭患者90例为实验组,按照LVEF将其分为HFrEF组(n=33)、HFmrEF组(n=27)和HFpEF组(n=30)。此外选取排除心功能不全诊断的同期住院患者30例为对照组。对比各组患者血清中氨基末端脑钠肽前体(NT-proBNP)、PⅢNP、HMGB1水平的差异,分析PⅢNP、HMGB1水平与心功能指标的相关性,并借助ROC曲线评估NT-proBNP、HMGB1、PⅢNP单独以及联合应用对不同表型CHF患者的诊断价值。结果:HFrEF组PⅢNP、HMGB1及NT-proBNP水平均高于HFpEF组和对照组,差异有统计学意义(P<0.05)。PⅢNP与HMGB1呈正相关(P<0.05);PⅢNP、HMGB1均与NT-proBNP、LVEDD呈正相关,与LVEF呈明显负相关(P<0.05);HMGB1与LAD呈正相关(P<0.05),PⅢNP与LAD无明显相关性(P>0.05)。血清NT-proBNP、HMGB1、PⅢNP水平诊断HFrEF患者的AUC分别为0.867、0.871、0.779;诊断HFmrEF患者的AUC分别为0.840、0.804、0.760;诊断HFpEF患者的AUC分别为0.851、0.728、0.769。多生物标志物模型NT-proBNP+PⅢNP、NT-proBNP+HMGB1、NT-proBNP+PⅢNP+HMGB1诊断HFrEF患者的AUC分别为0.887、0.954、0.954;诊断HFmrEF患者的AUC分别为0.942、0.937、0.951;诊断HFpEF患者的AUC分别为0.904、0.910、0.914。结论:CHF患者血清PⅢNP、HMGB1明显升高,并且,CHF患者血清PⅢNP、HMGB1水平与心脏功能指标具有良好的相关性,说明PⅢNP、HMGB1可反映疾病的严重程度。PⅢNP、HMGB1对各表型CHF患者均具有诊断价值,并且,多生物标志物联合检测能提高对CHF患者诊断的敏感性。展开更多
This study presents the design of a modified attributed control chart based on a double sampling(DS)np chart applied in combination with generalized multiple dependent state(GMDS)sampling to monitor the mean life of t...This study presents the design of a modified attributed control chart based on a double sampling(DS)np chart applied in combination with generalized multiple dependent state(GMDS)sampling to monitor the mean life of the product based on the time truncated life test employing theWeibull distribution.The control chart developed supports the examination of the mean lifespan variation for a particular product in the process of manufacturing.Three control limit levels are used:the warning control limit,inner control limit,and outer control limit.Together,they enhance the capability for variation detection.A genetic algorithm can be used for optimization during the in-control process,whereby the optimal parameters can be established for the proposed control chart.The control chart performance is assessed using the average run length,while the influence of the model parameters upon the control chart solution is assessed via sensitivity analysis based on an orthogonal experimental design withmultiple linear regression.A comparative study was conducted based on the out-of-control average run length,in which the developed control chart offered greater sensitivity in the detection of process shifts while making use of smaller samples on average than is the case for existing control charts.Finally,to exhibit the utility of the developed control chart,this paper presents its application using simulated data with parameters drawn from the real set of data.展开更多
A study was carried out on the effects of processing and composition on the structure and properties of P/M EP741NP type alloys. The objectives of this study were to understand the role of Hf in a P/M superalloy conta...A study was carried out on the effects of processing and composition on the structure and properties of P/M EP741NP type alloys. The objectives of this study were to understand the role of Hf in a P/M superalloy containing high niobium used in aircraft engines and to determine the effects of extrusion and forging the powders as contrasted to HIPing （hot isostatic pressing） only. Two alloys of the P/M EP741NP composition were atomized： one alloy contained 0.26%Hfand the other was Hf free. After the as-atomized powders from both alloys were characterized, the powders were extruded into billets, forged and heat treated. After each process, the microstructures were characterized by SEM and the phases were extracted and identified by X-ray diffraction. The presence of Hf in the residues was probed by EDS （energy dispersive spectroscopy）. The alloys were given the published Russian heat treatment as well as a more conventional heat treatment more typical of western powder alloys. Tensile, creep and stress rupture mechanical property tests were run. Results of the structural behavior of the alloys after each processing step will be presented and discussed. The role of the Hfon the mechanical properties will be discussed.展开更多
Two silver(I) complexes were prepared by the reaction of [Ag(C≡CPh)]n with NP3 [NP3 = N(CH2CH2PPh2)3] or with NP3 and [Cu(CH3CN)4]ClO4. Complex 1 [(Ag2Cl(NP3)2)(Ag5- (C≡CPh)6)] contains both NP3 and PhC≡C- ligand...Two silver(I) complexes were prepared by the reaction of [Ag(C≡CPh)]n with NP3 [NP3 = N(CH2CH2PPh2)3] or with NP3 and [Cu(CH3CN)4]ClO4. Complex 1 [(Ag2Cl(NP3)2)(Ag5- (C≡CPh)6)] contains both NP3 and PhC≡C- ligands. The complex cation is (Ag2Cl(NP3)2)+, in which two Ag(NP3)+ cations were bridged by a Cl- donor. The anion is (Ag5(C≡CPh)6)-, where five Ag+ ions are linked by six C≡CPh- to form a pentanuclear cluster. Complex 2 only contains NP3 ligand, where the silver center adopts a trigonal-bipyramidal geometry. Crystal data for 1: C133H116Ag7Cl3- N2P6, Mr = 2789.54, triclinic, space group P1, a = 13.0780(2), b = 15.3678(2), c = 31.2041(3) ?, α = 91.3928(7), β = 90.9328(8), γ = 96.0244(4)o, V = 6233.8(1) ?3, T = 293(2) K, Z = 2, Dc = 1.486 g/cm3, F(000) = 2796, μ = 1.266 mm-1, the final R = 0.0746 and wR = 0.1953 for 16475 observed reflections with I > 2σ(I). Crystal data for 2: C42H42AgClNO4P3, Mr = 861.00, trigonal, space group R3, a = 17.451(1), b = 17.451(1), c = 11.3985(7) ?, V = 3006.0(3) ?3, T = 293(2) K, Z = 3, Dc = 1.427 g/cm3, F(000) = 1326, μ = 0.731 mm-1, the final R = 0.0251 and wR = 0.0663 for 1499 observed reflections with I > 2σ(I).展开更多
In the present study,samples of a titanium carbide nanoparticle-reinforced nickel alloy(Ni-TiC_(NP)composite)were irradiated with 1 MeV He ions at 700°C.The evolution of He bubbles and nanohardness was characteri...In the present study,samples of a titanium carbide nanoparticle-reinforced nickel alloy(Ni-TiC_(NP)composite)were irradiated with 1 MeV He ions at 700°C.The evolution of He bubbles and nanohardness was characterized using transmission electron microscopy(TEM)and nanoindentation,respectively.TEM images showed that the size and number density of He bubbles in the grains were affected by the He ion fluence.The number density first increased significantly and then decreased with increasing ion dose,while the size exhibited an inverse trend.Moreover,the swelling induced by He bubbles continuously increased with increasing ion dose.He bubbles also formed in the grain boundaries,interior of the TiC nanoparticles,and interfaces between the TiC nanoparticles and Ni matrix.Nanoindentation measurements indicated a decrease in nanohardness after irradiation,which is attributed to the disappearance of intrinsic dislocation lines caused by He ion irradiation.展开更多
文摘目的探讨β胶原特殊序列(β-crosslaps,β-CTX)、总1型胶原氨基端延长肽(t-P1NP)及N端中段骨钙素(N-MID-OT)在绝经后女性骨质疏松性骨折风险评估中的应用价值。方法回顾性分析2020年2月至2022年12月解放军总医院第六医学中心收治的102例绝经后骨质疏松(postmenopausal osteoporosis,PMOP)患者的临床资料,将其作为研究组,并根据是否发生骨折将其分为PMOP骨折组(39例)与PMOP未骨折组(63例),另选100名健康体检者作为对照组。记录所有研究对象的β-CTX、t-P1NP及N-MID-OT水平并进行比较,用ROC曲线评价β-CTX、t-P1NP及N-MID-OT在绝经后女性骨质疏松性骨折风险评估中的应用价值。结果研究组的平均体重、体质量指数、股骨颈骨密度(bone mineral density,BMD)、左髋总和BMD及L 1~4总和BMD均明显低于对照组(P<0.05);而两组研究对象的平均年龄、平均身高及绝经年龄等比较差异均无统计学意义(P>0.05)。研究组的β-CTX、t-P1NP及N-MID-OT均明显高于对照组(t值依次为12.688、37.430、26.599,P<0.05)。β-CTX+t-P1NP+N-MID-OT联合检测用于预测PMOP的AUC值为0.978,敏感度为98.04%,特异度为97.00%,表明β-CTX+t-P1NP+N-MID-OT三指标联合检测用于预测PMOP的效能更高。PMOP骨折组的β-CTX、t-P1NP及N-MID-OT均明显高于PMOP未骨折组(t值依次为6.078、16.363、12.227,P<0.05)。β-CTX+t-P1NP+N-MID-OT联合检测用于评估PMOP骨折风险的AUC值为0.939,敏感度为94.87%,特异度为95.24%,表明β-CTX+t-P1NP+N-MID-OT联合检测用于评估PMOP骨折风险的效能更高。结论PMOP患者β-CTX、t-P1NP及N-MID-OT水平均明显升高,而PMOP骨折患者β-CTX、t-P1NP及N-MID-OT水平升高更为明显,且β-CTX+t-P1NP+N-MID-OT联合检测可显著提高对PMOP预测及骨折风险评估效能,值得借鉴。
文摘目的:检测慢性心力衰竭(CHF)患者血清Ⅲ型前胶原氨基末端前肽(N-terminal peptide of typeⅢprocollagen,PⅢNP)、高迁移率族蛋白B1(high mobility group box-1,HMGB1)的表达水平,探讨二者与左室射血分数(LVEF)的相关性以及对CHF的诊断价值。方法:收集2021年12月至2022年11月期间于佳木斯大学附属第一医院心内科住院治疗的慢性心力衰竭患者90例为实验组,按照LVEF将其分为HFrEF组(n=33)、HFmrEF组(n=27)和HFpEF组(n=30)。此外选取排除心功能不全诊断的同期住院患者30例为对照组。对比各组患者血清中氨基末端脑钠肽前体(NT-proBNP)、PⅢNP、HMGB1水平的差异,分析PⅢNP、HMGB1水平与心功能指标的相关性,并借助ROC曲线评估NT-proBNP、HMGB1、PⅢNP单独以及联合应用对不同表型CHF患者的诊断价值。结果:HFrEF组PⅢNP、HMGB1及NT-proBNP水平均高于HFpEF组和对照组,差异有统计学意义(P<0.05)。PⅢNP与HMGB1呈正相关(P<0.05);PⅢNP、HMGB1均与NT-proBNP、LVEDD呈正相关,与LVEF呈明显负相关(P<0.05);HMGB1与LAD呈正相关(P<0.05),PⅢNP与LAD无明显相关性(P>0.05)。血清NT-proBNP、HMGB1、PⅢNP水平诊断HFrEF患者的AUC分别为0.867、0.871、0.779;诊断HFmrEF患者的AUC分别为0.840、0.804、0.760;诊断HFpEF患者的AUC分别为0.851、0.728、0.769。多生物标志物模型NT-proBNP+PⅢNP、NT-proBNP+HMGB1、NT-proBNP+PⅢNP+HMGB1诊断HFrEF患者的AUC分别为0.887、0.954、0.954;诊断HFmrEF患者的AUC分别为0.942、0.937、0.951;诊断HFpEF患者的AUC分别为0.904、0.910、0.914。结论:CHF患者血清PⅢNP、HMGB1明显升高,并且,CHF患者血清PⅢNP、HMGB1水平与心脏功能指标具有良好的相关性,说明PⅢNP、HMGB1可反映疾病的严重程度。PⅢNP、HMGB1对各表型CHF患者均具有诊断价值,并且,多生物标志物联合检测能提高对CHF患者诊断的敏感性。
基金the Science,Research and Innovation Promotion Funding(TSRI)(Grant No.FRB660012/0168)managed under Rajamangala University of Technology Thanyaburi(FRB66E0646O.4).
文摘This study presents the design of a modified attributed control chart based on a double sampling(DS)np chart applied in combination with generalized multiple dependent state(GMDS)sampling to monitor the mean life of the product based on the time truncated life test employing theWeibull distribution.The control chart developed supports the examination of the mean lifespan variation for a particular product in the process of manufacturing.Three control limit levels are used:the warning control limit,inner control limit,and outer control limit.Together,they enhance the capability for variation detection.A genetic algorithm can be used for optimization during the in-control process,whereby the optimal parameters can be established for the proposed control chart.The control chart performance is assessed using the average run length,while the influence of the model parameters upon the control chart solution is assessed via sensitivity analysis based on an orthogonal experimental design withmultiple linear regression.A comparative study was conducted based on the out-of-control average run length,in which the developed control chart offered greater sensitivity in the detection of process shifts while making use of smaller samples on average than is the case for existing control charts.Finally,to exhibit the utility of the developed control chart,this paper presents its application using simulated data with parameters drawn from the real set of data.
文摘A study was carried out on the effects of processing and composition on the structure and properties of P/M EP741NP type alloys. The objectives of this study were to understand the role of Hf in a P/M superalloy containing high niobium used in aircraft engines and to determine the effects of extrusion and forging the powders as contrasted to HIPing （hot isostatic pressing） only. Two alloys of the P/M EP741NP composition were atomized： one alloy contained 0.26%Hfand the other was Hf free. After the as-atomized powders from both alloys were characterized, the powders were extruded into billets, forged and heat treated. After each process, the microstructures were characterized by SEM and the phases were extracted and identified by X-ray diffraction. The presence of Hf in the residues was probed by EDS （energy dispersive spectroscopy）. The alloys were given the published Russian heat treatment as well as a more conventional heat treatment more typical of western powder alloys. Tensile, creep and stress rupture mechanical property tests were run. Results of the structural behavior of the alloys after each processing step will be presented and discussed. The role of the Hfon the mechanical properties will be discussed.
基金This work was supported by the NSF of Fujian Province (E0310029) and the Innovation Fund of Fujian Province (2003J044)
文摘Two silver(I) complexes were prepared by the reaction of [Ag(C≡CPh)]n with NP3 [NP3 = N(CH2CH2PPh2)3] or with NP3 and [Cu(CH3CN)4]ClO4. Complex 1 [(Ag2Cl(NP3)2)(Ag5- (C≡CPh)6)] contains both NP3 and PhC≡C- ligands. The complex cation is (Ag2Cl(NP3)2)+, in which two Ag(NP3)+ cations were bridged by a Cl- donor. The anion is (Ag5(C≡CPh)6)-, where five Ag+ ions are linked by six C≡CPh- to form a pentanuclear cluster. Complex 2 only contains NP3 ligand, where the silver center adopts a trigonal-bipyramidal geometry. Crystal data for 1: C133H116Ag7Cl3- N2P6, Mr = 2789.54, triclinic, space group P1, a = 13.0780(2), b = 15.3678(2), c = 31.2041(3) ?, α = 91.3928(7), β = 90.9328(8), γ = 96.0244(4)o, V = 6233.8(1) ?3, T = 293(2) K, Z = 2, Dc = 1.486 g/cm3, F(000) = 2796, μ = 1.266 mm-1, the final R = 0.0746 and wR = 0.1953 for 16475 observed reflections with I > 2σ(I). Crystal data for 2: C42H42AgClNO4P3, Mr = 861.00, trigonal, space group R3, a = 17.451(1), b = 17.451(1), c = 11.3985(7) ?, V = 3006.0(3) ?3, T = 293(2) K, Z = 3, Dc = 1.427 g/cm3, F(000) = 1326, μ = 0.731 mm-1, the final R = 0.0251 and wR = 0.0663 for 1499 observed reflections with I > 2σ(I).
基金suported by the National Natural Science Foundation of China(Nos.11705264,11975304,12022515,and 12175323)。
文摘In the present study,samples of a titanium carbide nanoparticle-reinforced nickel alloy(Ni-TiC_(NP)composite)were irradiated with 1 MeV He ions at 700°C.The evolution of He bubbles and nanohardness was characterized using transmission electron microscopy(TEM)and nanoindentation,respectively.TEM images showed that the size and number density of He bubbles in the grains were affected by the He ion fluence.The number density first increased significantly and then decreased with increasing ion dose,while the size exhibited an inverse trend.Moreover,the swelling induced by He bubbles continuously increased with increasing ion dose.He bubbles also formed in the grain boundaries,interior of the TiC nanoparticles,and interfaces between the TiC nanoparticles and Ni matrix.Nanoindentation measurements indicated a decrease in nanohardness after irradiation,which is attributed to the disappearance of intrinsic dislocation lines caused by He ion irradiation.
