Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

The eye,a complex organ isolated from the systemic circulation,presents significant drug delivery challenges owing to its protective mechanisms,such as the blood-retinal barrier and corneal impermeability.Conventional drug administration methods often fail to sustain therapeutic levels and may compromise patient safety and compliance.Polysaccharidebased microneedles(PSMNs)have emerged as a transformative solution for ophthalmic drug delivery.However,a comprehensive review of PSMNs in ophthalmology has not been published to date.In this review,we critically examine the synergy between polysaccharide chemistry and microneedle technology for enhancing ocular drug delivery.We provide a thorough analysis of PSMNs,summarizing the design principles,fabrication processes,and challenges addressed during fabrication,including improving patient comfort and compliance.We also describe recent advances and the performance of various PSMNs in both research and clinical scenarios.Finally,we review the current regulatory frameworks and market barriers that are relevant to the clinical and commercial advancement of PSMNs and provide a final perspective on this research area.

Nonuniform Dependence on the Initial Data for Solutions of Conservation Laws

In this paper,we study systems of conservation laws in one space dimension.We prove that for classical solutions in Sobolev spaces H^(s),with s>3/2,the data-to-solution map is not uniformly continuous.Our results apply to all nonlinear scalar conservation laws and to nonlinear hyperbolic systems of two equations.

On the Use of Monotonicity-Preserving Interpolatory Techniques in Multilevel Schemes for Balance Laws

Cost-effective multilevel techniques for homogeneous hyperbolic conservation laws are very successful in reducing the computational cost associated to high resolution shock capturing numerical schemes.Because they do not involve any special data structure,and do not induce savings in memory requirements,they are easily implemented on existing codes and are recommended for 1D and 2D simulations when intensive testing is required.The multilevel technique can also be applied to balance laws,but in this case,numerical errors may be induced by the technique.We present a series of numerical tests that point out that the use of monotonicity-preserving interpolatory techniques eliminates the numerical errors observed when using the usual 4-point centered Lagrange interpolation,and leads to a more robust multilevel code for balance laws,while maintaining the efficiency rates observed forhyperbolic conservation laws.

Distribution law and susceptibility of geohazards across a gradient belt of the Western Sichuan Plateau

Across a gradient belt of the Western Sichuan Plateau,geohazards have seriously limited economic and social development.According to incomplete statistics,15,673 geohazards have been recorded in the study area.In order to mitigate the threat of geohazards to human engineering activities in the region,an overall understanding of the distribution pattern of geohazards and susceptibility assessment are necessary.In this paper,a gradient belt of the Western Sichuan Plateau and its zoning criteria were defined.Subsequently,on the basis of relief amplitude,distance to faults,rainfall,and human activities,three indicators of endogenic process were introduced:Bouguer gravity anomaly gradient,vertical deformation gradient,and horizontal deformation gradient.Thereafter,the distribution patterns of geohazards were investigated through mathematical statistics and ArcGIS software.By randomly selecting 10,449 hazards,a geohazard susceptibility map was generated using the Information Value(IV)model.Finally,the IV model was validated against 5224 hazards using the Area Under Curve(AUC)method.The results show that 47.6%of the geohazards were distributed in the zone of steep slope.Geohazards showed strong responses to distance to faults,human activities,and annual rainfall.The distribution of geohazards in the gradient belt of the Western Sichuan Plateau is more sensitive to vertical internal dynamics factors(such as vertical deformation gradient and Bouguer gravity anomaly gradient)without any apparent sensitivity to horizontal internal dynamics factors.The areas of high and very-high risk account for up to 32.22%,mainly distributed in the Longmenshan and Anning River faults.According to the AUC plot,the success rate of the IV model for generating the susceptibility map is 76%.This susceptibility map and geohazard distribution pattern can provide a reference for geological disaster monitoring,preparation of post-disaster emergency measures,and town planning.

Nuclear magnetic resonance experiments on the time-varying law of oil viscosity and wettability in high-multiple waterflooding sandstone cores

A simulated oil viscosity prediction model is established according to the relationship between simulated oil viscosity and geometric mean value of T2spectrum,and the time-varying law of simulated oil viscosity in porous media is quantitatively characterized by nuclear magnetic resonance(NMR)experiments of high multiple waterflooding.A new NMR wettability index formula is derived based on NMR relaxation theory to quantitatively characterize the time-varying law of rock wettability during waterflooding combined with high-multiple waterflooding experiment in sandstone cores.The remaining oil viscosity in the core is positively correlated with the displacing water multiple.The remaining oil viscosity increases rapidly when the displacing water multiple is low,and increases slowly when the displacing water multiple is high.The variation of remaining oil viscosity is related to the reservoir heterogeneity.The stronger the reservoir homogeneity,the higher the content of heavy components in the remaining oil and the higher the viscosity.The reservoir wettability changes after water injection:the oil-wet reservoir changes into water-wet reservoir,while the water-wet reservoir becomes more hydrophilic;the degree of change enhances with the increase of displacing water multiple.There is a high correlation between the time-varying oil viscosity and the time-varying wettability,and the change of oil viscosity cannot be ignored.The NMR wettability index calculated by considering the change of oil viscosity is more consistent with the tested Amott(spontaneous imbibition)wettability index,which agrees more with the time-varying law of reservoir wettability.

Two innovative equivalent statements of the third law of thermodynamics

It is found from textbooks and literature that there are three different statements for the third law of thermodynamics,i.e., the Nernst theorem, the unattainability statement of absolute zero temperature, and the heat capacity statement. It is pointed out that such three statements correspond to three thermodynamic parameters, which are, respectively, the entropy,temperature, and heat capacity, and can be obtained by extrapolating the experimental results of different parameters at ultralow temperatures to absolute zero. It is expounded that because there is no need for additional assumptions in the derivation of the Nernst equation, the Nernst theorem should be renamed as the Nernst statement. Moreover, it is proved that both the Nernst statement and the heat capacity statement are mutually deducible and equivalent, while the unattainability of absolute zero temperature is only a corollary of the Nernst statement or the heat capacity statement so that it is unsuitably referred to as one statement of the third law of thermodynamics. The conclusion is that the Nernst statement and the heat capacity statement are two equivalent statements of the third law of thermodynamics.

The Rule of Law is the Most Important Means of Human Rights Protection

Today,we are here to commemorate the 75^(th) anniversary of the adoption of the Universal Declaration of Human Rights.In this Declaration,which consists of only30 articles,seven articles are related to the constitution,law,court,and the rule of law,making it a declaration filled with the rule of law.Coincidentally,today is also the 10^(th) National Constitution Day of China.Nineteen years ago,“the state respects and protects human rights”was enshrined in the Constitution,becoming a constitutional principle.Since then,human rights protection in China has been based on fundamental law.

How to Predict the Temperature of the CMB Directly Using the Hubble Parameter and the Planck Scale Using the Stefan-Boltzmann Law

Based on recent progress in quantum gravity and quantum cosmology, we are also presenting a way to estimate the temperature in the cosmos, the Hubble sphere, from a relation between the Planck temperature and the Hubble scale. Our analysis predicts the Hubble sphere temperature of 2.72 K with the one standard deviation confidence interval between 2.65 K and 2.80 K, which corresponds well with the measured temperature observed from the cosmic microwave background (CMB) of about 2.72 K. This adds evidence that there is a close connection between the Planck scale, gravity, and the cosmological scales as anticipated by Eddington already in 1918.1.

Analysis of the Characterization of the Old Man in“The Law of Life”from the Narrative Perspective

“The Law of Life”is one of Jack London’s representative works,depicting the story of an elderly Native American abandoned by his family,alone and waiting for life to fade away.This paper,based on narrative theory,aims to explore how the author employs narrative techniques to present the image of the old man in the short story.The narrative techniques of dual focalization and dual narrative timelines in the text demonstrate the abandonment of the old man’s homeland and his inescapable death under a naturalistic view of life and reflect a desolate life picture of resignation towards death under naturalistic determinism,depicting a grim elderly world under the naturalistic concept of“survival of the fittest.”Studying this short story helps us reflect on the living conditions of the elderly and provides insights into how to better care for the elderly population amid the global trend of aging.

The Connotations of the Constitutional Clause on Human Rights Protection From the Perspective of Foreign-related Rule of Law

The inclusion of the human rights clause in the Chi-nese Constitution is the core normative manifestation of the constitu-tionalization of human rights,and points to the relationship between international law and the Constitution in the sense of positive law.The inclusion of the human rights clauses in the Chinese Constitution itself is an inherent part of the development of China’s socialist constitution,and socialism has already contributed valuable concepts and practices of human rights protection to the modern world in its early stage.The constitutionalization of human rights protection does not necessarily lead to the superiority of international law over the constitutional order of a country,but rather to the convergence of international law and domestic law through the constitutional order.The relevant rules of international law will be effective only when they are transformed into domestic law through the Constitution and the human rights clause in the Constitution.Correspondingly,the domestic legal order is brought into line with the international legal order through the Con-stitution and its human rights clause.Behind the system of fundamen-tal rights in the constitutional order is the value foundation of the en-tire legal system.The advancement of foreign-related rule of law has brought new opportunities for China’s judicial practice to further pro-mote the protection of human rights.In the future,we should further integrate the human rights values embedded in socialism into China’s constitutional practice,enhance human rights protection around the country,and take a more active part in global human rights gover-nance.

An Empirical Evaluation of the Impact of Moral and Law Course Teaching on the Effectiveness of University Students’Ideals and Beliefs Education

The Moral and Law course serves as a critical platform for educating university students about ideals and beliefs,and it has a significant impact on the effectiveness of ideals and beliefs education.This paper establishes a mechanism through which Moral and Law course teaching influences the effectiveness of ideals and beliefs education and conducts an empirical evaluation.The results reveal that factors such as the relevance and applicability of the teaching content,the integration of theory and practice,the innovation,interactivity,and participation of teaching methods,as well as classroom atmosphere,teaching facilities,and campus culture,all have a significant positive impact on the effectiveness of ideals and beliefs education for university students.

Research on the Application of Juvenile Psychological Development and Sports Acquisition Law System in Physical Education Teaching

Adolescents’physical and mental development has obvious age-stage characteristics.Therefore,before the implementation of physical education teaching,it is necessary to fully analyze the laws of adolescents’psychological development and fully understand the laws of adolescents’physical development and exercise acquisition.The purpose of this study is to start from the actual needs of physical education teaching and to fully understand the laws of psychological development of adolescent groups.After the review and analysis,the law of adolescents’sports acquisition is summarized and summarized,so as to form the system of adolescents’psychological development and sports acquisition law in physical education teaching,lay a good foundation for physical education teachers to implement teaching on the teaching objects of adolescent students in a targeted and efficient manner,and ultimately promote the benign development of school sports.

Cooperative game theory-based steering law design of a CMG system

Spacecraft require a large-angle manoeuvre when performing agile manoeuvring tasks, therefore a control moment gyroscope(CMG) is employed to provide a strong moment.However, the control of the CMG system easily falls into singularity, which renders the actuator unable to output the required moment. To solve the singularity problem of CMGs, the control law design of a CMG system based on a cooperative game is proposed. First, the cooperative game model is constructed according to the quadratic programming problem, and the cooperative strategy is constructed. When the strategy falls into singularity, the weighting coefficient is introduced to carry out the strategy game to achieve the optimal strategy. In theory, it is proven that the cooperative game manipulation law of the CMG system converges, the sum of the CMG frame angular velocities is minimized, the energy consumption is small, and there is no output torque error. Then, the CMG group system is simulated.When the CMG system is near the singular point, it can quickly escape the singularity. When the CMG system falls into the singularity, it can also escape the singularity. Considering the optimization of angular momentum and energy consumption, the feasibility of the CMG system steering law based on a cooperative game is proven.

Broader applicability of the metacoupling framework than Tobler’s first law of geography for global sustainability:A systematic review

Complex sustainability issues in the Anthropocene,with rapid globalization and global environmental changes,are increasingly interlinked between not only nearby systems but also distant systems.Tobler’s first law of geog-raphy(TFL)states“near things are more related than distant things”.Evidence suggests that TFL is not infallible for sustainability issues.Recently,the integrated framework of metacoupling(MCF;human-nature interactions within as well as between adjacent and distant systems)has been applied to analyze the interactions between nearby and distant coupled human and natural systems simultaneously.However,previous work has been scat-tered and fragmented.It is crucial to understand the extent to which TFL and MCF apply across pressing issues in sustainability.Therefore,we reviewed and synthesized sustainability literature that used TFL and MCF across seven major topics:land change,species migration,tourism,trade,agricultural development,conservation,and governance.Results indicate MCF had a much broader applicability than TFL for these topics.The literature using MCF generally did not or likely did not obey TFL,especially in trade,governance,and agricultural de-velopment.In the TFL literature,most topics obeyed TFL,except for species migration and trade.The findings suggest the need to rethink and further test TFL’s relevance to sustainability issues,and highlight the potential of MCF to address complex interactions between both adjacent and distant systems across the world for global sustainability.

Determination of the Henry’s Law Constant of Hexane in High-Viscosity Polymer Systems

The Henry’s law constant of volatiles in polymer systems is a crucial parameter reflecting the gas-liquid equilibrium,which is very important for devolatilization.In this research,polyolefin elastomer(POE)-cyclohexane and polydimethylsiloxane(PDMS)-hexane systems were studied,and the Henry’s law constant was obtained by measuring the gas phase equilibrium partial pressure when polymer solutions containing different mass fractions of volatiles reached a saturated state.The effects of temperature,type of volatiles,and polymer viscosity on the gas phase equilibrium partial pressure and Henry’s law constant of the volatiles were investigated.The results indicate that,with the increase of temperature and polymer viscosity,the gas phase equilibrium partial pressure and Henry’s law constant of volatiles increase.As temperature increases,the solubility of gas in liquid decreases.The relationship between the Henry’s law constant and temperature is consistent with the Arrhenius law.In the PDMS-hexane system,the gas phase equilibrium partial pressure and Henry’s law constant of n-hexane are higher than those of cyclohexane.The obtained Henry’s law constants can be used as a reference for perfecting the devolatilization process and improving the devolatilization effect.

Miscibility of light oil and flue gas under thermal action

The miscibility of flue gas and different types of light oils is investigated through slender-tube miscible displacement experiment at high temperature and high pressure.Under the conditions of high temperature and high pressure,the miscible displacement of flue gas and light oil is possible.At the same temperature,there is a linear relationship between oil displacement efficiency and pressure.At the same pressure,the oil displacement efficiency increases gently and then rapidly to more than 90% to achieve miscible displacement with the increase of temperature.The rapid increase of oil displacement efficiency is closely related to the process that the light components of oil transit in phase state due to distillation with the rise of temperature.Moreover,at the same pressure,the lighter the oil,the lower the minimum miscibility temperature between flue gas and oil,which allows easier miscibility and ultimately better performance of thermal miscible flooding by air injection.The miscibility between flue gas and light oil at high temperature and high pressure is more typically characterized by phase transition at high temperature in supercritical state,and it is different from the contact extraction miscibility of CO_(2) under conventional high pressure conditions.

Optimization and Construction of Collaborative Office under the Background of Smart Campus in Universities

At present, with the continuous development of technologies such as the Internet, big data, and artificial intelligence, smart campuses in universities are being rapidly constructed. Improving the informatization level of administrative management work is also an important content. The collaborative office work in multiple departments requires more standardized, convenient, intelligent, and secure office systems. In response to this issue, this article analyzes the optimization and construction process of collaborative office systems based on the development of university informatization, summarizes the operational results, and explores the prospects of smart office.

Triple reverse order law for the Drazin inverse

In this paper,we investigate the reverse order law for Drazin inverse of three bound-ed linear operators under some commutation relations.Moreover,the Drazin invertibility of sum is also obtained for two bounded linear operators and its expression is presented.

Innovation Analysis of Rural Agricultural Economic Management Model in the Context of the Belt and Road Initiative

[Objectives]To explore innovative strategies for rural agricultural economic development in the context of the Belt and Road Initiative.[Methods]This research adopts the method of literature review and field research,systematically combs the research results related to the Belt and Road Initiative and rural agricultural economic management,and deeply understands the actual situation of rural agricultural economic management.[Results]The research shows that in the context of the Belt and Road Initiative,the rural agricultural economy is facing new development opportunities and challenges,but there are also some problems.In the new period,we should accelerate the innovative development of rural agricultural economy by promoting market-oriented reform,strengthening scientific and technological innovation,optimizing the industrial structure,deepening international cooperation and other measures.The Belt and Road Initiative provides an important opportunity for the innovation of rural agricultural economic management.Rural agricultural economic management should be actively integrated into the Belt and Road construction to improve the level of rural agricultural economic management.[Conclusions]This study provides useful exploration and reference for the innovation of rural agricultural economic management models,which helps to promote the healthy development of rural agricultural economy and achieve the goal of rural revitalization.

Applications of a Single Molecule Theory of Protein Dynamics

A single molecule theory for protein dynamics has been developed since 2012. It consists of the concepts of conformational Gibbs free energy function (CGF) and single molecule thermodynamic hypothesis (STH) that claims that all stable conformations are (local or global) minimizers of CGF. These are enough to give a unified explanations and mechanisms to many aspects of protein dynamics such as protein folding;allostery;denaturation;and intrinsically disordered proteins. Formulas of CGF in water environment had been derived via quantum statistics. Applications of them to soluble proteins are: docking Gibbs free energy difference formula and a practical way to search better docking site;single molecule binding affinity;predicting and explaining why structures of a monomeric globular protein looks like a globule and is tightly packed with a hydrophobic core;a representation of the hydrophobic effect;and a wholistic view to structures of water soluble proteins.