Deformation,structure and potential hazard of a landslide based on InSAR in Banbar county,Xizang(Tibet)

The Tibetan Plateau is characterized by complex geological conditions and a relatively fragile ecological environment.In recent years,there has been continuous development and increased human activity in the Tibetan Plateau region,leading to a rising risk of landslides.The landslide in Banbar County,Xizang(Tibet),have been perturbed by ongoing disturbances from human engineering activities,making it susceptible to instability and displaying distinct features.In this study,small baseline subset synthetic aperture radar interferometry(SBAS-InSAR)technology is used to obtain the Line of Sight(LOS)deformation velocity field in the study area,and then the slope-orientation deformation field of the landslide is obtained according to the spatial geometric relationship between the satellite’s LOS direction and the landslide.Subsequently,the landslide thickness is inverted by applying the mass conservation criterion.The results show that the movement area of the landslide is about 6.57×10^(4)m^(2),and the landslide volume is about 1.45×10^(6)m^(3).The maximum estimated thickness and average thickness of the landslide are 39 m and 22 m,respectively.The thickness estimation results align with the findings from on-site investigation,indicating the applicability of this method to large-scale earth slides.The deformation rate of the landslide exhibits a notable correlation with temperature variations,with rainfall playing a supportive role in the deformation process and displaying a certain lag.Human activities exert the most substantial influence on the spatial heterogeneity of landslide deformation,leading to the direct impact of several prominent deformation areas due to human interventions.Simultaneously,utilizing the long short-term memory(LSTM)model to predict landslide displacement,and the forecast results demonstrate the effectiveness of the LSTM model in predicting landslides that are in a continuous development and movement phase.The landslide is still active,and based on the spatial heterogeneity of landslide deformation,new recommendations have been proposed for the future management of the landslide in order to mitigate potential hazards associated with landslide instability.

A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling complexes that regulate genomic architecture.Here,we present a structural model of the endogenously purified human canonical BAF complex bound to the nucleosome,generated using cryoelectron microscopy(cryo-EM),cross-linking mass spectrometry,and homology modeling.BAF complexes bilaterally engage the nucleosome H2A/H2B acidic patch regions through the SMARCB1 C-terminalα-helix and the SMARCA4/2 C-terminal SnAc/postSnAc regions,with disease-associated mutations in either causing attenuated chromatin remodeling activities.Further,we define changes in BAF complex architecture upon nucleosome engagement and compare the structural model of endogenous BAF to those of related SWI/SNF-family complexes.Finally,we assign and experimentally interrogate cancer-associated hot-spot mutations localizing within the endogenous human BAF complex,identifying those that disrupt BAF subunit-subunit and subunit-nucleosome interfaces in the nucleosome-bound conformation.Taken together,this integrative structural approach provides important biophysical foundations for understanding the mechanisms of BAF complex function in normal and disease states.

Study on the secondary structure and hydration effect of human serum albumin under acidic pH and ethanol perturbation with IR/NIR spectroscopy

Human serum albumin(HSA)is the most abundant protein in plasma and plays an essential physiological role in the human body.Ethanol precipitation is the most widely used way to obtain HSA,and pH and ethanol are crucial factors affecting the process.In this study,infrared(IR)spectroscopy and near-infrared(NIR)spectroscopy in combination with chemometrics were used to investigate the changes in the secondary structure and hydration of HSA at acidic pH(5.6-3.2)and isoelectric pH when ethanol concentration was varied from 0%to 40%as a perturbation.IR spectroscopy combined with the two-dimensional correlation spectroscopy(2DCOS)analysis for acid pH system proved that the secondary structure of HSA changed significantly when pH was around 4.5.What's more,the IR spectroscopy and 2DCOS analysis showed different secondary structure forms under different ethanol concentrations at the isoelectric pH.For the hydration effect analysis,NIR spectroscopy combined with the McCabe-Fisher method and aquaphotomics showed that the free hydrogen-bonded water fluctuates dynamically,with ethanol at 0-20%enhancing the hydrogen-bonded water clusters,while weak hydrogen-bonded water clusters were formed when the ethanol concentration increased continuously from 20%to 30%.These measurements provide new insights into the structural changes and changes in the hydration behavior of HSA,revealing the dynamic process of protein purification,and providing a theoretical basis for the selection of HSA alcoholic precipitation process parameters,as well as for further studies of complex biological systems.

Well-Posedness and a Finite Difference Approximation for a Mathematical Model of HPV-Induced Cervical Cancer

We present a first-order finite difference scheme for approximating solutions of a mathematical model of cervical cancer induced by the human papillomavirus (HPV), which consists of four nonlinear partial differential equations and a nonlinear first-order ordinary differential equation. The scheme is analyzed and used to provide an existence-uniqueness result. Numerical simulations are performed in order to demonstrate the first-order rate of convergence. A sensitivity analysis was done in order to compare the effects of two drug types, those that increase the death rate of HPV-infected cells, and those that increase the death rate of the precancerous cell population. The model predicts that treatments that affect the precancerous cell population by directly increasing the corresponding death rate are far more effective than those that increase the death rate of HPV-infected cells.

Concept, Interests and Systems: Logical Consciousness of the China Campus Football Policy Trip

Based on the “Healthy China 2030 Planning Outline”, the literature method and logical analysis method are used to review and analyze the implementation process of China’s school football policy from three dimensions: value, interest appeal and institutional background. The study believes that in order to break through the bottleneck of policy implementation and improve the effect of policy implementation, it is necessary to establish correct values and form broad recognition of policies;meet the reasonable interests of all parties and form a synergy for policy implementation;optimize the institutional environment for policy implementation and form effective incentives.

Is the Genie of Artificial Intelligence Technology Out of the Bottle and Control?(A Short Review)

In recent years,AI(artificial intelligence)has made considerable strides,transforming a number of industries and facets of daily life.However,as AI develops more,worries about its potential dangers and unforeseen repercussions have surfaced.This article investigates the claim that AI technology has broken free from human control and is now unstoppable.We look at how AI is developing right now,what it means for society,and what steps are being taken to reduce the risks that come with it.We seek to highlight the need for responsible development and implementation of this game-changing technology by examining the opportunities and challenges that AI presents.

The Core Mechanism of Natural Selection: How the Natural Cycle of Potassium Resources Affects the Biological Evolution and the Change of Human Society

Darwin’s theory of evolution believes that biological evolution is a process of natural selection. This theory has been supported by much evidence, but the internal biological mechanism is not clear. Here, I elaborate on the cycle of potassium resources on the earth and the biological utilization and efficiency, which may be the core mechanism of natural selection and affect the evolution of organisms and the development of human society.

Evolution and Development of the Information Concept in Biological Systems: From Empirical Description to Informational Modeling of the Living Structures

With the purpose to smooth the way of a correct understanding of information concepts and their evolution,in this paper,is discussed the evolution and development of the concept of information in biological systems,showing that this concept was intuitively perceived even since ancient times by our predecessors,and described according to their language level of that times,but the crystallization of the real meaning of information is an achievement of our nowadays,by successive contribution of various scientific branches and personalities of the scientific community of the world,leading to a modern description/modeling of reality,in which information plays a fundamental role.It is shown that our reality can be understood as a contribution of matter/energy/information and represented/discussed as the model of the Universal Triangle of Reality(UTR),where various previous models can be suggestively inserted,as a function of their basic concern.The modern concepts on information starting from a theoretic experiment which would infringe the thermodynamics laws and reaching the theory of information and modern philosophic concepts on the world structuration allow us to show that information is a fundamental component of the material world and of the biological structures,in correlation with the structuration/destructuration processes of matter,involving absorption/release of information.Based on these concepts,is discussed the functionality of the biologic structures and is presented the informational model of the human body and living structures,as a general model of info-organization on the entire biological scale,showing that a rudimentary proto-consciousness should be operative even at the low-scale biological systems,because they work on the same principles,like the most developed bio-systems.The operability of biologic structures as informational devices is also pointed out.

The Environment of a Hyper-Connected Network Society and Occupational Ethics

The hyper-connected network society is a society environment in which all people-people,people-objects,things-things can be connected quickly and intelligently.In this environment of the hyper-connected network society,anyone can easily get the information they want,and the information and the knowledge will be a source of wealth.However,in the environment of a hyper-connected network society,the advanced information technology can harm human dignity or life if the information communication technology is used unfavorably (distortion,manipulation) by crime technique to satisfy the personal greed or pay back the grudge.Therefore,in this study,it established the direction of related occupational ethics in preparation for the hyper-connected network society in order to enable ethical values to be applied to experts and stakeholders in each field.And it made some suggestions necessary for the establishment of relevant policies at the national/social level.As a result of this study,it was found to be necessary:(1) personal information and privacy protection,(2) fair and autonomous ethical consciousness,(3) technology development for public interest,(4) enactment of ethical code for each field,(5) interests and strategic contrasts for occupational ethics of national dimension,(6) social learning (home-school-work) of occupation ethics,(7) changes for basic principles and virtue of work ethics in the hyper-connected social environment.

Letter from Li Peng Chairman of the Standing Committee of the National People's Congress, To China Society for Human Rights Studies

China Society for Human Rights Studies, I would like to extend my warm greetings to the launch of your Human Rights magazine. Enjoying human rights fully is a lofty goal long pursued after by human race. Over the years when they carried out revolution, construction and reforms, the Chinese people have struggled indomitably and strived incessantly to achieve this goal. Progress made in this regard has caught worldwide attention. When struggling for, safeguarding, promoting and developing human rights, the Chinese people have always combined the universality prin-

Resolving Doubts,Enhancing Mutual Trust and Promoting Cultural Exchanges among Civilizations:The visit of the Delegation of China Society for Human Rights Studies to the UK and Greece

The delegation of China Society for Human Rights Studies visited the UK and Greece from the 30th of June to the 7th of July.During their stay in the UK,the delegation visited the Foreign and Commonwealth Office,the Parliament, research institutes and think tanks,having indepth discussions on human rights issues with people from various circles.

Working for the Happiness of the People: The Scientific Analysis and Demarcation of the Principal Contradiction Facing the Chinese Society by the Communist Party of China

The report to the 19th national Congress of the Communist Party of China stated an important new definition of the principal contradiction facing Chinese society.in a century’s development,the formulation of the CPC’s major strategies,paths,guidelines,and policies is closely related to the Party’s scientific analysis and evaluation of the principal contradiction according to the development stage of Chinese society in different historical periods.This is of great significance for identifying the work focus of the Party and the State and for realizing China’s progress and development.in the course of its striving to solve the principal contradiction facing the Chinese society,the Party has always been unremittingly committed to seeking happiness for the people.from the perspective of localization of the Marxist human rights theory in China,this is the ultimate reason why the Party and the State can make great achievements in various undertakings,including the construction of human rights.

Speech at the Symposium on Study and Implementation of the Spirit of the 19^(th) CPC National Congress at the China Society for Human Rights Studies

Following the successful conclusion of the 19thCommunist Party of China National Congress,there has been a nationwide upsurge in the study and implementation of the spirit of the Congress.It was therefore both necessary and timely for the China Society for Human Rights Studies to organize a symposium on the study and implementation of the spirit of the Congress.I’d like to express my understanding of the study and implementation of the spirit of the 19th CPC National Congress from three aspects:

Role of flavonoids in plant interactions with the environment and against human pathogens-A review

Flavonoids are widely-distributed polyphenolic secondary metabolites with diverse biological activities in plants and benefit human health as protective dietary agents.They participate in plants' responses to harsh environmental conditions and effectively regulate the cell differentiation and growth.In plants,the majority of their functions are attributed to their strong antioxidative properties.Similarly,dietary flavonoids protect the human body against free radicals which are associated with the development of cancer and atherosclerosis.Plants rich in polyphenols have been used to cure various diseases because of their antibacterial,antiviral,antifungal and anticancer properties.This review summarizes the up-to-date research trends and development on flavonoids and its derivatives,working mechanisms and potential functions and applications particularly in relation to plant protection and human health.Towards the end,notable concluding remarks with a close-up look at the future research directions have also been presented briefly.

Human Capital Structure and Economic Growth:From the Perspective of New Structural Economics

The Chinese economy has achieved remarkable development over the past 40 years of reform and opening-up.However,with the narrowing of potential for efficiency improvement from resources reallocation and changes in population age structure,the Chinese economy has moved from high-speed growth to high-quality development.In this setting,understanding factor endowment and comparative advantages of the economy from a perspective of human capital structure so as to enhance industrial structure adaptability by riding the trend is of significance for cultivating new driving force for economic development.This paper,following a theoretical paradigm of new structural economics,demonstrates how human capital structure matches industrial structure and the presence of optimal human capital structure using mathematical deduction.On this basis,national level panel data and instrumental variables are adopted for generalized method of moments,the results of which shows that there are varied impacts on economic growth in light of different human capital structure characteristics.The proportions of high-level human capital and medium-level human capital boost economic development,while that of low-level human capital has an inhibitory effect on economic growth.The policy implication of this study is that large economies should diversify efforts as per different human capital structure characteristics in terms of development need of tapping growth impetus from human capital structure improvement.It is of equal importance to raise the proportion of high and medium human capital in order to stimulate economic growth and to cut the proportion of low human capital that hinders economic development.

Effect of human disturbance on the structure and regeneration of forests in the Nevado de Toluca National Park, Mexico

Sample plots were established in the principal forest types in the the Nevado de Toluca National Park, Mexico including those domi- nated by Pinus hartwegii, Abies religiosa, Quercus laurina and Alnus jorullensis. The vertical structure was defined by three strata in the coniferous forests and two strata in the broadleaved forests. Timber harvesting in Abies religiosa and Quercus laurina forests and fires generated by humans in Pinus hartwegii forests impeded the recruitment of saplings. Mature trees were also heavily impacted by logging in Pinus hartwegii forests. On the contrary, Alnusjorullensis forests were increas- ing due to the disturbance of Pinus and Quercus forests, as well aban- doned crop lands within the park. A combination of logging, uncon- trolled fire, and grazing appears to be compromising the recruitment of important tree species in this national park. These factors, together with human settlements, have also increased the proportion of early succes- sional species. Changes in forest structure from human disturbance indicate a need to control these activities if conservation goals are not to be compromised.

Mapping theme trends and knowledge structures for human neural stem cells:a quantitative and co-word biclustering analysis for the 2013-2018 period

Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends and knowledge structures for human neural stem cells have not yet been studied bibliometrically.In this study,we retrieved 2742 articles from the PubMed database from 2013 to 2018 using "Neural Stem Cells" as the retrieval word.Co-word analysis was conducted to statistically quantify the characteristics and popular themes of human neural stem cell-related studies.Bibliographic data matrices were generated with the Bibliographic Item Co-Occurrence Matrix Builder.We identified 78 high-frequency Medical Subject Heading(MeSH)terms.A visual matrix was built with the repeated bisection method in gCLUTO software.A social network analysis network was generated with Ucinet 6.0 software and GraphPad Prism 5 software.The analyses demonstrated that in the 6-year period,hot topics were clustered into five categories.As suggested by the constructed strategic diagram,studies related to cytology and physiology were well-developed,whereas those related to neural stem cell applications,tissue engineering,metabolism and cell signaling,and neural stem cell pathology and virology remained immature.Neural stem cell therapy for stroke and Parkinson’s disease,the genetics of microRNAs and brain neoplasms,as well as neuroprotective agents,Zika virus,Notch receptor,neural crest and embryonic stem cells were identified as emerging hot spots.These undeveloped themes and popular topics are potential points of focus for new studies on human neural stem cells.

Impacts of environmental conditions on woody plant diversity,structure and regeneration in forest patches of Guna Mountain:Este District,South Gondar Zone,Ethiopia

Environmental conditions determine woody plant life such as species diversity,structure and regeneration status.This research aimed to assess the impact of environmental conditions on woody plant species diversity,structure and regeneration in forest patches of Guna Mountain:the case of Este District,South Gondar Zone,north-west Ethiopia.A total of 71 square sample plots(400 m~2 each) were established at 10 transects laid in five forest patches of the study area to collect vegetation data including the abundance of species,height and diameter at breast height(DBH).Environmental data including available potassium,available phosphorus,cation exchange capacity,soil texture,electrical conductivity,soil acidity,total nitrogen,organic matter,organic carbon,sodium adsorption ratio,exchangeable sodium percentage,bulk density,aspect,elevation,slope,latitude and longitude data were collected in the same plots.A correlation analysis between vegetation and environmental data was performed using rcorr(x) function in package Hmisc in R Programming Language.The most pronounced impacts were observed in altitude,grazing and pH,positively and silt,sand,electrical conductivity and cation exchange capacity,negatively.In addition,strong and significant impacts on plant structure were also observed due to the variation in soil texture and p H.The difference in aspect,sand and slope also impacted plant regeneration.The study showed that environmental parameters influence the diversity,structure and regeneration of woody plants.These parameters can be considered in the rehabilitation of the vegetation cover and conservation efforts of the rare woody species.Conservation measures that can minimalize the negative influences of environmental conditions can be applied through collaboration with communities around the forest patches.

Conformal Human–Machine Integration Using Highly Bending‑Insensitive,Unpixelated,and Waterproof Epidermal Electronics Toward Metaverse

Efficient and flexible interactions require precisely converting human intentions into computer-recognizable signals,which is critical to the breakthrough development of metaverse.Interactive electronics face common dilemmas,which realize highprecision and stable touch detection but are rigid,bulky,and thick or achieve high flexibility to wear but lose precision.Here,we construct highly bending-insensitive,unpixelated,and waterproof epidermal interfaces(BUW epidermal interfaces)and demonstrate their interactive applications of conformal human–machine integration.The BUW epidermal interface based on the addressable electrical contact structure exhibits high-precision and stable touch detection,high flexibility,rapid response time,excellent stability,and versatile“cut-and-paste”character.Regardless of whether being flat or bent,the BUW epidermal interface can be conformally attached to the human skin for real-time,comfortable,and unrestrained interactions.This research provides promising insight into the functional composite and structural design strategies for developing epidermal electronics,which offers a new technology route and may further broaden human–machine interactions toward metaverse.

A review on the coordinative structure of human walking and the application of principal component analysis

Walking is a complex task which includes hundreds of muscles, bones and joints working together to deliver smooth movements. With the complexity, walking has been widely investigated in order to identify the pattern of multi-segment movement and reveal the control mechanism. The degree of freedom and dimensional properties provide a view of the coordinative structure during walking, which has been extensively studied by using dimension reduction technique. In this paper, the studies related to the coordinative structure, dimensions detection and pattern reorganization during walking have been reviewed. Principal component analysis, as a popular technique, is widely used in the processing of human movement data. Both the principle and the outcomes of principal component analysis were introduced in this paper. This technique has been reported to successfully reduce the redundancy within the original data, identify the physical meaning represented by the extracted principal components and discriminate the different patterns. The coordinative structure during walking assessed by this technique could provide further information of the body control mechanism and correlate walking pattern with injury.