Application and mechanisms of Sanhua Decoction in the treatment of cerebral ischemia-reperfusion injury

Cerebral ischemia-reperfusion is a process in which the blood supply to the brain is temporarily interrupted and subsequently restored.However,it is highly likely to lead to further aggravation of pathological damage to ischemic tissues or the nervous system.,and has accordingly been a focus of extensive clinical research.As a traditional Chinese medicinal formulation,Sanhua Decoction has gradually gained importance in the treatment of cerebrovascular diseases.Its main constituents include Citrus aurantium,Magnolia officinalis,rhubarb,and Qiangwu,which are primarily used to regulate qi.In the treatment of neurological diseases,the therapeutic effects of the Sanhua Decoction are mediated via different pathways,including antioxidant,anti-inflammatory,and neurotransmitter regu-latory pathways,as well as through the protection of nerve cells and a reduction in cerebral edema.Among the studies conducted to date,many have found that the application of Sanhua Decoction in the treatment of neurological diseases has clear therapeutic effects.In addition,as a natural treatment,the Sanhua Decoction has received widespread attention,given that it is safer and more effective than traditional Western medicines.Consequently,research on the mechanisms of action and efficacy of the Sanhua Decoctions in the treatment of cerebral ischemia-reperfusion injury is of considerable significance.In this paper,we describe the pathogenesis of cerebral ischemia-reperfusion injury and review the current status of its treatment to examine the therapeutic mechanisms of action of the Sanhua Decoction.We hope that the findings of the research presented herein will contribute to a better understanding of the efficacy of this formulation in the treatment of cerebral ischemia-reperfusion,and provide a scientific basis for its application in clinical practice.

Explore the value and potential of traditional Chinese medicine against cancer with the methodology and practice spirit of natural science

Traditional Chinese medicine （TCM） is a life science with original characteristics of our nation, which has its own advantages in facing modern medicine. As a clinical discipline with distinct characteristics of life medical science, oncology is a typical discipline that combines the advantages of Chinese and Western medicine. TCM has two different cultural attributes, the humanities and the natural sciences. However, when confronted with such a serious disease as cancer, the approach of natural science of TCM should be emphasized to participate in anti-cancer practice.

China's Science: Tradition and the Future

I.Was Science Known in Ancient China? Kexue(Science)is China's oldest scientific journal.Its publishing office is in Shanghai,and the present editor--in-chief is Prof.

Struggling Between Tradition and Modernity: A Feminist Interpretation of Yu Opera China Women

Yu Opera China Women (some translated it into Our Company)(2000) has been well received by audiences for its simple folk description, vivid characters, touching story lines, stunning stage backgrounds, and exquisite stage performances. The opera describes a story of Xiangxiang and Huanhuan, mother-in-law and daughter-in-law, two generations of women in the reform and opening up years in the 20th century in China. These Chinese women try to break the shackles of fate, with the strength to overcome hardships, work hard to gain wealth, and be brave to pursue true love, so it has a strong sense of feminism. However, rooted in the deep traditional Chinese culture, Xiangxiang and Huanhuan are always struggling between tradition and modernity and they make difficult choices along with the awakening of women’s consciousness.

Research hotspots and trends in Chinese minority traditional medicine during 2021:a visual bibliometrics analysis

Background:Chinese minority traditional medicine(CMTM)is an important component of Chinese traditional culture and medicine that has contributed to the health and prosperity of Chinese people of all ethnic groups.Although this type of medicine has attracted interest,its developmental trends and research status remain unclear.Therefore,we used literature metrology to evaluate the publications on CMTM during 2021 and explore hotspots and frontier areas.Methods:Reports associated with CMTM published between January 1,2021,and December 31,2021,were downloaded from the Web of Science database.The authors,institutions,countries,journals,keywords,and other standard bibliometric indicators were analyzed and visualized using CiteSpace,and research hotspots and trends were identified.Results:We retrieved 152 CMTM-related publications,among which Tibetan medicine attracted the most interest.Journals covering alternative and complementary medicine topics were the most prevalent sources of reports about CMTM,particularly the Journal of Ethnopharmacology.Most research in this field was conducted in China and frequently published by traditional Chinese medicine colleges and universities.One author,Yi Zhang,has extensively investigated Tibetan and Korean medicine.The keyword co-occurrence network revealed that investigations into ethnic groups mainly focused on the pharmacological activities and phytochemical components of ethnic medicines.The keywords of gut microbiota and autophagy in some publications reflect the direction of future CMTM investigations.Conclusion:Our findings showed the current status and trends in CMTM investigations.This information will help identify new research directions and hotspots in this field.

Chinese Medicine History and Contemporary Practice in the West

In the health care professions today, research guides best clinical practice. Yet, the methodological constraints required by the two main branches of research into Chinese medicine--bio-scientific and socio-historical--rarely assist Chinese medicine students, practitioners, or clinical researchers with treatment and practice issues. A great deal of bio-scientific research assumes that it must be possible to utilise and test Chinese medicine from within a biomedical framework. However, by isolating therapeutic techniques and substances and standardising treatment protocols, bio-scientific research removes Chinese medicine＇s inbuilt flexibility and responsiveness to clinical instances and changes. While researchers in the historical and social sciences can reveal the sophisticated discourses built around Chinese medicine＇s distinctive approach to knowing the world and the body-person, they normally do not discuss the implications of their work for contemporary clinical practice. The paper advocates a synthetic approach using multidisciplinary sources within and adjacent to the field of Chinese medicine. Multidisciplinary researchers contest the simplified and biomedicalised version of Chinese medicine generally available in English speaking countries today. They can assist English speakers to approach Chinese medicine＇s traditional perspectives, demonstrate their relevance for contemporary clinical practice and help restore the traditional connectedness between Chinese medicine＇s theoretical concepts and its treatment methods.

Reflections on Amendments to the Journal's Editing Standards

A 10-year-old unified editing standard was recently abolished in the field of humanities and social science journals. This is because the standard failed in showing equal respect to disciplinary differences, in keeping with Chinese culturaltraditions, and in gaining acceptance among journal editors. As such, amendment efforts to the National Standard should be undertaken patiently and in a practical manner to achieve agreement within this publishing field.

Research trends of machine learning in traditional medicine:a big-data based tenyear bibliometric analysis

Background:With the rapid development of the world’s technology,the connection and integration between traditional medicine and modern machine learning technology are increasingly close.In this study,we aimed to analyze publications on machine learning in traditional medicine by using bibliometric methods and explore global trends in the field.Methods:Relevant research on machine learning in traditional medicine extracted from the Web of Science Core Collection database.Bibliometric analysis and visualization were performed using the Bibliometrix package in R software.Global trends,source journals,authorship,and thematic keywords analysis were performed in this study.Results:From 2012 to 2022,a total of 282 publications on machine learning in traditional medicine were identified and analyzed.The average annual growth rate of the publications was 13.35%.China had the largest contribution in this field(53.9%),followed by the United States(32.6%).IEEE Access had the largest number of published articles,with a total of 15 articles.Calvin Yu-Chian Chen,Xiao-juan Hu and Jue Wang were the main researchers in this field.Shanghai University of Traditional Chinese Medicine and University of California,San Francisco were the main research institutions.Conclusion:This study provides information on research trends in machine learning in traditional medicine to better understand research hotspots and future developments in this field.According to current global trends,the number of publications in this field will gradually increase.China currently dominated the field.Applied research of machine learning techniques may be the next hot topic in this field and deserves further attention.

小儿推拿联合中医护理在婴幼儿运动发育迟缓康复中的应用

目的 探究小儿推拿联合中医护理在婴幼儿运动发育迟缓康复治疗中的临床效果。方法 选取聊城市人民医院2021年12月—2022年2月收治的68例运动发育迟缓患儿作为研究对象,随机分成对照组和试验组,各34例。对照组予常规治疗和护理,试验组在对照组基础上予小儿推拿联合中医护理干预,比较2组患儿干预前后的粗大运动发育商(GMQ)、精细运动发育商(FMQ)和总体发育商(TMQ)变化情况。结果 干预前,2组患者的GMQ、FMQ、TMQ评分比较,差异无统计学意义(P>0.05);干预后,试验组患者的GMQ、FMQ、TMQ评分均显著高于对照组,差异有统计学意义(P<0.05)。结论 小儿推拿联合中医护理应用于婴幼儿运动发育迟缓康复的临床效果显著,可有效提高患儿的运动发育水平,改善生活质量,值得在临床推广。

科学基金稳定支持中医药基础研究创新发展

本文聚焦科学基金在中医药基础研究创新发展中的支撑和引领作用,系统梳理了医学科学部成立以来对中医药基础研究的支持投入和领域布局,在分析问题和挑战,把握中医药研究时代机遇的基础上,论述了科学基金在中医药基础研究中发挥支撑和引导作用,并,对未来发展进行展望。

发现驱动中医药研究的新范式

发挥中医药原创优势、推动我国生命科学实现创新突破是国家需求,但如何挖掘中医药的原创优势,还需要进一步提升思想认知,用现代科学解读中医药学原理。本文在建国以来中医药实证性研究的基础上,正本清源,传承精华,厘清中医学中未加工事实与理性推演之间的关系,发现其中的科学事实;阐幽明微,守正创新,应用现代科学技术,发现中医理论与效应的独特原创优势,从中医出发为医学与生命科学做贡献,解决生物医药“卡脖子”问题两方面,面向未来,列举例证,发现驱动中医药研究的新范式:在厘清古籍医学事实、明确中医药临床效应的基础上,深入研究中国医学中尚不能被现代医学解释的独特生物学现象和过程,以期揭示新的生理现象、阐释新的病理机制、创建新的治疗策略,更加充分地发挥中医药原创优势,推动我国生物医学实现创新突破。

2022年NSFC心血管领域中、西医申请资助情况分析

系统梳理分析2022年国家自然科学基金心血管领域中、西医学面上项目、青年科学基金项目和地区科学基金项目3类常规项目的申请和资助情况、所涉及主要病种、研究热点和研究思路。结果显示,两个领域研究的主要病种相似,研究热点也基本一致。均以动脉粥样硬化、冠心病、心力衰竭、高血压、继发性心肌损伤和心律失常为主,主要开展表观遗传学、外泌体、细胞焦亡或铁死亡、细胞自噬、肠道微生物群以及线粒体功能方面的研究,思路呈现多样化的特点。但西医心血管领域的病种更为广泛,还包括心脏移植等中医心血管领域不涉及的病种。在科学问题导向和研究内容方面,中医心血管领域要求在中医药理论的指导下,以解决中医学科的关键科学问题为导向,体现中医药的特色。此外,研究热点只是探索科学问题的技术手段,应深入凝练科学问题,避免盲目追求结合研究热点反而缺乏了创新性思想和科学依据,鼓励原创性基础研究。

以效为标·以数为据·以调为治——论中医学的数据科学思维

中医学的本质是追求人与自然的统一和健康平衡,是人类智慧与疾病对抗并寻找和逼近健康解决方案中最优解的过程。中医学持续的生命力源于对临床疗效的追求、从大量复杂数据中寻找促进健康的证据,以及调整健康状态的干预模式。中医学的诊疗模式本身就蕴含着数据科学思维,体现了以数据驱动的决策模式,是一种天然基于数据的科学。

针灸专业学术型研究生培养之问题及策略

针灸是中医走向世界的先行官。随着中医的认可度越来越高,国际上迫切需要大量针灸学专业的高端人才。我国医学研究生分为学术型和专业型。专业型研究生教育与住院医师规范化培训并轨,四证合一的模式使其成为众多医学生的首要选择;针灸学专业学术型研究生的培养模式尚不成熟且无统一标准,严重影响学生报考的积极性和针灸科研学术的未来发展。如何使针灸学专业学术型研究生提高创新能力,成为当下亟待解决的重要问题。文章就学术型研究生培养中遇到的问题进行商榷,旨在为针灸学专业学术型研究生培养提供一些对策,从而提升针灸学专业学术型研究生科研、教学以及临床等方面的能力。

中华优秀传统文化融入新时代青年大学生培养实践——以四川文理学院为例

教育的功能在于人格塑造,促进人生成长.将中华优秀传统文化融入新时代青年大学生培养,引领青年大学生坚定文化自信、涵养人文情怀、强化责任担当,推动中华优秀传统文化的创造性转化和创新性发展.作为一项系统工程,四川文理学院创新开展“三融入”体系建设,将中华优秀传统文化融入课程体系、校园文化、实践活动等,丰富教育载体,创新开展方式,培养德智体美劳全面发展的高素质应用型复合型人才.

儒家“藏礼于器”思想的伦理审视及当代启示

“藏礼于器”思想是儒家科技伦理思想的核心内容,同时也是我国古代造物制器的基本法则。在“藏礼于器”思想影响下,“器物”成为“礼制”的指示器和强化剂,二者呈现出一种双向互构的关系:一方面,器物是礼制的物化形态,器物的设计与使用要遵循礼制规定,礼制在器物中以物化的形态得以显现,另一方面,器物反作用于礼制,对礼制具有强化作用,发挥着重要的“无言之教”的道德教化功能。“藏礼于器”思想是极具中国文化特色的科技伦理思想资源,对于当代构建科技伦理治理的中国话语体系具有重要参考价值,经过创造性转化与创新性发展,仍然能够对当今科技伦理治理发挥一定的指导作用。

以三伏贴为例探究中医药科普现状及其提升路径

[目的]以三伏贴为例,调查居民中医药科普知识现状及其影响因素,为制定中医药科普宣教策略与方法提供科学建议。[方法]采用网络调查问卷及Logistic回归分析法,研究居民对三伏贴的认知、行为、意愿及影响因素,探讨中医药科普的有效策略及方法。[结果]居民对其治病类型的认知正确率分别为支气管炎或慢性阻塞性肺疾病(22.9%)、鼻炎(21.4%)、保健和增强免疫力(19.3%);对治疗方式的认知正确率分别为医保可报销(35.0%)和每疗程用药次数(20.3%);只有7.8%居民曾有治疗体验;获取知识途径单一,主要为口口相传(26.6%)和网络(22.6%)。治病类型认知正确率的最大促进因素为基础疾病患者,其比值比(odds ratio,OR)为2.44(P<0.05);治疗方式认知正确率的促进因素有女性(OR=1.70,P<0.01)和参保人员(OR=2.41,P<0.01)。居民知识需求率为71.7%,60岁及以上老年人为100%,国内外科普宣教认同率为78.2%和80.0%。[结论]居民三伏贴科普知识及应用水平较低,但治疗意愿、知识需求及科普宣教认同率较高。建议加大特定疗法的微观宣教,以女性、基础病患者、参保居民与老年人为突破口,扩大科普宣教的受众人群,开拓多元化科普宣教路径,进行科普宣教的精准施策,从而提高居民健康素养,助力健康中国。

以培养动手能力为主的针灸学教学方法探讨

通过以培养临床本科生动手实践能力为主的针灸学教学方法,让学生更好地掌握中医针灸理论知识及操作技术,为加强以后中西医之间的交流及合作打好基础。该教学模式通过在临床实习过程中让学生模拟、代入医生角色,展开针灸诊断及治疗操作,激发了学生强烈的学习兴趣,培养了临床学生从不主动学习针灸知识转向主动学习的能力,同时增强了学生的责任心及使命感,达到了培养其独立自主创新学习能力的目的,取得了较好的教学效果,也为以后中西临床诊疗合作打下基础。

高等中医药院校西医内科学教学的创新探索

在高等中医药院校中医专业的学习中,西医内科学亦为重要的临床专业课程之一,但西医内科学教学面临与中医课程交叉、课时压缩、学生基础薄弱等相应问题,增加了该课程的学习难度。随着现代社会对医学人才的要求不断提高,中医药院校的临床专业学生也必须掌握西医的理论基础和临床疾病。为了贯彻国家“新医科”建设,提高中医专业西医内科学教学水平,提升本科生分析及解决临床问题的能力,笔者所在教研室总结出内科专业主讲教师+教学秘书责任制、现代化教学手段+问题/病例切入式教学、充分利用现代网络和床旁教学等不同教学模式,在实际运用中取得了很好的教学效果,得到授课教师和学生的广泛认可。文章就相关教学经验进行总结,以期为中医药院校本科生的西医内科学教学提供一定的有益建议,提高本科生的西医内科学教学水平。

岭南乡村居民中医药文化认知需求现状问题与对策——基于广州市从化区江埔街道科普调研的思考

党的十八大以来,习近平总书记高度重视中医药发展,党中央把中医药发展上升为国家战略。岭南乡村作为中医药文化根植的沃土,也是新时代背景下反映农村居民在中医药文化背景、认知、情感、行为方面现状与问题的缩影。为全面了解当前中医药文化认知需求现状,发掘其面临的突出问题与成因,提升中医药基层科普的活力与发展前景,该项目组通过现场问卷调查、知识竞赛、深度访谈,对岭南地区的中医药文化乡村传承发展现状进行了深入的调查。结果显示,乡村居民对中医药文化的认知度较低,而需求度较高。文章针对上述问题,提出因人、因地、因时制宜的对策与建议。