Grouting theories and technologies for the reinforcement of fractured rocks surrounding deep roadways

Grouting is an effective method to improve the integrity and stability of fractured rocks that surround deep roadways.After years of research and practice,various theories and a complete set of grouting technologies for deep roadways with fractured rocks have been developed and are widely applied in Chinese coal mining production.This paper systematically summarizes and analyzes the research results concerning the theory,design,materials,processes,and equipment for the grouting and reinforcement of fractured rocks surrounding deep roadways.Specifically,in terms of grouting methods,pregrouting,groutingwhile-excavation,and postgrouting methods are explored;in terms of grouting theory,backfill grouting,compaction grouting,infiltration grouting,and fracture grouting theories are studied.In addition,this paper also studies grouting borehole arrangement,water-cement ratio,grouting pressure,grouting volume,grout diffusion radius,and other grouting parameters and their determination methods.On this basis,this paper explores the physical and mechanical properties of organic and organic-inorganic composite grouting materials,and assess grouting reinforcement quality testing methods and instruments.Taken as the field cases,the application of pregrouting in front of heading faces,groutingwhile-excavation,and postgrouting in the Kouzidong coal mine are then introduced,and the effects of the grouting reinforcements are evaluated.This paper proposes a development direction for grouting technology based on problems existing in the grouting reinforcement of fractured rocks surrounding deep roadways.

A Study on Advertisements in The Chinese Recorder and Missionary Journal

The Chinese Recorder and Missionary Journal is one of the most valued English literature in China’s history of Christianity and the key publications of missionaries from the second half of the 19th Century to the first half of the 20th Century.The advertisements in it have not been properly stressed by the academic world,most of which are even deleted in the bound volumes.This paper aims to give a preliminary study on the advertisements in Chinese Recorder and Missionary Journal,comparing and analyzing advertisers,slogans and text structures and appeal methods of advertisements of shipping,banking,schools and book introduction in Chinese Recorder and Missionary Journal,thus demonstrating its significance in China’s modern advertising industry and Sino-western commercial trade and cultural exchange.

The Historical Fiction Based on True Stories:An Analysis of the Menghui Gushu by Huang Jianhua with the Aid of Historical Records and Archaeological Objects of Art

The Gushu Chuanqi[Legend of Ancient Shu]trilogy is historically grounded,although it is largely fictional.Five characteristics of the society represented in the trilogy,i.e.,walled cities,sacred statues,silk fabrics,burials,and pottery,were examined with the aid of related historical records and archaeological objects of art unearthed in Sichuan.This paper made a comparative study of these things with their respective textual descriptions in the Menghui Gushu[Ancient Shu Revisited in the Dream],the first volume of the Gushu Chuanqi[Legend of Ancient Shu]trilogy by Huang Jianhua.The results support the assertion that the trilogy is not a free interpretation of history but historical fiction based on true stories.

Constructing Large Scale Cohort for Clinical Study on Heart Failure with Electronic Health Record in Regional Healthcare Platform:Challenges and Strategies in Data Reuse

Regional healthcare platforms collect clinical data from hospitals in specific areas for the purpose of healthcare management.It is a common requirement to reuse the data for clinical research.However,we have to face challenges like the inconsistence of terminology in electronic health records (EHR) and the complexities in data quality and data formats in regional healthcare platform.In this paper,we propose methodology and process on constructing large scale cohorts which forms the basis of causality and comparative effectiveness relationship in epidemiology.We firstly constructed a Chinese terminology knowledge graph to deal with the diversity of vocabularies on regional platform.Secondly,we built special disease case repositories (i.e.,heart failure repository) that utilize the graph to search the related patients and to normalize the data.Based on the requirements of the clinical research which aimed to explore the effectiveness of taking statin on 180-days readmission in patients with heart failure,we built a large-scale retrospective cohort with 29647 cases of heart failure patients from the heart failure repository.After the propensity score matching,the study group (n=6346) and the control group (n=6346) with parallel clinical characteristics were acquired.Logistic regression analysis showed that taking statins had a negative correlation with 180-days readmission in heart failure patients.This paper presents the workflow and application example of big data mining based on regional EHR data.

Primary tumor location and survival in colorectal cancer: A retrospective cohort study

BACKGROUND Primary tumor location is a prognostic factor for metastatic colorectal cancer(m CRC).Post hoc analyses of m CRC clinical trials,including FIRE-3,CALGB/SWOG 80405,suggest that primary tumor location is also predictive of survival benefit with cetuximab or bevacizumab in combination with 5-fluorouracil-based chemotherapy.AIM Evaluate prognostic/predictive roles of primary tumor location in real-world m CRC patients treated with cetuximab or bevacizumab plus 5-fluorouracil-based chemotherapy.METHODS This retrospective cohort study selected patients with KRAS wild-type m CRC who initiated first-line therapy with cetuximab or bevacizumab in combination with 5-fluorouracil/leucovorin/irinotecan(FOLFIRI)or 5-fluorouracil/leucovorin/oxaliplatin(FOLFOX)between January 2013 and April 2017 from the Flatiron Health electronic health record-derived database of de-identified patientlevel data in the United States.Primary tumor location was abstracted from patients’charts.Left-sided primary tumor location(LPTL)was defined as tumors that originated in the splenic flexure,descending colon,sigmoid colon,or rectum;right-sided primary tumor location(RPTL)was defined as tumors that originated from the appendix,cecum,ascending colon,hepatic flexure,or transverse colon.Propensity score matching was used to balance the baseline demographic and clinical characteristics between patients treated with cetuximab and patientstreated with bevacizumab.Kaplan-Meier and Cox regression methods were used for survival analyses.RESULTS A total of 1312 patients met the selection criteria.Of 248 cetuximab plus FOLFIRI or FOLFOX patients,164 had LPTL and 84 had RPTL;of 1064 bevacizumab plus FOLFIRI or FOLFOX patients,679 had LPTL and 385 had RPTL.Cetuximab LPTL and RPTL patients were more likely to receive FOLFIRI vs bevacizumab patients(LPTL:64.0%vs 24.3%;RPTL:76.2%vs 24.9%,P<0.001).Stage at initial diagnosis was different between cetuximab RPTL vs bevacizumab RPTL patients(P<0.001);cetuximab RPTL patients were more likely to have stage III disease(44.0%vs 22.6%),while bevacizumab RPTL patients were more likely to have stage IV disease(65.7%vs 48.8%).Cetuximab RPTL patients were more likely to have a documented history of adjuvant chemotherapy vs bevacizumab RPTL patients(47.6%vs 22.3%,P<0.001).In the propensity score-matched sample,median overall survival(OS)was 29.7 mo(95%CI:26.9-35.2)for LPTL patients vs 18.3 mo(95%CI:15.8-21.3)for RPTL patients(P<0.001).Median OS was 29.7 mo(95%CI:27.4-NA)for cetuximab LPTL patients vs 29.1 mo(95%CI:26.6-35.6)for bevacizumab LPTL patients(HR=0.87;95%CI:0.63-1.19;P=0.378)and 17.0 mo(95%CI:12.0-32.6)for cetuximab RPTL patients vs 18.8 mo(95%CI:15.8-22.3)for bevacizumab RPTL patients(HR=1.00;95%CI:0.68-1.46;P=0.996).The interaction of treatment and primary tumor location was not significant in the Cox regression.CONCLUSION In this real-world m CRC cohort,the prognostic role of primary tumor location was substantiated,but not the predictive role for treatment with cetuximab vs bevacizumab in combination with 5-fluorouracil-based chemotherapy.

Visual response characteristics of neurons in the second visual area of marmosets

The physiological characteristics of the marmoset second visual area(V2) are poorly understood compared with those of the primary visual area(V1). In this study, we observed the physiological response characteristics of V2 neurons in four healthy adult marmosets using intracortical tungsten microelectrodes. We recorded 110 neurons in area V2, with receptive fields located between 8° and 15° eccentricity. Most(88.2%) of these neurons were orientation selective, with half-bandwidths typically ranging between 10° and 30°. A significant proportion of neurons(28.2%) with direction selectivity had a direction index greater than 0.5. The vast majority of V2 neurons had separable spatial frequency and temporal frequency curves and, according to this criterion, they were not speed selective. The basic functional response characteristics of neurons in area V2 resemble those found in area V1. Our findings show that area V2 together with V1 are important in primate visual processing, especially in locating objects in space and in detecting an object's direction of motion. The methods used in this study were approved by the Monash University Animal Ethics Committee, Australia(MARP 2009-2011) in 2009.

Roles of Case Studies and Case Reports in US East Asian Medicine:A Narrative-Medicine Perspective

Recorded stories of the clinical encounter stretch back to ancient times.Throughout their history,these narratives have been called by different names,reflecting changes in format,function,and audience.This paper examines and explains the differences in two related forms of clinical writing as practiced by East Asian Medicine clinicians in the United States today-the case study and the case report.Each has its strengths and weaknesses;each is suited to different roles.The case study is ideal for education and the practice of narrative medicine,whereas the case report has played a vital role in propelling East Asian Medicine into the arena of modern scientific research.

Recording the direct surgeon’s view with an operating microscopic view improves microscopic ophthalmic surgery training

AIM:To establish a recording system with a direct view of the surgeon to supplement video recording under an operating microscope,which lacks information on the movement and position of the surgeon’s hands,and to facilitate the reproduction of a skilled surgeon’s technique by a surgeon in training.METHODS:A small camera was attached to the operating microscope with a custom adapter.Microscopic surgeon’s view and direct surgeon’s view through this new camera were recorded in the surgical recording system.Both movies were synchronized and analyzed how do surgeons handle the instruments.RESULTS:A small camera attached to the operating microscope allowed the surgeon’s hands motion to be recorded without interfering with the surgeon’s movements.Different surgeons used different methods to manipulate the ultrasound handpiece and the irrigation/aspiration device.Even in the simple paracentesis procedure,different surgeons used different methods.Surgeons-in-training were able to identify and improve their weaknesses by watching synchronized movies of their hand motions and microscopic view.CONCLUSION:Simultaneous recording the surgical field out of the operating microscopic view by a small camera set on the microscope is comprehensive and improves surgeons-in-training understanding and learning surgeries.

J-Grof法直接胆红素测定中的间接胆红素反应动力学研究

目的：研究间接胆红素在Ｊ－Ｇｒｏｆ法直接胆红素测定中的反应动力学问题。方法：配制胆红素标准液，考察Ｂｕ（未结合胆红素或称间接胆红素）在直接反应中其反应率与稀释液酸度、蛋白质基质、预保温时间、偶氮反应时间、反应温度及Ｂｕ浓度之间的关系。结果：当稀释液酸度ｐＨ在２．０～５．０范围时，间接胆红素在Ｊ－Ｇｒｏｆ法直接反应中反应成直接胆红素的值达一平台。标本在稀释液中预保时间越短，Ｂｕ的直接反应的反应率越高，反应温度越高，偶氮反应时间越长，Ｂｕ的直接反应的反应率越高。在无稀释液时，在一定温度和偶氮反应时间下，Ｂｕ在Ｊ－Ｇｒｏｆ法直接反应中的反应率（ｘ）与其浓度Ｃ的关系基本符合ｘ＝ＡＣ－ｋ。结论：ｘ＝ＡＣ－ｋ很好地说明间接胆红素在Ｊ－Ｇｒｏｆ法直接反应中的反应率与其浓度的关系。

Upper gastrointestinal endoscopy:Are preparatory interventions or conscious sedation effective? A randomized trial

AIM: The fears and concerns are associated with gastroscopy (EGD) decrease patient compliance. Conscious sedation (CS) and non-pharmacological interventions have been proposed to reduce anxiety and allow better execution of EGD. The aim of this study was to assess whether CS, supplementary information with a videotape, or presence of a relative during the examination could improve the tolerance to EGD. METHODS: Two hundred and twenty-six outpatients (pts), scheduled for a first-time non-emergency EGD were randomly assigned to 4 groups: Co-group (62 pts): throat anaesthesia only; Mi-group (52 pts): CS with i.v. midazolam; Re-group (58 pts): presence of a relative throughout the procedure; Vi-group (54 pts): additional information with a videotape. Anxiety was measured using the “Spielberger State and Trait Anxiety Scales” The patients assessed the overall discomfort during the procedure on an 100-mm visual analogue scale, and their tolerance to EGD answering a questionnaire. The endoscopist evaluated the technical difficulty of the examination and the tolerance of the patients on an 100-mm visual analogue scale and answering a questionnaire. RESULTS: Pre-endoscopy anxiety levels were higher in the Mi-group than in the other groups (P<0.001). On the basis of the patients' evaluation, EGD was well tolerated by 80.7% of patients in Mi-group, 43.5% in Co-group, 58.6% in Regroup, and 50% in Vi-group (P<0.01). The discomfort caused by EGD, evaluated by either the endoscopist or the patients, was lower in Mi-group than in the other groups. The discomfort was correlated with “age” (P<0.001) and “groups of patients” (P<0.05) in the patients' evaluation, and with “gender” (females tolerated better than males, P<0.001) and “groups of patients” (P<0.05) in the endoscopist's evaluation. CONCLUSION: Conscious sedation can improve the tolerance to EGD. Male gender and young age are predictive factors of bad tolerance to the procedure.

Prevalence of Family History of Cancer among Gastric Cancer Patients at Brazilian National Cancer Institute

Background: Gastric cancer is the third most incident malignancy and the fifth leading cause of death in the world. In Brazil, it is the fourth most common tumour in men and the fifth in women. Familial aggregation of this tumour is being studied and discussed by experts. Aim: Determine the frequency of family history of cancer in patients with gastric cancer, suggesting familial aggregation or increased risk for hereditary cancer syndromes. Methods: This is a retrospective cross-sectional study carried out from January 2011 to March 2015 at the Department of Abdominal and Pelvic Surgery of the Brazilian National Cancer Institute (INCA). Data were collected from electronic medical records and analyzed using SPSS Statistics? version 20. Results: 873 patients with gastric adenocarcinoma were analyzed. A family history of cancer was reported by 451 patients (51.6%), which reported cancer in 878 relatives, of which 110 (12.6%), reported having more than three relatives with any type of cancer. The most prevalent malignancies among these relatives were gastric cancer (21.3%) and breast cancer (9.5%). Conclusion: Most of the patients had cancer family history, being gastric cancer the most common. The high percentage of cancer family history confirms the importance of collecting this information, whose lack reflects professional negligence, as family history study can serve as a low-cost tool, favoring prevention and early diagnosis, situations where morbidity and mortality are smaller, thus reducing health costs and assistance and preserving lives.

Prospectively Recording Errors Is Valuable in Reducing Complications

Errors have traditionally been a less commonly discussed topic but are becoming increasingly examined due to a trend towards expanded awareness about the high human and financial cost of errors in medicine. Recording and reporting of errors has been a difficult issue in the health sector due to fear of litigation from patients, complaint to governing bodies, and embarrassment from colleagues. In this article we examine the advantages of prospective error recording. The studies on this subject report that the culture of prospective error recording is of high value in improving most parameters of errors and may indeed reduce complications.

Efficacies of Different Methods of Teaching Transcultural Nursing Practice in China

Purpose： This study assessed the effectiveness of three teaching methods for developing cultural competency based upon Leininger＇s theoretical framework with nursing students in China： case studies, traditional didactic learning, and self-directed learning. These methods were used in tran- scultural nursing teaching practices to identify the method that resulted in the greatest improve- ments in the nursing student＇s understanding and clinical application of transcultural nursing. Methods： The Transcultural Nursing Questionnaire（TNQ） was used for pre-and post-test comparisons of all participants in four areas of cultural knowledge and the Evaluation of Transcultural Nursing Competency（ETNC） was applied via role-play to evaluate the cultural competency of 120 of the 305 participants from three general hospitals in the PuDong New District, Shanghai, China. Individual transcultural nursing courses that focused on case study, traditional didactic or self-di- rected methods persisted for four months in three hospitals. Results： Statistical analyses of the cognitive scores of the participants in the transcultural nursing courses revealed a significant difference（P〈0.01） between scores collected before and after the teaching with the three methods. Comparisons of the three hospitals revealed that the scores for transcultural nursing cognition and simulating service assessment were significantly different（P〈0.01） for the case study nursing students. The scores of the students who were taught with the traditional didactic and self-directed methods were not significantly different across the three hospitals（P〉0.05）. Conclusion： The results revealed that the case study, traditional didactic and self-directed method effectively improved the transcultural nursing cognitive levels of the nursing students. The case study method appeared to be the most effective approach based upon the TNQ pre-and post-tests and the ETNC cultural competency scores.

Study on the optical system for the record of the pulsed acoustic field and the scattering of the cylindrical-like objects buried in underwater sand

The response of the two working mode of the optical systems, the schlieren mode and shadowgraph mode, for taking of optical photograph of the pulsed acoustic field in liquid are studied. It shows that, the response of the optical intensity on the screen to the acoustic pressure is linear for shadowgraph mode and nonlinear for the schlieren mode. Because the function of shadowgraph mode has no limit on working frequency, it is suitable for the studies of the acoustic field of laboratory model of the seabed or the buried objects at low ultrasonic range. The ultrasonic pulse scattered by the cylindrical-like objects buried in underwater sand was studied experimentally by the shadowgraph mode at low ultrasonic frequency. There are five kinds of the scattered waves from the half-buried object and three kinds of the waves from the full-buried objects were recorded. The two kinds of creeping waves (the longitudinal wave and the shear wave of the object) appear in both of the two cases.

美国汉学刊物与中国文化的海外传播

学术刊物是美国汉学成果发表与传播的重要媒介,其创办进程一定程度上呈现了汉学史发展脉络,推动了汉学的纵深发展。以汉学刊物为窗口,可以透视美国汉学的阶段性特点。根据时间的历史坐标,美国汉学刊物大致可以分为如下阶段:传教士时期,以《中国丛报》与《教务杂志》为代表;本土化与分化时期,以各学会会刊为典型;当代学科细分化时期,以《中国文学》为代表。不同时期的汉学刊物体现了特定的创刊理念与发展思路。分析代表性的汉学刊物,可以为推进整体的美国汉学史研究提供方向和指南。

有机玻璃管道直接水锤压力特性试验研究

为了了解黏弹性管道的水锤压力特性,文中通过搭建水库-管道-阀门系统模型,进行了系列关阀水锤试验,针对有机玻璃管道中末端阀门初始开度分别为30%,100%时关阀产生的直接水锤压力变化规律进行了研究,从黏弹性材料的本构关系角度分析了关阀时间对黏弹性材料直接水锤的影响机理,并对2种不同初始开度下阀门附近的流场进行了三维数值模拟.研究结果表明:黏弹性管道中直接水锤压力变化规律与传统的水锤理论不符,直接水锤压力不仅与阀门的关闭时间有关,还与阀门的初始开度有关,满足“阀门关闭越快,直接水锤压力越大”与“阀门初始开度越小,直接水锤压力越大”的规律.

刘光蕡《史记·太史公自序注》的评注内容、方式及特点

刘光蕡《史记·太史公自序注》是清末《史记》研究的重要文献,其评注内容广泛,有评论史家之职、评论《史记》的性质、阐释注解《论六家要指》、评《春秋》与《史记》关系、评《史记》体例、评笔法、评列传的安排及主旨等。评注方法形式多样,就评注结构而言,有篇前总评、篇中夹评、篇末结评;从评注方法而言,有阐释、释义、辨疑。评注特点鲜明突出,评论注重“治道”,推崇孔子之道,以“道”贯穿《太史公自序》评注始终,评注创见新论较多,值得关注。

论朱熹对《史记》的研读与传播

朱熹对司马迁与《史记》,既有肯定,也有批评。他称赞司马迁敢于秉笔直书的史学精神,并从体例、史料价值等方面对《史记》进行客观评价。在研读《史记》过程中,对《史记》记载失实的地方进行了批评,记载错误的地方进行了精心校勘。为了反对浙东学派推崇《史记》,朱熹对《史记》进行了刻意批评。正是在这种矛盾的心理状态下,在书院的教学中,他时而鼓励学生学习研读《史记》,时而又反对学习《史记》。朱熹对《史记》的研究与传播,与他的理学思想、南宋书院的发展和印刷业的发达等文化背景分不开。

管理研究中的质性元分析方法:适用问题、操作策略与应用展望

以往管理领域的元分析研究重点关注定量元分析方法的使用,导致众多质性研究结论未得到有效的整理与提炼,而质性元分析作为对质性研究进行整合的方法,能够有效解决以往管理质性研究之间存在的孤岛现象,旨在构建一般性的管理理论。鉴于此,首先,介绍了质性元分析方法的内涵、认识论基础和相较其他研究方法的优势。在此基础上,回顾以往研究,归纳总结了该方法目前的应用现状,包括适用的研究问题和规范的操作策略。最后,从问题、操作和方法3个方面提出了未来管理研究中质性元分析方法的应用前景。

“通过自然学习科学”的Nature-study教育方法的探索

Nature-study是一种基于直接经验、通过与自然的互动而学习科学的方法。它从学习自然的角度强调了学生与自然的互动;从直接获取经验的角度强调了户外活动;从以人为本的角度,强调了学生的兴趣。达到将非正式的学习融入课堂中,以更注重经验的、直接获取的方式,让老师站在协助者的位置上完成"通过自然学习科学"的目的。因此,通过对Nature-study开展历史研究,收集和分析其相关文献,绘制Nature-study的教育观点并提取其方法将对当今的科学教育有着重要的意义。